Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP04968
DateWed Jan 25 15:20:11 GMT 2012
Unique Job IDe690cbfadd411e98

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1tdjA_
Top template information
PDB header:allostery
Chain: A: PDB Molecule:biosynthetic threonine deaminase;
PDBTitle: threonine deaminase (biosynthetic) from e. coli
Confidence and coverage
Confidence:100.0% Coverage: 96%
494 residues ( 96% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MADSQPLSGAPEGAEYLRAVLRAPVYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHS
Secondary structure 
SS confidence 
Disorder  ????????????
?
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  FKLRGAYAMMAGLTEEQKAHGVITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDA
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  VRGFGGEVLLHGANFDEAKAKAIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQDAHL
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  DRVFVPVGGGGLAAGVAVLIKQLMPQIKVIAVEAEDSACLKAALDAGHPVDLPRVGLFAE
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  GVAVKRIGDETFRLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYI
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  ALHNIRGERLAHILSGANVNFHGLRYVSERCELGEQREALLAVTIPEEKGSFLKFCQLLG
Secondary structure 
SS confidence 
Disorder  ?????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  GRSVTEFNYRFADAKNACIFVGVRLSRGLEERKEILQMLNDGGYSVVDLSDDEMAKLHVR
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  YMVGGRPSHPLQERLYSFEFPESPGALLRFLNTLGTYWNISLFHYRSHGTDYGRVLAAFE
Secondary structure 
SS confidence 
Disorder 
??????
Disorder confidence 
 
   .........490.........500.........510....
Sequence  LGDHEPDFETRLNELGYDCHDETNNPAFRFFLAG
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1tdj chain A

3D model

Region: 5 - 514
Aligned: 494
Modelled: 494
Confidence: 100.0%
Identity: 100%
PDB header:allostery
Chain: A: PDB Molecule:biosynthetic threonine deaminase;
PDBTitle: threonine deaminase (biosynthetic) from e. coli

Phyre2

PDB 3iau chain A

3D model

Region: 12 - 334
Aligned: 322
Modelled: 323
Confidence: 100.0%
Identity: 49%
PDB header:lyase
Chain: A: PDB Molecule:threonine deaminase;
PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum

Phyre2

PDB 1tdj chain A domain 1

3D model

Region: 5 - 335
Aligned: 331
Modelled: 331
Confidence: 100.0%
Identity: 100%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 2gn0 chain A

3D model

Region: 1 - 328
Aligned: 325
Modelled: 328
Confidence: 100.0%
Identity: 36%
PDB header:lyase
Chain: A: PDB Molecule:threonine dehydratase catabolic;
PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation)

Phyre2

PDB 1v71 chain A domain 1

3D model

Region: 11 - 330
Aligned: 316
Modelled: 320
Confidence: 100.0%
Identity: 32%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 1pwh chain A

3D model

Region: 28 - 338
Aligned: 310
Modelled: 311
Confidence: 100.0%
Identity: 27%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 3l6c chain A

3D model

Region: 22 - 324
Aligned: 302
Modelled: 303
Confidence: 100.0%
Identity: 30%
PDB header:isomerase
Chain: A: PDB Molecule:serine racemase;
PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor

Phyre2

PDB 1p5j chain A

3D model

Region: 28 - 333
Aligned: 305
Modelled: 306
Confidence: 100.0%
Identity: 28%
PDB header:lyase
Chain: A: PDB Molecule:l-serine dehydratase;
PDBTitle: crystal structure analysis of human serine dehydratase

Phyre2

PDB 1p5j chain A

3D model

Region: 28 - 333
Aligned: 305
Modelled: 306
Confidence: 100.0%
Identity: 28%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 3r0z chain A

3D model

Region: 29 - 331
Aligned: 300
Modelled: 303
Confidence: 100.0%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:d-serine dehydratase;
PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium

Phyre2

PDB 1ve5 chain A domain 1

3D model

Region: 11 - 321
Aligned: 301
Modelled: 311
Confidence: 100.0%
Identity: 39%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 2rkb chain E

3D model

Region: 28 - 330
Aligned: 302
Modelled: 303
Confidence: 100.0%
Identity: 30%
PDB header:lyase
Chain: E: PDB Molecule:serine dehydratase-like;
PDBTitle: serine dehydratase like-1 from human cancer cells

