Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	V	N	L	L	I	T	M	I	I	F	A	L	I	W	P	V	T	A	L	R	A	A	V	S	K	T	T	W	A	D	A	P	A	R	E	F	V	F	V	E	N	N	S	D	D	N	F	F	V	T	P	G	G	A	L	D	P	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	T	G	A	N	R	W	T	G	L	K	Y	T	G	S	G	T	I	Y	Q	Q	S	L	G	Y	I	D	N	G	Y	N	T	G	L	Y	T	N	W	K	F	D	M	W	L	E	N	S	P	V	S	S	P	L	T	G	L	R	C	I	N
Secondary structure
SS confidence
Disorder												?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	Y	A	G	C	N	M	T	T	S	L	I	L	P	Q	T	T	D	A	S	G	F	Y	G	A	T	V	T	S	G	G	A	K	W	M	H	G	M	L	S	D	A	F	Y	Q	Y	M	Q	Q	M	P	V	G	S	S	F	T	M	T	I
Secondary structure
SS confidence
Disorder											?												?				?		?		?	?	?																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	A	C	Q	T	S	V	N	Y	D	A	S	S	G	A	R	C	K	D	Q	A	S	G	N	W	Y	V	R	N	V	T	H	T	K	A	A	N	L	R	L	I	N	T	H	S	L	A	E	V	F	I	N	S	D	G	V	P	T	L	G
Secondary structure
SS confidence
Disorder			?	?	?		?	?			?			?	?		?	?	?	?	?	?	?	?	?								?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	G	N	A	D	C	R	T	Q	T	I	G	S	R	S	G	L	S	C	K	M	V	N	Y	T	L	Q	T	N	G	L	S	N	T	S	I	H	I	F	P	A	I	A	N	S	S	L	A	S	A	V	G	A	Y	D	M	Q	F	S	L
Secondary structure
SS confidence
Disorder		?											?																	?														?		?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	G	S	S	W	K	P	V	S	N	T	A	Y	Y	Y	T	F	N	E	M	K	S	A	D	S	I	Y	V	F	F	S	S	N	F	F	K	Q	M	V	N	L	G	I	S	D	I	N	T	K	D	L	F	N	F	R	F	Q	N	T	T
Secondary structure
SS confidence
Disorder																					?	?	?																			?	?	?	?	?	?	?	?										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	P	E	S	G	W	Y	E	F	S	T	S	N	T	L	I	I	K	P	R	D	F	S	I	S	I	I	S	D	E	Y	T	Q	T	P	S	R	E	G	Y	V	G	S	G	E	S	A	L	D	F	G	Y	I	V	T	T	S	G	K	T
Secondary structure
SS confidence
Disorder		?			?																		?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	A	D	E	V	L	I	K	V	T	G	P	A	Q	V	I	G	G	R	S	Y	C	V	F	S	S	D	D	G	K	A	K	V	P	F	P	A	T	L	S	F	I	T	R	N	G	A	T	K	T	Y	D	A	G	C	D	D	S	W	R
Secondary structure
SS confidence
Disorder		?	?								?	?	?	?	?	?	?																											?	?		?	?	?		?		?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		D	M	T	D	A	L	W	L	T	T	P	W	T	D	I	S	G	E	V	G	Q	M	D	K	T	T	V	K	F	S	I	P	M	D	N	A	I	S	L	R	T	V	D	D	N	G	W	F	G	E	V	S	A	S	G	E	I	H	V	Q
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		A	T	W	R	N	I	N
Secondary structure
SS confidence
Disorder					?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1cb8 chain A Region: 255 - 456 Aligned: 186 Modelled: 202 Confidence: 75.4% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:protein (chondroitinase ac); PDBTitle: chondroitinase ac lyase from flavobacterium heparinum Phyre2 PDB 1o7d chain D Region: 324 - 452 Aligned: 121 Modelled: 127 Confidence: 75.0% Identity: 12% PDB header:hydrolase Chain: D: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase2 suggests a novel mechanism for low ph activation Phyre2 PDB 2wda chain A Region: 255 - 453 Aligned: 176 Modelled: 199 Confidence: 30.9% Identity: 12% PDB header:lyase Chain: A: PDB Molecule:putative secreted lyase; PDBTitle: the x-ray structure of the streptomyces coelicolor a32 chondroitin ac lyase in complex with chondroitin sulphate Phyre2 PDB 2wj9 chain A Region: 492 - 533 Aligned: 34 Modelled: 42 Confidence: 29.8% Identity: 21% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:intergenic-region protein; PDBTitle: ardb Phyre2 PDB 2gtl chain M domain 1 Region: 362 - 387 Aligned: 25 Modelled: 26 Confidence: 28.8% Identity: 24% Fold: Streptavidin-like Superfamily: Extracellular hemoglobin linker subunit, receptor domain Family: Extracellular hemoglobin linker subunit, receptor domain Phyre2 PDB 2qqo chain B Region: 291 - 308 Aligned: 18 Modelled: 18 Confidence: 23.4% Identity: 33% PDB header:signaling protein Chain: B: