Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	T	T	I	L	Q	N	S	T	H	V	I	K	P	K	K	S	V	A	L	S	G	V	P	A	G	N	T	A	L	C	T	V	G	K	S	G	N	D	L	H	Y	R	G	Y	D	I	L	D	L	A	K	H	C	E	F	E	E
Secondary structure
SS confidence
Disorder		?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	H	L	L	I	H	G	K	L	P	T	R	D	E	L	A	A	Y	K	T	K	L	K	A	L	R	G	L	P	A	N	V	R	T	V	L	E	A	L	P	A	A	S	H	P	M	D	V	M	R	T	G	V	S	A	L	G	C	T
Secondary structure
SS confidence
Disorder																																									?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	P	E	K	E	G	H	T	V	S	G	A	R	D	I	A	D	K	L	L	A	S	L	S	S	I	L	L	Y	W	Y	H	Y	S	H	N	G	E	R	I	Q	P	E	T	D	D	D	S	I	G	G	H	F	L	H	L	L	H	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	P	S	Q	S	W	E	K	A	M	H	I	S	L	V	L	Y	A	E	H	E	F	N	A	S	T	F	T	S	R	V	I	A	G	T	G	S	D	M	Y	S	A	I	I	G	A	I	G	A	L	R	G	P	K	H	G	G	A	N	E
Secondary structure
SS confidence
Disorder																																																			?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	S	L	E	I	Q	Q	R	Y	E	T	P	D	E	A	E	A	D	I	R	K	R	V	E	N	K	E	V	V	I	G	F	G	H	P	V	Y	T	I	A	D	P	R	H	Q	V	I	K	R	V	A	K	Q	L	S	Q	E	G	G	S
Secondary structure
SS confidence
Disorder																												?			?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	K	M	Y	N	I	A	D	R	L	E	T	V	M	W	E	S	K	K	M	F	P	N	L	D	W	F	S	A	V	S	Y	N	M	M	G	V	P	T	E	M	F	T	P	L	F	V	I	A	R	V	T	G	W	A	A	H	I	I	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.
Sequence		Q	R	Q	D	N	K	I	I	R	P	S	A	N	Y	V	G	P	E	D	R	P	F	V	A	L	D	K	R	Q
Secondary structure
SS confidence
Disorder																									?				?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2h12 chain C Region: 3 - 388 Aligned: 383 Modelled: 386 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) Phyre2 PDB 1k3p chain A Region: 3 - 388 Aligned: 382 Modelled: 386 Confidence: 100.0% Identity: 30% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 1iom chain A Region: 18 - 388 Aligned: 370 Modelled: 371 Confidence: 100.0% Identity: 36% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 2ibp chain B Region: 4 - 388 Aligned: 383 Modelled: 385 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: B: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from pyrobaculum aerophilum Phyre2 PDB 1aj8 chain A Region: 18 - 389 Aligned: 370 Modelled: 372 Confidence: 100.0% Identity: 36% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 3o8j chain H Region: 28 - 388 Aligned: 361 Modelled: 361 Confidence: 100.0% Identity: 97% PDB header:transferase Chain: H: PDB Molecule:2-methylcitrate synthase; PDBTitle: crystal structure of 2-methylcitrate synthase (prpc) from salmonella2 typhimurium Phyre2 PDB 3msu chain A Region: 3 - 382 Aligned: 370 Modelled: 380 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from francisella tularensis Phyre2 PDB 1a59 chain A Region: 15 - 383 Aligned: 368 Modelled: 369 Confidence: 100.0% Identity: 41% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 3hwk chain E Region: 18 - 386 Aligned: 365 Modelled: 369 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: E: PDB Molecule:methylcitrate synthase; PDBTitle: crystal structure of methylcitrate synthase from2 mycobacterium tuberculosis Phyre2 PDB 3tqg chain A Region: 27 - 389 Aligned: 360 Modelled: 363 Confidence: 100.0% Identity: 52% PDB header:transferase Chain: A: PDB Molecule:2-methylcitrate synthase; PDBTitle: structure of the 2-methylcitrate synthase (prpc) from coxiella2 burnetii Phyre2 PDB 1vgp chain A Region: 17 - 388 Aligned: 367 Modelled: 372 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: A: PDB Molecule:373aa long hypothetical citrate synthase; PDBTitle: crystal structure of an isozyme of citrate synthase from sulfolbus2 tokodaii strain7 Phyre2 PDB 2r26 chain C Region: 18 - 388 Aligned: 369 Modelled: 371 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: the structure of the ternary complex of carboxymethyl2 coenzyme a and oxalateacetate with citrate synthase from3 the thermophilic archaeonthermoplasma acidophilum Phyre2 PDB 1vgm chain B Region: 17 - 388 Aligned: 369 Modelled: 372 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: B: PDB Molecule:378aa long hypothetical citrate synthase; PDBTitle: crystal structure of an isozyme of citrate synthase from sulfolbus2 tokodaii strain7 Phyre2 PDB 2p2w chain A Region: 18 - 389 Aligned: 354 Modelled: 372 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from thermotoga maritima msb8 Phyre2 PDB 2c6x chain A Region: 18 - 382 Aligned: 359 Modelled: 365 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:citrate synthase 1; PDBTitle: structure of bacillus subtilis citrate synthase Phyre2 PDB 1csh chain A Region: 12 - 376 Aligned: 359 Modelled: 365 Confidence: 100.0% Identity: 23% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 2cts chain A