Phyre2

PDB 3pc3 chain A

3D model

Region: 25 - 408
Aligned: 347
Modelled: 367
Confidence: 100.0%
Identity: 20%
PDB header:lyase
Chain: A: PDB Molecule:cg1753, isoform a;
PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate

Phyre2

PDB 1jbq chain A

3D model

Region: 5 - 318
Aligned: 305
Modelled: 314
Confidence: 100.0%
Identity: 21%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 1jbq chain D

3D model

Region: 5 - 318
Aligned: 305
Modelled: 314
Confidence: 100.0%
Identity: 21%
PDB header:lyase
Chain: D: PDB Molecule:cystathionine beta-synthase;
PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein

Phyre2

PDB 1ve1 chain A domain 1

3D model

Region: 24 - 318
Aligned: 282
Modelled: 283
Confidence: 100.0%
Identity: 24%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 1z7w chain A domain 1

3D model

Region: 23 - 317
Aligned: 283
Modelled: 295
Confidence: 100.0%
Identity: 23%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2

PDB 2pqm chain A

3D model

Region: 18 - 317
Aligned: 287
Modelled: 300
Confidence: 100.0%
Identity: 23%
PDB header:lyase
Chain: A: PDB Molecule:cysteine synthase;
PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution

Phyre2

PDB 1x1q chain A

3D model

Region: 17 - 329
Aligned: 311
Modelled: 313
Confidence: 100.0%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:tryptophan synthase beta chain;
PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8

