Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	Q	L	T	I	L	G	S	T	G	S	I	G	C	S	T	L	D	V	V	R	H	N	P	E	H	F	R	V	V	A	L	V	A	G	K	N	V	T	R	M	V	E	Q	C	L	E	F	S	P	R	Y	A	V	M	D	D	E	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	A	K	L	L	K	T	M	L	Q	Q	Q	G	S	R	T	E	V	L	S	G	Q	Q	A	A	C	D	M	A	A	L	E	D	V	D	Q	V	M	A	A	I	V	G	A	A	G	L	L	P	T	L	A	A	I	R	A	G	K	T	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	A	N	K	E	S	L	V	T	C	G	R	L	F	M	D	A	V	K	Q	S	K	A	Q	L	L	P	V	D	S	E	H	N	A	I	F	Q	S	L	P	Q	P	I	Q	H	N	L	G	Y	A	D	L	E	Q	N	G	V	V	S
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	L	L	T	G	S	G	G	P	F	R	E	T	P	L	R	D	L	A	T	M	T	P	D	Q	A	C	R	H	P	N	W	S	M	G	R	K	I	S	V	D	S	A	T	M	M	N	K	G	L	E	Y	I	E	A	R	W	L	F	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	S	A	S	Q	M	E	V	L	I	H	P	Q	S	V	I	H	S	M	V	R	Y	Q	D	G	S	V	L	A	Q	L	G	E	P	D	M	R	T	P	I	A	H	T	M	A	W	P	N	R	V	N	S	G	V	K	P	L	D	F	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	L	S	A	L	T	F	A	A	P	D	Y	D	R	Y	P	C	L	K	L	A	M	E	A	F	E	Q	G	Q	A	A	T	T	A	L	N	A	A	N	E	I	T	V	A	A	F	L	A	Q	Q	I	R	F	T	D	I	A	A	L	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.
Sequence		L	S	V	L	E	K	M	D	M	R	E	P	Q	C	V	D	D	V	L	S	V	D	A	N	A	R	E	V	A	R	K	E	V	M	R	L	A	S
Secondary structure
SS confidence
Disorder											?	?	?																								?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2egh chain A Region: 2 - 398 Aligned: 397 Modelled: 397 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase2 complexed with a magnesium ion, nadph and fosmidomycin Phyre2 PDB 3au9 chain A Region: 2 - 397 Aligned: 396 Modelled: 396 Confidence: 100.0% Identity: 36% PDB header:isomerase/isomerase inhibitor Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of the quaternary complex-1 of an isomerase Phyre2 PDB 1k5h chain B Region: 1 - 396 Aligned: 391 Modelled: 396 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose-5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose-5-phosphate reductoisomerase Phyre2 PDB 2jcy chain A Region: 2 - 396 Aligned: 374 Modelled: 383 Confidence: 100.0% Identity: 41% PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: x-ray structure of mutant 1-deoxy-d-xylulose 5-phosphate2 reductoisomerase, dxr, rv2870c, from mycobacterium3 tuberculosis Phyre2 PDB 1r0l chain D Region: 2 - 396 Aligned: 376 Modelled: 395 Confidence: 100.0% Identity: 51% PDB header:oxidoreductase Chain: D: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose 5-phosphate reductoisomerase from2 zymomonas mobilis in complex with nadph Phyre2 PDB 3a14 chain B Region: 2 - 398 Aligned: 364 Modelled: 383 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of dxr from thermotoga maritima, in complex with2 nadph Phyre2 PDB 1q0q chain A domain 3 Region: 126 - 274 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 100% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 1r0k chain A domain 3 Region: 127 - 274 Aligned: 132 Modelled: 148 Confidence: 100.0% Identity: 61% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 1q0q chain A domain 2 Region: 1 - 150 Aligned: 149 Modelled: 150 Confidence: 100.0% Identity: 86% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1r0k chain A domain 2 Region: 2 - 155 Aligned: 148 Modelled: 154 Confidence: 100.0% Identity: 39% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1t1r chain A domain 2 Region: 2 - 126 Aligned: 125 Modelled: 125 Confidence: 100.0% Identity: 100% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1q0q chain A domain 1 Region: 301 - 398 Aligned: 98 Modelled: 98 Confidence: 100.0% Identity: 100% Fold: Left-handed superhelix Superfamily: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Phyre2 PDB 1r0k chain A domain 1 Region: 301 - 394 Aligned: 94 Modelled: 94 Confidence: 100.0% Identity: 43% Fold: Left-handed superhelix Superfamily: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Phyre2 PDB 3mtj chain A Region: 1 - 147 Aligned: 123 Modelled: 143 Confidence: 99.8% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:homoserine dehydrogenase; PDBTitle: the crystal structure of a homoserine dehydrogenase from thiobacillus2 denitrificans to 2.15a Phyre2 PDB 3c8m chain A Region: 3 - 147 Aligned: 124 Modelled: 128 Confidence: 99.7% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:homoserine dehydrogenase; PDBTitle: crystal structure of homoserine dehydrogenase from thermoplasma2 volcanium Phyre2 PDB 3do5 chain A Region: 3 - 147 Aligned: 130 Modelled: 130 Confidence: 99.6% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:homoserine dehydrogenase; PDBTitle: crystal structure of putative homoserine dehydrogenase (np_069768.1)2 from archaeoglobus fulgidus at 2.20 a resolution Phyre2 PDB 2ejw chain B Region: 1 - 143 Aligned: 114 Modelled: 115 Confidence: 99.5% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:homoserine dehydrogenase; PDBTitle: homoserine dehydrogenase from thermus thermophilus hb8 Phyre2 PDB 3ing chain A Region: 3 - 147 Aligned: 126 Modelled: 127 Confidence: 99.5% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:homoserine dehydrogenase; PDBTitle: crystal structure of homoserine dehydrogenase (np_394635.1) from2 thermoplasma acidophilum at 1.95 a resolution Phyre2 PDB 1ebu chain A Region: 3 - 145 Aligned: 129 Modelled: 130 Confidence: 99.3% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:homoserine dehydrogenase; PDBTitle: homoserine dehydrogenase complex with nad analogue and l-2 homoserine Phyre2 PDB 1ebf chain A domain 1 Region: 1 - 147 Aligned: 133 Modelled: 134 Confidence: 99.0% Identity: 14% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 1 c2eghA_ 2 c3au9A_ 3 c1k5hB_ 4 c2jcyA_ 5 c1r0lD_ 6 c3a14B_ 7 d1q0qa3 8 d1r0ka3 9 d1q0qa2 10 d1r0ka2 11 d1t1ra2 12 d1q0qa1 13 d1r0ka1 14 c3mtjA_ 15 c3c8mA_ 16 c3do5A_ 17 c2ejwB_ 18 c3ingA_ 19 c1ebuA_ 20 d1ebfa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499