Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	K	K	I	F	A	L	P	V	I	E	Q	I	S	P	V	L	S	R	R	K	L	D	E	L	D	L	I	V	V	D	H	P	Q	V	K	A	S	F	A	L	Q	G	A	H	L	L	S	W	K	P	A	G	E	E	E	V	L	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	S	N	N	T	P	F	K	N	G	V	A	I	R	G	G	V	P	V	C	W	P	W	F	G	P	A	A	Q	Q	G	L	P	A	H	G	F	A	R	N	L	P	W	T	L	K	S	H	H	E	D	A	D	G	V	A	L	T	F	E
Secondary structure
SS confidence
Disorder						?	?	?	?	?			?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	T	Q	S	E	E	T	K	K	F	W	P	H	D	F	T	L	L	A	H	F	R	V	G	K	T	C	E	I	D	L	E	S	H	G	E	F	E	T	T	S	A	L	H	T	Y	F	N	V	G	D	I	A	K	V	S	V	S	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	D	R	F	I	D	K	V	N	D	A	K	E	N	V	L	T	D	G	I	Q	T	F	P	D	R	T	D	R	V	Y	L	N	P	Q	D	C	S	V	I	N	D	E	A	L	N	R	I	I	A	V	G	H	Q	H	H	L	N	V	V
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.
Sequence		G	W	N	P	G	P	A	L	S	I	S	M	G	D	M	P	D	D	G	Y	K	T	F	V	C	V	E	T	A	Y	A	S	E	T	Q	K	V	T	K	E	K	P	A	H	L	A	Q	S	I	R	V	A	K	R
Secondary structure
SS confidence
Disorder								?	?	?	?				?	?	?																																				?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2htb chain B Region: 1 - 294 Aligned: 294 Modelled: 294 Confidence: 100.0% Identity: 83% PDB header:isomerase Chain: B: PDB Molecule:putative enzyme related to aldose 1-epimerase; PDBTitle: crystal structure of a putative mutarotase (yead) from2 salmonella typhimurium in monoclinic form Phyre2 PDB 1jov chain A Region: 10 - 290 Aligned: 264 Modelled: 281 Confidence: 100.0% Identity: 35% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: Hypothetical protein HI1317 Phyre2 PDB 2cis chain A Region: 20 - 290 Aligned: 268 Modelled: 271 Confidence: 100.0% Identity: 28% PDB header:isomerase Chain: A: PDB Molecule:hexose-6-phosphate mutarotase; PDBTitle: structure-based functional annotation: yeast ymr099c codes2 for a d-hexose-6-phosphate mutarotase. complex with3 tagatose-6-phosphate Phyre2 PDB 3k25 chain B Region: 24 - 293 Aligned: 253 Modelled: 256 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:slr1438 protein; PDBTitle: crystal structure of slr1438 protein from synechocystis sp. pcc 6803,2 northeast structural genomics consortium target sgr112 Phyre2 PDB 3dcd chain A Region: 29 - 293 Aligned: 243 Modelled: 261 Confidence: 100.0% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:galactose mutarotase related enzyme; PDBTitle: x-ray structure of the galactose mutarotase related enzyme q5fkd7 from2 lactobacillus acidophilus at the resolution 1.9a. northeast3 structural genomics consortium target lar33. Phyre2 PDB 3os7 chain B Region: 18 - 292 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: B: PDB Molecule:galactose mutarotase-like protein; PDBTitle: crystal structure of a galactose mutarotase-like protein (ca_c0697)2 from clostridium acetobutylicum at 1.80 a resolution Phyre2 PDB 3q1n chain A Region: 28 - 291 Aligned: 242 Modelled: 253 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:galactose mutarotase related enzyme; PDBTitle: crystal structure of a galactose mutarotase-like protein (lsei_2598)2 from lactobacillus casei atcc 334 at 1.61 a resolution Phyre2 PDB 3os7 chain D Region: 18 - 292 Aligned: 262 Modelled: 274 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: D: PDB Molecule:galactose mutarotase-like protein; PDBTitle: crystal structure of a galactose mutarotase-like protein (ca_c0697)2 from clostridium acetobutylicum at 1.80 a resolution Phyre2 PDB 3nre chain B Region: 25 - 292 Aligned: 247 Modelled: 268 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: B: PDB Molecule:aldose 1-epimerase; PDBTitle: crystal structure of a putative aldose 1-epimerase (b2544) from2 escherichia coli k12 at 1.59 a resolution Phyre2 PDB 3mwx chain A Region: 15 - 293 Aligned: 266 Modelled: 265 Confidence: 100.0% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:aldose 1-epimerase; PDBTitle: crystal structure of a putative galactose mutarotase (bsu18360) from2 bacillus subtilis at 1.45 a resolution Phyre2 PDB 3imh chain B Region: 13 - 292 Aligned: 