Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	T	T	Q	Q	S	G	F	A	P	A	A	S	P	L	A	S	T	I	V	Q	T	P	D	D	A	I	V	A	G	F	T	S	I	P	S	Q	G	D	N	M	P	A	Y	H	A	R	P	K	Q	S	D	G	P	L	P	V	V	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	V	Q	E	I	F	G	V	H	E	H	I	R	D	I	C	R	R	L	A	L	E	G	Y	L	A	I	A	P	E	L	Y	F	R	E	G	D	P	N	D	F	A	D	I	P	T	L	L	S	G	L	V	A	K	V	P	D	S	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	A	D	L	D	H	V	A	S	W	A	S	R	N	G	G	D	V	H	R	L	M	I	T	G	F	C	W	G	G	R	I	T	W	L	Y	A	A	H	N	P	Q	L	K	A	A	V	A	W	Y	G	K	L	T	G	D	K	S	L	N
Secondary structure
SS confidence
Disorder																																																										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	P	K	Q	P	V	D	I	A	T	D	L	N	A	P	I	L	G	L	Y	G	G	Q	D	N	S	I	P	Q	E	S	V	E	T	M	R	Q	A	L	R	A	A	N	A	K	A	E	I	I	V	Y	P	D	A	G	H	A	F	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		D	Y	R	P	S	Y	H	A	A	S	A	E	D	G	W	Q	R	M	L	E	W	F	K	Q	Y	G	G	K	K	S	L
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?																					?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3f67 chain A Region: 26 - 265 Aligned: 240 Modelled: 240 Confidence: 100.0% Identity: 81% PDB header:hydrolase Chain: A: PDB Molecule:putative dienelactone hydrolase; PDBTitle: crystal structure of putative dienelactone hydrolase from klebsiella2 pneumoniae subsp. pneumoniae mgh 78578 Phyre2 PDB 3azq chain A Region: 7 - 267 Aligned: 248 Modelled: 260 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase; PDBTitle: crystal structure of puromycin hydrolase s511a mutant complexed with2 pgg Phyre2 PDB 2ecf chain A Region: 26 - 268 Aligned: 229 Modelled: 242 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase iv; PDBTitle: crystal structure of dipeptidyl aminopeptidase iv from2 stenotrophomonas maltophilia Phyre2 PDB 2hu7 chain A Region: 29 - 268 Aligned: 225 Modelled: 239 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:acylamino-acid-releasing enzyme; PDBTitle: binding of inhibitors by acylaminoacyl peptidase Phyre2 PDB 1z68 chain A Region: 28 - 266 Aligned: 225 Modelled: 239 Confidence: 100.0% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:fibroblast activation protein, alpha subunit; PDBTitle: crystal structure of human fibroblast activation protein alpha Phyre2 PDB 2eep chain A Region: 19 - 266 Aligned: 234 Modelled: 242 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl aminopeptidase iv, putative; PDBTitle: prolyl tripeptidyl aminopeptidase complexed with an inhibitor Phyre2 PDB 2g5t chain A Region: 29 - 266 Aligned: 225 Modelled: 238 Confidence: 100.0% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: crystal structure of human dipeptidyl peptidase iv (dppiv)2 complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag Phyre2 PDB 2qtb chain B Region: 29 - 267 Aligned: 226 Modelled: 239 Confidence: 100.0% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl2 cyclohexylalanine inhibitor Phyre2 PDB 1din chain A Region: 28 - 268 Aligned: 228 Modelled: 240 Confidence: 100.0% Identity: 25% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Dienelactone hydrolase Phyre2 PDB 3hlk chain B Region: 31 - 266 Aligned: 217 Modelled: 222 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:acyl-coenzyme a thioesterase 2, mitochondrial; PDBTitle: crystal structure of human mitochondrial acyl-coa2 thioesterase (acot2) Phyre2 PDB 3k2i chain A Region: 28 - 266 Aligned: 222 Modelled: 225 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:acyl-coenzyme a thioesterase 4; PDBTitle: human acyl-coenzyme a thioesterase 4 Phyre2 PDB 1xfd chain D Region: 28 - 268 Aligned: 228 Modelled: 241 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: D: PDB Molecule:dipeptidyl aminopeptidase-like protein 6; PDBTitle: structure of a human a-type potassium channel accelerating factor2 dppx, a member of the dipeptidyl aminopeptidase family Phyre2 PDB 1qfm chain A Region: 5 - 269 Aligned: 253 Modelled: 265 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:protein (prolyl oligopeptidase); PDBTitle: prolyl oligopeptidase from porcine muscle Phyre2 PDB 2bkl chain B Region: 14 - 269 Aligned: 244 Modelled: 256 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:prolyl endopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl2 