Phyre 2 Results for P39401

Email	l.a.kelley@imperial.ac.uk
Description	P39401
Date	Thu Jan 5 12:00:36 GMT 2012
Unique Job ID	5feb9c95edd1fc64

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2w5tA_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:processed glycerol phosphate lipoteichoic acid
PDBTitle: structure-based mechanism of lipoteichoic acid synthesis by2 staphylococcus aureus ltas.

Confidence and coverage

Confidence:

100.0%

Coverage:

39%

301 residues ( 39% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S E L L S F A L F L A S V L I Y A W K A G R N T W W F A A T L T V L G L F V V L N I T L F A S D Y F T G D G I N D A V

Secondary structure

SS confidence

Disorder ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence L Y T L T N S L T G A G V S K Y I L P G I G I V L G L T A V F G A L G W I L R R R R H H P H H F G Y S L L A L L L A L G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence S V D A S P A F R Q I T E L V K S Q S R D G D P D F A A Y Y K E P S K T I P D P K L N L V Y I Y G E S L E R T Y F D N E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence A F P D L T P E L G A L K N E G L D F S H T Q Q L P G T D Y T I A G M V A S Q C G I P L F A P F E G N A S A S V S S F F

Secondary structure

SS confidence

Disorder
?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence P Q N I C L G D I L K N S G Y Q N Y F V Q G A N L R F A G K D V F L K S H G F D H L Y G S E E L K S V V A D P H Y R N D

Secondary structure

SS confidence

Disorder ? ?
?
? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence W G F Y D D T V L D E A W K K F E E L S R S G Q R F S L F T L T V D T H H P D G F I S R T C N R K K Y D F D G K P N Q S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence F S A V S C S Q E N I A T F I N K I K A S P W F K D T V I V V S S D H L A M N N T A W K Y L N K Q D R N N L F F V I R G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence D K P Q Q E T L A V K R N T M D N G A T V L D I L G G D N Y L G L G R S S L S G Q S M S E I F L N I K E K T L A W K P D

Secondary structure

SS confidence

Disorder
? ? ?
? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence I I R L W K F P K E M K E F T I D Q Q K N M I A F S G S H F R L P L L L R V S D K R V E P L P E S E Y S A P L R F Q L A

Secondary structure

SS confidence

Disorder
? ?
? ? ?
?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence D F A P R D N F V W V D R C Y K M A Q L W A P E L A L S T D W C V S Q G Q L G G Q Q I V Q H V D K T T W Q G K T A F K D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence T V I D M A R Y K G N V D T L K I V D N D I R Y K A D S F I F N V A G A P E E V K Q F S G I S R P E S W G R W S N A Q L

Secondary structure

SS confidence

Disorder ? ?
?
? ?
? ? ? ? ? ?
?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence G D E V K I E Y K H P L P K K F D L V I T A K A Y G N N A S R P I P V R V G N E E Q T L V L G N E V T T T T L H F D N P

Secondary structure

SS confidence

Disorder
?
?
?
?
? ?
? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . .

Sequence T D A D T L V I V P P E P V S T N E G N I L G H S P R K L G I G M V E I K V V E R E G

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2w5t chain A

Region: 152 - 462
Aligned: 301
Modelled: 311
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:processed glycerol phosphate lipoteichoic acid
PDBTitle: structure-based mechanism of lipoteichoic acid synthesis by2 staphylococcus aureus ltas.

Phyre2

PDB 2w8d chain B

Region: 152 - 462
Aligned: 299
Modelled: 309
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: B: PDB Molecule:processed glycerol phosphate lipoteichoic acid synthase 2;
PDBTitle: distinct and essential morphogenic functions for wall- and2 lipo-teichoic acids in bacillus subtilis

Phyre2

PDB 3lxq chain B

Region: 153 - 462
Aligned: 295
Modelled: 310
Confidence: 100.0%
Identity: 25%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein vp1736;
PDBTitle: the crystal structure of a protein in the alkaline2 phosphatase superfamily from vibrio parahaemolyticus to3 1.95a

Phyre2

PDB 1fsu chain A

Region: 159 - 458
Aligned: 295
Modelled: 292
Confidence: 100.0%
Identity: 15%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: Arylsulfatase

Phyre2

PDB 3ed4 chain A

Region: 161 - 458
Aligned: 295
Modelled: 296
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:arylsulfatase;
PDBTitle: crystal structure of putative arylsulfatase from escherichia coli