PDB Molecule:neuropilin-2; PDBTitle: crystal structure of the a2b1b2 domains from human neuropilin-2 Phyre2 PDB 1gea chain A Region: 157 - 172 Aligned: 16 Modelled: 16 Confidence: 19.5% Identity: 38% PDB header:neuropeptide Chain: A: PDB Molecule:pituitary adenylate cyclase activating PDBTitle: receptor-bound conformation of pacap21 Phyre2 PDB 2nqd chain A domain 1 Region: 383 - 430 Aligned: 48 Modelled: 48 Confidence: 19.4% Identity: 23% Fold: Immunoglobulin-like beta-sandwich Superfamily: ICP-like Family: ICP-like Phyre2 PDB 1ogm chain X domain 1 Region: 380 - 467 Aligned: 69 Modelled: 75 Confidence: 18.9% Identity: 20% Fold: Dextranase, N-terminal domain Superfamily: Dextranase, N-terminal domain Family: Dextranase, N-terminal domain Phyre2 PDB 2b9s chain B Region: 56 - 64 Aligned: 9 Modelled: 9 Confidence: 18.5% Identity: 33% PDB header:isomerase/dna Chain: B: PDB Molecule:dna topoisomerase i-like protein; PDBTitle: crystal structure of heterodimeric l. donovani2 topoisomerase i-vanadate-dna complex Phyre2 PDB 2gtl chain N domain 1 Region: 362 - 387 Aligned: 25 Modelled: 26 Confidence: 18.3% Identity: 40% Fold: Streptavidin-like Superfamily: Extracellular hemoglobin linker subunit, receptor domain Family: Extracellular hemoglobin linker subunit, receptor domain Phyre2 PDB 1tpn chain A Region: 437 - 455 Aligned: 17 Modelled: 19 Confidence: 16.3% Identity: 41% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 PDB 1hxm chain A domain 1 Region: 343 - 380 Aligned: 38 Modelled: 38 Confidence: 15.1% Identity: 24% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: V set domains (antibody variable domain-like) Phyre2 PDB 2c34 chain A domain 1 Region: 383 - 430 Aligned: 48 Modelled: 48 Confidence: 14.9% Identity: 25% Fold: Immunoglobulin-like beta-sandwich Superfamily: ICP-like Family: ICP-like Phyre2 PDB 3pst chain A Region: 401 - 417 Aligned: 17 Modelled: 17 Confidence: 14.6% Identity: 18% PDB header:nuclear protein Chain: A: PDB Molecule:protein doa1; PDBTitle: crystal structure of pul and pfu(mutate) domain Phyre2 PDB 3biy chain A Region: 401 - 445 Aligned: 32 Modelled: 45 Confidence: 14.5% Identity: 47% PDB header:transferase Chain: A: PDB Molecule:histone acetyltransferase p300; PDBTitle: crystal structure of p300 histone acetyltransferase domain in complex2 with a bisubstrate inhibitor, lys-coa Phyre2 PDB 3o7o chain B Region: 93 - 108 Aligned: 16 Modelled: 16 Confidence: 14.1% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:endoglucanase; PDBTitle: use of synthetic symmetrization in the crystallization and structure2 determination of cela from thermotoga maritima Phyre2 PDB 3ts3 chain D Region: 253 - 308 Aligned: 46 Modelled: 56 Confidence: 13.5% Identity: 24% PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution Phyre2 PDB 1dgj chain A Region: 379 - 408 Aligned: 28 Modelled: 30 Confidence: 13.1% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:aldehyde oxidoreductase; PDBTitle: crystal structure of the aldehyde oxidoreductase from2 desulfovibrio desulfuricans atcc 27774 Phyre2 PDB 2jan chain D Region: 124 - 178 Aligned: 54 Modelled: 55 Confidence: 12.8% Identity: 24% PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state Phyre2 1 c1cb8A_ 2 c1o7dD_ 3 c2wdaA_ 4 c2wj9A_ 5 d2gtlm1 6 c2qqoB_ 7 c1geaA_ 8 d2nqda1 9 d1ogmx1 10 c2b9sB_ 11 d2gtln1 12 d1tpna_ 13 d1hxma1 14 d2c34a1 15 c3pstA_ 16 c3biyA_ 17 c3o7oB_ 18 c3ts3D_ 19 c1dgjA_ 20 c2janD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1cb8A_ 75.4 19 PDB header:lyase Chain: A: PDB Molecule:protein (chondroitinase ac); PDBTitle: chondroitinase ac lyase from flavobacterium heparinum 2 c1o7dD_ 75.0 12 PDB header:hydrolase Chain: D: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase2 suggests a novel mechanism for low ph activation 3 c2wdaA_ 30.9 12 PDB header:lyase Chain: A: PDB Molecule:putative secreted lyase; PDBTitle: the x-ray structure of the streptomyces coelicolor a32 chondroitin ac lyase in complex with chondroitin sulphate 4 c2wj9A_ 29.8 21 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:intergenic-region protein; PDBTitle: ardb 5 d2gtlm1 28.8 24 Fold:Streptavidin-like Superfamily:Extracellular hemoglobin linker subunit, receptor domain Family:Extracellular hemoglobin linker subunit, receptor domain 6 c2qqoB_ 23.4 33 PDB header:signaling protein Chain: B: PDB Molecule:neuropilin-2; PDBTitle: crystal structure of the a2b1b2 domains from human neuropilin-2 7 c1geaA_ 19.5 38 PDB header:neuropeptide Chain: A: PDB Molecule:pituitary adenylate cyclase activating PDBTitle: receptor-bound conformation of pacap21 8 d2nqda1 19.4 23 Fold:Immunoglobulin-like beta-sandwich Superfamily:ICP-like Family:ICP-like 9 d1ogmx1 18.9 20 Fold:Dextranase, N-terminal domain Superfamily:Dextranase, N-terminal domain Family:Dextranase, N-terminal domain 10 c2b9sB_ 18.5 33 PDB header:isomerase/dna Chain: B: PDB Molecule:dna topoisomerase i-like protein; PDBTitle: crystal structure of heterodimeric l. donovani2 topoisomerase i-vanadate-dna complex 11 d2gtln1 18.3 40 Fold:Streptavidin-like Superfamily:Extracellular hemoglobin linker subunit, receptor domain Family:Extracellular hemoglobin linker subunit, receptor domain 12 d1tpna_ 16.3 41 Fold:FnI-like domain Superfamily:FnI-like domain Family:Fibronectin type I module 13 d1hxma1 15.1 24 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 14 d2c34a1 14.9 25 Fold:Immunoglobulin-like beta-sandwich Superfamily:ICP-like Family:ICP-like 15 c3pstA_ 14.6 18 PDB header:nuclear protein Chain: A: PDB Molecule:protein doa1; PDBTitle: crystal structure of pul and pfu(mutate) domain 16 c3biyA_ 14.5 47 PDB header:transferase Chain: A: PDB Molecule:histone acetyltransferase p300; PDBTitle: crystal structure of p300 histone acetyltransferase domain in complex2 with a bisubstrate inhibitor, lys-coa 17 c3o7oB_ 14.1 25 PDB header:hydrolase Chain: B: PDB Molecule:endoglucanase; PDBTitle: use of synthetic symmetrization in the crystallization and structure2 determination of cela from thermotoga maritima 18 c3ts3D_ 13.5 24 PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution 19 c1dgjA_ 13.1 32 PDB header:oxidoreductase Chain: A: PDB Molecule:aldehyde oxidoreductase; PDBTitle: crystal structure of the aldehyde oxidoreductase from2 desulfovibrio desulfuricans atcc 27774 20 c2janD_ 12.8 24 PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state 21 d2icya1 not modelled 12.6 28 Fold:Single-stranded left-handed beta-helix Superfamily:Trimeric LpxA-like enzymes Family:GlmU C-terminal domain-like 22 c2k89A_ not modelled 12.1 18 PDB header:protein binding Chain: A: PDB Molecule:phospholipase a-2-activating protein; PDBTitle: solution structure of a novel ubiquitin-binding domain from2 human plaa (pfuc, gly76-pro77 cis isomer) 23 c2kmgA_ not modelled 11.9 32 PDB header:gene regulation Chain: A: PDB Molecule:klca; PDBTitle: the structure of the klca and ardb proteins show a novel2 fold and antirestriction activity against type i dna3 restriction systems in vivo but not in vitro 24 d1wioa2 not modelled 11.9 23 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 25 c1hn0A_ not modelled 11.8 10 PDB header:lyase Chain: A: PDB Molecule:chondroitin abc lyase i; PDBTitle: crystal structure of chondroitin abc lyase i from proteus2 vulgaris at 1.9 angstroms resolution 26 c3csyJ_ not modelled 11.3 21 PDB header:immune system/viral protein Chain: J: PDB