Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	Q	T	Q	L	L	S	A	L	A	L	S	V	G	L	T	L	S	A	S	F	Q	A	V	A	S	I	P	G	Q	V	A	D	Q	A	P	L	P	S	L	A	P	M	L	E	K	V	L	P	A	V	V	S	V	R	V	E	G
Secondary structure
SS confidence
Disorder		?	?	?	?														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	S	Q	G	Q	K	I	P	E	E	F	K	K	F	F	G	D	D	L	P	D	Q	P	A	Q	P	F	E	G	L	G	S	G	V	I	I	N	A	S	K	G	Y	V	L	T	N	N	H	V	I	N	Q	A	Q	K	I	S	I	Q
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	N	D	G	R	E	F	D	A	K	L	I	G	S	D	D	Q	S	D	I	A	L	L	Q	I	Q	N	P	S	K	L	T	Q	I	A	I	A	D	S	D	K	L	R	V	G	D	F	A	V	A	V	G	N	P	F	G	L	G	Q	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	T	S	G	I	V	S	A	L	G	R	S	G	L	N	L	E	G	L	E	N	F	I	Q	T	D	A	S	I	N	R	G	N	S	G	G	A	L	L	N	L	N	G	E	L	I	G	I	N	T	A	I	L	A	P	G	G	G	S	V
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?																																			?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	I	G	F	A	I	P	S	N	M	A	R	T	L	A	Q	Q	L	I	D	F	G	E	I	K	R	G	L	L	G	I	K	G	T	E	M	S	A	D	I	A	K	A	F	N	L	D	V	Q	R	G	A	F	V	S	E	V	L	P	G
Secondary structure
SS confidence
Disorder																																					?								?			?	?	?	?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	G	S	A	K	A	G	V	K	A	G	D	I	I	T	S	L	N	G	K	P	L	N	S	F	A	E	L	R	S	R	I	A	T	T	E	P	G	T	K	V	K	L	G	L	L	R	N	G	K	P	L	E	V	E	V	T	L	D	T
Secondary structure
SS confidence
Disorder		?					?																?	?	?										?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	T	S	S	S	A	S	A	E	M	I	T	P	A	L	E	G	A	T	L	S	D	G	Q	L	K	D	G	G	K	G	I	K	I	D	E	V	V	K	G	S	P	A	A	Q	A	G	L	Q	K	D	D	V	I	I	G	V	N	R	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Sequence		R	V	N	S	I	A	E	M	R	K	V	L	A	A	K	P	A	I	I	A	L	Q	I	V	R	G	N	E	S	I	Y	L	L	M	R
Secondary structure
SS confidence
Disorder																																				?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 4a8a chain I Region: 38 - 455 Aligned: 385 Modelled: 395 Confidence: 100.0% Identity: 98% PDB header:hydrolase/hydrolase Chain: I: PDB Molecule:periplasmic ph-dependent serine endoprotease degq; PDBTitle: asymmetric cryo-em reconstruction of e. coli degq 12-mer in complex2 with lysozyme Phyre2 PDB 3pv5 chain B Region: 40 - 454 Aligned: 377 Modelled: 392 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: B: PDB Molecule:degq; PDBTitle: structure of legionella fallonii degq (n189g/p190g variant) Phyre2 PDB 3stj chain C Region: 38 - 361 Aligned: 300 Modelled: 300 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: C: PDB Molecule:protease degq; PDBTitle: crystal structure of the protease + pdz1 domain of degq from2 escherichia coli Phyre2 PDB 1ky9 chain A Region: 38 - 357 Aligned: 311 Modelled: 315 Confidence: 100.0% Identity: 63% PDB header:hydrolase Chain: A: PDB Molecule:protease do; PDBTitle: crystal structure of degp (htra) Phyre2 PDB 3pv4 chain A Region: 39 - 360 Aligned: 280 Modelled: 301 Confidence: 100.0% Identity: 51% PDB header:hydrolase Chain: A: PDB Molecule:degq; PDBTitle: structure of legionella fallonii degq (delta-pdz2 variant) Phyre2 PDB 3gds chain A Region: 34 - 357 Aligned: 291 Modelled: 307 Confidence: 100.0% Identity: 42% PDB header:hydrolase/hydrolase activator Chain: A: PDB Molecule:protease degs; PDBTitle: crystal structure of degs h198p/d320a mutant modified by dfp in2 complex with