Phyre 2 Results for P16916

Email	l.a.kelley@imperial.ac.uk
Description	P16916
Date	Wed Jan 25 15:20:39 GMT 2012
Unique Job ID	47ca9e2d682e1b9a

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2oy7A_

Top template information

PDB header:membrane protein
Chain: A: PDB Molecule:outer surface protein a;
PDBTitle: the crystal structure of ospa mutant

Confidence and coverage

Confidence:

95.2%

Coverage:

19%

256 residues ( 19% of your sequence) have been modelled with 95.2% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S G K P A A R Q G D M T Q Y G G S I V Q G S A G V R I G A P T G V A C S V C P G G V T S G H P V N P L L G A K V L P G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence E T D I A L P G P L P F I L S R T Y S S Y R T K T P A P V G S L G P G W K M P A D I R L Q L R D N T L I L S D N G G R S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence L Y F E H L F P G E D G Y S R S E S L W L V R G G V A K L D E G H R L A A L W Q A L P E E L R L S P H R Y L A T N S P Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence G P W W L L G W C E R V P E A D E V L P A P L P P Y R V L T G L V D R F G R T Q T F H R E A A G E F S G E I T G V T D G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence A W R H F R L V L T T Q A Q R A E E A R Q Q A I S G G T E P S A F P D T L P G Y T E Y G R D N G I R L S A V W L T H D P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E Y P E N L P A A P L V R Y G W T P R G E L A V V Y D R S G K Q V R S F T Y D D K Y R G R M V A H R H T G R P E I R Y R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y D S D G R V T E Q L N P A G L S Y T Y Q Y E K D R I T I T D S L D R R E V L H T Q G E A G L K R V V K K E H A D G S V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence T Q S Q F D A V G R L R A Q T D A A G R T T E Y S P D V V T G L I T R I T T P D G R A S A F Y Y N H H N Q L T S A T G P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence D G L E L R R E Y D E L G R L I Q E T A P D G D I T R Y R Y D N P H S D L P C A T E D A T G S R K T M T W S R Y G Q L L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S F T D C S G Y V T R Y D H D R F G Q M T A V H R E E G L S Q Y R A Y D S R G Q L I A V K D T Q G H E T R Y E Y N I A G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence D L T A V I A P D G S R N G T Q Y D A W G K A V R T T Q G G L T R S M E Y D A A G R V I R L T S E N G S H T T F R Y D V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence L D R L I Q E T G F D G R T Q R Y H H D L T G K L I R S E D E G L V T H W H Y D E A D R L T H R T V K G E T A E R W Q Y

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence D E R G W L T D I S H I S E G H R V A V H Y R Y D E K G R L T G E R Q T V H H P Q T E A L L W Q H E T R H A Y N A Q G L

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence A N R C I P D S L P A V E W L T Y G S G Y L A G M K L G D T P L V E Y T R D R L H R E T L R S F G R Y E L T T A Y T P A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence G Q L Q S Q H L N S L L S D R D Y T W N D N G E L I R I S S P R Q T R S Y S Y S T T G R L T G V H T T A A N L D I R I P

Secondary structure

SS confidence

Disorder
? ? ?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence Y A T D P A G N R L P D P E L H P D S T L S M W P D N R I A R D A H Y L Y R Y D R H G R L T E K T D L I P E G V I R T D

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence D E R T H R Y H Y D S Q H R L V H Y T R T Q Y E E P L V E S R Y L Y D P L G R R V A K R V W R R E R D L T G W M S L S R

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence K P Q V T W Y G W D G D R L T T I Q N D R T R I Q T I Y Q P G S F T P L I R V E T A T G E L A K T Q R R S L A D A L Q Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S G G E D G G S V V F P P V L V Q M L D R L E S E I L A D R V S E E S R R W L A S C G L T V E Q M Q N Q M D P V Y T P A

Secondary structure

SS confidence

Disorder
? ? ?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence R K I H L Y H C D H R G L P L A L I S K E G T T E W C A E Y D E W G N L L N E E N P H Q L Q Q L I R L P G Q Q Y D E E S

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence G L Y Y N R H R Y Y D P L Q G R Y I T Q D P I G L K G G W N F Y Q Y P L N P V T N T D P L G L E V F P R P F P L P I P W

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence P K S P A Q Q Q A D D N A A K A L T K W W N D T A S Q R I F D S L I L N N P G L A L D I T M I A S R G N V A D T G I T D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . .

Sequence R V N D I I N D R F W S D G K K P D R C D V L Q E L I D C G D I S A K D A K S T Q K A W N C R H S R Q S N D K K R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2oy7 chain A

Region: 432 - 724
Aligned: 256
Modelled: 266
Confidence: 95.2%
Identity: 16%
PDB header:membrane protein
Chain: A: PDB Molecule:outer surface protein a;
PDBTitle: the crystal structure of ospa mutant

Phyre2

PDB 1x3z chain A domain 1

Region: 1209 - 1242
Aligned: 32
Modelled: 34
Confidence: 52.2%
Identity: 19%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Transglutaminase core

Phyre2

PDB 1ulv chain A domain 3

Region: 1220 - 1303
Aligned: 77
Modelled: 84
Confidence: 45.0%
Identity: 19%
Fold: Immunoglobulin-like beta-sandwich
Superfamily: CBD9-like
Family: Glucodextranase, domain C

Phyre2

PDB 1n7d chain A

Region: 470 - 647
Aligned: 178
Modelled: 178
Confidence: 44.1%
Identity: 11%
PDB header:lipid transport
Chain: A: PDB Molecule:low-density lipoprotein receptor;
PDBTitle: extracellular domain of the ldl receptor

Phyre2

PDB 3esw chain A

Region: 1209 - 1242
Aligned: 32
Modelled: 34
Confidence: 31.3%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine
PDBTitle: complex of yeast pngase with glcnac2-iac.

Phyre2

PDB 3msw chain A

Region: 926 - 975
Aligned: 34
Modelled: 34
Confidence: 30.2%
Identity: 21%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a protein with unknown function (bf3112) from2 bacteroides fragilis nctc 9343 at 1.90 a resolution

Phyre2

PDB 1oey chain A

Region: 1345 - 1371
Aligned: 27
Modelled: 27
Confidence: 29.6%
Identity: 15%
Fold: beta-Grasp (ubiquitin-like)
Superfamily: CAD & PB1 domains
Family: PB1 domain

Phyre2

PDB 2f4m chain A domain 1

Region: 1209 - 1242
Aligned: 34
Modelled: 34
Confidence: 29.4%
Identity: 18%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Transglutaminase core

Phyre2

PDB 2ivz chain D

Region: 385 - 626
Aligned: 238
Modelled: 242
Confidence: 26.0%
Identity: 11%
PDB header:protein transport/hydrolase
Chain: D: PDB Molecule:protein tolb;
PDBTitle: structure of tolb in complex with a peptide of the colicin2 e9 t-domain

Phyre2

PDB 3rwx chain A

Region: 62 - 75
Aligned: 14
Modelled: 14
Confidence: 24.5%
Identity: 21%
PDB header:transport protein
Chain: A: PDB Molecule:hypothetical bacterial outer membrane protein;
PDBTitle: crystal structure of a hypothetical bacterial outer membrane protein2 (bf2706) from bacteroides fragilis nctc 9343 at 2.40 a resolution

Phyre2

PDB 2w8b chain B

Region: 347 - 599
Aligned: 243
Modelled: 253
Confidence: 23.3%
Identity: 12%
PDB header:protein transport/membrane protein
Chain: B: PDB Molecule:protein tolb;
PDBTitle: crystal structure of processed tolb in complex with pal

Phyre2

PDB 1mje chain A

Region: 1220 - 1258
Aligned: 39
Modelled: 39
Confidence: 23.3%
Identity: 28%
PDB header:gene regulation/antitumor protein/dna
Chain: A: PDB Molecule:breast cancer 2;
PDBTitle: structure of a brca2-dss1-ssdna complex

