Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	D	V	F	T	P	L	L	K	L	F	A	N	E	P	L	E	R	L	M	Y	T	I	I	I	F	G	L	T	L	W	L	I	P	K	E	F	T	V	A	F	N	A	Y	T	E	I	P	W	L	F	Q	I	I	V	F	A	F	S
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	V	V	A	I	S	F	S	R	L	R	A	H	I	Q	K	H	Y	S	L	L	P	E	Q	R	V	L	L	R	L	S	E	K	E	I	A	V	F	K	D	F	L	K	T	G	N	L	I	I	T	S	P	C	R	N	P	V	M	K	K
Secondary structure
SS confidence
Disorder																						?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
Sequence		L	E	R	K	G	I	I	Q	H	Q	S	D	S	A	N	C	S	Y	Y	L	V	T	E	K	Y	S	H	F	M	K	L	F	W	N	S	R	S	R	R	F	N	R
Secondary structure
SS confidence
Disorder						?			?	?	?																										?		?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1htr chain P Region: 89 - 115 Aligned: 27 Modelled: 27 Confidence: 46.3% Identity: 26% PDB header:aspartyl protease Chain: P: PDB Molecule:progastricsin (pro segment); PDBTitle: crystal and molecular structures of human progastricsin at 1.622 angstroms resolution Phyre2 PDB 2wa1 chain A Region: 82 - 162 Aligned: 81 Modelled: 81 Confidence: 38.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:non-structural protein 5; PDBTitle: structure of the methyltransferase domain from modoc virus,2 a flavivirus with no known vector (nkv) Phyre2 PDB 2d1h chain A domain 1 Region: 84 - 161 Aligned: 76 Modelled: 0 Confidence: 35.5% Identity: 16% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: TrmB-like Phyre2 PDB 1hsj chain A Region: 62 - 159 Aligned: 88 Modelled: 98 Confidence: 32.3% Identity: 14% PDB header:transcription/sugar binding protein Chain: A: PDB Molecule:fusion protein consisting of staphylococcus PDBTitle: sarr mbp fusion structure Phyre2 PDB 2frh chain A domain 1 Region: 61 - 159 Aligned: 88 Modelled: 99 Confidence: 31.5% Identity: 17% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: MarR-like transcriptional regulators Phyre2 PDB 2eth chain A domain 1 Region: 66 - 161 Aligned: 95 Modelled: 96 Confidence: 24.4% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: MarR-like transcriptional regulators Phyre2 PDB 1stz chain A domain 1 Region: 89 - 133 Aligned: 45 Modelled: 45 Confidence: 22.7% Identity: 27% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Heat-inducible transcription repressor HrcA, N-terminal domain Phyre2 PDB 1sfx chain A Region: 90 - 161 Aligned: 71 Modelled: 69 Confidence: 22.5% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: TrmB-like Phyre2 PDB 1jhf chain A domain 1 Region: 89 - 136 Aligned: 48 Modelled: 48 Confidence: 20.8% Identity: 23% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: LexA repressor, N-terminal DNA-binding domain Phyre2 PDB 2px2 chain B Region: 82 - 162 Aligned: 81 Modelled: 81 Confidence: 20.5% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:genome polyprotein [contains: capsid protein c PDBTitle: crystal structure of the murray valley encephalitis virus2 ns5 2'-o methyltransferase domain in complex with sah3 (monoclinic form 1) Phyre2 PDB 1u61 chain A Region: 66 - 122 Aligned: 53 Modelled: 57 Confidence: 20.3% Identity: 19% Fold: RNase III domain-like Superfamily: RNase III domain-like Family: RNase III catalytic domain-like Phyre2 PDB 3cta chain A Region: 109 - 162 Aligned: 53 Modelled: 54 Confidence: 19.5% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:riboflavin kinase; PDBTitle: crystal structure of riboflavin kinase from thermoplasma2 acidophilum Phyre2 PDB 1lnw chain A Region: 59 - 162 Aligned: 99 Modelled: 102 Confidence: 18.1% Identity: 14% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: MarR-like transcriptional regulators Phyre2 PDB 1stz chain B Region: 89 - 133 Aligned: 45 Modelled: 45 Confidence: 16.8% Identity: 29% PDB header:transcription Chain: B: PDB Molecule:heat-inducible transcription repressor hrca homolog; PDBTitle: crystal structure of a hypothetical protein at 2.2 a resolution Phyre2 PDB 2col chain A Region: 115 - 138 Aligned: 23 Modelled: 24 Confidence: 16.1% Identity: 17% PDB header:lyase/metal binding protein Chain: A: PDB Molecule:bifunctional hemolysin-adenylate cyclase; PDBTitle: crystal structure analysis of cyaa/c-cam with pyrophosphate Phyre2 PDB 1s58 