Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP32690
DateThu Jan 5 11:50:14 GMT 2012
Unique Job ID1553516dc34a8b86

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3nb2B_
Top template information
PDB header:ligase
Chain: B: PDB Molecule:secreted effector protein;
PDBTitle: crystal structure of e. coli o157:h7 effector protein nlel
Confidence and coverage
Confidence:100.0% Coverage: 93%
410 residues ( 93% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKKIECACNFLMDKDAQGYIDLSDLDLTSCHFKGDVISKVSFLSSNLQHVTFECKEIGDC
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   .........70.........80.........90.........100.........110.........120
Sequence  NFTTAIVDNVIFRCRRLHNVIFIKASGECVDFSKNILDTVDFSQSQLGHSNFRECQIRNS
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   .........130.........140.........150.........160.........170.........180
Sequence  NFDNCYLYASHFTRAEFLSAKEISFIKSNLTAVMFDYVRMSTGNFKDCITEQLELTIDYS
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   .........190.........200.........210.........220.........230.........240
Sequence  DIFWNEDLDGYINNIIKMIDTLPDNAMILKSVLAVKLVMQLKILNIVNKNFIENMKKIFS
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   .........250.........260.........270.........280.........290.........300
Sequence  HCPYIKDPIIRSYIHSDEDNKFDDFMRQHRFSEVNFDTQQMIDFINRFNTNKWLIDKNNN
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?????????????
??

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   .........310.........320.........330.........340.........350.........360
Sequence  FFIQLIDQALRSTDDMIKANVWHLYKEWIRSDDVSPIFIETEDNLRTFNTNELTRNDNIF
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   .........370.........380.........390.........400.........410.........420
Sequence  ILFSSVDDGPVMVVSSQRLHDMLNPTKDTNWNSTYIYKSRHEMLPVNLTQETLFSSKSHG
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   .........430.........440..
Sequence  KYALFPIFTASWRAHRIMNKGV
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???????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3nb2 chain B

3D model

Region: 9 - 433
Aligned: 410
Modelled: 419
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: B: PDB Molecule:secreted effector protein;
PDBTitle: crystal structure of e. coli o157:h7 effector protein nlel

Phyre2

PDB 2qza chain A

3D model

Region: 36 - 433
Aligned: 384
Modelled: 393
Confidence: 100.0%
Identity: 17%
PDB header:ligase
Chain: A: PDB Molecule:secreted effector protein;
PDBTitle: crystal structure of salmonella effector protein sopa

Phyre2

PDB 3du1 chain X

3D model

Region: 11 - 175
Aligned: 162
Modelled: 165
Confidence: 99.9%
Identity: 13%
PDB header:structural protein
Chain: X: PDB Molecule:all3740 protein;
PDBTitle: the 2.0 angstrom resolution crystal structure of hetl, a pentapeptide2 repeat protein involved in heterocyst differentiation regulation from3 the cyanobacterium nostoc sp. strain pcc 7120

Phyre2

PDB 2o6w chain A

3D model

Region: 21 - 167
Aligned: 143
Modelled: 144
Confidence: 99.9%
Identity: 15%
PDB header:unknown function
Chain: A: PDB Molecule:repeat five residue (rfr) protein or
PDBTitle: crystal structure of a pentapeptide repeat protein (rfr23)2 from the cyanobacterium cyanothece 51142

Phyre2

PDB 2xt4 chain B

3D model

Region: 12 - 180
Aligned: 166
Modelled: 169
Confidence: 99.9%
Identity: 19%
PDB header:cell cycle
Chain: B: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.

Phyre2

PDB 3pss chain B

3D model

Region: 17 - 178
Aligned: 159
Modelled: 162
Confidence: 99.9%
Identity: 11%
PDB header:cell cycle
Chain: B: PDB Molecule:qnr;
PDBTitle: crystal structure of ahqnr, the qnr protein from aeromonas hydrophila2 (p21 crystal form)

Phyre2

PDB 2j8k chain A domain 1

3D model

Region: 11 - 176
Aligned: 166
Modelled: 166
Confidence: 99.9%
Identity: 17%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 2j8k chain A

3D model

Region: 11 - 176
Aligned: 166
Modelled: 166
Confidence: 99.9%
Identity: 17%
PDB header:toxin
Chain: A: PDB Molecule:np275-np276;
PDBTitle: structure of the fusion of np275 and np276, pentapeptide2 repeat proteins from nostoc punctiforme

Phyre2

PDB 2w7z chain B

3D model

Region: 20 - 176
Aligned: 156
Modelled: 157
Confidence: 99.8%
Identity: 16%
PDB header:inhibitor
Chain: B: PDB Molecule:pentapeptide repeat family protein;
PDBTitle: structure of the pentapeptide repeat protein efsqnr, a dna2 gyrase inhibitor. free amines modified by cyclic3 pentylation with glutaraldehyde.

