Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	K	H	T	L	E	Q	L	A	A	D	L	R	R	A	A	E	Q	G	E	A	I	A	P	L	R	D	L	I	G	I	D	N	A	E	A	A	Y	A	I	Q	H	I	N	V	Q	H	D	V	A	Q	G	R	R	V	V	G	R	K
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	L	T	H	P	K	V	Q	Q	Q	L	G	V	D	Q	P	D	F	G	T	L	F	A	D	M	C	Y	G	D	N	E	I	I	P	F	S	R	V	L	Q	P	R	I	E	A	E	I	A	L	V	L	N	R	D	L	P	A	T	D
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	F	D	E	L	Y	N	A	I	E	W	V	L	P	A	L	E	V	V	G	S	R	I	R	D	W	S	I	Q	F	V	D	T	V	A	D	N	A	S	C	G	V	Y	V	I	G	G	P	A	Q	R	P	A	G	L	D	L	K	N
Secondary structure
SS confidence
Disorder																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	A	M	K	M	T	R	N	N	E	E	V	S	S	G	R	G	S	E	C	L	G	H	P	L	N	A	A	V	W	L	A	R	K	M	A	S	L	G	E	P	L	R	T	G	D	I	I	L	T	G	A	L	G	P	M	V	A	V	N
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.
Sequence		A	G	D	R	F	E	A	H	I	E	G	I	G	S	V	A	A	T	F	S	S	A	A	P	K	G	S	L	S
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1sv6 chain A Region: 1 - 261 Aligned: 261 Modelled: 261 Confidence: 100.0% Identity: 100% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 2eb5 chain D Region: 1 - 259 Aligned: 257 Modelled: 257 Confidence: 100.0% Identity: 35% PDB header:lyase Chain: D: PDB Molecule:2-oxo-hept-3-ene-1,7-dioate hydratase; PDBTitle: crystal structure of hpcg complexed with oxalate Phyre2 PDB 3qdf chain A Region: 59 - 263 Aligned: 186 Modelled: 205 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from mycobacterium marinum Phyre2 PDB 1saw chain A Region: 59 - 261 Aligned: 188 Modelled: 203 Confidence: 100.0% Identity: 16% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 3l53 chain F Region: 59 - 261 Aligned: 196 Modelled: 203 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative fumarylacetoacetate isomerase/hydrolase; PDBTitle: crystal structure of a putative fumarylacetoacetate2 isomerase/hydrolase from oleispira antarctica Phyre2 PDB 1gtt chain A domain 1 Region: 59 - 264 Aligned: 192 Modelled: 206 Confidence: 100.0% Identity: 18% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1wzo chain C Region: 59 - 261 Aligned: 188 Modelled: 203 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: C: PDB Molecule:hpce; PDBTitle: crystal structure of the hpce from thermus thermophilus hb8 Phyre2 PDB 1gtt chain A domain 2 Region: 59 - 261 Aligned: 189 Modelled: 203 Confidence: 100.0% Identity: 17% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1nr9 chain A Region: 59 - 260 Aligned: 188 Modelled: 202 Confidence: 100.0% Identity: 15% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1i7o chain C Region: 59 - 264 Aligned: 192 Modelled: 206 Confidence: 100.0% Identity: 20% PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce Phyre2 PDB 3r6o chain A Region: 59 - 264 Aligned: 191 Modelled: 206 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1, 7-dioateisomerase; PDBTitle: crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7-2 dioateisomerase from mycobacterium abscessus Phyre2 PDB 2dfu chain B Region: 59 - 267 Aligned: 197 Modelled: 209 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: B: PDB Molecule:probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from thermus thermophilus hb8 Phyre2 PDB 1nkq chain A Region: 59 - 265 Aligned: 201 Modelled: 207 Confidence: 100.0% Identity: 19% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 3lzk chain C Region: 59 - 263 Aligned: 195 Modelled: 205 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:fumarylacetoacetate hydrolase family protein; PDBTitle: the crystal structure of a probably aromatic amino acid2 degradation protein from sinorhizobium meliloti 1021 Phyre2 PDB 2q1d chain X Region: 59 - 263 Aligned: 186 Modelled: 205 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: X: PDB Molecule:2-keto-3-deoxy-d-arabinonate dehydratase; PDBTitle: 2-keto-3-deoxy-d-arabinonate dehydratase complexed with magnesium and2 2,5-dioxopentanoate Phyre2 PDB 1hyo chain A domain 2 Region: 77 - 262 Aligned: 180 Modelled: 186 Confidence: 100.0% Identity: 17% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1hyo chain B Region: 75 - 262 Aligned: 182 Modelled: 188 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:fumarylacetoacetate hydrolase; PDBTitle: crystal structure of fumarylacetoacetate hydrolase2 complexed with 4-(hydroxymethylphosphinoyl)-3-oxo-butanoic3 acid Phyre2 PDB 1t8s chain A Region: 185 - 248 Aligned: 56 Modelled: 64 Confidence: 65.1% Identity: 20% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 3frn chain A Region: 188 - 255 Aligned: 66 Modelled: 68 Confidence: 41.7% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:flagellar protein flga; PDBTitle: crystal structure of flagellar protein flga