Molecule:envelope glycoprotein gp2; PDBTitle: crystal structure of the trimeric prefusion ebola virus glycoprotein2 in complex with a neutralizing antibody from a human survivor 27 d2guma1 not modelled 11.3 21 Fold:Viral glycoprotein ectodomain-like Superfamily:Viral glycoprotein ectodomain-like Family:Glycoprotein B-like 28 d1j8hd1 not modelled 11.1 22 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 29 d1sddb4 not modelled 10.9 39 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) 30 c3nw8B_ not modelled 10.8 21 PDB header:viral protein Chain: B: PDB Molecule:envelope glycoprotein b; PDBTitle: glycoprotein b from herpes simplex virus type 1, y179s mutant, high-ph 31 c2ol3A_ not modelled 10.4 26 PDB header:immune system Chain: A: PDB Molecule:bm3.3 t-cell receptor alpha-chain; PDBTitle: crystal structure of bm3.3 scfv tcr in complex with pbm8-h-2kbm8 mhc2 class i molecule 32 d2gtlo1 not modelled 10.1 37 Fold:Streptavidin-like Superfamily:Extracellular hemoglobin linker subunit, receptor domain Family:Extracellular hemoglobin linker subunit, receptor domain 33 c1wygA_ not modelled 9.8 32 PDB header:oxidoreductase Chain: A: PDB Molecule:xanthine dehydrogenase/oxidase; PDBTitle: crystal structure of a rat xanthine dehydrogenase triple mutant2 (c535a, c992r and c1324s) 34 c2lcyA_ not modelled 9.7 19 PDB header:viral protein Chain: A: PDB Molecule:virion spike glycoprotein; PDBTitle: nmr structure of the complete internal fusion loop from ebolavirus gp22 at ph 5.5 35 d1ehxa_ not modelled 9.3 19 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Cellulosomal scaffoldin protein CipC, module x2.1 36 d1ks5a_ not modelled 9.0 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Xylanase/endoglucanase 11/12 37 d1czsa_ not modelled 9.0 39 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) 38 c1bhgB_ not modelled 8.9 33 PDB header:glycosidase Chain: B: PDB Molecule:beta-glucuronidase; PDBTitle: human beta-glucuronidase at 2.6 a resolution 39 d1ypze1 not modelled 8.9 14 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 40 c2e7mA_ not modelled 8.8 15 PDB header:structural protein Chain: A: PDB Molecule:protein kiaa0319; PDBTitle: solution structure of the pkd domain (329-428) from human2 kiaa0319 41 c2l3iA_ not modelled 8.8 33 PDB header:antimicrobial protein Chain: A: PDB Molecule:aoxki4a, antimicrobial peptide in spider venom; PDBTitle: oxki4a, spider derived antimicrobial peptide 42 d2je8a4 not modelled 8.6 18 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:beta-Galactosidase/glucuronidase, N-terminal domain 43 d1fvca_ not modelled 8.5 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 44 c1sddB_ not modelled 8.2 39 PDB header:blood clotting Chain: B: PDB Molecule:coagulation factor v; PDBTitle: crystal structure of bovine factor vai 45 d2phna1 not modelled 8.2 32 Fold:CofE-like Superfamily:CofE-like Family:CofE-like 46 c2rqeA_ not modelled 7.8 21 PDB header:sugar binding protein Chain: A: PDB Molecule:beta-1,3-glucan-binding protein; PDBTitle: solution structure of the silkworm bgrp/gnbp3 n-terminal2 domain reveals the mechanism for b-1,3-glucan specific3 recognition 47 d2z15a1 not modelled 7.8 45 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 48 d1wtla_ not modelled 7.7 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 49 c2jemB_ not modelled 7.6 31 PDB header:hydrolase Chain: B: PDB Molecule:endo-beta-1,4-glucanase; PDBTitle: native family 12 xyloglucanase from bacillus licheniformis 50 d3e9va1 not modelled 7.6 45 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 51 d1oa2a_ not modelled 7.6 19 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Xylanase/endoglucanase 11/12 52 d1dl0a_ not modelled 