Phyre2

PDB 2xtw chain B

3D model

Region: 20 - 172
Aligned: 150
Modelled: 153
Confidence: 99.8%
Identity: 15%
PDB header:cell cycle
Chain: B: PDB Molecule:qnrb1;
PDBTitle: structure of qnrb1 (full length), a plasmid-mediated2 fluoroquinolone resistance protein

Phyre2

PDB 2xt4 chain A

3D model

Region: 17 - 176
Aligned: 157
Modelled: 160
Confidence: 99.8%
Identity: 14%
PDB header:cell cycle
Chain: A: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.

Phyre2

PDB 3n90 chain A

3D model

Region: 17 - 165
Aligned: 142
Modelled: 149
Confidence: 99.8%
Identity: 12%
PDB header:unknown function
Chain: A: PDB Molecule:thylakoid lumenal 15 kda protein 1, chloroplastic;
PDBTitle: the 1.7 angstrom resolution crystal structure of at2g44920, a2 pentapeptide repeat protein from arabidopsis thaliana thylakoid3 lumen.

Phyre2

PDB 2g0y chain A

3D model

Region: 29 - 166
Aligned: 132
Modelled: 138
Confidence: 99.8%
Identity: 11%
PDB header:unknown function
Chain: A: PDB Molecule:pentapeptide repeat protein;
PDBTitle: crystal structure of a lumenal pentapeptide repeat protein from2 cyanothece sp 51142 at 2.3 angstrom resolution. tetragonal crystal3 form

Phyre2

PDB 2bm5 chain A domain 1

3D model

Region: 17 - 176
Aligned: 160
Modelled: 160
Confidence: 99.8%
Identity: 9%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 2f3l chain A domain 1

3D model

Region: 30 - 166
Aligned: 131
Modelled: 137
Confidence: 99.8%
Identity: 11%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 2j8i chain B

3D model

Region: 25 - 137
Aligned: 113
Modelled: 113
Confidence: 99.8%
Identity: 15%
PDB header:toxin
Chain: B: PDB Molecule:np275;
PDBTitle: structure of np275, a pentapeptide repeat protein from2 nostoc punctiforme

Phyre2

PDB 2j8i chain A domain 1

3D model

Region: 22 - 113
Aligned: 92
Modelled: 92
Confidence: 99.5%
Identity: 14%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 3etv chain A

3D model

Region: 291 - 383
Aligned: 87
Modelled: 93
Confidence: 78.7%
Identity: 15%
PDB header:transport protein
Chain: A: PDB Molecule:protein transport protein tip20,linker,protein
PDBTitle: crystal structure of a tip20p-dsl1p fusion protein

Phyre2

PDB 3bux chain B domain 2

3D model

Region: 201 - 261
Aligned: 53
Modelled: 61
Confidence: 52.8%
Identity: 13%
Fold: N-cbl like
Superfamily: N-terminal domain of cbl (N-cbl)
Family: N-terminal domain of cbl (N-cbl)

Phyre2

PDB 3bun chain B

3D model

Region: 201 - 261
Aligned: 53
Modelled: 61
Confidence: 47.1%
Identity: 13%
PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4

Phyre2
1

c3nb2B_
2

c2qzaA_
3

c3du1X_
4

c2o6wA_
5

c2xt4B_
6

c3pssB_
7

d2j8ka1
8

c2j8kA_
9

c2w7zB_
10

c2xtwB_
11

c2xt4A_
12

c3n90A_
13

c2g0yA_
14

d2bm5a1
15

d2f3la1
16

c2j8iB_
17

d2j8ia1
18

c3etvA_
19

d3buxb2
20

c3bunB_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



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51



52



53



54



55



56






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3nb2B_



100.0 20 PDB header:ligase
Chain: B: PDB Molecule:secreted effector protein;
PDBTitle: crystal structure of e. coli o157:h7 effector protein nlel
2c2qzaA_



100.0 17 PDB header:ligase
Chain: A: PDB Molecule:secreted effector protein;
PDBTitle: crystal structure of salmonella effector protein sopa
3c3du1X_



99.9 13 PDB header:structural protein
Chain: X: PDB Molecule:all3740 protein;
PDBTitle: the 2.0 angstrom resolution crystal structure of hetl, a pentapeptide2 repeat protein involved in heterocyst differentiation regulation from3 the cyanobacterium nostoc sp. strain pcc 7120
4c2o6wA_