dnrdgnvyyf peptide Phyre2 PDB 3qo6 chain B Region: 41 - 364 Aligned: 304 Modelled: 310 Confidence: 100.0% Identity: 37% PDB header:photosynthesis Chain: B: PDB Molecule:protease do-like 1, chloroplastic; PDBTitle: crystal structure analysis of the plant protease deg1 Phyre2 PDB 2z9i chain B Region: 38 - 352 Aligned: 267 Modelled: 269 Confidence: 100.0% Identity: 42% PDB header:hydrolase Chain: B: PDB Molecule:probable serine protease pepd; PDBTitle: crystal structure of rv0983 from mycobacterium tuberculosis-2 proteolytically active form Phyre2 PDB 1lcy chain A Region: 31 - 362 Aligned: 290 Modelled: 314 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:htra2 serine protease; PDBTitle: crystal structure of the mitochondrial serine protease htra2 Phyre2 PDB 2r3y chain C Region: 41 - 362 Aligned: 268 Modelled: 282 Confidence: 100.0% Identity: 46% PDB header:hydrolase/hydrolase activator Chain: C: PDB Molecule:protease degs; PDBTitle: crystal structure of the degs protease in complex with the2 ywf activating peptide Phyre2 PDB 1ky9 chain A domain 2 Region: 38 - 263 Aligned: 217 Modelled: 226 Confidence: 100.0% Identity: 64% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 1l1j chain A Region: 42 - 260 Aligned: 217 Modelled: 219 Confidence: 100.0% Identity: 42% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 2rce chain I Region: 33 - 260 Aligned: 195 Modelled: 205 Confidence: 100.0% Identity: 47% PDB header:hydrolase Chain: I: PDB Molecule:protease degs; PDBTitle: dfp modified degs delta pdz Phyre2 PDB 3sti chain C Region: 38 - 261 Aligned: 183 Modelled: 192 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: C: PDB Molecule:protease degq; PDBTitle: crystal structure of the protease domain of degq from escherichia coli Phyre2 PDB 2qf3 chain A domain 1 Region: 41 - 262 Aligned: 186 Modelled: 201 Confidence: 100.0% Identity: 52% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 3nzi chain A Region: 42 - 261 Aligned: 196 Modelled: 202 Confidence: 100.0% Identity: 43% PDB header:hydrolase/hydrolase substrate Chain: A: PDB Molecule:serine protease htra1; PDBTitle: substrate induced remodeling of the active site regulates htra12 activity Phyre2 PDB 2z9i chain A domain 2 Region: 41 - 263 Aligned: 192 Modelled: 194 Confidence: 100.0% Identity: 47% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 1lcy chain A domain 2 Region: 31 - 255 Aligned: 195 Modelled: 207 Confidence: 100.0% Identity: 39% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 3nwu chain B Region: 42 - 255 Aligned: 172 Modelled: 188 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: B: PDB Molecule:serine protease htra1; PDBTitle: substrate induced remodeling of the active site regulates htra12 activity Phyre2 PDB 3k6z chain A Region: 32 - 258 Aligned: 189 Modelled: 195 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:possible membrane-associated serine protease; PDBTitle: crystal structure of rv3671c protease, inactive form Phyre2 1 c4a8aI_ 2 c3pv5B_ 3 c3stjC_ 4 c1ky9A_ 5 c3pv4A_ 6 c3gdsA_ 7 c3qo6B_ 8 c2z9iB_ 9 c1lcyA_ 10 c2r3yC_ 11 d1ky9a2 12 d1l1ja_ 13 c2rceI_ 14 c3stiC_ 15 d2qf3a1 16 c3nziA_ 17 d2z9ia2 18 d1lcya2 19 c3nwuB_ 20 c3k6zA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478