from thermotoga maritima2 msb8 Phyre2 PDB 1ybf chain A Region: 186 - 248 Aligned: 55 Modelled: 63 Confidence: 38.9% Identity: 16% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 1 d1sv6a_ 2 c2eb5D_ 3 c3qdfA_ 4 d1sawa_ 5 c3l53F_ 6 d1gtta1 7 c1wzoC_ 8 d1gtta2 9 d1nr9a_ 10 c1i7oC_ 11 c3r6oA_ 12 c2dfuB_ 13 d1nkqa_ 14 c3lzkC_ 15 c2q1dX_ 16 d1hyoa2 17 c1hyoB_ 18 d1t8sa_ 19 c3frnA_ 20 d1ybfa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1sv6a_ 100.0 100 Fold:FAH Superfamily:FAH Family:FAH 2 c2eb5D_ 100.0 35 PDB header:lyase Chain: D: PDB Molecule:2-oxo-hept-3-ene-1,7-dioate hydratase; PDBTitle: crystal structure of hpcg complexed with oxalate 3 c3qdfA_ 100.0 19 PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from mycobacterium marinum 4 d1sawa_ 100.0 16 Fold:FAH Superfamily:FAH Family:FAH 5 c3l53F_ 100.0 16 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative fumarylacetoacetate isomerase/hydrolase; PDBTitle: crystal structure of a putative fumarylacetoacetate2 isomerase/hydrolase from oleispira antarctica 6 d1gtta1 100.0 18 Fold:FAH Superfamily:FAH Family:FAH 7 c1wzoC_ 100.0 16 PDB header:isomerase Chain: C: PDB Molecule:hpce; PDBTitle: crystal structure of the hpce from thermus thermophilus hb8 8 d1gtta2 100.0 17 Fold:FAH Superfamily:FAH Family:FAH 9 d1nr9a_ 100.0 15 Fold:FAH Superfamily:FAH Family:FAH 10 c1i7oC_ 100.0 20 PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce 11 c3r6oA_ 100.0 19 PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1, 7-dioateisomerase; PDBTitle: crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7-2 dioateisomerase from mycobacterium abscessus 12 c2dfuB_ 100.0 17 PDB header:isomerase Chain: B: PDB Molecule:probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from thermus thermophilus hb8 13 d1nkqa_ 100.0 19 Fold:FAH Superfamily:FAH Family:FAH 14 c3lzkC_ 100.0 18 PDB header:hydrolase Chain: C: PDB Molecule:fumarylacetoacetate hydrolase family protein; PDBTitle: the crystal structure of a probably aromatic amino acid2 degradation protein from sinorhizobium meliloti 1021 15 c2q1dX_ 100.0 16 PDB header:lyase Chain: X: PDB Molecule:2-keto-3-deoxy-d-arabinonate dehydratase; PDBTitle: 2-keto-3-deoxy-d-arabinonate dehydratase complexed with magnesium and2 2,5-dioxopentanoate 16 d1hyoa2 100.0 17 Fold:FAH Superfamily:FAH Family:FAH 17 c1hyoB_ 100.0 17 PDB header:hydrolase Chain: B: PDB Molecule:fumarylacetoacetate hydrolase; PDBTitle: crystal structure of fumarylacetoacetate hydrolase2 complexed with 4-(hydroxymethylphosphinoyl)-3-oxo-butanoic3 acid 18 d1t8sa_ 65.1 20 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 19 c3frnA_ 41.7 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:flagellar protein flga; PDBTitle: crystal structure of flagellar protein flga from thermotoga maritima2 msb8 20 d1ybfa_ 38.9 16 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 21 c3qrqA_ not modelled 30.3 17 PDB header:rna binding protein/rna Chain: A: PDB Molecule:putative uncharacterized protein tthb192; PDBTitle: structure of thermus thermophilus cse3 bound to an rna representing a2 pre-cleavage complex 22 c3pcoD_ not modelled 28.7 15 PDB header:ligase Chain: D: PDB Molecule:phenylalanyl-trna synthetase, beta chain; PDBTitle: crystal structure of e. coli phenylalanine-trna synthetase complexed2 with phenylalanine and amp 23 c3m9bK_ not modelled 23.3 17 PDB header:chaperone Chain: K: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain and the2 inter domain of the mycobacterium tuberculosis proteasomal atpase mpa 24 d1m1la_ not modelled 22.1 20 Fold:Suppressor of Fused, N-terminal domain Superfamily:Suppressor of Fused, N-terminal domain Family:Suppressor of Fused, N-terminal domain 25 c3mb8A_ not modelled 21.7 17 PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of purine nucleoside phosphorylase from toxoplasma2 gondii in complex with immucillin-h 26 c2zy3A_ not modelled 21.1 18 PDB header:lyase Chain: A: PDB Molecule:l-aspartate beta-decarboxylase; PDBTitle: dodecameric l-aspartate beta-decarboxylase 27 c3butA_ not modelled 19.2 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein af_0446; PDBTitle: crystal structure of protein af_0446 from archaeoglobus fulgidus 28 d1q1ga_ not modelled 18.3 15 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 29 c1nw4C_ not modelled 18.3 15 PDB header:transferase Chain: C: PDB Molecule:uridine phosphorylase, putative; PDBTitle: crystal structure of plasmodium falciparum purine nucleoside2 phosphorylase in complex with immh and sulfate 30 c3f6tA_ not modelled 17.8 18 PDB header:transferase Chain: A: PDB Molecule:aspartate aminotransferase; PDBTitle: crystal structure of