272 Modelled: 276 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: B: PDB Molecule:galactose-1-epimerase; PDBTitle: crystal structure of galactose 1-epimerase from lactobacillus2 acidophilus ncfm Phyre2 PDB 1nsz chain A Region: 17 - 294 Aligned: 272 Modelled: 278 Confidence: 100.0% Identity: 17% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: Aldose 1-epimerase (mutarotase) Phyre2 PDB 1lur chain A Region: 28 - 290 Aligned: 254 Modelled: 263 Confidence: 100.0% Identity: 15% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: Aldose 1-epimerase (mutarotase) Phyre2 PDB 1yga chain A Region: 24 - 290 Aligned: 256 Modelled: 265 Confidence: 100.0% Identity: 13% PDB header:isomerase Chain: A: PDB Molecule:hypothetical 37.9 kda protein in bio3-hxt17 PDBTitle: crystal structure of saccharomyces cerevisiae yn9a protein,2 new york structural genomics consortium Phyre2 PDB 1so0 chain A Region: 14 - 292 Aligned: 272 Modelled: 275 Confidence: 100.0% Identity: 13% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: Aldose 1-epimerase (mutarotase) Phyre2 PDB 1z45 chain A domain 1 Region: 23 - 292 Aligned: 260 Modelled: 263 Confidence: 100.0% Identity: 14% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: Aldose 1-epimerase (mutarotase) Phyre2 PDB 1z45 chain A Region: 28 - 292 Aligned: 254 Modelled: 265 Confidence: 100.0% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:gal10 bifunctional protein; PDBTitle: crystal structure of the gal10 fusion protein galactose2 mutarotase/udp-galactose 4-epimerase from saccharomyces3 cerevisiae complexed with nad, udp-glucose, and galactose Phyre2 PDB 3ty1 chain B Region: 25 - 292 Aligned: 256 Modelled: 263 Confidence: 99.9% Identity: 14% PDB header:isomerase Chain: B: PDB Molecule:hypothetical aldose 1-epimerase; PDBTitle: crystal structure of a hypothetical aldose 1-epimerase (kpn_04629)2 from klebsiella pneumoniae subsp. pneumoniae mgh 78578 at 1.90 a3 resolution Phyre2 PDB 3bs6 chain B Region: 24 - 161 Aligned: 129 Modelled: 138 Confidence: 96.6% Identity: 11% PDB header:membrane protein, protein transport Chain: B: PDB Molecule:inner membrane protein oxaa; PDBTitle: 1.8 angstrom crystal structure of the periplasmic domain of2 the membrane insertase yidc Phyre2 PDB 3blc chain B Region: 24 - 161 Aligned: 130 Modelled: 138 Confidence: 96.4% Identity: 10% PDB header:chaperone,protein transport Chain: B: PDB Molecule:inner membrane protein oxaa; PDBTitle: crystal structure of the periplasmic domain of the escherichia coli2 yidc Phyre2 1 c2htbB_ 2 d1jova_ 3 c2cisA_ 4 c3k25B_ 5 c3dcdA_ 6 c3os7B_ 7 c3q1nA_ 8 c3os7D_ 9 c3nreB_ 10 c3mwxA_ 11 c3imhB_ 12 d1nsza_ 13 d1lura_ 14 c1ygaA_ 15 d1so0a_ 16 d1z45a1 17 c1z45A_ 18 c3ty1B_ 19 c3bs6B_ 20 c3blcB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2htbB_ 100.0 83 PDB header:isomerase Chain: B: PDB Molecule:putative enzyme related to aldose 1-epimerase; PDBTitle: crystal structure of a putative mutarotase (yead) from2 salmonella typhimurium in monoclinic form 2 d1jova_ 100.0 35 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Hypothetical protein HI1317 3 c2cisA_ 100.0 28 PDB header:isomerase Chain: A: PDB Molecule:hexose-6-phosphate mutarotase; PDBTitle: structure-based functional annotation: yeast ymr099c codes2 for a d-hexose-6-phosphate mutarotase. complex with3 tagatose-6-phosphate 4 c3k25B_ 100.0 20 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:slr1438 protein; PDBTitle: crystal structure of slr1438 protein from synechocystis sp. pcc 6803,2 northeast structural genomics consortium target sgr112 5 c3dcdA_ 100.0 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:galactose mutarotase related enzyme; PDBTitle: x-ray structure of the galactose mutarotase related enzyme q5fkd7 from2 lactobacillus acidophilus at the resolution 1.9a. northeast3 structural genomics consortium target lar33. 