7.5 57 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:omega toxin-like Family:Spider toxins 53 c1dl0A_ not modelled 7.5 57 PDB header:toxin Chain: A: PDB Molecule:j-atracotoxin-hv1c; PDBTitle: solution structure of the insecticidal neurotoxin j-2 atracotoxin-hv1c 54 c3cdzB_ not modelled 7.4 22 PDB header:blood clotting Chain: B: PDB Molecule:coagulation factor viii light chain; PDBTitle: crystal structure of human factor viii 55 d1sddb3 not modelled 7.4 17 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) 56 c2qqlA_ not modelled 7.4 33 PDB header:signaling protein Chain: A: PDB Molecule:neuropilin-2; PDBTitle: neuropilin-2 a1a2b1b2 domains in complex with a semaphorin-blocking2 fab 57 d1dc1a_ not modelled 7.4 24 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Restriction endonuclease BsobI 58 d2bw8a1 not modelled 7.3 21 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Xylanase/endoglucanase 11/12 59 c1h0bA_ not modelled 7.3 21 PDB header:hydrolase Chain: A: PDB Molecule:cellulase; PDBTitle: endoglucanase cel12a from rhodothermus marinus 60 d1oa3a_ not modelled 7.3 19 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Xylanase/endoglucanase 11/12 61 d1y4wa1 not modelled 7.2 26 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolases family 32 C-terminal domain 62 c3f59A_ not modelled 7.2 25 PDB header:structural protein Chain: A: PDB Molecule:ankyrin-1; PDBTitle: crystal structure of zu5-ank, the spectrin binding region of human2 erythroid ankyrin 63 d2qaln1 not modelled 7.0 25 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:Ribosomal protein S14 64 d1olra_ not modelled 6.9 24 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Xylanase/endoglucanase 11/12 65 c3ie4A_ not modelled 6.8 39 PDB header:immune system Chain: A: PDB Molecule:gram-negative binding protein 3; PDBTitle: b-glucan binding domain of drosophila gnbp3 defines a novel2 family of pattern recognition receptor 66 c2orxA_ not modelled 6.7 33 PDB header:signaling protein, membrane protein Chain: A: PDB Molecule:neuropilin-1; PDBTitle: structural basis for ligand binding and heparin mediated activation of2 neuropilin 67 c1g6iA_ not modelled 6.4 33 PDB header:hydrolase Chain: A: PDB Molecule:class i alpha-1,2-mannosidase; PDBTitle: crystal structure of the yeast alpha-1,2-mannosidase with bound 1-2 deoxymannojirimycin at 1.59 a resolution 68 c3dnlG_ not modelled 6.3 45 PDB header:viral protein Chain: G: PDB Molecule:hiv-1 envelope glycoprotein gp120; PDBTitle: molecular structure for the hiv-1 gp120 trimer in the b12-2 bound state 69 d1tifa_ not modelled 6.3 12 Fold:beta-Grasp (ubiquitin-like) Superfamily:Translation initiation factor IF3, N-terminal domain Family:Translation initiation factor IF3, N-terminal domain 70 c2cseB_ not modelled 6.3 10 PDB header:virus Chain: B: PDB Molecule:major outer-capsid protein mu1; PDBTitle: features of reovirus outer-capsid protein mu1 revealed by2 electron and image reconstruction of the virion at 7.0-a3 resolution 71 c1jmuD_ not modelled 6.2 10 PDB header:viral protein Chain: D: PDB Molecule:protein mu-1; PDBTitle: crystal structure of the reovirus mu1/sigma3 complex 72 d1sgoa_ not modelled 6.1 20 Fold:N domain of copper amine oxidase-like Superfamily:Hypothetical protein c14orf129, hspc210 Family:Hypothetical protein c14orf129, hspc210 73 d1vl4a_ not modelled 6.1 20 Fold:Putative modulator of DNA gyrase, PmbA/TldD Superfamily:Putative modulator of DNA gyrase, PmbA/TldD Family:Putative modulator of DNA gyrase, PmbA/TldD 74 c1w3gA_ not modelled 6.0 20 PDB header:toxin/lectin Chain: A: PDB Molecule:hemolytic lectin from laetiporus sulphureus; PDBTitle: hemolytic lectin from the mushroom laetiporus sulphureus2 complexed with two n-acetyllactosamine molecules. 