endopeptidases: role of inter-domain dynamics in3 catalysis and specificity Phyre2 PDB 2xe4 chain A Region: 7 - 268 Aligned: 251 Modelled: 262 Confidence: 100.0% Identity: 11% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:oligopeptidase b; PDBTitle: structure of oligopeptidase b from leishmania major Phyre2 PDB 1qfm chain A domain 2 Region: 24 - 271 Aligned: 236 Modelled: 242 Confidence: 100.0% Identity: 15% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Prolyl oligopeptidase, C-terminal domain Phyre2 PDB 1l7a chain A Region: 19 - 268 Aligned: 234 Modelled: 249 Confidence: 100.0% Identity: 24% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetyl xylan esterase-like Phyre2 PDB 3ium chain A Region: 16 - 271 Aligned: 236 Modelled: 241 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:prolyl endopeptidase; PDBTitle: appep_wtx opened state Phyre2 PDB 2o2g chain A Region: 27 - 267 Aligned: 213 Modelled: 233 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:dienelactone hydrolase; PDBTitle: crystal structure of dienelactone hydrolase (yp_324580.1) from2 anabaena variabilis atcc 29413 at 1.92 a resolution Phyre2 PDB 3ksr chain A Region: 28 - 269 Aligned: 220 Modelled: 242 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative serine hydrolase; PDBTitle: crystal structure of a putative serine hydrolase (xcc3885) from2 xanthomonas campestris pv. campestris at 2.69 a resolution Phyre2 1 c3f67A_ 2 c3azqA_ 3 c2ecfA_ 4 c2hu7A_ 5 c1z68A_ 6 c2eepA_ 7 c2g5tA_ 8 c2qtbB_ 9 d1dina_ 10 c3hlkB_ 11 c3k2iA_ 12 c1xfdD_ 13 c1qfmA_ 14 c2bklB_ 15 c2xe4A_ 16 d1qfma2 17 d1l7aa_ 18 c3iumA_ 19 c2o2gA_ 20 c3ksrA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3f67A_ 100.0 81 PDB header:hydrolase Chain: A: PDB Molecule:putative dienelactone hydrolase; PDBTitle: crystal structure of putative dienelactone hydrolase from klebsiella2 pneumoniae subsp. pneumoniae mgh 78578 2 c3azqA_ 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase; PDBTitle: crystal structure of puromycin hydrolase s511a mutant complexed with2 pgg 3 c2ecfA_ 100.0 18 PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase iv; PDBTitle: crystal structure of dipeptidyl aminopeptidase iv from2 stenotrophomonas maltophilia 4 c2hu7A_ 100.0 21 PDB header:hydrolase Chain: A: PDB Molecule:acylamino-acid-releasing enzyme; PDBTitle: binding of inhibitors by acylaminoacyl peptidase 5 c1z68A_ 100.0 15 PDB header:lyase Chain: A: PDB Molecule:fibroblast activation protein, alpha subunit; PDBTitle: crystal structure of human fibroblast activation protein alpha 6 c2eepA_ 100.0 14 PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl aminopeptidase iv, putative; PDBTitle: prolyl tripeptidyl aminopeptidase complexed with an inhibitor 7 c2g5tA_ 100.0 11 PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: crystal structure of human dipeptidyl peptidase iv (dppiv)2 complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag 8 c2qtbB_ 100.0 12 PDB header:hydrolase Chain: B: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl2 cyclohexylalanine inhibitor 9 d1dina_ 100.0 25 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Dienelactone hydrolase 10 c3hlkB_ 100.0 21 PDB header:hydrolase Chain: B: PDB Molecule:acyl-coenzyme a thioesterase 2, mitochondrial; PDBTitle: crystal structure of human mitochondrial acyl-coa2 thioesterase (acot2) 11 c3k2iA_ 100.0 26 PDB header:hydrolase Chain: A: PDB Molecule:acyl-coenzyme a thioesterase 4; PDBTitle: human acyl-coenzyme a thioesterase 4 12 c1xfdD_ 100.0 13 PDB header:membrane protein Chain: D: PDB Molecule:dipeptidyl aminopeptidase-like protein 6; PDBTitle: structure of a human a-type potassium channel accelerating factor2 dppx, a member of the dipeptidyl aminopeptidase family 13 c1qfmA_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:protein (prolyl oligopeptidase); PDBTitle: prolyl oligopeptidase from porcine muscle 14 c2bklB_ 100.0 16 PDB header:hydrolase Chain: B: PDB Molecule:prolyl endopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl2 endopeptidases: role of inter-domain dynamics in3 catalysis and specificity 15 c2xe4A_ 100.0 11 PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:oligopeptidase