Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	S	F	Q	F	E	Q	I	G	V	I	R	S	P	Y	K	E	K	F	A	V	P	R	Q	P	G	L	V	K	S	A	N	G	E	L	H	L	I	A	P	Y	N	Q	A	D	A	V	R	G	L	E	A	F	S	H	L	W	I	L
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	V	F	H	Q	T	M	E	G	G	W	R	P	T	V	R	P	P	R	L	G	G	N	A	R	M	G	V	F	A	T	R	S	T	F	R	P	N	P	I	G	M	S	L	V	E	L	K	E	V	V	C	H	K	D	S	V	I	L	K
Secondary structure
SS confidence
Disorder								?	?		?	?							?		?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	G	S	L	D	L	V	D	G	T	P	V	V	D	I	K	P	Y	L	P	F	A	E	S	L	P	D	A	S	A	S	Y	A	Q	S	A	P	A	A	E	M	A	V	S	F	T	A	E	V	E	K	Q	L	L	T	L	E	K	R	Y
Secondary structure
SS confidence
Disorder																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Sequence		P	Q	L	T	L	F	I	R	E	V	L	A	Q	D	P	R	P	A	Y	R	K	G	E	E	T	G	K	T	Y	A	V	W	L	H	D	F	N	V	R	W	R	V	T	D	A	G	F	E	V	F	A	L	E	P	R
Secondary structure
SS confidence
Disorder																					?	?	?	?																															?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1xqb chain A Region: 1 - 228 Aligned: 186 Modelled: 192 Confidence: 100.0% Identity: 48% Fold: YaeB-like Superfamily: YaeB-like Family: YaeB-like Phyre2 PDB 3okx chain A Region: 2 - 156 Aligned: 141 Modelled: 155 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:yaeb-like protein rpa0152; PDBTitle: crystal structure of yaeb-like protein from rhodopseudomonas palustris Phyre2 PDB 2nv4 chain A Region: 6 - 147 Aligned: 131 Modelled: 142 Confidence: 100.0% Identity: 38% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0066 protein af_0241; PDBTitle: crystal structure of upf0066 protein af0241 in complex with2 s-adenosylmethionine. northeast structural genomics3 consortium target gr27 Phyre2 PDB 3g5o chain C Region: 159 - 235 Aligned: 77 Modelled: 77 Confidence: 97.4% Identity: 17% PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 3bpq chain D Region: 163 - 235 Aligned: 73 Modelled: 73 Confidence: 97.0% Identity: 14% PDB header:toxin Chain: D: PDB Molecule:toxin rele3; PDBTitle: crystal structure of relb-rele antitoxin-toxin complex from2 methanococcus jannaschii Phyre2 PDB 1wmi chain A domain 1 Region: 160 - 235 Aligned: 76 Modelled: 76 Confidence: 96.6% Identity: 26% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 2khe chain A Region: 160 - 235 Aligned: 76 Modelled: 76 Confidence: 95.6% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 Phyre2 PDB 3kix chain Y Region: 160 - 235 Aligned: 76 Modelled: 76 Confidence: 93.6% Identity: 14% PDB header:ribosome Chain: Y: PDB Molecule: PDBTitle: structure of rele nuclease bound to the 70s ribosome2 (postcleavage state; part 3 of 4) Phyre2 PDB 2a6s chain A domain 1 Region: 161 - 232 Aligned: 72 Modelled: 72 Confidence: 91.9% Identity: 13% Fold: RelE-like Superfamily: RelE-like Family: YoeB/Txe-like Phyre2 PDB 3oei chain H Region: 162 - 232 Aligned: 71 Modelled: 71 Confidence: 89.0% Identity: 14% PDB header:toxin, protein binding Chain: H: PDB Molecule:relk (toxin rv3358); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 3kxe chain B Region: 162 - 232 Aligned: 70 Modelled: 71 Confidence: 71.6% Identity: 16% PDB header:protein binding Chain: B: PDB Molecule:toxin protein pare-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 PDB 2otr chain A Region: 161 - 233 Aligned: 73 Modelled: 73 Confidence: 58.2% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hp0892; PDBTitle: solution structure of conserved hypothetical protein hp0892 from2 helicobacter pylori Phyre2 PDB 1x6o chain A domain 1 Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 55.3% Identity: 15% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: eIF5a N-terminal domain-like Phyre2 PDB 1z8m chain A domain 1 