chain A Region: 31 - 48 Aligned: 18 Modelled: 18 Confidence: 15.7% Identity: 33% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: ssDNA viruses Family: Parvoviridae-like VP Phyre2 PDB 1ub9 chain A Region: 109 - 161 Aligned: 53 Modelled: 53 Confidence: 15.6% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: MarR-like transcriptional regulators Phyre2 PDB 1yku chain B Region: 97 - 115 Aligned: 19 Modelled: 19 Confidence: 14.8% Identity: 16% PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein pxo2-61; PDBTitle: crystal structure of a sensor domain homolog Phyre2 PDB 1t3l chain A domain 2 Region: 89 - 117 Aligned: 28 Modelled: 29 Confidence: 14.1% Identity: 29% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nucleotide and nucleoside kinases Phyre2 PDB 1p4x chain A domain 2 Region: 61 - 162 Aligned: 92 Modelled: 102 Confidence: 12.7% Identity: 17% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: MarR-like transcriptional regulators Phyre2 1 c1htrP_ 2 c2wa1A_ 3 d2d1ha1 4 c1hsjA_ 5 d2frha1 6 d2etha1 7 d1stza1 8 d1sfxa_ 9 d1jhfa1 10 c2px2B_ 11 d1u61a_ 12 c3ctaA_ 13 d1lnwa_ 14 c1stzB_ 15 c2colA_ 16 d1s58a_ 17 d1ub9a_ 18 c1ykuB_ 19 d1t3la2 20 d1p4xa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1htrP_ 46.3 26 PDB header:aspartyl protease Chain: P: PDB Molecule:progastricsin (pro segment); PDBTitle: crystal and molecular structures of human progastricsin at 1.622 angstroms resolution 2 c2wa1A_ 38.9 14 PDB header:transferase Chain: A: PDB Molecule:non-structural protein 5; PDBTitle: structure of the methyltransferase domain from modoc virus,2 a flavivirus with no known vector (nkv) 3 d2d1ha1 35.5 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:TrmB-like 4 c1hsjA_ 32.3 14 PDB header:transcription/sugar binding protein Chain: A: PDB Molecule:fusion protein consisting of staphylococcus PDBTitle: sarr mbp fusion structure 5 d2frha1 31.5 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 6 d2etha1 24.4 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 7 d1stza1 22.7 27 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Heat-inducible transcription repressor HrcA, N-terminal domain 8 d1sfxa_ 22.5 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:TrmB-like 9 d1jhfa1 20.8 23 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:LexA repressor, N-terminal DNA-binding domain 10 c2px2B_ 20.5 15 PDB header:transferase Chain: B: PDB Molecule:genome polyprotein [contains: capsid protein c PDBTitle: crystal structure of the murray valley encephalitis virus2 ns5 2'-o methyltransferase domain in complex with sah3 (monoclinic form 1) 11 d1u61a_ 20.3 19 Fold:RNase III domain-like Superfamily:RNase III domain-like Family:RNase III catalytic domain-like 12 c3ctaA_ 19.5 19 PDB header:transferase Chain: A: PDB Molecule:riboflavin kinase; PDBTitle: crystal structure of riboflavin kinase from thermoplasma2 acidophilum 13 d1lnwa_ 18.1 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 14 c1stzB_ 16.8 29 PDB header:transcription Chain: B: PDB Molecule:heat-inducible transcription repressor hrca homolog; PDBTitle: crystal structure of a hypothetical protein at 2.2 a resolution 15 c2colA_ 16.1 17 PDB header:lyase/metal binding protein Chain: A: PDB Molecule:bifunctional hemolysin-adenylate cyclase; PDBTitle: crystal structure analysis of cyaa/c-cam with pyrophosphate 16 d1s58a_ 15.7 33 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Parvoviridae-like VP 17 d1ub9a_ 15.6 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 18 c1ykuB_ 14.8 16 PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein pxo2-61; PDBTitle: crystal structure of a sensor domain homolog 19 d1t3la2 14.1 29 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 20 d1p4xa2 12.7 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 21 d2fbha1 not modelled 12.7 20 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 22 c1z1cA_ not modelled 12.3 24 PDB header:virus/dna Chain: A: PDB Molecule:coat protein vp2; PDBTitle: structural determinants of tissue tropism and in vivo2 pathogenicity for the parvovirus minute virus of mice 23 d1nava_ not modelled 12.3 11 