b; PDBTitle: structure of oligopeptidase b from leishmania major 16 d1qfma2 100.0 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Prolyl oligopeptidase, C-terminal domain 17 d1l7aa_ 100.0 24 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acetyl xylan esterase-like 18 c3iumA_ 100.0 13 PDB header:hydrolase Chain: A: PDB Molecule:prolyl endopeptidase; PDBTitle: appep_wtx opened state 19 c2o2gA_ 100.0 18 PDB header:hydrolase Chain: A: PDB Molecule:dienelactone hydrolase; PDBTitle: crystal structure of dienelactone hydrolase (yp_324580.1) from2 anabaena variabilis atcc 29413 at 1.92 a resolution 20 c3ksrA_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:putative serine hydrolase; PDBTitle: crystal structure of a putative serine hydrolase (xcc3885) from2 xanthomonas campestris pv. campestris at 2.69 a resolution 21 d2hu7a2 not modelled 100.0 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acylamino-acid-releasing enzyme, C-terminal donain 22 d1vlqa_ not modelled 100.0 18 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acetyl xylan esterase-like 23 c3bxpA_ not modelled 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:putative lipase/esterase; PDBTitle: crystal structure of a putative carboxylesterase (lp_2923) from2 lactobacillus plantarum wcfs1 at 1.70 a resolution 24 c1yr2A_ not modelled 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:prolyl oligopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl endopeptidases: role2 of inter-domain dynamics in catalysis and specificity 25 c3fnbB_ not modelled 100.0 16 PDB header:hydrolase Chain: B: PDB Molecule:acylaminoacyl peptidase smu_737; PDBTitle: crystal structure of acylaminoacyl peptidase smu_737 from2 streptococcus mutans ua159 26 c2jbwB_ not modelled 100.0 18 PDB header:hydrolase Chain: B: PDB Molecule:2,6-dihydroxy-pseudo-oxynicotine hydrolase; PDBTitle: crystal structure of the 2,6-dihydroxy-pseudo-oxynicotine2 hydrolase. 27 d2jbwa1 not modelled 100.0 18 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:2,6-dihydropseudooxynicotine hydrolase-like 28 c2i3dA_ not modelled 100.0 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein atu1826; PDBTitle: crystal structure of protein of unknown function atu1826, a putative2 alpha/beta hydrolase from agrobacterium tumefaciens 29 d2i3da1 not modelled 100.0 13 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Atu1826-like 30 d1xfda2 not modelled 100.0 13 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like 31 d1orva2 not modelled 100.0 12 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like 32 d2fuka1 not modelled 100.0 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Atu1826-like 33 d2bgra2 not modelled 100.0 11 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like 34 c3bjrA_ not modelled 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:putative carboxylesterase; PDBTitle: crystal structure of a putative carboxylesterase (lp_1002) from2 lactobacillus plantarum wcfs1 at 2.09 a resolution 35 c2hdwB_ not modelled 100.0 18 PDB header:hydrolase Chain: B: PDB Molecule:hypothetical protein pa2218; PDBTitle: crystal structure of hypothetical protein pa2218 from pseudomonas2 aeruginosa 36 d1ju3a2 not modelled 100.0 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like 37 c3ed1E_ not modelled 100.0 16 PDB header:hydrolase receptor Chain: E: PDB Molecule:gibberellin receptor gid1; PDBTitle: crystal structure of rice gid1 complexed with ga3 38 c3doiA_ not modelled 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:esterase; PDBTitle: crystal structure of a thermostable esterase complex with2 paraoxon 39 c3mveB_ not modelled 100.0 15 PDB header:lyase Chain: B: PDB Molecule:upf0255 protein vv1_0328; PDBTitle: crystal structure of a novel pyruvate decarboxylase 40 c3ga7A_ not modelled 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:acetyl esterase; PDBTitle: 1.55 angstrom crystal structure of an acetyl esterase from salmonella2 typhimurium 41 c3hxkB_ not modelled 100.0 12 PDB header:hydrolase Chain: B: PDB Molecule:sugar hydrolase; PDBTitle: crystal structure of a sugar hydrolase (yeeb) from2 lactococcus lactis, northeast structural genomics3 