Region: 161 - 232 Aligned: 72 Modelled: 72 Confidence: 46.5% Identity: 13% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 1bkb chain A domain 1 Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 34.4% Identity: 18% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: eIF5a N-terminal domain-like Phyre2 PDB 1iz6 chain A domain 1 Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 27.8% Identity: 15% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: eIF5a N-terminal domain-like Phyre2 PDB 2eif chain A domain 1 Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 19.8% Identity: 9% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: eIF5a N-terminal domain-like Phyre2 PDB 1b74 chain A domain 2 Region: 83 - 92 Aligned: 10 Modelled: 10 Confidence: 16.0% Identity: 40% Fold: ATC-like Superfamily: Aspartate/glutamate racemase Family: Aspartate/glutamate racemase Phyre2 PDB 1veh chain A Region: 181 - 226 Aligned: 44 Modelled: 46 Confidence: 15.5% Identity: 23% Fold: Alpha-lytic protease prodomain-like Superfamily: Fe-S cluster assembly (FSCA) domain-like Family: NifU C-terminal domain-like Phyre2 PDB 3but chain A Region: 97 - 130 Aligned: 26 Modelled: 34 Confidence: 13.9% Identity: 8% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein af_0446; PDBTitle: crystal structure of protein af_0446 from archaeoglobus fulgidus Phyre2 1 d1xqba_ 2 c3okxA_ 3 c2nv4A_ 4 c3g5oC_ 5 c3bpqD_ 6 d1wmia1 7 c2kheA_ 8 c3kixy_ 9 d2a6sa1 10 c3oeiH_ 11 c3kxeB_ 12 c2otrA_ 13 d1x6oa1 14 d1z8ma1 15 d1bkba1 16 d1iz6a1 17 d2eifa1 18 d1b74a2 19 d1veha_ 20 c3butA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1xqba_ 100.0 48 Fold:YaeB-like Superfamily:YaeB-like Family:YaeB-like 2 c3okxA_ 100.0 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:yaeb-like protein rpa0152; PDBTitle: crystal structure of yaeb-like protein from rhodopseudomonas palustris 3 c2nv4A_ 100.0 38 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0066 protein af_0241; PDBTitle: crystal structure of upf0066 protein af0241 in complex with2 s-adenosylmethionine. northeast structural genomics3 consortium target gr27 4 c3g5oC_ 97.4 17 PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis 5 c3bpqD_ 97.0 14 PDB header:toxin Chain: D: PDB Molecule:toxin rele3; PDBTitle: crystal structure of relb-rele antitoxin-toxin complex from2 methanococcus jannaschii 6 d1wmia1 96.6 26 Fold:RelE-like Superfamily:RelE-like Family:RelE-like 7 c2kheA_ 95.6 24 PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 8 c3kixy_ 93.6 14 PDB header:ribosome Chain: Y: PDB Molecule: PDBTitle: structure of rele nuclease bound to the 70s ribosome2 (postcleavage state; part 3 of 4) 9 d2a6sa1 91.9 13 Fold:RelE-like Superfamily:RelE-like Family:YoeB/Txe-like 10 c3oeiH_ 89.0 14 PDB header:toxin, protein binding Chain: H: PDB Molecule:relk (toxin rv3358); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) 11 c3kxeB_ 71.6 16 PDB header:protein binding Chain: B: PDB Molecule:toxin protein pare-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex 12 c2otrA_ 58.2 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hp0892; PDBTitle: solution structure of conserved hypothetical protein hp0892 from2 helicobacter pylori 13 d1x6oa1 55.3 15 Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:eIF5a N-terminal domain-like 14 d1z8ma1 46.5 13 Fold:RelE-like Superfamily:RelE-like Family:RelE-like 15 d1bkba1 34.4 18 Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:eIF5a N-terminal domain-like 16 d1iz6a1 27.8 15 Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:eIF5a N-terminal domain-like 17 d2eifa1 19.8 9 Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:eIF5a