Phyre2

PDB 2qzu chain A

Region: 158 - 458
Aligned: 299
Modelled: 301
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:putative sulfatase yidj;
PDBTitle: crystal structure of the putative sulfatase yidj from bacteroides2 fragilis. northeast structural genomics consortium target bfr123

Phyre2

PDB 1auk chain A

Region: 160 - 458
Aligned: 290
Modelled: 299
Confidence: 100.0%
Identity: 16%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: Arylsulfatase

Phyre2

PDB 1hdh chain A

Region: 160 - 458
Aligned: 293
Modelled: 295
Confidence: 100.0%
Identity: 19%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: Arylsulfatase

Phyre2

PDB 2vqr chain A

Region: 161 - 458
Aligned: 291
Modelled: 298
Confidence: 100.0%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:putative sulfatase;
PDBTitle: crystal structure of a phosphonate monoester hydrolase2 from rhizobium leguminosarum: a new member of the3 alkaline phosphatase superfamily

Phyre2

PDB 3b5q chain B

Region: 160 - 458
Aligned: 286
Modelled: 292
Confidence: 100.0%
Identity: 17%
PDB header:hydrolase
Chain: B: PDB Molecule:putative sulfatase yidj;
PDBTitle: crystal structure of a putative sulfatase (np_810509.1)2 from bacteroides thetaiotaomicron vpi-5482 at 2.40 a3 resolution

Phyre2

PDB 1p49 chain A

Region: 158 - 459
Aligned: 293
Modelled: 302
Confidence: 100.0%
Identity: 17%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: Arylsulfatase

Phyre2

PDB 1o98 chain A domain 2

Region: 161 - 458
Aligned: 265
Modelled: 297
Confidence: 100.0%
Identity: 17%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain

Phyre2

PDB 2i09 chain A domain 1

Region: 159 - 458
Aligned: 264
Modelled: 286
Confidence: 99.9%
Identity: 14%
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Family: DeoB catalytic domain-like

Phyre2

PDB 2zkt chain B

Region: 161 - 452
Aligned: 264
Modelled: 269
Confidence: 99.9%
Identity: 17%
PDB header:isomerase
Chain: B: PDB Molecule:2,3-bisphosphoglycerate-independent phosphoglycerate
PDBTitle: structure of ph0037 protein from pyrococcus horikoshii

Phyre2

PDB 3m8y chain C

Region: 160 - 459
Aligned: 277
Modelled: 295
Confidence: 99.9%
Identity: 14%
PDB header:isomerase
Chain: C: PDB Molecule:phosphopentomutase;
PDBTitle: phosphopentomutase from bacillus cereus after glucose-1,6-bisphosphate2 activation

Phyre2

PDB 2gso chain B

Region: 161 - 458
Aligned: 261
Modelled: 273
Confidence: 99.8%
Identity: 19%
PDB header:hydrolase
Chain: B: PDB Molecule:phosphodiesterase-nucleotide pyrophosphatase;
PDBTitle: structure of xac nucleotide2 pyrophosphatase/phosphodiesterase in complex with vanadate

Phyre2

PDB 3q3q chain A

Region: 154 - 448
Aligned: 279
Modelled: 295
Confidence: 99.8%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:alkaline phosphatase;
PDBTitle: crystal structure of spap: an novel alkaline phosphatase from2 bacterium sphingomonas sp. strain bsar-1

Phyre2

PDB 2i09 chain A

Region: 159 - 458
Aligned: 270
Modelled: 275
Confidence: 99.8%
Identity: 18%
PDB header:isomerase
Chain: A: PDB Molecule:phosphopentomutase;
PDBTitle: crystal structure of putative phosphopentomutase from streptococcus2 mutans

Phyre2

PDB 2xr9 chain A

Region: 151 - 462
Aligned: 254
Modelled: 258
Confidence: 99.7%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2)

Phyre2

PDB 2xrg chain A

Region: 151 - 462
Aligned: 256
Modelled: 261
Confidence: 99.7%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2) in complex with the2 ha155 boronic acid inhibitor