Fold:Nuclear receptor ligand-binding domain Superfamily:Nuclear receptor ligand-binding domain Family:Nuclear receptor ligand-binding domain 24 c3da5A_ not modelled 11.5 42 PDB header:rna binding protein Chain: A: PDB Molecule:argonaute; PDBTitle: crystal structure of piwi/argonaute/zwille(paz) domain from2 thermococcus thioreducens 25 c3h8dE_ not modelled 11.3 42 PDB header:motor protein/signaling protein Chain: E: PDB Molecule:disabled homolog 2; PDBTitle: crystal structure of myosin vi in complex with dab2 peptide 26 c3u5gK_ not modelled 11.0 21 PDB header:ribosome Chain: K: PDB Molecule:40s ribosomal protein s10-a; PDBTitle: the structure of the eukaryotic ribosome at 3.0 a resolution 27 d1mvma_ not modelled 10.8 24 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Parvoviridae-like VP 28 d1k3va_ not modelled 10.7 33 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Parvoviridae-like VP 29 c1k3vA_ not modelled 10.7 33 PDB header:virus Chain: A: PDB Molecule:capsid protein vp2; PDBTitle: porcine parvovirus capsid 30 c3cjnA_ not modelled 10.5 15 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, marr family; PDBTitle: crystal structure of transcriptional regulator, marr family, from2 silicibacter pomeroyi 31 d2gmga1 not modelled 10.5 24 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:PF0610-like 32 c3nttA_ not modelled 10.3 18 PDB header:virus Chain: A: PDB Molecule:capsid protein; PDBTitle: structural insights of adeno-associated virus 5. a gene therapy vector2 for cystic fibrosis 33 d1hsja1 not modelled 10.2 9 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:MarR-like transcriptional regulators 34 d1k8ta_ not modelled 10.0 13 Fold:Adenylylcyclase toxin (the edema factor) Superfamily:Adenylylcyclase toxin (the edema factor) Family:Adenylylcyclase toxin (the edema factor) 35 c3dkxA_ not modelled 9.9 18 PDB header:replication Chain: A: PDB Molecule:replication protein repb; PDBTitle: crystal structure of the replication initiator protein2 encoded on plasmid pmv158 (repb), trigonal form, to 2.7 ang3 resolution 36 c2xzm7_ not modelled 9.8 14 PDB header:ribosome Chain: 7: PDB Molecule:plectin/s10 domain containing protein; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 37 d1c8da_ not modelled 9.6 22 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Parvoviridae-like VP 38 c3kieF_ not modelled 9.6 12 PDB header:virus Chain: F: PDB Molecule:capsid protein vp1; PDBTitle: crystal structure of adeno-associated virus serotype 3b 39 d1lp3a_ not modelled 9.6 12 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Parvoviridae-like VP 40 c2j8pA_ not modelled 9.1 19 PDB header:nuclear protein Chain: A: PDB Molecule:cleavage stimulation factor 64 kda subunit; PDBTitle: nmr structure of c-terminal domain of human cstf-64 41 c2g8gA_ not modelled 9.0 12 PDB header:virus Chain: A: PDB Molecule:capsid; PDBTitle: structurally mapping the diverse phenotype of adeno-2 associated virus serotype 4 42 c4a5mH_ not modelled 8.7 22 PDB header:transcription Chain: H: PDB Molecule:uncharacterized hth-type transcriptional regulator yybr; PDBTitle: redox regulator hypr in its oxidized form 43 c3bjaA_ not modelled 8.5 16 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, marr family, putative; PDBTitle: crystal structure of putative marr-like transcription regulator2 (np_978771.1) from bacillus cereus atcc 10987 at 2.38 a resolution 44 c2jtvA_ not modelled 7.9 18 PDB header:structural genomics Chain: A: PDB Molecule:protein of unknown function; PDBTitle: solution structure of protein rpa3401, northeast structural genomics2 consortium target rpt7, ontario center for structural proteomics3 target rp3384 45 c3pmdA_ not modelled 7.3 16 PDB header:lipid binding protein Chain: A: PDB Molecule:conserved domain protein; PDBTitle: crystal structure of the sporulation inhibitor pxo1-118 from bacillus2 anthracis 46 c1xfzA_ not modelled 7.2 13 PDB header:lyase/metal binding protein Chain: A: PDB Molecule:calmodulin-sensitive adenylate cyclase; PDBTitle: crystal structure of anthrax edema factor (ef) in complex2 with calmodulin in the presence of 1 millimolar3 exogenously added calcium chloride 47 c1xfuE_ not modelled 7.2 13 PDB header:lyase/metal binding protein Chain: E: PDB Molecule:calmodulin-sensitive adenylate cyclase; PDBTitle: crystal structure of anthrax edema factor (ef) truncation2 mutant, ef-delta 64 in complex with calmodulin 48 c2gslE_ not modelled 7.2 15 PDB header:structural genomics, unknown function Chain: E: PDB Molecule:hypothetical protein; PDBTitle: x-ray crystal structure of protein fn1578 from fusobacterium2 nucleatum. northeast structural genomics consortium target nr1. 