Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	I	R	A	L	L	V	A	M	S	V	A	T	V	L	T	G	C	Q	N	M	D	S	N	G	L	L	S	S	G	A	E	A	F	Q	A	Y	S	L	S	D	A	Q	V	K	T	L	S	D	Q	A	C	Q	E	M	D	S	K	A
Secondary structure
SS confidence
Disorder		?	?	?																	?				?	?	?	?	?	?	?	?	?	?	?	?			?	?	?																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	I	A	P	A	N	S	E	Y	A	K	R	L	T	T	I	A	N	A	L	G	N	N	I	N	G	Q	P	V	N	Y	K	V	Y	M	A	K	D	V	N	A	F	A	M	A	N	G	C	I	R	V	Y	S	G	L	M	D	M	M	T
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	N	E	V	E	A	V	I	G	H	E	M	G	H	V	A	L	G	H	V	K	K	G	M	Q	V	A	L	G	T	N	A	V	R	V	A	A	A	S	A	G	G	I	V	G	S	L	S	Q	S	Q	L	G	N	L	G	E	K	L	V
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	S	Q	F	S	Q	R	Q	E	A	E	A	D	D	Y	S	Y	D	L	L	R	Q	R	G	I	S	P	A	G	L	A	T	S	F	E	K	L	A	K	L	E	E	G	R	Q	S	S	M	F	D	D	H	P	A	S	A	E	R	A	Q
Secondary structure
SS confidence
Disorder		?	?	?	?																																				?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.
Sequence		H	I	R	D	R	M	S	A	D	G	I	K
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3c37 chain B Region: 36 - 252 Aligned: 199 Modelled: 217 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 3cqb chain B Region: 62 - 139 Aligned: 78 Modelled: 78 Confidence: 99.7% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 3dtk chain A Region: 67 - 200 Aligned: 102 Modelled: 106 Confidence: 97.6% Identity: 18% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 3b7u chain X Region: 71 - 134 Aligned: 62 Modelled: 64 Confidence: 89.6% Identity: 21% PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan Phyre2 PDB 2gtq chain A Region: 67 - 134 Aligned: 68 Modelled: 68 Confidence: 85.6% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis Phyre2 PDB 3qnf chain A Region: 67 - 134 Aligned: 68 Modelled: 68 Confidence: 85.2% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 Phyre2 PDB 2ejq chain A domain 1 Region: 100 - 137 Aligned: 38 Modelled: 38 Confidence: 84.6% Identity: 26% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 1r55 chain A Region: 120 - 134 Aligned: 15 Modelled: 15 Confidence: 84.1% Identity: 33% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3cia chain A Region: 70 - 134 Aligned: 63 Modelled: 65 Confidence: 83.9% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea Phyre2 PDB 2i47 chain A domain 1 Region: 120 - 134 Aligned: 15 Modelled: 15 Confidence: 83.8% Identity: 40% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TNF-alpha converting enzyme, TACE, catalytic domain Phyre2 PDB 2xs4 chain A Region: 124 - 135 Aligned: 12 Modelled: 12 Confidence: 83.6% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium Phyre2 PDB 2i47 chain A Region: 120 - 134 Aligned: 15 Modelled: 15 Confidence: 83.6% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor Phyre2 PDB 3ebh chain A Region: 67 - 134 Aligned: 68 Modelled: 68 Confidence: 83.3% Identity: 19% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin Phyre2 PDB 1atl chain A Region: 124 - 134 Aligned: 11 Modelled: 11 Confidence: 83.2% Identity: 36% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 2erp chain A Region: 123 - 134 Aligned: 12 Modelled: 12 Confidence: 82.9% Identity: 50% PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) Phyre2 PDB 2dw1 chain B Region: 124 - 134 Aligned: 11 Modelled: 11 Confidence: 82.7% Identity: 55% PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) Phyre2 PDB 3k7l chain A Region: 124 - 134 Aligned: 11 Modelled: 11 Confidence: 82.5% Identity: 55% PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 1bsw chain A Region: 120 - 134 Aligned: 15 Modelled: 15 Confidence: 82.3% Identity: 33% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 2qr4 chain B Region: 126 - 233 Aligned: 108 Modelled: 108 Confidence: 82.1% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f; PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium Phyre2 PDB 2e3x chain A Region: 124 - 134 Aligned: 11 Modelled: 11 Confidence: 81.4% Identity: 27% PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase Phyre2 1 c3c37B_ 2 c3cqbB_ 3 c3dtkA_ 4 c3b7uX_ 5 c2gtqA_ 6 c3qnfA_ 7 d2ejqa1 8 d1r55a_ 9 c3ciaA_ 10 d2i47a1 11 c2xs4A_ 12 c2i47A_ 13 c3ebhA_ 14 d1atla_ 15 c2erpA_ 16 c2dw1B_ 17 c3k7lA_ 18 d1bswa_ 19 c2qr4B_ 20 c2e3xA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3c37B_ 100.0 24 PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a 2 c3cqbB_ 99.7 28 PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 3 c3dtkA_ 97.6 18 PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae 4 c3b7uX_ 89.6 21 PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan 5 c2gtqA_ 85.6 18 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis 6 c3qnfA_ 85.2 10 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 7 d2ejqa1 84.6 26 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 8 d1r55a_ 84.