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	E	L	L	S	F	A	L	F	L	A	S	V	L	I	Y	A	W	K	A	G	R	N	T	W	W	F	A	A	T	L	T	V	L	G	L	F	V	V	L	N	I	T	L	F	A	S	D	Y	F	T	G	D	G	I	N	D	A	V
Secondary structure
SS confidence
Disorder	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	L	Y	T	L	T	N	S	L	T	G	A	G	V	S	K	Y	I	L	P	G	I	G	I	V	L	G	L	T	A	V	F	G	A	L	G	W	I	L	R	R	R	R	H	H	P	H	H	F	G	Y	S	L	L	A	L	L	L	A	L	G
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?																										?	?		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	S	V	D	A	S	P	A	F	R	Q	I	T	E	L	V	K	S	Q	S	R	D	G	D	P	D	F	A	A	Y	Y	K	E	P	S	K	T	I	P	D	P	K	L	N	L	V	Y	I	Y	G	E	S	L	E	R	T	Y	F	D	N	E
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?																					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	A	F	P	D	L	T	P	E	L	G	A	L	K	N	E	G	L	D	F	S	H	T	Q	Q	L	P	G	T	D	Y	T	I	A	G	M	V	A	S	Q	C	G	I	P	L	F	A	P	F	E	G	N	A	S	A	S	V	S	S	F	F
Secondary structure
SS confidence
Disorder																												?			?								?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	P	Q	N	I	C	L	G	D	I	L	K	N	S	G	Y	Q	N	Y	F	V	Q	G	A	N	L	R	F	A	G	K	D	V	F	L	K	S	H	G	F	D	H	L	Y	G	S	E	E	L	K	S	V	V	A	D	P	H	Y	R	N	D
Secondary structure
SS confidence
Disorder	?	?																							?		?	?	?																				?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	W	G	F	Y	D	D	T	V	L	D	E	A	W	K	K	F	E	E	L	S	R	S	G	Q	R	F	S	L	F	T	L	T	V	D	T	H	H	P	D	G	F	I	S	R	T	C	N	R	K	K	Y	D	F	D	G	K	P	N	Q	S
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	F	S	A	V	S	C	S	Q	E	N	I	A	T	F	I	N	K	I	K	A	S	P	W	F	K	D	T	V	I	V	V	S	S	D	H	L	A	M	N	N	T	A	W	K	Y	L	N	K	Q	D	R	N	N	L	F	F	V	I	R	G
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	D	K	P	Q	Q	E	T	L	A	V	K	R	N	T	M	D	N	G	A	T	V	L	D	I	L	G	G	D	N	Y	L	G	L	G	R	S	S	L	S	G	Q	S	M	S	E	I	F	L	N	I	K	E	K	T	L	A	W	K	P	D
Secondary structure
SS confidence
Disorder		?	?	?																																																	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	I	I	R	L	W	K	F	P	K	E	M	K	E	F	T	I	D	Q	Q	K	N	M	I	A	F	S	G	S	H	F	R	L	P	L	L	L	R	V	S	D	K	R	V	E	P	L	P	E	S	E	Y	S	A	P	L	R	F	Q	L	A
Secondary structure
SS confidence
Disorder																				?	?							?	?	?													?					?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	D	F	A	P	R	D	N	F	V	W	V	D	R	C	Y	K	M	A	Q	L	W	A	P	E	L	A	L	S	T	D	W	C	V	S	Q	G	Q	L	G	G	Q	Q	I	V	Q	H	V	D	K	T	T	W	Q	G	K	T	A	F	K	D
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?									?											?	?						?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	T	V	I	D	M	A	R	Y	K	G	N	V	D	T	L	K	I	V	D	N	D	I	R	Y	K	A	D	S	F	I	F	N	V	A	G	A	P	E	E	V	K	Q	F	S	G	I	S	R	P	E	S	W	G	R	W	S	N	A	Q	L
Secondary structure
SS confidence
Disorder	?	?		?							?	?					?	?	?	?	?	?			?																					?	?		?										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	G	D	E	V	K	I	E	Y	K	H	P	L	P	K	K	F	D	L	V	I	T	A	K	A	Y	G	N	N	A	S	R	P	I	P	V	R	V	G	N	E	E	Q	T	L	V	L	G	N	E	V	T	T	T	T	L	H	F	D	N	P
Secondary structure
SS confidence
Disorder																								?			?		?							?									?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.
Sequence	T	D	A	D	T	L	V	I	V	P	P	E	P	V	S	T	N	E	G	N	I	L	G	H	S	P	R	K	L	G	I	G	M	V	E	I	K	V	V	E	R	E	G
Secondary structure
SS confidence
Disorder			?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																?	?	?	?
Disorder confidence