consortium target kr108 42 d1jfra_ not modelled 99.9 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Lipase 43 c2wtmC_ not modelled 99.9 21 PDB header:hydrolase Chain: C: PDB Molecule:est1e; PDBTitle: est1e from butyrivibrio proteoclasticus 44 d1ufoa_ not modelled 99.9 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Hypothetical protein TT1662 45 c3trdA_ not modelled 99.9 18 PDB header:hydrolase Chain: A: PDB Molecule:alpha/beta hydrolase; PDBTitle: structure of an alpha-beta serine hydrolase homologue from coxiella2 burnetii 46 c1l7qA_ not modelled 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:cocaine esterase; PDBTitle: ser117ala mutant of bacterial cocaine esterase coce 47 c3fcyB_ not modelled 99.9 19 PDB header:hydrolase Chain: B: PDB Molecule:xylan esterase 1; PDBTitle: crystal structure of acetyl xylan esterase 1 from2 thermoanaerobacterium sp. jw/sl ys485 48 d1lzla_ not modelled 99.9 20 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase 49 c3fcxA_ not modelled 99.9 13 PDB header:hydrolase Chain: A: PDB Molecule:s-formylglutathione hydrolase; PDBTitle: crystal structure of human esterase d 50 d1jkma_ not modelled 99.9 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase 51 c3i6yA_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:esterase apc40077; PDBTitle: structure of an esterase from the oil-degrading bacterium oleispira2 antarctica 52 c2zshA_ not modelled 99.9 16 PDB header:hormone receptor Chain: A: PDB Molecule:probable gibberellin receptor gid1l1; PDBTitle: structural basis of gibberellin(ga3)-induced della2 recognition by the gibberellin receptor 53 d1fj2a_ not modelled 99.9 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1 54 c2b9vB_ not modelled 99.9 14 PDB header:hydrolase Chain: B: PDB Molecule:alpha-amino acid ester hydrolase; PDBTitle: acetobacter turbidans alpha-amino acid ester hydrolase 55 c3ls2D_ not modelled 99.9 15 PDB header:hydrolase Chain: D: PDB Molecule:s-formylglutathione hydrolase; PDBTitle: crystal structure of an s-formylglutathione hydrolase from2 pseudoalteromonas haloplanktis tac125 56 d2b9va2 not modelled 99.9 14 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like 57 d1u4na_ not modelled 99.9 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase 58 c2c7bA_ not modelled 99.9 21 PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: the crystal structure of este1, a new thermophilic and2 thermostable carboxylesterase cloned from a metagenomic3 library 59 c2wirB_ not modelled 99.9 19 PDB header:hydrolase Chain: B: PDB Molecule:alpha/beta hydrolase fold-3 domain protein; PDBTitle: hyperthermophilic esterase from the archeon pyrobaculum2 calidifontis 60 c3jw8A_ not modelled 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:mgll protein; PDBTitle: crystal structure of human mono-glyceride lipase 61 c3aikB_ not modelled 99.9 14 PDB header:hydrolase Chain: B: PDB Molecule:303aa long hypothetical esterase; PDBTitle: crystal structure of a hsl-like carboxylesterase from sulfolobus2 tokodaii 62 d2h1ia1 not modelled 99.9 13 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1 63 c2o7vA_ not modelled 99.9 14 PDB header:hydrolase Chain: A: PDB Molecule:cxe carboxylesterase; PDBTitle: carboxylesterase aecxe1 from actinidia eriantha covalently inhibited2 by paraoxon 64 d1mpxa2 not modelled 99.9 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like 65 c3hjuB_ not modelled 99.9 16 PDB header:hydrolase Chain: B: PDB Molecule:monoglyceride lipase; PDBTitle: crystal structure of human monoglyceride lipase 66 c2fx5A_ not modelled 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:lipase; PDBTitle: pseudomonas mendocina lipase 67 c3og9A_ not modelled 99.9 13 PDB header:hydrolase Chain: A: PDB Molecule:protein yahd a copper inducible hydrolase; PDBTitle: structure of yahd with malic acid 68 c3fakA_ not modelled 99.9 14 PDB header:hydrolase Chain: A: PDB Molecule:esterase/lipase; PDBTitle: structural and functional analysis of a hormone-sensitive2 lipase like este5 from a metagenome library 69 c3d59B_ not modelled 99.9 12 PDB header:hydrolase Chain: B: PDB Molecule:platelet-activating factor acetylhydrolase; PDBTitle: crystal structure of