Phyre2

PDB 2bhs chain A domain 1

3D model

Region: 23 - 317
Aligned: 274
Modelled: 276
Confidence: 100.0%
Identity: 19%
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Phyre2
1
c1tdjA_
2
c3iauA_
3
d1tdja1
4
c2gn0A_
5
d1v71a1
6
d1pwha_
7
c3l6cA_
8
c1p5jA_
9
d1p5ja_
10
c3r0zA_
11
d1ve5a1
12
c2rkbE_
13
c3pc3A_
14
d1jbqa_
15
c1jbqD_
16
d1ve1a1
17
d1z7wa1
18
c2pqmA_
19
c1x1qA_
20
d2bhsa1
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1tdjA_
100.0 100 PDB header:allostery
Chain: A: PDB Molecule:biosynthetic threonine deaminase;
PDBTitle: threonine deaminase (biosynthetic) from e. coli
2c3iauA_
100.0 49 PDB header:lyase
Chain: A: PDB Molecule:threonine deaminase;
PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum
3d1tdja1
100.0 100 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
4c2gn0A_
100.0 36 PDB header:lyase
Chain: A: PDB Molecule:threonine dehydratase catabolic;
PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation)
5d1v71a1
100.0 32 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
6d1pwha_
100.0 27 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
7c3l6cA_
100.0 30 PDB header:isomerase
Chain: A: PDB Molecule:serine racemase;
PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor
8c1p5jA_
100.0 28 PDB header:lyase
Chain: A: PDB Molecule:l-serine dehydratase;
PDBTitle: crystal structure analysis of human serine dehydratase
9d1p5ja_
100.0 28 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
10c3r0zA_
100.0 21 PDB header:lyase
Chain: A: PDB Molecule:d-serine dehydratase;
PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium
11d1ve5a1
100.0 39 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
12c2rkbE_
100.0 30 PDB header:lyase
Chain: E: PDB Molecule:serine dehydratase-like;
PDBTitle: serine dehydratase like-1 from human cancer cells
13c3pc3A_
100.0 20 PDB header:lyase
Chain: A: PDB Molecule:cg1753, isoform a;
PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate
14d1jbqa_
100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
15c1jbqD_
100.0 21 PDB header:lyase
Chain: D: PDB Molecule:cystathionine beta-synthase;
PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein
16d1ve1a1
100.0 24 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
17d1z7wa1
100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
18c2pqmA_
100.0 23 PDB header:lyase
Chain: A: PDB Molecule:cysteine synthase;
PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution
19c1x1qA_
100.0 21 PDB header:lyase
Chain: A: PDB Molecule:tryptophan synthase beta chain;
PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8
20d2bhsa1
100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
21c2d1fA_
not modelled 100.0 24 PDB header:lyase
Chain: A: PDB Molecule:threonine synthase;
PDBTitle: structure of mycobacterium tuberculosis threonine synthase
22d1qopb_
not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
23d1y7la1
not modelled 100.0 25 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
24c2zsjB_
not modelled 100.0 25 PDB header:lyase
Chain: B: PDB Molecule:threonine synthase;
PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5
25d1v8za1
not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
26d1wkva1
not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
27c3dwgA_
not modelled 100.0 19 PDB header:transferase
Chain: A: PDB Molecule:cysteine synthase b;
PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis
28d1v7ca_
not modelled 100.0 25 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
29d1e5xa_
not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
30d1fcja_
not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
31c2q3bA_
not modelled 100.0 24 PDB header:transferase
Chain: A: PDB Molecule:cysteine synthase a;
PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis
32d1o58a_
not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
33c2eguA_
not modelled 100.0 28 PDB header:transferase
Chain: A: PDB Molecule:cysteine synthase;
PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426
34c2o2jA_
not modelled 100.0 25 PDB header:lyase
Chain: A: PDB Molecule:tryptophan synthase beta chain;
PDBTitle: mycobacterium tuberculosis tryptophan synthase beta chain2 dimer (apoform)
35d1j0aa_
not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
36d1f2da_
not modelled 100.0 20 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
37d1tyza_
not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
38d1vb3a1
not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
39c3v7nA_
not modelled 100.0 14 PDB header:lyase
Chain: A: PDB Molecule:threonine synthase;
PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis
40d1kl7a_
not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes
Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes
41d1tdja3
not modelled 100.0 100 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Allosteric threonine deaminase C-terminal domain
42d1tdja2
not modelled 99.9 100 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Allosteric threonine deaminase C-terminal domain
43c1u8sB_
not modelled 97.6 7 PDB header:transcription
Chain: B: PDB Molecule:glycine cleavage system transcriptional
PDBTitle: crystal structure of putative glycine cleavage system2 transcriptional repressor
44c2f06B_
not modelled 97.5 14 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:conserved hypothetical protein;
PDBTitle: crystal structure of protein bt0572 from bacteroides thetaiotaomicron
45c2nyiB_
not modelled 97.3 16 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:unknown protein;
PDBTitle: crystal structure of an unknown protein from galdieria2 sulphuraria
46c3ibwA_
not modelled 96.5 11 PDB header:transferase
Chain: A: PDB Molecule:gtp pyrophosphokinase;
PDBTitle: crystal structure of the act domain from gtp2 pyrophosphokinase of chlorobium tepidum. northeast3 structural genomics consortium target ctr148a
47d2f06a1
not modelled 96.4 17 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:BT0572-like
48d1phza1
not modelled 95.4 23 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Phenylalanine metabolism regulatory domain
49c2qmxB_
not modelled 94.3 18 PDB header:ligase
Chain: B: PDB Molecule:prephenate dehydratase;
PDBTitle: the crystal structure of l-phe inhibited prephenate dehydratase from2 chlorobium tepidum tls
50d2qmwa2
not modelled 94.1 11 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Phenylalanine metabolism regulatory domain
51c3luyA_
not modelled 93.4 16 PDB header:isomerase
Chain: A: PDB Molecule:probable chorismate mutase;
PDBTitle: putative chorismate mutase from bifidobacterium adolescentis
52c1y7pB_
not modelled 93.3 21 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:hypothetical protein af1403;
PDBTitle: 1.9 a crystal structure of a protein of unknown function2 af1403 from archaeoglobus fulgidus, probable metabolic3 regulator
53c3mwbA_
not modelled 92.7 12 PDB header:lyase
Chain: A: PDB Molecule:prephenate dehydratase;
PDBTitle: the crystal structure of prephenate dehydratase in complex with l-phe2 from arthrobacter aurescens to 2.0a
54d1vp8a_
not modelled 91.6 14 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:MTH1675-like
55d1sc6a3
not modelled 91.6 8 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain
56d1zpva1
not modelled 91.0 6 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:SP0238-like
57d1u8sa2
not modelled 91.0 17 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Glycine cleavage system transcriptional repressor
58d2f1fa1
not modelled 90.7 15 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:IlvH-like
59c2qmwA_
not modelled 90.4 10 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:prephenate dehydratase;
PDBTitle: the crystal structure of the prephenate dehydratase (pdt) from2 staphylococcus aureus subsp. aureus mu50
60d1ygya3
not modelled 89.8 16 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain
61d2pc6a2
not modelled 89.5 15 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:IlvH-like
62c2f1fA_
not modelled 88.2 15 PDB header:transferase
Chain: A: PDB Molecule:acetolactate synthase isozyme iii small subunit;
PDBTitle: crystal structure of the regulatory subunit of2 acetohydroxyacid synthase isozyme iii from e. coli
63c3mgjA_
not modelled 86.3 29 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein mj1480;
PDBTitle: crystal structure of the saccharop_dh_n domain of mj14802 protein from methanococcus jannaschii. northeast structural3 genomics consortium target mjr83a.
64d2f06a2
not modelled 85.4 13 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:BT0572-like
65d2fgca2
not modelled 85.0 14 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:IlvH-like
66c2hk8B_
not modelled 84.9 15 PDB header:oxidoreductase
Chain: B: PDB Molecule:shikimate dehydrogenase;
PDBTitle: crystal structure of shikimate dehydrogenase from aquifex2 aeolicus at 2.35 angstrom resolution
67c3eywA_
not modelled 84.2 22 PDB header:transport protein
Chain: A: PDB Molecule:c-terminal domain of glutathione-regulated potassium-efflux
PDBTitle: crystal structure of the c-terminal domain of e. coli kefc in complex2 with keff
68d1p0fa2
not modelled 84.2 14 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Alcohol dehydrogenase-like, C-terminal domain
69c2pc6C_
not modelled 83.7 14 PDB header:lyase
Chain: C: PDB Molecule:probable acetolactate synthase isozyme iii (small subunit);