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 9 c3ciaA_ 83.9 10 PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea 10 d2i47a1 83.8 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TNF-alpha converting enzyme, TACE, catalytic domain 11 c2xs4A_ 83.6 42 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 12 c2i47A_ 83.6 40 PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor 13 c3ebhA_ 83.3 19 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin 14 d1atla_ 83.2 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 15 c2erpA_ 82.9 50 PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) 16 c2dw1B_ 82.7 55 PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) 17 c3k7lA_ 82.5 55 PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 18 d1bswa_ 82.3 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 19 c2qr4B_ 82.1 14 PDB header:hydrolase Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f; PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium 20 c2e3xA_ 81.4 27 PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase 21 c3k7nA_ not modelled 81.3 40 PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 22 d4aiga_ not modelled 80.6 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 23 d2ovxa1 not modelled 80.5 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 24 c3p24C_ not modelled 80.5 50 PDB header:hydrolase Chain: C: PDB Molecule:bft-3; PDBTitle: structure of profragilysin-3 from bacteroides fragilis 25 d1rm8a_ not modelled 80.5 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 26 c3b37A_ not modelled 80.4 19 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine 27 c1yp1A_ not modelled 80.2 45 PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus 28 d1cxva_ not modelled 80.1 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 29 d1bqqm_ not modelled 80.1 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 30 d1y93a1 not modelled 80.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 31 d1qiba_ not modelled 79.9 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 32 d1quaa_ not modelled 79.7 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 33 d1i76a_ not modelled 79.6 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 34 d1xuca1 not modelled 79.6 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 35 d1hv5a_ not modelled 79.0 50 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 36 d1hfca_ not modelled 78.3 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 37 d1wnia_ not modelled 78.2 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 38 c2xpyA_ not modelled 78.2 14 PDB header:hydrolase Chain: A: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: structure of native leukotriene a4 hydrolase from saccharomyces2 cerevisiae 39 d1hy7a_ not modelled 77.6 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 40 d1kufa_ not modelled 77.5 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 41 c3g5cA_ not modelled 77.5 10 PDB header:membrane protein Chain: A: PDB Molecule:adam 22; PDBTitle: structural and biochemical studies on the ectodomain of human adam22 42 d1mmqa_ not modelled 77.3 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 43 c3sksA_ not modelled 76.6 38 PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames 44 d1nd1a_ not modelled 76.5 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 45 c2v4bB_ not modelled 76.5 45 PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) 46 d1hova_ not modelled 76.5 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 47 c2cltB_ not modelled 76.5 33 PDB header:hydrolase Chain: B: PDB Molecule:interstitial collagenase; PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase. 48 c2jsdA_ not modelled 76.3 42 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-20; PDBTitle: solution structure of mmp20 complexed with nngh 49 c3b8zB_ not modelled 76.3 36 PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) 50 d1cgla_ not modelled 76.2 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 51 d1c7ka_ not modelled 75.2 67 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Zinc protease 52 c1slmA_ not modelled 75.2 42 PDB header:hydrolase Chain: A: PDB Molecule:stromelysin-1; PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme 53 d1q3aa_ not modelled 75.2 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 54 c2h1jA_ not modelled 75.2 42 PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding 55 c2rjqA_ not modelled 75.1 40 PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound 56 c2rjpC_ not modelled 74.8 30 PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound 57 d1fbla2 not modelled 74.7 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 58 c2x3bB_ not modelled 74.2 11 PDB header:hydrolase Chain: B: PDB Molecule:toxic extracellular endopeptidase; PDBTitle: asap1 inactive mutant e294a, an extracellular toxic zinc2 metalloendopeptidase 59 c3mdjB_ not modelled 73.7 10 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor,2 bestatin 60 d1eaka2 not modelled 73.6 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 61 d3e11a1 not modelled 73.6 32 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 62 d3b7sa3 not modelled 73.5 19 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leukotriene A4 hydrolase catalytic domain 63 d1npca_ not modelled 72.5 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 64 c1z5hB_ not modelled 72.2 15 PDB header:hydrolase Chain: B: PDB Molecule:tricorn protease interacting factor f3; PDBTitle: crystal structures of the tricorn interacting factor f32 from thermoplasma acidophilum 65 d1k9xa_ not modelled 70.4 7 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 66 d1kjpa_ not modelled 70.1 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 67 c1y791_ not modelled 69.8 42 PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor 68 d1bqba_ not modelled 69.3 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 69 c2vqxA_ not modelled 69.1 31 PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. 