human plasma platelet activating2 factor acetylhydrolase 70 c3u0vA_ not modelled 99.9 13 PDB header:hydrolase Chain: A: PDB Molecule:lysophospholipase-like protein 1; PDBTitle: crystal structure analysis of human lyplal1 71 c3h04A_ not modelled 99.9 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of the protein with unknown function from2 staphylococcus aureus subsp. aureus mu50 72 c3e4dD_ not modelled 99.9 14 PDB header:hydrolase Chain: D: PDB Molecule:esterase d; PDBTitle: structural and kinetic study of an s-formylglutathione2 hydrolase from agrobacterium tumefaciens 73 c3g8yA_ not modelled 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:susd/ragb-associated esterase-like protein; PDBTitle: crystal structure of a putative hydrolase (bvu_4111) from bacteroides2 vulgatus atcc 8482 at 1.90 a resolution 74 c3ib3A_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:coce/nond family hydrolase; PDBTitle: crystal structure of sacol2612 - coce/nond family hydrolase from2 staphylococcus aureus 75 d1auoa_ not modelled 99.9 14 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1 76 d1hlga_ not modelled 99.9 17 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Gastric lipase 77 c3dnmA_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:esterase/lipase; PDBTitle: crystal structure hormone-sensitive lipase from a2 metagenome library 78 c3cn9B_ not modelled 99.9 13 PDB header:hydrolase Chain: B: PDB Molecule:carboxylesterase; PDBTitle: crystal structure analysis of the carboxylesterase pa3859 from2 pseudomonas aeruginosa pao1- orthorhombic crystal form 79 c3qm1A_ not modelled 99.9 13 PDB header:hydrolase Chain: A: PDB Molecule:cinnamoyl esterase; PDBTitle: crystal structure of the lactobacillus johnsonii cinnamoyl esterase2 lj0536 s106a mutant in complex with ethylferulate, form ii 80 c3llcA_ not modelled 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:putative hydrolase; PDBTitle: crystal structure of putative hydrolase (yp_002548124.1) from2 agrobacterium vitis s4 at 1.80 a resolution 81 c3d0kA_ not modelled 99.9 14 PDB header:hydrolase Chain: A: PDB Molecule:putative poly(3-hydroxybutyrate) depolymerase lpqc; PDBTitle: crystal structure of the lpqc, poly(3-hydroxybutyrate) depolymerase2 from bordetella parapertussis 82 c2qruA_ not modelled 99.9 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an alpha/beta hydrolase superfamily protein from2 enterococcus faecalis 83 d1k8qa_ not modelled 99.9 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Gastric lipase 84 c2h1iA_ not modelled 99.9 12 PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: crystal structure of the bacillus cereus carboxylesterase 85 d1jjfa_ not modelled 99.9 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase 86 c3h2iA_ not modelled 99.9 18 PDB header:hydrolase Chain: A: PDB Molecule:esterase; PDBTitle: crystal structure of n228w mutant of the rice cell wall2 degrading esterase lipa from xanthomonas oryzae 87 c1mpxB_ not modelled 99.9 17 PDB header:hydrolase Chain: B: PDB Molecule:alpha-amino acid ester hydrolase; PDBTitle: alpha-amino acid ester hydrolase labeled with selenomethionine 88 d2r8ba1 not modelled 99.9 14 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1 89 c2r8bA_ not modelled 99.9 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein atu2452; PDBTitle: the crystal structure of the protein atu2452 of unknown function from2 agrobacterium tumefaciens str. c58 90 d1jjia_ not modelled 99.9 18 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase 91 c2veoA_ not modelled 99.9 14 PDB header:hydrolase Chain: A: PDB Molecule:lipase a; PDBTitle: x-ray structure of candida antarctica lipase a in its2 closed state. 