PDBTitle: crystal structure of putative acetolactate synthase- small subunit2 from nitrosomonas europaea
70d1bg6a2
not modelled 80.5 13 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:6-phosphogluconate dehydrogenase-like, N-terminal domain
71d1nsaa2
not modelled 79.5 15 Fold:Ferredoxin-like
Superfamily:Protease propeptides/inhibitors
Family:Pancreatic carboxypeptidase, activation domain
72d1kwma2
not modelled 78.4 13 Fold:Ferredoxin-like
Superfamily:Protease propeptides/inhibitors
Family:Pancreatic carboxypeptidase, activation domain
73c3mtjA_
not modelled 77.8 8 PDB header:oxidoreductase
Chain: A: PDB Molecule:homoserine dehydrogenase;
PDBTitle: the crystal structure of a homoserine dehydrogenase from thiobacillus2 denitrificans to 2.15a
74d1ml4a2
not modelled 77.4 15 Fold:ATC-like
Superfamily:Aspartate/ornithine carbamoyltransferase
Family:Aspartate/ornithine carbamoyltransferase
75c3iupB_
not modelled 75.4 18 PDB header:oxidoreductase
Chain: B: PDB Molecule:putative nadph:quinone oxidoreductase;
PDBTitle: crystal structure of putative nadph:quinone oxidoreductase2 (yp_296108.1) from ralstonia eutropha jmp134 at 1.70 a resolution
76d1g8fa3
not modelled 74.6 16 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:ATP sulfurylase C-terminal domain
77c1ulzA_
not modelled 73.8 18 PDB header:ligase
Chain: A: PDB Molecule:pyruvate carboxylase n-terminal domain;
PDBTitle: crystal structure of the biotin carboxylase subunit of pyruvate2 carboxylase
78d1u8sa1
not modelled 72.9 9 Fold:Ferredoxin-like
Superfamily:ACT-like
Family:Glycine cleavage system transcriptional repressor
79c1vlvA_
not modelled 72.8 14 PDB header:transferase
Chain: A: PDB Molecule:ornithine carbamoyltransferase;
PDBTitle: crystal structure of ornithine carbamoyltransferase (tm1097) from2 thermotoga maritima at 2.25 a resolution
80c2fgcA_
not modelled 70.2 16 PDB header:transferase
Chain: A: PDB Molecule:acetolactate synthase, small subunit;
PDBTitle: crystal structure of acetolactate synthase- small subunit from2 thermotoga maritima
81d1l7da1
not modelled 69.5 14 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Formate/glycerate dehydrogenases, NAD-domain
82d1jqga2
not modelled 69.2 15 Fold:Ferredoxin-like
Superfamily:Protease propeptides/inhibitors
Family:Pancreatic carboxypeptidase, activation domain
83c3nrbD_
not modelled 66.5 13 PDB header:hydrolase
Chain: D: PDB Molecule:formyltetrahydrofolate deformylase;
PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (puru,2 pp_1943) from pseudomonas putida kt2440 at 2.05 a resolution
84d1o8ca2
not modelled 66.3 17 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Alcohol dehydrogenase-like, C-terminal domain
85c2rghA_
not modelled 65.7 23 PDB header:oxidoreductase
Chain: A: PDB Molecule:alpha-glycerophosphate oxidase;
PDBTitle: structure of alpha-glycerophosphate oxidase from2 streptococcus sp.: a template for the mitochondrial alpha-3 glycerophosphate dehydrogenase
86c3pgjB_
not modelled 65.3 15 PDB header:oxidoreductase
Chain: B: PDB Molecule:shikimate dehydrogenase;
PDBTitle: 2.49 angstrom resolution crystal structure of shikimate 5-2 dehydrogenase (aroe) from vibrio cholerae o1 biovar eltor str. n169613 in complex with shikimate
87c3louB_
not modelled 65.2 11 PDB header:hydrolase
Chain: B: PDB Molecule:formyltetrahydrofolate deformylase;
PDBTitle: crystal structure of formyltetrahydrofolate deformylase (yp_105254.1)2 from burkholderia mallei atcc 23344 at 1.90 a resolution
88c3fwzA_
not modelled 65.0 19 PDB header:membrane protein
Chain: A: PDB Molecule:inner membrane protein ybal;
PDBTitle: crystal structure of trka-n domain of inner membrane protein ybal from2 escherichia coli
89c2phmA_
not modelled 64.4 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:protein (phenylalanine-4-hydroxylase);
PDBTitle: structure of phenylalanine hydroxylase dephosphorylated
90d1pbaa_
not modelled 63.1 15 Fold:Ferredoxin-like
Superfamily:Protease propeptides/inhibitors
Family:Pancreatic carboxypeptidase, activation domain
91d1ulua_
not modelled 62.6 17 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
92d1t57a_
not modelled 61.3 16 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:MTH1675-like
93c2dzdB_
not modelled 61.2 16 PDB header:ligase
Chain: B: PDB Molecule:pyruvate carboxylase;
PDBTitle: crystal structure of the biotin carboxylase domain of2 pyruvate carboxylase
94d1c1da1
not modelled 61.1 19 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Aminoacid dehydrogenase-like, C-terminal domain
95c1ml4A_
not modelled 60.4 15 PDB header:transferase
Chain: A: PDB Molecule:aspartate transcarbamoylase;
PDBTitle: the pala-liganded aspartate transcarbamoylase catalytic subunit from2 pyrococcus abyssi