99.9 15 PDB header:unknown function
Chain: A: PDB Molecule:repeat five residue (rfr) protein or
PDBTitle: crystal structure of a pentapeptide repeat protein (rfr23)2 from the cyanobacterium cyanothece 51142
5c2xt4B_



99.9 19 PDB header:cell cycle
Chain: B: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.
6c3pssB_



99.9 11 PDB header:cell cycle
Chain: B: PDB Molecule:qnr;
PDBTitle: crystal structure of ahqnr, the qnr protein from aeromonas hydrophila2 (p21 crystal form)
7d2j8ka1



99.9 17 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
8c2j8kA_



99.9 17 PDB header:toxin
Chain: A: PDB Molecule:np275-np276;
PDBTitle: structure of the fusion of np275 and np276, pentapeptide2 repeat proteins from nostoc punctiforme
9c2w7zB_



99.8 16 PDB header:inhibitor
Chain: B: PDB Molecule:pentapeptide repeat family protein;
PDBTitle: structure of the pentapeptide repeat protein efsqnr, a dna2 gyrase inhibitor. free amines modified by cyclic3 pentylation with glutaraldehyde.
10c2xtwB_



99.8 15 PDB header:cell cycle
Chain: B: PDB Molecule:qnrb1;
PDBTitle: structure of qnrb1 (full length), a plasmid-mediated2 fluoroquinolone resistance protein
11c2xt4A_



99.8 14 PDB header:cell cycle
Chain: A: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.
12c3n90A_



99.8 12 PDB header:unknown function
Chain: A: PDB Molecule:thylakoid lumenal 15 kda protein 1, chloroplastic;
PDBTitle: the 1.7 angstrom resolution crystal structure of at2g44920, a2 pentapeptide repeat protein from arabidopsis thaliana thylakoid3 lumen.
13c2g0yA_



99.8 11 PDB header:unknown function
Chain: A: PDB Molecule:pentapeptide repeat protein;
PDBTitle: crystal structure of a lumenal pentapeptide repeat protein from2 cyanothece sp 51142 at 2.3 angstrom resolution. tetragonal crystal3 form
14d2bm5a1



99.8 9 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
15d2f3la1



99.8 11 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
16c2j8iB_



99.8 15 PDB header:toxin
Chain: B: PDB Molecule:np275;
PDBTitle: structure of np275, a pentapeptide repeat protein from2 nostoc punctiforme
17d2j8ia1



99.5 14 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
18c3etvA_



78.7 15 PDB header:transport protein
Chain: A: PDB Molecule:protein transport protein tip20,linker,protein
PDBTitle: crystal structure of a tip20p-dsl1p fusion protein
19d3buxb2



52.8 13 Fold:N-cbl like
Superfamily:N-terminal domain of cbl (N-cbl)
Family:N-terminal domain of cbl (N-cbl)
20c3bunB_



47.1 13 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
21c2cblA_



not modelled 42.8 13 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
22d1td6a_



not modelled 39.9 16 Fold:Hypothetical protein MPN330
Superfamily:Hypothetical protein MPN330
Family:Hypothetical protein MPN330
23d1h8ba_



not modelled 37.4 19 Fold:EF Hand-like
Superfamily:EF-hand
Family:EF-hand modules in multidomain proteins
24c3ddrC_



not modelled 36.0 11 PDB header:membrane protein/heme binding protein
Chain: C: PDB Molecule:hemophore hasa;
PDBTitle: structure of the serratia marcescens hemophore receptor hasr-ile671gly2 mutant in complex with its hemophore hasa and heme
25c1fbvA_



not modelled 35.1 13 PDB header:ligase
Chain: A: PDB Molecule:signal transduction protein cbl;
PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases
26d1dlya_



not modelled 33.4 22 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
27c1dlyA_



not modelled 33.4 22 PDB header:oxygen storage/transport
Chain: A: PDB Molecule:hemoglobin;
PDBTitle: x-ray crystal structure of hemoglobin from the green2 unicellular alga chlamydomonas eugametos
28d1idra_



not modelled 30.7 23 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
29c2kscA_



not modelled 28.9 16 PDB header:unknown function
Chain: A: PDB Molecule:cyanoglobin;
PDBTitle: solution structure of synechococcus sp. pcc 7002 hemoglobin
30d1dk0a_



not modelled 26.9 12 Fold:Heme-binding protein A (HasA)
Superfamily:Heme-binding protein A (HasA)
Family:Heme-binding protein A (HasA)
31c3aq8A_



