Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	I	L	L	G	Y	L	V	V	L	G	T	V	F	G	G	Y	L	M	T	G	G	S	L	G	A	L	Y	Q	P	A	E	L	V	I	I	A	G	A	G	I	G	S	F	I	V	G	N	N	G	K	A	I	K	G	T	L	K	A
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	P	L	L	F	R	R	S	K	Y	T	K	A	M	Y	M	D	L	L	A	L	L	Y	R	L	M	A	K	S	R	Q	M	G	M	F	S	L	E	R	D	I	E	N	P	R	E	S	E	I	F	A	S	Y	P	R	I	L	A	D	S
Secondary structure
SS confidence
Disorder										?	?	?	?																													?		?	?	?		?	?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	M	L	D	F	I	V	D	Y	L	R	L	I	I	S	G	H	M	N	T	F	E	I	E	A	L	M	D	E	E	I	E	T	H	E	S	E	A	E	V	P	A	N	S	L	A	L	V	G	D	S	L	P	A	F	G	I	V	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	M	G	V	V	H	A	L	G	S	A	D	R	P	A	A	E	L	G	A	L	I	A	H	A	M	V	G	T	F	L	G	I	L	L	A	Y	G	F	I	S	P	L	A	T	V	L	R	Q	K	S	A	E	T	S	K	M	M	Q	C
Secondary structure
SS confidence
Disorder										?				?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.
Sequence		V	K	V	T	L	L	S	N	L	N	G	Y	A	P	P	I	A	V	E	F	G	R	K	T	L	Y	S	S	E	R	P	S	F	I	E	L	E	E	H	V	R	A	V	K	N	P	Q	Q	Q	T	T	T	E	E	A
Secondary structure
SS confidence
Disorder																									?		?				?	?	?											?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1byg chain A Region: 254 - 287 Aligned: 34 Modelled: 34 Confidence: 59.4% Identity: 32% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Protein kinases, catalytic subunit Phyre2 PDB 2hep chain A domain 1 Region: 77 - 100 Aligned: 24 Modelled: 24 Confidence: 57.4% Identity: 21% Fold: Long alpha-hairpin Superfamily: YnzC-like Family: YznC-like Phyre2 PDB 2hep chain A Region: 77 - 100 Aligned: 24 Modelled: 24 Confidence: 57.4% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the upf0291 protein ynzc from2 bacillus subtilis. northeast structural genomics target3 sr384. Phyre2 PDB 2w1i chain B Region: 205 - 285 Aligned: 81 Modelled: 81 Confidence: 56.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:jak2; PDBTitle: structure determination of aurora kinase in complex with2 inhibitor Phyre2 PDB 1u46 chain A Region: 254 - 284 Aligned: 31 Modelled: 31 Confidence: 55.3% Identity: 16% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Protein kinases, catalytic subunit Phyre2 PDB 1vjy chain A Region: 254 - 288 Aligned: 35 Modelled: 35 Confidence: 49.1% Identity: 6% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Protein kinases, catalytic subunit Phyre2 PDB 1ias chain A Region: 254 - 285 Aligned: 32 Modelled: 32 Confidence: 48.7% Identity: 6% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Protein kinases, catalytic subunit Phyre2 PDB 1p4o chain A Region: 254 - 286 Aligned: 33 Modelled: 33 Confidence: 46.9% Identity: 27% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Protein kinases, catalytic subunit Phyre2 PDB 2jvd chain A Region: 77 - 98 Aligned: 22 Modelled: 22 Confidence: 46.6% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the folded n-terminal fragment of2 upf0291 protein ynzc from bacillus subtilis. northeast3 structural genomics target sr384-1-46 Phyre2 PDB 3zzw chain A Region: 254 - 282 Aligned: 29 Modelled: 29 Confidence: 46.5% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2; PDBTitle: crystal structure of the kinase domain of ror2 Phyre2 PDB 2buj chain A Region: 254 - 287 Aligned: 34 Modelled: 34 Confidence: 45.2% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 16; PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine Phyre2 PDB 1cii chain A Region: 148 - 215 Aligned: 68 Modelled: 68 Confidence: 43.8% Identity: 12% PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia Phyre2 PDB 3cc6 chain A Region: 254 - 293 Aligned: 40 Modelled: 40 Confidence: 41.7% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:protein tyrosine kinase 2 beta; PDBTitle: crystal structure of kinase domain of protein tyrosine kinase 2 beta2 (ptk2b) Phyre2 PDB 1k9a chain B Region: 254 - 289 Aligned: 36 Modelled: 36 Confidence: 41.5% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution Phyre2 PDB 3cbl chain A Region: 254 - 287 Aligned: 34 Modelled: 34 Confidence: 41.5% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide Phyre2 PDB 3bhp chain A Region: 77 - 98 Aligned: 22 Modelled: 22 Confidence: 38.7% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: crystal structure of upf0291 protein ynzc from bacillus2 subtilis at resolution 2.0 a. northeast structural3 genomics consortium target sr384 Phyre2 PDB 2xba chain A Region: 254 - 293 Aligned: 40 Modelled: 40 Confidence: 38.