92 c3d7rB_ not modelled 99.9 13 PDB header:hydrolase Chain: B: PDB Molecule:esterase; PDBTitle: crystal structure of a putative esterase from staphylococcus aureus 93 d1pv1a_ not modelled 99.9 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Hypothetical esterase YJL068C 94 c3qh4A_ not modelled 99.9 21 PDB header:hydrolase Chain: A: PDB Molecule:esterase lipw; PDBTitle: crystal structure of esterase lipw from mycobacterium marinum 95 d1sfra_ not modelled 99.9 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens 96 c3dyvA_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:esterase d; PDBTitle: snapshots of esterase d from lactobacillus rhamnosus:2 insights into a rotation driven catalytic mechanism 97 d1lnsa3 not modelled 99.9 19 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like 98 d1f0na_ not modelled 99.9 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens 99 d3b5ea1 not modelled 99.9 12 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1 100 c3nuzF_ not modelled 99.9 18 PDB header:hydrolase Chain: F: PDB Molecule:putative acetyl xylan esterase; PDBTitle: crystal structure of a putative acetyl xylan esterase (bf1801) from2 bacteroides fragilis nctc 9343 at 2.30 a resolution 101 c2uz0B_ not modelled 99.9 14 PDB header:hydrolase Chain: B: PDB Molecule:tributyrin esterase; PDBTitle: the crystal crystal structure of the esta protein, a2 virulence factor esta protein from streptococcus pneumonia 102 d1uxoa_ not modelled 99.8 14 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:YdeN-like 103 c2cjpA_ not modelled 99.8 17 PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase; PDBTitle: structure of potato (solanum tuberosum) epoxide hydrolase i2 (steh1) 104 c1ycdA_ not modelled 99.8 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical 27.3 kda protein in aap1-smf2 PDBTitle: crystal structure of yeast fsh1/yhr049w, a member of the2 serine hydrolase family 105 c2qjwA_ not modelled 99.8 17 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein xcc1541; PDBTitle: crystal structure of a putative hydrolase of the alpha/beta2 superfamily (xcc1541) from xanthomonas campestris pv. campestris at3 1.35 a resolution 106 d2gzsa1 not modelled 99.8 13 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:IroE-like 107 c3i1iA_ not modelled 99.8 17 PDB header:transferase Chain: A: PDB Molecule:homoserine o-acetyltransferase; PDBTitle: x-ray crystal structure of homoserine o-acetyltransferase from2 bacillus anthracis 108 d1vkha_ not modelled 99.8 8 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Putative serine hydrolase Ydr428c 109 d2b61a1 not modelled 99.8 19 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:O-acetyltransferase 110 d1mtza_ not modelled 99.8 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Proline iminopeptidase-like 111 c2qm0B_ not modelled 99.8 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:bes; PDBTitle: crystal structure of bes protein from bacillus cereus 112 c1cr6A_ not modelled 99.8 15 PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase; PDBTitle: crystal structure of murine soluble epoxide hydrolase2 complexed with cpu inhibitor 113 c2q0xA_ not modelled 99.8 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: alpha/beta hydrolase fold protein of unknown function 114 d1dqza_ not modelled 99.8 15 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens 115 c3c8dA_ not modelled 99.8 12 PDB header:hydrolase Chain: A: PDB Molecule:enterochelin esterase; PDBTitle: crystal structure of the enterobactin esterase fes from2 shigella flexneri in the presence of 2,3-di-hydroxy-n-3 benzoyl-glycine 116 c3picB_ not modelled 99.8 14 PDB header:hydrolase Chain: B: PDB Molecule:cip2; PDBTitle: glucuronoyl esterase catalytic domain (cip2_ge) from hypocrea jecorina 117 c2y6vB_ not modelled 99.8 11 PDB header:hydrolase Chain: B: PDB Molecule:peroxisomal membrane protein lpx1; PDBTitle: peroxisomal alpha-beta-hydrolase lpx1 (yor084w) from2 saccharomyces cerevisiae (crystal form i) 118 c1lnsA_ not modelled 99.8 17 PDB header:hydrolase Chain: A: PDB Molecule:x-prolyl dipeptidyl aminopetidase; PDBTitle: crystal structure analysis of the x-prolyl dipeptidyl2 aminopeptidase from lactococcus lactis 119 c2r11D_ not modelled 99.8 15 PDB header:hydrolase Chain: D: PDB Molecule:carboxylesterase np; PDBTitle: crystal structure of putative hydrolase (2632844) from2 bacillus subtilis at 1.96 a resolution 120 c2e3jA_ not modelled 99.8 23 PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase ephb; PDBTitle: the crystal structure of epoxide hydrolase b (rv1938) from2 mycobacterium tuberculosis at 2.1 angstrom

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0