not modelled 25.6 26 PDB header:oxygen binding
Chain: A: PDB Molecule:group 1 truncated hemoglobin;
PDBTitle: crystal structure of truncated hemoglobin from tetrahymena pyriformis,2 q46e mutant, fe(iii) form
32d1s69a_



not modelled 23.4 13 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
33d1m8na_



not modelled 23.3 11 Fold:Single-stranded left-handed beta-helix
Superfamily:An insect antifreeze protein
Family:An insect antifreeze protein
34d1dlwa_



not modelled 21.5 13 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
35d1ngka_



not modelled 20.6 13 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
36c3op0B_



not modelled 17.2 8 PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
37c1z9eA_



not modelled 16.0 11 PDB header:protein binding/transcription
Chain: A: PDB Molecule:pc4 and sfrs1 interacting protein 2;
PDBTitle: solution structure of the hiv-1 integrase-binding domain in2 ledgf/p75
38d1ogmx2



not modelled 15.1 18 Fold:Single-stranded right-handed beta-helix
Superfamily:Pectin lyase-like
Family:Dextranase, catalytic domain
39d2b4jc1



not modelled 15.0 11 Fold:N-cbl like
Superfamily:HIV integrase-binding domain
Family:HIV integrase-binding domain
40d1fqia_



not modelled 14.1 14 Fold:Regulator of G-protein signaling, RGS
Superfamily:Regulator of G-protein signaling, RGS
Family:Regulator of G-protein signaling, RGS
41c2crpA_



not modelled 12.3 13 PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signaling 5;
PDBTitle: solution structure of the rgs domain of regulator of g-2 protein signalling 5 (rgs 5)
42c2p90B_



not modelled 11.8 12 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:hypothetical protein cgl1923;
PDBTitle: the crystal structure of a protein of unknown function from2 corynebacterium glutamicum atcc 13032
43d1ko7a1



not modelled 11.5 20 Fold:MurF and HprK N-domain-like
Superfamily:HprK N-terminal domain-like
Family:HPr kinase/phoshatase HprK N-terminal domain
44c2bmmA_



not modelled 11.3 9 PDB header:oxygen storage/transport
Chain: A: PDB Molecule:thermostable hemoglobin from thermobifida fusca;
PDBTitle: x-ray structure of a novel thermostable hemoglobin from the2 actinobacterium thermobifida fusca
45c2gtpD_



not modelled 10.4 19 PDB header:signaling protein
Chain: D: PDB Molecule:regulator of g-protein signaling 1;
PDBTitle: crystal structure of the heterodimeric complex of human rgs1 and2 activated gi alpha 1
46c2pbiA_



not modelled 10.0 13 PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signaling 9;
PDBTitle: the multifunctional nature of gbeta5/rgs9 revealed from its crystal2 structure
47c2d9jA_



not modelled 8.7 13 PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signalling 7;
PDBTitle: solution structure of the rgs domain of regulator of g-2 protein signaling 7
48c1d0rA_



not modelled 8.7 0 PDB header:hormone/growth factor
Chain: A: PDB Molecule:glucagon-like peptide-1-(7-36)-amide;
PDBTitle: solution structure of glucagon-like peptide-1-(7-36)-amide2 in trifluoroethanol/water
49d3buxb3



not modelled 8.2 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1jg5a_



not modelled 7.6 31 Fold:GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily:GTP cyclohydrolase I feedback regulatory protein, GFRP
Family:GTP cyclohydrolase I feedback regulatory protein, GFRP
51c2xykB_



not modelled 7.1 11 PDB header:oxygen storage/transport
Chain: B: PDB Molecule:2-on-2 hemoglobin;
PDBTitle: group ii 2-on-2 hemoglobin from the plant pathogen2 agrobacterium tumefaciens
52d2etda1



not modelled 6.3 24 Fold:Bromodomain-like
Superfamily:LemA-like
Family:LemA-like
53c2af0A_



not modelled 6.1 10 PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signaling 2;
PDBTitle: structure of the regulator of g-protein signaling domain of2 rgs2
54d7pcka_



not modelled 6.1 11 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Papain-like
55c1jrjA_



not modelled 5.8 6 PDB header:hormone/growth factor
Chain: A: PDB Molecule:exendin-4;
PDBTitle: solution structure of exendin-4 in 30-vol% trifluoroethanol
56c2ebzA_



not modelled 5.6 6 PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signaling 12;
PDBTitle: solution structure of the rgs domain from human regulator2 of g-protein signaling 12 (rgs12)

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0