aspartate aminotransferase (e.c. 2.6.1.1)2 (yp_194538.1) from lactobacillus acidophilus ncfm at 2.15 a3 resolution 31 d1d4oa_ not modelled 14.8 19 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Transhydrogenase domain III (dIII) 32 d1g7sa1 not modelled 14.0 19 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Translation proteins Family:Elongation factors 33 c1yycA_ not modelled 13.5 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative late embryogenesis abundant protein; PDBTitle: solution structure of a putative late embryogenesis2 abundant (lea) protein at2g46140.1 34 c1pt9B_ not modelled 12.8 19 PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase, mitochondrial; PDBTitle: crystal structure analysis of the diii component of transhydrogenase2 with a thio-nicotinamide nucleotide analogue 35 d2f4la1 not modelled 11.8 30 Fold:CUB-like Superfamily:Acetamidase/Formamidase-like Family:Acetamidase/Formamidase-like 36 d3dm8a1 not modelled 11.4 35 Fold:Cystatin-like Superfamily:NTF2-like Family:Rpa4348-like 37 c1z34A_ not modelled 11.0 17 PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of trichomonas vaginalis purine nucleoside2 phosphorylase complexed with 2-fluoro-2'-deoxyadenosine 38 d1k9sa_ not modelled 11.0 16 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 39 d2qamc2 not modelled 10.9 38 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 40 d1rl2a2 not modelled 9.3 31 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 41 c3b9tD_ not modelled 9.3 41 PDB header:hydrolase Chain: D: PDB Molecule:twin-arginine translocation pathway signal protein; PDBTitle: crystal structure of predicted acetamidase/formamidase (yp_546212.1)2 from methylobacillus flagellatus kt at 1.58 a resolution 42 d2j5wa4 not modelled 9.1 30 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 43 c3qpbB_ not modelled 8.9 23 PDB header:transferase Chain: B: PDB Molecule:uridine phosphorylase; PDBTitle: crystal structure of streptococcus pyogenes uridine phosphorylase2 reveals a subclass of the np-i superfamily 44 d2djia1 not modelled 7.9 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 45 c3qo6B_ not modelled 7.9 19 PDB header:photosynthesis Chain: B: PDB Molecule:protease do-like 1, chloroplastic; PDBTitle: crystal structure analysis of the plant protease deg1 46 d2j5wa3 not modelled 7.8 30 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 47 d1pnoa_ not modelled 7.7 16 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Transhydrogenase domain III (dIII) 48 d1vhwa_ not modelled 7.7 13 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 49 d2j5wa1 not modelled 7.3 35 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 50 d1pj3a1 not modelled 7.2 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 51 c3icaB_ not modelled 7.1 15 PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: the crystal structure of the beta subunit of a phenylalanyl-trna2 synthetase from porphyromonas gingivalis w83 52 d1sdda1 not modelled 6.9 37 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 53 c1gr3A_ not modelled 6.6 9 PDB header:collagen Chain: A: PDB Molecule:collagen x; PDBTitle: structure of the human collagen x nc1 trimer 54 d1gr3a_ not modelled 6.6 9 Fold:TNF-like Superfamily:TNF-like Family:TNF-like 55 c3ggsA_ not modelled 6.3 24 PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: human purine nucleoside phosphorylase double mutant e201q,n243d2 complexed with 2-fluoro-2'-deoxyadenosine 56 c3khsB_ not modelled 6.2 24 PDB header:hydrolase Chain: B: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of grouper iridovirus purine nucleoside2 phosphorylase 57 c2csdB_ not modelled 6.2 23 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase v; PDBTitle: crystal structure of topoisomerase v (61 kda fragment) 58 d1c3ha_ not modelled 6.1 9 Fold:TNF-like Superfamily:TNF-like Family:TNF-like 59 c1sddA_ not modelled 5.9 35 PDB header:blood clotting Chain: A: PDB Molecule:coagulation factor v; PDBTitle: crystal structure of bovine factor vai 60 d3bgsa1 not modelled 5.7 24 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 61 c2p4sA_ not modelled 5.7 23 PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: structure of purine nucleoside phosphorylase from anopheles gambiae in2 complex with dadme-immh 62 d1hfua1 not modelled 5.4 30 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 63 d1vmka_ not modelled 5.2 15 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 64 d1xo8a_ not modelled 5.2 6 Fold:Immunoglobulin-like beta-sandwich Superfamily:LEA14-like Family:LEA14-like 65 d1odka_ not modelled 5.2 17 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0