N-terminal domain-like 18 d1b74a2 16.0 40 Fold:ATC-like Superfamily:Aspartate/glutamate racemase Family:Aspartate/glutamate racemase 19 d1veha_ 15.5 23 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 20 c3butA_ 13.9 8 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein af_0446; PDBTitle: crystal structure of protein af_0446 from archaeoglobus fulgidus 21 d1ixsa_ not modelled 13.4 28 Fold:RuvA C-terminal domain-like Superfamily:DNA helicase RuvA subunit, C-terminal domain Family:DNA helicase RuvA subunit, C-terminal domain 22 d1p2za1 not modelled 12.7 20 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Group II dsDNA viruses VP Family:Adenovirus hexon 23 c2vakF_ not modelled 12.3 29 PDB header:viral protein Chain: F: PDB Molecule:sigma a; PDBTitle: crystal structure of the avian reovirus inner capsid2 protein sigmaa 24 c3cu2A_ not modelled 12.1 26 PDB header:isomerase Chain: A: PDB Molecule:ribulose-5-phosphate 3-epimerase; PDBTitle: crystal structure of ribulose-5-phosphate 3-epimerase (yp_718263.1)2 from haemophilus somnus 129pt at 1.91 a resolution 25 d1xo8a_ not modelled 11.9 12 Fold:Immunoglobulin-like beta-sandwich Superfamily:LEA14-like Family:LEA14-like 26 c2vlcB_ not modelled 11.6 9 PDB header:hydrolase Chain: B: PDB Molecule:type 2 ribosome-inactivating protein cinnamomin PDBTitle: crystal structure of natural cinnamomin (isoform iii) 27 d3etja3 not modelled 11.6 27 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 28 c3k1qE_ not modelled 11.5 14 PDB header:virus Chain: E: PDB Molecule:vp6a and vp6b, the clamping proteins; PDBTitle: backbone model of an aquareovirus virion by cryo-electron2 microscopy and bioinformatics 29 c1yycA_ not modelled 11.4 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative late embryogenesis abundant protein; PDBTitle: solution structure of a putative late embryogenesis2 abundant (lea) protein at2g46140.1 30 c2inyA_ not modelled 10.8 27 PDB header:viral protein Chain: A: PDB Molecule:hexon protein; PDBTitle: nanoporous crystals of chicken embryo lethal orphan (celo) adenovirus2 major coat protein, hexon 31 d1p30a1 not modelled 8.9 36 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Group II dsDNA viruses VP Family:Adenovirus hexon 32 c1ej6D_ not modelled 8.3 29 PDB header:virus Chain: D: PDB Molecule:sigma2; PDBTitle: reovirus core 33 c3c9fB_ not modelled 8.3 30 PDB header:hydrolase Chain: B: PDB Molecule:5'-nucleotidase; PDBTitle: crystal structure of 5'-nucleotidase from candida albicans sc5314 34 d3c9fa2 not modelled 8.3 28 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain 35 d1jfla2 not modelled 8.2 33 Fold:ATC-like Superfamily:Aspartate/glutamate racemase Family:Aspartate/glutamate racemase 36 d1kjqa3 not modelled 8.1 25 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 37 d2j9ga3 not modelled 7.6 9 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 38 c2pn1A_ not modelled 7.2 9 PDB header:ligase Chain: A: PDB Molecule:carbamoylphosphate synthase large subunit; PDBTitle: crystal structure of carbamoylphosphate synthase large subunit (split2 gene in mj) (zp_00538348.1) from exiguobacterium sp. 255-15 at 2.00 a3 resolution 39 d1u46a_ not modelled 7.2 22 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 40 c3k54A_ not modelled 7.1 10 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases. 41 c3i38L_ not modelled 7.1 14 PDB header:chaperone Chain: L: PDB Molecule:putative chaperone dnaj; PDBTitle: structure of a putative chaperone protein dnaj from klebsiella2 pneumoniae subsp. pneumoniae mgh 78578 42 c3etjB_ not modelled 7.0 30 PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase atpase