49 d2i9ca1 not modelled 6.9 8 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:RPA1889-like 50 d1bh9b_ not modelled 6.6 33 Fold:Histone-fold Superfamily:Histone-fold Family:TBP-associated factors, TAFs 51 d2j5pa1 not modelled 6.6 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:FtsK C-terminal domain-like 52 c2oqgA_ not modelled 6.5 8 PDB header:transcription Chain: A: PDB Molecule:possible transcriptional regulator, arsr family protein; PDBTitle: arsr-like transcriptional regulator from rhodococcus sp. rha1 53 d1okra_ not modelled 6.3 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 54 c3obhA_ not modelled 6.2 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: x-ray crystal structure of protein sp_0782 (7-79) from streptococcus2 pneumoniae. northeast structural genomics consortium target spr104 55 d1dmga_ not modelled 6.2 13 Fold:Ribosomal protein L4 Superfamily:Ribosomal protein L4 Family:Ribosomal protein L4 56 c2qenA_ not modelled 6.2 14 PDB header:unknown function Chain: A: PDB Molecule:walker-type atpase; PDBTitle: the walker-type atpase paby2304 of pyrococcus abyssi 57 d2b50a1 not modelled 6.1 12 Fold:Nuclear receptor ligand-binding domain Superfamily:Nuclear receptor ligand-binding domain Family:Nuclear receptor ligand-binding domain 58 c3f6oB_ not modelled 6.1 10 PDB header:transcription regulator Chain: B: PDB Molecule:probable transcriptional regulator, arsr family PDBTitle: crystal structure of arsr family transcriptional regulator,2 rha00566 59 c2w9yA_ not modelled 5.9 14 PDB header:lipid transport Chain: A: PDB Molecule:fatty acid/retinol binding protein protein 7, PDBTitle: the structure of the lipid binding protein ce-far-7 from2 caenorhabditis elegans 60 d1y88a1 not modelled 5.9 23 Fold:SAM domain-like Superfamily:Rad51 N-terminal domain-like Family:Hypothetical protein AF1548, C-terminal domain 61 c1fpvA_ not modelled 5.9 22 PDB header:virus Chain: A: PDB Molecule:feline panleukopenia virus (strain b) viral PDBTitle: structure determination of feline panleukopenia virus empty2 particles 62 c2b1wA_ not modelled 5.8 17 PDB header:apoptosis Chain: A: PDB Molecule:caspase recruitment domain protein 4; PDBTitle: solution structure of the nod1 caspase activating and recruitment2 domain 63 c3g3zA_ not modelled 5.8 20 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator, marr family; PDBTitle: the structure of nmb1585, a marr family regulator from neisseria2 meningitidis 64 d1q3ma_ not modelled 5.8 44 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 65 d1q8ha_ not modelled 5.7 44 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 66 c1q8hA_ not modelled 5.7 44 PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin 67 d2olua1 not modelled 5.7 16 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:PBP transglycosylase domain-like 68 d1un2a_ not modelled 5.6 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:DsbA-like 69 d1pq9a_ not modelled 5.4 11 Fold:Nuclear receptor ligand-binding domain Superfamily:Nuclear receptor ligand-binding domain Family:Nuclear receptor ligand-binding domain 70 c3elkA_ not modelled 5.3 15 PDB header:transcription regulator Chain: A: PDB Molecule:putative transcriptional regulator ta0346; PDBTitle: crystal structure of putative transcriptional regulator ta0346 from2 thermoplasma acidophilum 71 c2nyxB_ not modelled 5.3 10 PDB header:transcription Chain: B: PDB Molecule:probable transcriptional regulatory protein, rv1404; PDBTitle: crystal structure of rv1404 from mycobacterium tuberculosis

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0