Email l.a.kelley@imperial.ac.uk Description P09348 Date Thu Jan 5 11:02:13 GMT 2012 Unique Job ID 49ab608070e27ce3

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1byga_ 59.4 32 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 2 d2hepa1 57.4 21 Fold:Long alpha-hairpin Superfamily:YnzC-like Family:YznC-like 3 c2hepA_ 57.4 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the upf0291 protein ynzc from2 bacillus subtilis. northeast structural genomics target3 sr384. 4 c2w1iB_ 56.0 14 PDB header:transferase Chain: B: PDB Molecule:jak2; PDBTitle: structure determination of aurora kinase in complex with2 inhibitor 5 d1u46a_ 55.3 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 6 d1vjya_ 49.1 6 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 7 d1iasa_ 48.7 6 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 8 d1p4oa_ 46.9 27 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 9 c2jvdA_ 46.6 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the folded n-terminal fragment of2 upf0291 protein ynzc from bacillus subtilis. northeast3 structural genomics target sr384-1-46 10 c3zzwA_ 46.5 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2; PDBTitle: crystal structure of the kinase domain of ror2 11 c2bujA_ 45.2 15 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 16; PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine 12 c1ciiA_ 43.8 12 PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia 13 c3cc6A_ 41.7 25 PDB header:transferase Chain: A: PDB Molecule:protein tyrosine kinase 2 beta; PDBTitle: crystal structure of kinase domain of protein tyrosine kinase 2 beta2 (ptk2b) 14 c1k9aB_ 41.5 22 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 15 c3cblA_ 41.5 15 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 16 c3bhpA_ 38.7 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: crystal structure of upf0291 protein ynzc from bacillus2 subtilis at resolution 2.0 a. northeast structural3 genomics consortium target sr384 17 c2xbaA_ 38.0 15 PDB header:transferase Chain: A: PDB Molecule:alk tyrosine kinase receptor; PDBTitle: structure of human anaplastic lymphoma kinase in complex2 with pha-e429 18 c3c1xA_ 37.3 27 PDB header:transferase Chain: A: PDB Molecule:hepatocyte growth factor receptor; PDBTitle: crystal structure of the tyrosine kinase domain of the2 hepatocyte growth factor receptor c-met in complex with a3 pyrrolotriazine based inhibitor 19 c2c0iA_ 36.9 18 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 20 c3lvpD_ 36.8 23 PDB header:transferase Chain: D: PDB Molecule:insulin-like growth factor 1 receptor; PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor 21 c3d4qA_ not modelled 36.6 18 PDB header:transferase Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase; PDBTitle: pyrazole-based inhibitors of b-raf kinase 22 c3lxnA_ not modelled 34.6 23 PDB header:transferase Chain: A: PDB Molecule:non-receptor tyrosine-protein kinase tyk2; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6 23 c2yhvA_ not modelled 34.4 16 PDB header:transferase Chain: A: PDB Molecule:alk tyrosine kinase receptor; PDBTitle: structure of l1196m mutant anaplastic lymphoma kinase 24 c3lxkA_ not modelled 33.9 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6 25 c2qofA_ not modelled 33.2 17 PDB header:transferase Chain: A: PDB Molecule:ephrin receptor; PDBTitle: human epha3 kinase and juxtamembrane region, y596f mutant 26 c3mtfB_ not modelled 31.8 7 PDB header:transferase Chain: B: PDB Molecule:activin receptor type-1; PDBTitle: crystal structure of the acvr1 kinase in complex with a 2-2 aminopyridine inhibitor 27 c2j0kB_ not modelled 30.8 26 PDB header:transferase Chain: B: PDB Molecule:focal adhesion kinase 1; PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains. 28 c2qluA_ not modelled 30.0 16 PDB header:transferase Chain: A: PDB Molecule:activin receptor type iib; PDBTitle: crystal structure of activin receptor type ii kinase domain2 from human 29 c3fupB_ not modelled 29.4 30 PDB header:transferase Chain: B: PDB Molecule:tyrosine-protein kinase jak2; PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes 30 c3s95A_ not modelled 29.0 26 PDB header:transferase/antibiotic Chain: A: PDB Molecule:lim domain kinase 1; PDBTitle: crystal structure of the human limk1 kinase domain in complex with2 staurosporine 31 c3kmuA_ not modelled 28.8 13 PDB header:cell adhesion Chain: A: PDB Molecule:integrin-linked kinase; PDBTitle: crystal structure of the ilk/alpha-parvin core complex (apo) 32 c2oidA_ not modelled 27.9 10 PDB header:transferase Chain: A: PDB Molecule:interleukin-1 receptor-associated kinase 4; PDBTitle: crystal structure of irak4 kinase domain complexed with2 amppnp 33 c3mdyC_ not modelled 27.2 6 PDB header:transferase/isomerase Chain: C: PDB Molecule:bone morphogenetic protein receptor type-1b; PDBTitle: crystal structure