Region: 12 - 375 Aligned: 358 Modelled: 364 Confidence: 100.0% Identity: 23% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 1o7x chain A Region: 18 - 380 Aligned: 360 Modelled: 363 Confidence: 100.0% Identity: 33% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 1csc chain A Region: 21 - 375 Aligned: 349 Modelled: 355 Confidence: 100.0% Identity: 23% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 2xzm chain S Region: 44 - 65 Aligned: 22 Modelled: 22 Confidence: 48.8% Identity: 36% PDB header:ribosome Chain: S: PDB Molecule:rps15e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 Phyre2 1 c2h12C_ 2 d1k3pa_ 3 d1ioma_ 4 c2ibpB_ 5 d1aj8a_ 6 c3o8jH_ 7 c3msuA_ 8 d1a59a_ 9 c3hwkE_ 10 c3tqgA_ 11 c1vgpA_ 12 c2r26C_ 13 c1vgmB_ 14 c2p2wA_ 15 c2c6xA_ 16 d1csha_ 17 d2ctsa_ 18 d1o7xa_ 19 d1csca_ 20 c2xzmS_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2h12C_ 100.0 31 PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) 2 d1k3pa_ 100.0 30 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 3 d1ioma_ 100.0 36 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 4 c2ibpB_ 100.0 34 PDB header:transferase Chain: B: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from pyrobaculum aerophilum 5 d1aj8a_ 100.0 36 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 6 c3o8jH_ 100.0 97 PDB header:transferase Chain: H: PDB Molecule:2-methylcitrate synthase; PDBTitle: crystal structure of 2-methylcitrate synthase (prpc) from salmonella2 typhimurium 7 c3msuA_ 100.0 30 PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from francisella tularensis 8 d1a59a_ 100.0 41 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 9 c3hwkE_ 100.0 38 PDB header:transferase Chain: E: PDB Molecule:methylcitrate synthase; PDBTitle: crystal structure of methylcitrate synthase from2 mycobacterium tuberculosis 10 c3tqgA_ 100.0 52 PDB header:transferase Chain: A: PDB Molecule:2-methylcitrate synthase; PDBTitle: structure of the 2-methylcitrate synthase (prpc) from coxiella2 burnetii 11 c1vgpA_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:373aa long hypothetical citrate synthase; PDBTitle: crystal structure of an isozyme of citrate synthase from sulfolbus2 tokodaii strain7 12 c2r26C_ 100.0 35 PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: the structure of the ternary complex of carboxymethyl2 coenzyme a and oxalateacetate with citrate synthase from3 the thermophilic archaeonthermoplasma acidophilum 13 c1vgmB_ 100.0 34 PDB header:transferase Chain: B: PDB Molecule:378aa long hypothetical citrate synthase; PDBTitle: crystal structure of an isozyme of citrate synthase from sulfolbus2 tokodaii strain7 14 c2p2wA_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from thermotoga maritima msb8 15 c2c6xA_ 100.0 33 PDB header:transferase Chain: A: PDB Molecule:citrate synthase 1; PDBTitle: structure of bacillus subtilis citrate synthase 16 d1csha_ 100.0 23 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 17 d2ctsa_ 100.0 23 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 18 d1o7xa_ 100.0 33 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 19 d1csca_ 100.0 23 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 20 c2xzmS_ 48.8 36 PDB header:ribosome Chain: S: PDB Molecule:rps15e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 21 d2huec1 not modelled 27.0 20 Fold:Histone-fold Superfamily:Histone-fold Family:Nucleosome core histones 22 d1poib_ not modelled 24.8 12 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase beta subunit-like 23 d1khda2 not modelled 22.2 21 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 24 d1kx5b_ not modelled 20.7 20 Fold:Histone-fold Superfamily:Histone-fold Family:Nucleosome core histones 25 d1id3b_ not modelled 17.6 15 Fold:Histone-fold Superfamily:Histone-fold Family:Nucleosome core histones 26 c2iouC_ not modelled 14.7 30 PDB header:viral protein/membrane protein Chain: C: PDB Molecule:major tropism determinant p1; PDBTitle: major tropism determinant p1 (mtd-p1) variant complexed with2 bordetella brochiseptica virulence factor pertactin extracellular3 domain (prn-e). 