70 c3nqxA_ not modelled 68.7 31 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family 71 c2xdtA_ not modelled 68.6 15 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the soluble domain of human2 endoplasmic reticulum aminopeptidase 1 erap1 72 c3ba0A_ not modelled 68.0 33 PDB header:hydrolase Chain: A: PDB Molecule:macrophage metalloelastase; PDBTitle: crystal structure of full-length human mmp-12 73 c3se6A_ not modelled 67.9 13 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2; PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2 74 c1su3A_ not modelled 67.6 42 PDB header:hydrolase Chain: A: PDB Molecule:interstitial collagenase; PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action 75 c3nqzB_ not modelled 66.5 31 PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation 76 c2j83B_ not modelled 66.3 44 PDB header:hydrolase Chain: B: PDB Molecule:ulilysin; PDBTitle: ulilysin metalloprotease in complex with batimastat. 77 d1s4bp_ not modelled 65.7 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 78 d1u4ga_ not modelled 65.2 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 79 d1i1ip_ not modelled 62.3 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 80 c1eakA_ not modelled 61.8 33 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: catalytic domain of prommp-2 e404q mutant 81 d1sata2 not modelled 61.3 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 82 d1k7ia2 not modelled 59.6 24 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 83 d1lmla_ not modelled 59.5 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leishmanolysin 84 d1kapp2 not modelled 59.0 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 85 d1g9ka2 not modelled 58.8 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 86 c2c6nA_ not modelled 57.7 45 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform; PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril 87 d2ajfa1 not modelled 57.6 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 88 c1wgzC_ not modelled 55.1 14 PDB header:hydrolase Chain: C: PDB Molecule:carboxypeptidase 1; PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus 89 c3b4rB_ not modelled 53.6 42 PDB header:hydrolase Chain: B: PDB Molecule:putative zinc metalloprotease mj0392; PDBTitle: site-2 protease from methanocaldococcus jannaschii 90 d1j36a_ not modelled 53.6 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 91 c1l6jA_ not modelled 48.0 42 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-9; PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b). 92 c1jiwP_ not modelled 47.4 44 PDB header:hydrolase/hyrolase inhibitor Chain: P: PDB Molecule:alkaline metalloproteinase; PDBTitle: crystal structure of the apr-aprin complex 93 c2l0rA_ not modelled 45.5 36 PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center 94 c3lqbA_ not modelled 43.4 23 PDB header:hydrolase Chain: A: PDB Molecule:loc792177 protein; PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio 95 d1uzea_ not modelled 42.2 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 96 c1gxdA_ not modelled 40.8 29 PDB header:hydrolase Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: prommp-2/timp-2 complex 97 d1asta_ not modelled 40.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Astacin 98 c3edhA_ not modelled 39.7 38 PDB header:hydrolase Chain: A: PDB Molecule:bone morphogenetic protein 1; PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso 99 c1om8A_ not modelled 39.7 36 PDB header:hydrolase Chain: A: PDB Molecule:serralysin; PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta 100 d1j7na2 not modelled 38.1 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Anthrax toxin lethal factor, N- and C-terminal domains 101 c3lq0A_ not modelled 37.0 25 PDB header:hydrolase Chain: A: PDB Molecule:proastacin; PDBTitle: zymogen structure of crayfish astacin metallopeptidase 102 c3dwbA_ not modelled 33.0 23 PDB header:hydrolase Chain: A: PDB Molecule:endothelin-converting enzyme 1; PDBTitle: structure of human ece-1 complexed with phosphoramidon 103 d1saza1 not modelled 31.0 19 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Acetokinase-like 104 d2di4a1 not modelled 30.4 33 Fold:FtsH protease domain-like Superfamily:FtsH protease domain-like Family:FtsH protease domain-like 105 d2ce7a1 not modelled 30.1 28 Fold:FtsH protease domain-like Superfamily:FtsH protease domain-like Family:FtsH protease domain-like 106 c3zukB_ not modelled 29.3 30 PDB header:hydrolase/inhibitor Chain: B: PDB Molecule:endopeptidase, peptidase family m13; PDBTitle: crystal structure of mycobacterium tuberculosis zinc metalloprotease2 zmp1 in complex with inhibitor 107 c2xhqA_ not modelled 25.1 16 PDB header:hydrolase Chain: A: PDB Molecule:archaemetzincin; PDBTitle: crystal structure of archaemetzincin (amza) from archaeoglobus2 fulgidus at 1.45 a resolution 108 c1e1hC_ not modelled 24.7 21 PDB header:hydrolase Chain: C: PDB Molecule:botulinum neurotoxin type a light chain; PDBTitle: crystal structure of recombinant botulinum neurotoxin type2 a light chain, self-inhibiting zn endopeptidase. 109 d1dmta_ not modelled 22.5 20 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neutral endopeptidase (neprilysin) 110 c3k3qB_ not modelled 22.5 21 PDB header:immune system Chain: B: PDB Molecule:botulinum neurotoxin type a; PDBTitle: crystal structure of a llama antibody complexed with the c.2 botulinum neurotoxin serotype a catalytic domain 111 c3lmcA_ not modelled 21.9 33 PDB header:hydrolase Chain: A: PDB Molecule:peptidase, zinc-dependent; PDBTitle: crystal structure of zinc-dependent peptidase from methanocorpusculum2 labreanum (strain z), northeast structural genomics consortium target3 mur16 112 c1satA_ not modelled 21.9 50 PDB header:hydrolase (serine protease) Chain: A: PDB Molecule:serratia protease; PDBTitle: crystal structure of the 50 kda metallo protease from s.2 marcescens

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0