96c3o1lB_
not modelled 60.4 13 PDB header:hydrolase
Chain: B: PDB Molecule:formyltetrahydrofolate deformylase;
PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pspto_4314)2 from pseudomonas syringae pv. tomato str. dc3000 at 2.20 a resolution
97d1hyua1
not modelled 58.2 24 Fold:FAD/NAD(P)-binding domain
Superfamily:FAD/NAD(P)-binding domain
Family:FAD/NAD-linked reductases, N-terminal and central domains
98c3dgvB_
not modelled 58.1 14 PDB header:hydrolase
Chain: B: PDB Molecule:carboxypeptidase b2;
PDBTitle: crystal structure of thrombin activatable fibrinolysis inhibitor2 (tafi)
99d1trba1
not modelled 58.1 14 Fold:FAD/NAD(P)-binding domain
Superfamily:FAD/NAD(P)-binding domain
Family:FAD/NAD-linked reductases, N-terminal and central domains
100c1ygyA_
not modelled 57.8 14 PDB header:oxidoreductase
Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase;
PDBTitle: crystal structure of d-3-phosphoglycerate dehydrogenase from2 mycobacterium tuberculosis
101c3u9sE_
not modelled 57.8 25 PDB header:ligase
Chain: E: PDB Molecule:methylcrotonyl-coa carboxylase, alpha-subunit;
PDBTitle: crystal structure of p. aeruginosa 3-methylcrotonyl-coa carboxylase2 (mcc) 750 kd holoenzyme, coa complex
102c3n0vD_
not modelled 56.5 19 PDB header:hydrolase
Chain: D: PDB Molecule:formyltetrahydrofolate deformylase;
PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pp_0327)2 from pseudomonas putida kt2440 at 2.25 a resolution
103c3a14B_
not modelled 56.3 20 PDB header:oxidoreductase
Chain: B: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase;
PDBTitle: crystal structure of dxr from thermotoga maritima, in complex with2 nadph
104c3da1A_
not modelled 56.1 21 PDB header:oxidoreductase
Chain: A: PDB Molecule:glycerol-3-phosphate dehydrogenase;
PDBTitle: x-ray structure of the glycerol-3-phosphate dehydrogenase2 from bacillus halodurans complexed with fad. northeast3 structural genomics consortium target bhr167.
105d1cdoa2
not modelled 55.5 14 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Alcohol dehydrogenase-like, C-terminal domain
106d1xgka_
not modelled 55.3 8 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
107d1fl2a1
not modelled 55.1 26 Fold:FAD/NAD(P)-binding domain
Superfamily:FAD/NAD(P)-binding domain
Family:FAD/NAD-linked reductases, N-terminal and central domains
108c2fjaC_
not modelled 54.0 24 PDB header:oxidoreductase
Chain: C: PDB Molecule:adenylylsulfate reductase, subunit a;
PDBTitle: adenosine 5'-phosphosulfate reductase in complex with2 substrate
109c2qioA_
not modelled 53.8 9 PDB header:unknown function
Chain: A: PDB Molecule:enoyl-(acyl-carrier-protein) reductase;
PDBTitle: x-ray structure of enoyl-acyl carrier protein reductase from bacillus2 anthracis with triclosan
110d1vdca1
not modelled 52.8 24 Fold:FAD/NAD(P)-binding domain
Superfamily:FAD/NAD(P)-binding domain
Family:FAD/NAD-linked reductases, N-terminal and central domains
111c2rgoA_
not modelled 52.0 23 PDB header:oxidoreductase
Chain: A: PDB Molecule:alpha-glycerophosphate oxidase;
PDBTitle: structure of alpha-glycerophosphate oxidase from2 streptococcus sp.: a template for the mitochondrial alpha-3 glycerophosphate dehydrogenase
112d1pcaa1
not modelled 51.2 6 Fold:Ferredoxin-like
Superfamily:Protease propeptides/inhibitors
Family:Pancreatic carboxypeptidase, activation domain
113c2csuB_
not modelled 51.1 17 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:457aa long hypothetical protein;
PDBTitle: crystal structure of ph0766 from pyrococcus horikoshii ot3
114c2nloA_
not modelled 51.0 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:shikimate dehydrogenase;
PDBTitle: crystal structure of the quinate dehydrogenase from corynebacterium2 glutamicum
115c1vi2B_
not modelled 50.9 9 PDB header:oxidoreductase
Chain: B: PDB Molecule:shikimate 5-dehydrogenase 2;
PDBTitle: crystal structure of shikimate-5-dehydrogenase with nad
116d1o89a2
not modelled 50.9 18 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Alcohol dehydrogenase-like, C-terminal domain
117d2ay1a_
not modelled 50.8 15 Fold:PLP-dependent transferase-like
Superfamily:PLP-dependent transferases
Family:AAT-like
118d1d1ta2
not modelled 49.3 11 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Alcohol dehydrogenase-like, C-terminal domain
119c1nytC_
not modelled 49.3 17 PDB header:oxidoreductase
Chain: C: PDB Molecule:shikimate 5-dehydrogenase;
PDBTitle: shikimate dehydrogenase aroe complexed with nadp+
120c3d64A_
not modelled 48.9 14 PDB header:hydrolase
Chain: A: PDB Molecule:adenosylhomocysteinase;
PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from2 burkholderia pseudomallei

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0