of the cytoplasmic domain of the bone morphogenetic2 protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn-3 193189 34 c3sxrA_ not modelled 26.8 13 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: crystal structure of bmx non-receptor tyrosine kinase complex with2 dasatinib 35 c3eygA_ not modelled 26.6 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase; PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes 36 d1mp8a_ not modelled 25.9 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 37 c3g2fB_ not modelled 25.9 8 PDB header:transferase Chain: B: PDB Molecule:bone morphogenetic protein receptor type-2; PDBTitle: crystal structure of the kinase domain of bone morphogenetic protein2 receptor type ii (bmpr2) at 2.35 a resolution 38 c2qkwB_ not modelled 25.4 23 PDB header:transferase Chain: B: PDB Molecule:protein kinase; PDBTitle: structural basis for activation of plant immunity by2 bacterial effector protein avrpto 39 c3ll6B_ not modelled 25.2 15 PDB header:transferase Chain: B: PDB Molecule:cyclin g-associated kinase; PDBTitle: crystal structure of the human cyclin g associated kinase (gak) 40 d1r0pa_ not modelled 24.5 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 41 c2h8hA_ not modelled 24.3 16 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 42 c2ozoA_ not modelled 23.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 43 d1uwha_ not modelled 23.8 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 44 d3bu3a1 not modelled 23.7 21 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 45 d1opja_ not modelled 23.3 26 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 46 c1yvjA_ not modelled 23.2 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: crystal structure of the jak3 kinase domain in complex with2 a staurosporine analogue 47 d1jpaa_ not modelled 21.8 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 48 d1sm2a_ not modelled 20.2 13 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 49 c2pvfA_ not modelled 19.3 16 PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of tyrosine phosphorylated activated fgf2 receptor 2 (fgfr2) kinase domain in complex with atp3 analog and substrate peptide 50 d1u59a_ not modelled 19.2 28 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 51 d1mqba_ not modelled 19.1 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 52 c1y57A_ not modelled 18.8 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 53 c2kbrA_ not modelled 18.7 11 PDB header:structural protein/cell adhesion Chain: A: PDB Molecule:harmonin; PDBTitle: solution structure of harmonin n terminal domain in complex2 with a internal peptide of cadherin23 54 c3dtcA_ not modelled 17.7 17 PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 9; PDBTitle: crystal structure of mixed-lineage kinase mlk1 complexed2 with compound 16 55 c2y4iB_ not modelled 17.4 28 PDB header:transferase Chain: B: PDB Molecule:kinase suppressor of ras 2; PDBTitle: ksr2-mek1 heterodimer 56 c3qupA_ not modelled 17.3 17 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:tyrosine-protein kinase receptor tyro3; PDBTitle: inhibitor bound structure of the kinase domain of the murine receptor2 tyrosine kinase tyro3 (sky) 57 d1fgka_ not modelled 16.9 33 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 58 c3db8A_ not modelled 16.8 31 PDB header:transferase Chain: A: PDB Molecule:polo-like kinase 1; PDBTitle: crystal structure of an activated (thr->asp) polo-like2 kinase 1 (plk1) catalytic domain in complex with compound3 041 59 d2psqa1 not modelled 16.8 23 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 60 c2psqA_ not modelled 16.8 23 PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain 61 c3mogA_ not modelled 16.4 12 PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxybutyryl-coa dehydrogenase; PDBTitle: crystal structure of 3-hydroxybutyryl-coa dehydrogenase from2 escherichia coli k12 substr. mg1655 62 c2wqmA_ not modelled 16.2 7 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase nek7; PDBTitle: structure of apo human nek7 63 c3h9rA_ not modelled 16.1 7 PDB header:isomerase/protein kinase Chain: A: PDB Molecule:activin receptor type-1; PDBTitle: crystal structure of the kinase domain of type i activin receptor2 (acvr1) in complex with fkbp12 and dorsomorphin 64 d1fmka3 not modelled 15.8 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 65 d1qpca_ not modelled 15.7 21 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 66 d1cm8a_ not modelled 15.7 24 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 67 c2qobA_ not modelled 15.3 12 PDB header:transferase Chain: A: PDB Molecule:ephrin receptor; PDBTitle: human epha3 kinase domain, base structure 68 c3brbB_ not modelled 14.5 17 PDB header:transferase Chain: B: PDB Molecule:proto-oncogene tyrosine-protein kinase mer; PDBTitle: crystal structure of catalytic