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:alk tyrosine kinase receptor; PDBTitle: structure of human anaplastic lymphoma kinase in complex2 with pha-e429 Phyre2 PDB 3c1x chain A Region: 254 - 290 Aligned: 37 Modelled: 37 Confidence: 37.3% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:hepatocyte growth factor receptor; PDBTitle: crystal structure of the tyrosine kinase domain of the2 hepatocyte growth factor receptor c-met in complex with a3 pyrrolotriazine based inhibitor Phyre2 PDB 2c0i chain A Region: 254 - 294 Aligned: 39 Modelled: 41 Confidence: 36.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 Phyre2 PDB 3lvp chain D Region: 254 - 292 Aligned: 39 Modelled: 39 Confidence: 36.8% Identity: 23% PDB header:transferase Chain: D: PDB Molecule:insulin-like growth factor 1 receptor; PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor Phyre2 1 d1byga_ 2 d2hepa1 3 c2hepA_ 4 c2w1iB_ 5 d1u46a_ 6 d1vjya_ 7 d1iasa_ 8 d1p4oa_ 9 c2jvdA_ 10 c3zzwA_ 11 c2bujA_ 12 c1ciiA_ 13 c3cc6A_ 14 c1k9aB_ 15 c3cblA_ 16 c3bhpA_ 17 c2xbaA_ 18 c3c1xA_ 19 c2c0iA_ 20 c3lvpD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1byga_ 59.4 32 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 2 d2hepa1 57.4 21 Fold:Long alpha-hairpin Superfamily:YnzC-like Family:YznC-like 3 c2hepA_ 57.4 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the upf0291 protein ynzc from2 bacillus subtilis. northeast structural genomics target3 sr384. 4 c2w1iB_ 56.0 14 PDB header:transferase Chain: B: PDB Molecule:jak2; PDBTitle: structure determination of aurora kinase in complex with2 inhibitor 5 d1u46a_ 55.3 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 6 d1vjya_ 49.1 6 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 7 d1iasa_ 48.7 6 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 8 d1p4oa_ 46.9 27 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 9 c2jvdA_ 46.6 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the folded n-terminal fragment of2 upf0291 protein ynzc from bacillus subtilis. northeast3 structural genomics target sr384-1-46 10 c3zzwA_ 46.5 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2; PDBTitle: crystal structure of the kinase domain of ror2 11 c2bujA_ 45.2 15 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 16; PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine 12 c1ciiA_ 43.8 12 PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia 13 c3cc6A_ 41.7 25 PDB header:transferase Chain: A: PDB Molecule:protein tyrosine kinase 2 beta; PDBTitle: crystal structure of kinase domain of protein tyrosine kinase 2 beta2 (ptk2b) 14 c1k9aB_ 41.5 22 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 15 c3cblA_ 41.5 15 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 16 c3bhpA_ 38.7 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: crystal structure of upf0291 protein ynzc from bacillus2 subtilis at resolution 2.0 a. northeast structural3 genomics consortium target sr384 17 c2xbaA_ 38.0 15 PDB header:transferase Chain: A: PDB Molecule:alk tyrosine kinase receptor; PDBTitle: structure of human anaplastic lymphoma kinase in complex2 with pha-e429 18 c3c1xA_ 37.3 27 PDB header:transferase Chain: A: PDB Molecule:hepatocyte growth factor receptor; PDBTitle: crystal structure of the tyrosine kinase domain of the2 hepatocyte growth factor receptor c-met in complex with a3 pyrrolotriazine based inhibitor 19 c2c0iA_ 36.9 18 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 20 c3lvpD_ 36.8 23 PDB header:transferase Chain: D: PDB Molecule:insulin-like growth factor 1 