PDBTitle: crystal structure e. coli purk in complex with mg, adp, and2 pi 43 d2qi2a1 not modelled 6.9 5 Fold:Sm-like fold Superfamily:Dom34/Pelota N-terminal domain-like Family:Dom34/Pelota N-terminal domain-like 44 d1fgka_ not modelled 6.8 28 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 45 c3dtcA_ not modelled 6.7 22 PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 9; PDBTitle: crystal structure of mixed-lineage kinase mlk1 complexed2 with compound 16 46 c3sd2A_ not modelled 6.6 26 PDB header:unknown function Chain: A: PDB Molecule:putative member of duf3244 protein family; PDBTitle: crystal structure of a putative member of duf3244 protein family2 (bt_3571) from bacteroides thetaiotaomicron vpi-5482 at 1.40 a3 resolution 47 c1y56A_ not modelled 6.5 17 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein ph1363; PDBTitle: crystal structure of l-proline dehydrogenase from p.horikoshii 48 d1b64a_ not modelled 6.5 25 Fold:Ferredoxin-like Superfamily:eEF-1beta-like Family:eEF-1beta-like 49 c1pyaD_ not modelled 6.5 44 PDB header:carboxy-lyase Chain: D: PDB Molecule:pyruvoyl-dependent histidine decarboxylase (l- PDBTitle: refined structure of the pyruvoyl-dependent histidine2 decarboxylase from lactobacillus 30a 50 d1rjba_ not modelled 6.4 19 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 51 d1vkza3 not modelled 6.4 9 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 52 d2fhqa1 not modelled 6.0 12 Fold:Split barrel-like Superfamily:FMN-binding split barrel Family:PNP-oxidase like 53 c2bviK_ not modelled 5.9 36 PDB header:virus Chain: K: PDB Molecule:hexon protein; PDBTitle: the quasi-atomic model of human adenovirus type 52 capsid (part 2) 54 d2dx7a1 not modelled 5.8 36 Fold:ATC-like Superfamily:Aspartate/glutamate racemase Family:Aspartate/glutamate racemase 55 c3kl8C_ not modelled 5.8 28 PDB header:transferase/ transferase inhibitor Chain: C: PDB Molecule:calcium/calmodulin dependent protein kinase ii; PDBTitle: camkiintide inhibitor complex 56 c3qd2B_ not modelled 5.7 39 PDB header:gene regulation Chain: B: PDB Molecule:eukaryotic translation initiation factor 2-alpha kinase 3; PDBTitle: crsytal structure of mouse perk kinase domain 57 d1a9xa6 not modelled 5.6 23 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 58 c2c47D_ not modelled 5.6 24 PDB header:transferase Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform; PDBTitle: structure of casein kinase 1 gamma 2 59 c3dfaA_ not modelled 5.6 28 PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920; PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum 60 d1xhja_ not modelled 5.3 23 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 61 c3lheA_ not modelled 5.3 14 PDB header:transcription regulator Chain: A: PDB Molecule:gntr family transcriptional regulator; PDBTitle: the crystal structure of the c-terminal domain of a gntr2 family transcriptional regulator from bacillus anthracis3 str. sterne 62 c3cc6A_ not modelled 5.2 29 PDB header:transferase Chain: A: PDB Molecule:protein tyrosine kinase 2 beta; PDBTitle: crystal structure of kinase domain of protein tyrosine kinase 2 beta2 (ptk2b) 63 c3p2aA_ not modelled 5.2 24 PDB header:oxidoreductase Chain: A: PDB Molecule:putative thioredoxin-like protein; PDBTitle: crystal structure of thioredoxin 2 from yersinia pestis 64 d2q3nb2 not modelled 5.2 15 Fold:beta-Trefoil Superfamily:Ricin B-like lectins Family:Ricin B-like 65 d3bu3a1 not modelled 5.2 28 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 66 d1f60b_ not modelled 5.2 25 Fold:Ferredoxin-like Superfamily:eEF-1beta-like Family:eEF-1beta-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0