27 d1r3sa_ not modelled 12.3 15 Fold:TIM beta/alpha-barrel Superfamily:UROD/MetE-like Family:Uroporphyrinogen decarboxylase, UROD 28 c2kebA_ not modelled 11.9 18 PDB header:dna binding protein Chain: A: PDB Molecule:dna polymerase subunit alpha b; PDBTitle: nmr solution structure of the n-terminal domain of the dna polymerase2 alpha p68 subunit 29 d1yu0a2 not modelled 11.7 30 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Mtd variable domain 30 d1keaa_ not modelled 11.0 16 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Mismatch glycosylase 31 d1hiod_ not modelled 10.6 20 Fold:Histone-fold Superfamily:Histone-fold Family:Nucleosome core histones 32 d1orna_ not modelled 10.4 16 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Endonuclease III 33 c3ajvD_ not modelled 9.8 29 PDB header:hydrolase Chain: D: PDB Molecule:trna-splicing endonuclease; PDBTitle: splicing endonuclease from aeropyrum pernix 34 d1b8za_ not modelled 9.4 29 Fold:IHF-like DNA-binding proteins Superfamily:IHF-like DNA-binding proteins Family:Prokaryotic DNA-bending protein 35 d1mula_ not modelled 8.3 23 Fold:IHF-like DNA-binding proteins Superfamily:IHF-like DNA-binding proteins Family:Prokaryotic DNA-bending protein 36 c3c65A_ not modelled 8.0 20 PDB header:hydrolase Chain: A: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of bacillus stearothermophilus uvrc 5'2 endonuclease domain 37 d2o97b1 not modelled 7.8 29 Fold:IHF-like DNA-binding proteins Superfamily:IHF-like DNA-binding proteins Family:Prokaryotic DNA-bending protein 38 c1fctA_ not modelled 7.7 71 PDB header:transit peptide Chain: A: PDB Molecule:ferredoxin chloroplastic transit peptide PDBTitle: nmr structures of ferredoxin chloroplastic transit peptide2 from chlamydomonas reinhardtii promoted by3 trifluoroethanol in aqueous solution 39 d1yu3a2 not modelled 7.7 30 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Mtd variable domain 40 c2l5aA_ not modelled 7.7 15 PDB header:nuclear protein Chain: A: PDB Molecule:histone h3-like centromeric protein cse4, protein scm3, PDBTitle: structural basis for recognition of centromere specific histone h32 variant by nonhistone scm3 41 d2abka_ not modelled 7.1 12 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Endonuclease III 42 d1fhea1 not modelled 6.8 14 Fold:GST C-terminal domain-like Superfamily:GST C-terminal domain-like Family:Glutathione S-transferase (GST), C-terminal domain 43 c2q6vA_ not modelled 6.5 13 PDB header:transferase Chain: A: PDB Molecule:glucuronosyltransferase gumk; PDBTitle: crystal structure of gumk in complex with udp 44 c1jpkA_ not modelled 6.5 11 PDB header:lyase Chain: A: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: gly156asp mutant of human urod, human uroporphyrinogen iii2 decarboxylase 45 c3kgkA_ not modelled 6.2 46 PDB header:chaperone Chain: A: PDB Molecule:arsenical resistance operon trans-acting repressor arsd; PDBTitle: crystal structure of arsd 46 c3ktbD_ not modelled 6.1 15 PDB header:transcription regulator Chain: D: PDB Molecule:arsenical resistance operon trans-acting repressor; PDBTitle: crystal structure of arsenical resistance operon trans-acting2 repressor from bacteroides vulgatus atcc 8482 47 c3ts3D_ not modelled 5.9 24 PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution 48 d1o17a1 not modelled 5.8 18 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 49 d1brwa2 not modelled 5.7 13 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 50 d1m6ya1 not modelled 5.7 19 Fold:SAM domain-like Superfamily:Putative methyltransferase TM0872, insert domain Family:Putative methyltransferase TM0872, insert domain 51 c1j9zB_ not modelled 5.7 22 PDB header:oxidoreductase Chain: B: PDB Molecule:nadph-cytochrome p450 reductase; PDBTitle: cypor-w677g 52 d1wg8a1 not modelled 5.6 17 Fold:SAM domain-like Superfamily:Putative methyltransferase TM0872, insert domain Family:Putative methyltransferase TM0872, insert domain 53 c2nv4A_ not modelled 5.6 31 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0066 protein af_0241; PDBTitle: crystal structure of upf0066 protein af0241 in complex with2 s-adenosylmethionine. northeast structural genomics3 consortium target gr27 54 c2l0cA_ not modelled 5.4 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative membrane protein; PDBTitle: solution nmr structure of protein sty4237 (residues 36-120) from2 salmonella enterica, northeast structural genomics consortium target3 slr115 55 c2fheA_ not modelled 5.3 12 PDB header:transferase/substrate Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: fasciola hepatica glutathione s-transferase isoform 1 in complex with2 glutathione 56 c3gndC_ not modelled 5.2 12 PDB header:lyase Chain: C: PDB Molecule:aldolase lsrf; PDBTitle: crystal structure of e. coli lsrf in complex with ribulose-5-phosphate 57 d2bv3a3 not modelled 5.1 20 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Translational machinery components 58 c3ieyA_ not modelled 5.1 36 PDB header:hydrolase/rna binding protein Chain: A: PDB Molecule:trna-splicing endonuclease; PDBTitle: crystal structure of the functional nanoarchaeum equitans trna2 splicing endonuclease 59 d2elca2 not modelled 5.1 25 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 60 c2xzmV_ not modelled 5.0 24 PDB header:ribosome Chain: V: PDB Molecule:rps17e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0