receptor; PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor 21 c3d4qA_ not modelled 36.6 18 PDB header:transferase Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase; PDBTitle: pyrazole-based inhibitors of b-raf kinase 22 c3lxnA_ not modelled 34.6 23 PDB header:transferase Chain: A: PDB Molecule:non-receptor tyrosine-protein kinase tyk2; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6 23 c2yhvA_ not modelled 34.4 16 PDB header:transferase Chain: A: PDB Molecule:alk tyrosine kinase receptor; PDBTitle: structure of l1196m mutant anaplastic lymphoma kinase 24 c3lxkA_ not modelled 33.9 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6 25 c2qofA_ not modelled 33.2 17 PDB header:transferase Chain: A: PDB Molecule:ephrin receptor; PDBTitle: human epha3 kinase and juxtamembrane region, y596f mutant 26 c3mtfB_ not modelled 31.8 7 PDB header:transferase Chain: B: PDB Molecule:activin receptor type-1; PDBTitle: crystal structure of the acvr1 kinase in complex with a 2-2 aminopyridine inhibitor 27 c2j0kB_ not modelled 30.8 26 PDB header:transferase Chain: B: PDB Molecule:focal adhesion kinase 1; PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains. 28 c2qluA_ not modelled 30.0 16 PDB header:transferase Chain: A: PDB Molecule:activin receptor type iib; PDBTitle: crystal structure of activin receptor type ii kinase domain2 from human 29 c3fupB_ not modelled 29.4 30 PDB header:transferase Chain: B: PDB Molecule:tyrosine-protein kinase jak2; PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes 30 c3s95A_ not modelled 29.0 26 PDB header:transferase/antibiotic Chain: A: PDB Molecule:lim domain kinase 1; PDBTitle: crystal structure of the human limk1 kinase domain in complex with2 staurosporine 31 c3kmuA_ not modelled 28.8 13 PDB header:cell adhesion Chain: A: PDB Molecule:integrin-linked kinase; PDBTitle: crystal structure of the ilk/alpha-parvin core complex (apo) 32 c2oidA_ not modelled 27.9 10 PDB header:transferase Chain: A: PDB Molecule:interleukin-1 receptor-associated kinase 4; PDBTitle: crystal structure of irak4 kinase domain complexed with2 amppnp 33 c3mdyC_ not modelled 27.2 6 PDB header:transferase/isomerase Chain: C: PDB Molecule:bone morphogenetic protein receptor type-1b; PDBTitle: crystal structure of the cytoplasmic domain of the bone morphogenetic2 protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn-3 193189 34 c3sxrA_ not modelled 26.8 13 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: crystal structure of bmx non-receptor tyrosine kinase complex with2 dasatinib 35 c3eygA_ not modelled 26.6 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase; PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes 36 d1mp8a_ not modelled 25.9 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 37 c3g2fB_ not modelled 25.9 8 PDB header:transferase Chain: B: PDB Molecule:bone morphogenetic protein receptor type-2; PDBTitle: crystal structure of the kinase domain of bone morphogenetic protein2 receptor type ii (bmpr2) at 2.35 a resolution 38 c2qkwB_ not modelled 25.4 23 PDB header:transferase Chain: B: PDB Molecule:protein kinase; PDBTitle: structural basis for activation of plant immunity by2 bacterial effector protein avrpto 39 c3ll6B_ not modelled 25.2 15 PDB header:transferase Chain: B: PDB Molecule:cyclin g-associated kinase; PDBTitle: crystal structure of the human cyclin g associated kinase (gak) 40 d1r0pa_ not modelled 24.5 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 41 c2h8hA_ not modelled 24.3 16 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 42 c2ozoA_ not modelled 23.