6 c3os7B_ 100.0 19 PDB header:isomerase Chain: B: PDB Molecule:galactose mutarotase-like protein; PDBTitle: crystal structure of a galactose mutarotase-like protein (ca_c0697)2 from clostridium acetobutylicum at 1.80 a resolution 7 c3q1nA_ 100.0 21 PDB header:isomerase Chain: A: PDB Molecule:galactose mutarotase related enzyme; PDBTitle: crystal structure of a galactose mutarotase-like protein (lsei_2598)2 from lactobacillus casei atcc 334 at 1.61 a resolution 8 c3os7D_ 100.0 19 PDB header:isomerase Chain: D: PDB Molecule:galactose mutarotase-like protein; PDBTitle: crystal structure of a galactose mutarotase-like protein (ca_c0697)2 from clostridium acetobutylicum at 1.80 a resolution 9 c3nreB_ 100.0 17 PDB header:isomerase Chain: B: PDB Molecule:aldose 1-epimerase; PDBTitle: crystal structure of a putative aldose 1-epimerase (b2544) from2 escherichia coli k12 at 1.59 a resolution 10 c3mwxA_ 100.0 15 PDB header:isomerase Chain: A: PDB Molecule:aldose 1-epimerase; PDBTitle: crystal structure of a putative galactose mutarotase (bsu18360) from2 bacillus subtilis at 1.45 a resolution 11 c3imhB_ 100.0 16 PDB header:isomerase Chain: B: PDB Molecule:galactose-1-epimerase; PDBTitle: crystal structure of galactose 1-epimerase from lactobacillus2 acidophilus ncfm 12 d1nsza_ 100.0 17 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase) 13 d1lura_ 100.0 15 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase) 14 c1ygaA_ 100.0 13 PDB header:isomerase Chain: A: PDB Molecule:hypothetical 37.9 kda protein in bio3-hxt17 PDBTitle: crystal structure of saccharomyces cerevisiae yn9a protein,2 new york structural genomics consortium 15 d1so0a_ 100.0 13 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase) 16 d1z45a1 100.0 14 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase) 17 c1z45A_ 100.0 15 PDB header:isomerase Chain: A: PDB Molecule:gal10 bifunctional protein; PDBTitle: crystal structure of the gal10 fusion protein galactose2 mutarotase/udp-galactose 4-epimerase from saccharomyces3 cerevisiae complexed with nad, udp-glucose, and galactose 18 c3ty1B_ 99.9 14 PDB header:isomerase Chain: B: PDB Molecule:hypothetical aldose 1-epimerase; PDBTitle: crystal structure of a hypothetical aldose 1-epimerase (kpn_04629)2 from klebsiella pneumoniae subsp. pneumoniae mgh 78578 at 1.90 a3 resolution 19 c3bs6B_ 96.6 11 PDB header:membrane protein, protein transport Chain: B: PDB Molecule:inner membrane protein oxaa; PDBTitle: 1.8 angstrom crystal structure of the periplasmic domain of2 the membrane insertase yidc 20 c3blcB_ 96.4 10 PDB header:chaperone,protein transport Chain: B: PDB Molecule:inner membrane protein oxaa; PDBTitle: crystal structure of the periplasmic domain of the escherichia coli2 yidc 21 d1ejxb_ not modelled 37.9 10 Fold:beta-clip Superfamily:Urease, beta-subunit Family:Urease, beta-subunit 22 d4ubpb_ not modelled 36.4 14 Fold:beta-clip Superfamily:Urease, beta-subunit Family:Urease, beta-subunit 23 c2yfnA_ not modelled 35.5 11 PDB header:hydrolase Chain: A: PDB Molecule:alpha-galactosidase-sucrose kinase agask; PDBTitle: galactosidase domain of alpha-galactosidase-sucrose kinase,2 agask 24 d1e9ya1 not modelled 35.3 10 Fold:beta-clip Superfamily:Urease, beta-subunit Family:Urease, beta-subunit 25 d1jz8a4 not modelled 32.7 15 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:beta-Galactosidase, domain 5 26 c2js4A_ not modelled 31.2 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0434 protein bb2007; PDBTitle: solution nmr structure of bordetella bronchiseptica protein2 bb2007. northeast structural genomics consortium target3 bor54 27 c3qgaD_ not modelled 29.4 10 PDB header:hydrolase Chain: D: PDB Molecule:fusion of urease beta and gamma subunits; PDBTitle: 3.0 a model of iron containing urease urea2b2 from helicobacter2 mustelae 28 c1e9zA_ not modelled 26.7 10 PDB header:hydrolase Chain: A: PDB Molecule:urease subunit alpha; PDBTitle: crystal structure of helicobacter pylori urease 29 d1fcqa_ not modelled 21.2 32 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Bee venom hyaluronidase 30 c2jr6A_ not modelled 18.6 27 