PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3rg9A_

Fold library id	PDB Header	Molecule	Title
c3rg9A_	PDB header: oxidoreductase/oxidoreductase inhibitor	Chain: A: PDB Molecule: bifunctional dihydrofolate reductase-thymidylate synthase;	PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210

Links to external resources
Added to library: Mon Jul 4 03:55:20 2011

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence R P P L R P F S V V V A S D E K G G I G D G G T I P W E I P E D M Q Y F R R V T T N L R G K N V K P S P S K R N A V V M G R K T W D S L P P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S S S
S
S S S S
B T T B S
G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence K F R P L S N R L N V V L S R S A T K E Q L L A G I P D P I K R A E A A N D V V A V N G G L E D A L R M L V S K E H T S S I E T V F C I G G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G S S
T T S
S S
T T
S S G G G S S
T T S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence G T I Y K Q A L C A P C V N V L Q A I H R T V V R P A S N S C S V F F D I P A A G T K T P E G L E L V R E S I T D E R V S T G A G G K K Y Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S T T G G G G S
S S
T T
T T S
S S T T

. . . . . . . .

Sequence F E K L V P R N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	R	P	P	L	R	P	F	S	V	V	V	A	S	D	E	K	G	G	I	G	D	G	G	T	I	P	W	E	I	P	E	D	M	Q	Y	F	R	R	V	T	T	N	L	R	G	K	N	V	K	P	S	P	S	K	R	N	A	V	V	M	G	R	K	T	W	D	S	L	P	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)															T	T					S	S	S	S		S																		S	S	S	S				B	T	T	B														S		G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	K	F	R	P	L	S	N	R	L	N	V	V	L	S	R	S	A	T	K	E	Q	L	L	A	G	I	P	D	P	I	K	R	A	E	A	A	N	D	V	V	A	V	N	G	G	L	E	D	A	L	R	M	L	V	S	K	E	H	T	S	S	I	E	T	V	F	C	I	G	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	S	S		T	T	S							S	S								T	T		S	S								G	G	G					S	S									T	T	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	G	T	I	Y	K	Q	A	L	C	A	P	C	V	N	V	L	Q	A	I	H	R	T	V	V	R	P	A	S	N	S	C	S	V	F	F	D	I	P	A	A	G	T	K	T	P	E	G	L	E	L	V	R	E	S	I	T	D	E	R	V	S	T	G	A	G	G	K	K	Y	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	S	T	T	G	G	G	G											S			S	S										T	T				T	T	S															S	S	T	T
	.	.	.	.	.	.	.	.
Sequence	F	E	K	L	V	P	R	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)