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 43 d1uwha_ not modelled 23.8 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 44 d3bu3a1 not modelled 23.7 21 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 45 d1opja_ not modelled 23.3 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 46 c1yvjA_ not modelled 23.2 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: crystal structure of the jak3 kinase domain in complex with2 a staurosporine analogue 47 d1jpaa_ not modelled 21.8 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 48 d1sm2a_ not modelled 20.2 13 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 49 c2pvfA_ not modelled 19.3 16 PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of tyrosine phosphorylated activated fgf2 receptor 2 (fgfr2) kinase domain in complex with atp3 analog and substrate peptide 50 d1u59a_ not modelled 19.2 28 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 51 d1mqba_ not modelled 19.1 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 52 c1y57A_ not modelled 18.8 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 53 c2kbrA_ not modelled 18.7 11 PDB header:structural protein/cell adhesion Chain: A: PDB Molecule:harmonin; PDBTitle: solution structure of harmonin n terminal domain in complex2 with a internal peptide of cadherin23 54 c3dtcA_ not modelled 17.7 17 PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 9; PDBTitle: crystal structure of mixed-lineage kinase mlk1 complexed2 with compound 16 55 c2y4iB_ not modelled 17.4 28 PDB header:transferase Chain: B: PDB Molecule:kinase suppressor of ras 2; PDBTitle: ksr2-mek1 heterodimer 56 c3qupA_ not modelled 17.3 17 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:tyrosine-protein kinase receptor tyro3; PDBTitle: inhibitor bound structure of the kinase domain of the murine receptor2 tyrosine kinase tyro3 (sky) 57 d1fgka_ not modelled 16.9 33 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 58 c3db8A_ not modelled 16.8 31 PDB header:transferase Chain: A: PDB Molecule:polo-like kinase 1; PDBTitle: crystal structure of an activated (thr->asp) polo-like2 kinase 1 (plk1) catalytic domain in complex with compound3 041 59 d2psqa1 not modelled 16.8 23 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 60 c2psqA_ not modelled 16.8 23 PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain 61 c3mogA_ not modelled 16.4 12 PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxybutyryl-coa dehydrogenase; PDBTitle: crystal structure of 3-hydroxybutyryl-coa dehydrogenase from2 escherichia coli k12 substr. mg1655 62 c2wqmA_ not modelled 16.2 7 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase nek7; PDBTitle: structure of apo human nek7 63 c3h9rA_ not modelled 16.1 7 PDB header:isomerase/protein kinase Chain: A: PDB Molecule:activin receptor type-1; PDBTitle: crystal structure of the kinase domain of type i activin receptor2 (acvr1) in complex with fkbp12 and dorsomorphin 64 d1fmka3 not modelled 15.8 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 65 d1qpca_ not modelled 15.7 21 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 66 d1cm8a_ not modelled 15.7 24 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 67 c2qobA_ not modelled 15.3 12 PDB header:transferase Chain: A: PDB Molecule:ephrin receptor; PDBTitle: human epha3 kinase domain, base structure 68 c3brbB_ not modelled 14.5 17 PDB header:transferase Chain: B: PDB Molecule:proto-oncogene tyrosine-protein kinase mer; PDBTitle: crystal structure of catalytic domain of the proto-oncogene tyrosine-2 protein kinase mer in complex with adp 69 c1ua2A_ not modelled 14.5 11 PDB header:cell cycle, transferase Chain: A: PDB Molecule:cell division protein kinase 7; PDBTitle: crystal structure of human cdk7 70 d1ua2a_ not modelled 14.5 11 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 71 d1csna_ not modelled 14.4 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 72 d1h8ba_ not modelled 14.4 20 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 73 c3o6xC_ not modelled 14.3 13 PDB header:ligase Chain: C: PDB Molecule:glutamine synthetase; PDBTitle: crystal structure of the type iii glutamine synthetase from2 bacteroides fragilis 74 c2dylA_ not modelled 14.2 17 PDB header:transferase Chain: A: PDB Molecule:dual specificity mitogen-activated protein PDBTitle: crystal structure of human mitogen-activated protein kinase2 kinase 7 activated mutant (s287d, t291d) 75 c3p86B_ not modelled 13.8 19 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase ctr1; PDBTitle: crystal structure of ctr1 kinase domain mutant d676n in complex with2 staurosporine 76 c1y6aA_ not modelled 13.7 30 PDB header:transferase Chain: A: PDB Molecule:vascular endothelial growth factor receptor 2; PDBTitle: crystal structure of vegfr2 in complex with a 2-anilino-5-aryl-oxazole2 inhibitor 77 d1xbba_ not modelled 13.5 29 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 78 d1ckia_ not modelled 13.3 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 79 c2evaA_ not modelled 12.7 15 PDB header:transferase/transferase activator Chain: A: PDB Molecule:tak1 kinase - tab1 chimera fusion protein; PDBTitle: structural basis for the interaction of tak1 kinase with2 its activating protein tab1 80 d1xwsa_ not modelled 12.5 32 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 81 d1lufa_ not modelled 12.1 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 82 c1lufA_ not modelled 12.1 20 PDB header:transferase Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk; PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation 83 d1fvra_ not modelled 11.9 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 84 c3jzdA_ not modelled 11.8 13 PDB header:oxidoreductase Chain: A: PDB Molecule:iron-containing alcohol dehydrogenase; PDBTitle: crystal structure of putative alcohol dehedrogenase (yp_298327.1) from2 ralstonia eutropha jmp134 at 2.10 a resolution 85 d1ctda_ not modelled 11.7 13 Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like 86 c2x58B_ not modelled 11.5 12 PDB header:oxidoreductase Chain: B: PDB Molecule:peroxisomal bifunctional enzyme; PDBTitle: the crystal structure of mfe1 liganded with coa 87 c3kexA_ not modelled 11.3 19 PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-3; PDBTitle: crystal structure of the catalytically inactive kinase2 domain of the human epidermal growth factor receptor 33 (her3) 88 d1kqfb2 not modelled 10.5 36 Fold:Single transmembrane helix Superfamily:Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor Family:Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor 89 c3hkoA_ not modelled 10.5 16 PDB header:transferase Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase with a kinase PDBTitle: crystal structure of a cdpk kinase domain from cryptosporidium parvum,2 cgd7_40 90 c2a1aB_ not modelled 10.4 19 PDB header:protein synthesis/transferase Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein PDBTitle: pkr kinase domain-eif2alpha complex 91 d1k2pa_ not modelled 10.4 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 92 c2c47D_ not modelled 10.1 21 PDB header:transferase Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform; PDBTitle: structure of casein kinase 1 gamma 2 93 c1zy5B_ not modelled 10.0 17 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase gcn2; PDBTitle: crystal structure of eif2alpha protein kinase gcn2: r794g2 hyperactivating mutant complexed with amppnp. 94 c3k6jA_ not modelled 9.9 5 PDB header:oxidoreductase Chain: A: PDB Molecule:protein f01g10.3, confirmed by transcript evidence; PDBTitle: crystal structure of the dehydrogenase part of multifuctional enzyme 12 from c.elegans 95 d1f0ya1 not modelled 9.7 15 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:HCDH C-domain-like 96 c1oplA_ not modelled 9.7 31 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 97 c2vy9A_ not modelled 9.6 18 PDB header:gene regulation Chain: A: PDB Molecule:anti-sigma-factor antagonist; PDBTitle: molecular architecture of the stressosome, a signal2 integration and transduction hub 98 c3famA_ not modelled 9.4 26 PDB header:transferase Chain: A: PDB Molecule:carbon catabolite-derepressing protein kinase; PDBTitle: crystal structure of the protein kinase domain of yeast amp-2 activated protein kinase snf1 99 d2f05a1 not modelled 9.3 16 Fold:PAH2 domain Superfamily:PAH2 domain Family:PAH2 domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0