75 d2ijra1 not modelled 5.9 33 Fold:Api92-like Superfamily:Api92-like Family:Api92-like 76 d1udza_ not modelled 5.9 55 Fold:ValRS/IleRS/LeuRS editing domain Superfamily:ValRS/IleRS/LeuRS editing domain Family:ValRS/IleRS/LeuRS editing domain 77 d2ae8a2 not modelled 5.8 45 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 78 d2cu8a2 not modelled 5.7 25 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 79 c2z5cB_ not modelled 5.7 33 PDB header:chaperone/hydrolase Chain: B: PDB Molecule:uncharacterized protein ylr021w; PDBTitle: crystal structure of a novel chaperone complex for yeast2 20s proteasome assembly 80 c3nttA_ not modelled 5.6 7 PDB header:virus Chain: A: PDB Molecule:capsid protein; PDBTitle: structural insights of adeno-associated virus 5. a gene therapy vector2 for cystic fibrosis 81 c3lemA_ not modelled 5.6 19 PDB header:hydrolase Chain: A: PDB Molecule:fructosyltransferase; PDBTitle: crystal structure of fructosyltransferase (d191a) from a. japonicus in2 complex with nystose 82 c3l3fX_ not modelled 5.5 18 PDB header:protein binding Chain: X: PDB Molecule:protein doa1; PDBTitle: crystal structure of a pfu-pul domain pair of saccharomyces cerevisiae2 doa1/ufd3 83 d2qqia2 not modelled 5.5 14 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) 84 c3kieF_ not modelled 5.4 14 PDB header:virus Chain: F: PDB Molecule:capsid protein vp1; PDBTitle: crystal structure of adeno-associated virus serotype 3b 85 c2qqmA_ not modelled 5.4 29 PDB header:signaling protein Chain: A: PDB Molecule:neuropilin-1; PDBTitle: crystal structure of the a2b1b2 domains from human neuropilin-1 86 d2vzsa4 not modelled 5.4 25 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:beta-Galactosidase/glucuronidase, N-terminal domain 87 d1dl2a_ not modelled 5.3 33 Fold:alpha/alpha toroid Superfamily:Seven-hairpin glycosidases Family:Class I alpha-1;2-mannosidase, catalytic domain 88 d1rhya2 not modelled 5.3 32 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 89 d1vpba_ not modelled 5.3 20 Fold:Putative modulator of DNA gyrase, PmbA/TldD Superfamily:Putative modulator of DNA gyrase, PmbA/TldD Family:Putative modulator of DNA gyrase, PmbA/TldD 90 c2r7eB_ not modelled 5.2 22 PDB header:blood clotting Chain: B: PDB Molecule:coagulation factor viii; PDBTitle: crystal structure analysis of coagulation factor viii 91 d1x9da1 not modelled 5.2 36 Fold:alpha/alpha toroid Superfamily:Seven-hairpin glycosidases Family:Class I alpha-1;2-mannosidase, catalytic domain 92 c1x9dA_ not modelled 5.2 36 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum mannosyl-oligosaccharide 1, PDBTitle: crystal structure of human class i alpha-1,2-mannosidase in2 complex with thio-disaccharide substrate analogue 93 d1ky9a1 not modelled 5.2 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:HtrA-like serine proteases 94 d1klra_ not modelled 5.2 56 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 95 c1klrA_ not modelled 5.2 56 PDB header:transcription Chain: A: PDB Molecule:zinc finger y-chromosomal protein; PDBTitle: nmr structure of the zfy-6t[y10f] zinc finger 96 d1d0da_ not modelled 5.1 47 Fold:BPTI-like Superfamily:BPTI-like Family:Soft tick anticoagulant proteins 97 c3o0aB_ not modelled 5.1 27 PDB header:ligase Chain: B: PDB Molecule:leucyl-trna synthetase subunit alpha; PDBTitle: crystal structure of the wild type cp1 hydrolitic domain from aquifex2 aeolicus leucyl-trna 98 c2g8gA_ not modelled 5.0 14 PDB header:virus Chain: A: PDB Molecule:capsid; PDBTitle: structurally mapping the diverse phenotype of adeno-2 associated virus serotype 4

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0