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0434 protein nma0874; PDBTitle: solution structure of upf0434 protein nma0874. northeast structural2 genomics target mr32 31 d2pk7a1 not modelled 17.7 45 Fold:Trm112p-like Superfamily:Trm112p-like Family:Trm112p-like 32 d2jnya1 not modelled 16.8 36 Fold:Trm112p-like Superfamily:Trm112p-like Family:Trm112p-like 33 d2hf1a1 not modelled 16.6 27 Fold:Trm112p-like Superfamily:Trm112p-like Family:Trm112p-like 34 c2k5rA_ not modelled 14.6 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein xf2673; PDBTitle: solution nmr structure of xf2673 from xylella fastidiosa.2 northeast structural genomics consortium target xfr39 35 c2kpiA_ not modelled 14.3 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein sco3027; PDBTitle: solution nmr structure of streptomyces coelicolor sco30272 modeled with zn+2 bound, northeast structural genomics3 consortium target rr58 36 d1pxva_ not modelled 11.4 29 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Papain-like 37 c1y4hA_ not modelled 9.8 29 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:cysteine protease; PDBTitle: wild type staphopain-staphostatin complex 38 c1h4tD_ not modelled 9.0 16 PDB header:aminoacyl-trna synthetase Chain: D: PDB Molecule:prolyl-trna synthetase; PDBTitle: prolyl-trna synthetase from thermus thermophilus complexed2 with l-proline 39 c1qf6A_ not modelled 8.9 25 PDB header:ligase/rna Chain: A: PDB Molecule:threonyl-trna synthetase; PDBTitle: structure of e. coli threonyl-trna synthetase complexed with its2 cognate trna 40 c2qeaB_ not modelled 8.4 10 PDB header:oxidoreductase Chain: B: PDB Molecule:putative general stress protein 26; PDBTitle: crystal structure of a putative general stress protein 26 (jann_0955)2 from jannaschia sp. ccs1 at 2.46 a resolution 41 c1nj8C_ not modelled 8.3 8 PDB header:ligase Chain: C: PDB Molecule:proline-trna synthetase; PDBTitle: crystal structure of prolyl-trna synthetase from2 methanocaldococcus janaschii 42 d1pgw21 not modelled 7.8 21 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Comoviridae-like VP 43 d1ny721 not modelled 7.4 26 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Comoviridae-like VP 44 d1pgl21 not modelled 7.3 21 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Comoviridae-like VP 45 c3qbtH_ not modelled 7.2 7 PDB header:protein transport/hydrolase Chain: H: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: crystal structure of ocrl1 540-678 in complex with rab8a:gppnhp 46 c3dmbA_ not modelled 7.1 24 PDB header:oxidoreductase Chain: A: PDB Molecule:putative general stress protein 26 with a pnp-oxidase like PDBTitle: crystal structure of a putative general stress family protein2 (xcc2264) from xanthomonas campestris pv. campestris at 2.30 a3 resolution 47 c1yewI_ not modelled 6.6 5 PDB header:oxidoreductase, membrane protein Chain: I: PDB Molecule:particulate methane monooxygenase, b subunit; PDBTitle: crystal structure of particulate methane monooxygenase 48 c3rgbA_ not modelled 6.6 5 PDB header:oxidoreductase Chain: A: PDB Molecule:methane monooxygenase subunit b2; PDBTitle: crystal structure of particulate methane monooxygenase from2 methylococcus capsulatus (bath) 49 d1k1xa2 not modelled 6.6 15 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:4-alpha-glucanotransferase, C-terminal domain 50 c3ialB_ not modelled 6.6 9 PDB header:ligase Chain: B: PDB Molecule:prolyl-trna synthetase; PDBTitle: giardia lamblia prolyl-trna synthetase in complex with prolyl-2 adenylate 51 d1th5a1 not modelled 6.4 21 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 52 c3bmzA_ not modelled 5.1 22 PDB header:biosynthetic protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: violacein biosynthetic enzyme vioe 53 c2r5iL_ not modelled 5.1 26 PDB header:viral protein Chain: L: PDB Molecule:l1 protein; PDBTitle: pentamer structure of major capsid protein l1 of human2 papilloma virus type 18

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0