domain of the proto-oncogene tyrosine-2 protein kinase mer in complex with adp 69 c1ua2A_ not modelled 14.5 11 PDB header:cell cycle, transferase Chain: A: PDB Molecule:cell division protein kinase 7; PDBTitle: crystal structure of human cdk7 70 d1ua2a_ not modelled 14.5 11 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 71 d1csna_ not modelled 14.4 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 72 d1h8ba_ not modelled 14.4 20 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 73 c3o6xC_ not modelled 14.3 13 PDB header:ligase Chain: C: PDB Molecule:glutamine synthetase; PDBTitle: crystal structure of the type iii glutamine synthetase from2 bacteroides fragilis 74 c2dylA_ not modelled 14.2 17 PDB header:transferase Chain: A: PDB Molecule:dual specificity mitogen-activated protein PDBTitle: crystal structure of human mitogen-activated protein kinase2 kinase 7 activated mutant (s287d, t291d) 75 c3p86B_ not modelled 13.8 19 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase ctr1; PDBTitle: crystal structure of ctr1 kinase domain mutant d676n in complex with2 staurosporine 76 c1y6aA_ not modelled 13.7 30 PDB header:transferase Chain: A: PDB Molecule:vascular endothelial growth factor receptor 2; PDBTitle: crystal structure of vegfr2 in complex with a 2-anilino-5-aryl-oxazole2 inhibitor 77 d1xbba_ not modelled 13.5 29 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 78 d1ckia_ not modelled 13.3 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 79 c2evaA_ not modelled 12.7 15 PDB header:transferase/transferase activator Chain: A: PDB Molecule:tak1 kinase - tab1 chimera fusion protein; PDBTitle: structural basis for the interaction of tak1 kinase with2 its activating protein tab1 80 d1xwsa_ not modelled 12.5 32 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 81 d1lufa_ not modelled 12.1 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 82 c1lufA_ not modelled 12.1 20 PDB header:transferase Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk; PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation 83 d1fvra_ not modelled 11.9 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 84 c3jzdA_ not modelled 11.8 13 PDB header:oxidoreductase Chain: A: PDB Molecule:iron-containing alcohol dehydrogenase; PDBTitle: crystal structure of putative alcohol dehedrogenase (yp_298327.1) from2 ralstonia eutropha jmp134 at 2.10 a resolution 85 d1ctda_ not modelled 11.7 13 Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like 86 c2x58B_ not modelled 11.5 12 PDB header:oxidoreductase Chain: B: PDB Molecule:peroxisomal bifunctional enzyme; PDBTitle: the crystal structure of mfe1 liganded with coa 87 c3kexA_ not modelled 11.3 19 PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-3; PDBTitle: crystal structure of the catalytically inactive kinase2 domain of the human epidermal growth factor receptor 33 (her3) 88 d1kqfb2 not modelled 10.5 36 Fold:Single transmembrane helix Superfamily:Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor Family:Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor 89 c3hkoA_ not modelled 10.5 16 PDB header:transferase Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase with a kinase PDBTitle: crystal structure of a cdpk kinase domain from cryptosporidium parvum,2 cgd7_40 90 c2a1aB_ not modelled 10.4 19 PDB header:protein synthesis/transferase Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein PDBTitle: pkr kinase domain-eif2alpha complex 91 d1k2pa_ not modelled 10.4 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 92 c2c47D_ not modelled 10.1 21 PDB header:transferase Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform; PDBTitle: structure of casein kinase 1 gamma 2 93 c1zy5B_ not modelled 10.0 17 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase gcn2; PDBTitle: crystal structure of eif2alpha protein kinase gcn2: r794g2 hyperactivating mutant complexed with amppnp. 94 c3k6jA_ not modelled 9.9 5 PDB header:oxidoreductase Chain: A: PDB Molecule:protein f01g10.3, confirmed by transcript evidence; PDBTitle: crystal structure of the dehydrogenase part of multifuctional enzyme 12 from c.elegans 95 d1f0ya1 not modelled 9.7 15 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:HCDH C-domain-like 96 c1oplA_ not modelled 9.7 31 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 97 c2vy9A_ not modelled 9.6 18 PDB header:gene regulation Chain: A: PDB Molecule:anti-sigma-factor antagonist; PDBTitle: molecular architecture of the stressosome, a signal2 integration and transduction hub 98 c3famA_ not modelled 9.4 26 PDB header:transferase Chain: A: PDB Molecule:carbon catabolite-derepressing protein kinase; PDBTitle: crystal structure of the protein kinase domain of yeast amp-2 activated protein kinase snf1 99 d2f05a1 not modelled 9.3 16 Fold:PAH2 domain Superfamily:PAH2 domain Family:PAH2 domain