Phyre2

PDB 1miu chain A

Region: 1214 - 1258
Aligned: 45
Modelled: 45
Confidence: 23.0%
Identity: 27%
PDB header:gene regulation/antitumor protein
Chain: A: PDB Molecule:breast cancer type 2 susceptibility protein;
PDBTitle: structure of a brca2-dss1 complex

Phyre2

PDB 1khd chain A domain 2

Region: 1332 - 1366
Aligned: 34
Modelled: 35
Confidence: 22.8%
Identity: 35%
Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

Phyre2

PDB 2kij chain A

Region: 7 - 79
Aligned: 60
Modelled: 62
Confidence: 22.7%
Identity: 25%
PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the actuator domain of the copper-2 transporting atpase atp7a

Phyre2

PDB 2fz0 chain A

Region: 1318 - 1349
Aligned: 26
Modelled: 32
Confidence: 22.2%
Identity: 19%
PDB header:membrane protein
Chain: A: PDB Molecule:v-snare component of the vacuolar snare complex
PDBTitle: identification of yeast r-snare nyv1p as a novel longin2 domain protein

Phyre2

PDB 1j5q chain B

Region: 1189 - 1246
Aligned: 50
Modelled: 58
Confidence: 21.5%
Identity: 26%
PDB header:viral protein
Chain: B: PDB Molecule:major capsid protein;
PDBTitle: the structure and evolution of the major capsid protein of a large,2 lipid-containing, dna virus.

Phyre2

PDB 1qs0 chain B domain 1

Region: 1236 - 1266
Aligned: 31
Modelled: 31
Confidence: 18.8%
Identity: 32%
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Family: Branched-chain alpha-keto acid dehydrogenase Pyr module

Phyre2

PDB 1o5u chain A

Region: 96 - 137
Aligned: 39
Modelled: 42
Confidence: 18.5%
Identity: 8%
Fold: Double-stranded beta-helix
Superfamily: RmlC-like cupins
Family: Hypothetical protein TM1112

Phyre2

PDB 1bcg chain A

Region: 2 - 18
Aligned: 17
Modelled: 17
Confidence: 16.2%
Identity: 35%
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Scorpion toxin-like
Family: Long-chain scorpion toxins

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	G	K	P	A	A	R	Q	G	D	M	T	Q	Y	G	G	S	I	V	Q	G	S	A	G	V	R	I	G	A	P	T	G	V	A	C	S	V	C	P	G	G	V	T	S	G	H	P	V	N	P	L	L	G	A	K	V	L	P	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?		?	?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	E	T	D	I	A	L	P	G	P	L	P	F	I	L	S	R	T	Y	S	S	Y	R	T	K	T	P	A	P	V	G	S	L	G	P	G	W	K	M	P	A	D	I	R	L	Q	L	R	D	N	T	L	I	L	S	D	N	G	G	R	S
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	L	Y	F	E	H	L	F	P	G	E	D	G	Y	S	R	S	E	S	L	W	L	V	R	G	G	V	A	K	L	D	E	G	H	R	L	A	A	L	W	Q	A	L	P	E	E	L	R	L	S	P	H	R	Y	L	A	T	N	S	P	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	G	P	W	W	L	L	G	W	C	E	R	V	P	E	A	D	E	V	L	P	A	P	L	P	P	Y	R	V	L	T	G	L	V	D	R	F	G	R	T	Q	T	F	H	R	E	A	A	G	E	F	S	G	E	I	T	G	V	T	D	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	A	W	R	H	F	R	L	V	L	T	T	Q	A	Q	R	A	E	E	A	R	Q	Q	A	I	S	G	G	T	E	P	S	A	F	P	D	T	L	P	G	Y	T	E	Y	G	R	D	N	G	I	R	L	S	A	V	W	L	T	H	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	Y	P	E	N	L	P	A	A	P	L	V	R	Y	G	W	T	P	R	G	E	L	A	V	V	Y	D	R	S	G	K	Q	V	R	S	F	T	Y	D	D	K	Y	R	G	R	M	V	A	H	R	H	T	G	R	P	E	I	R	Y	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	D	S	D	G	R	V	T	E	Q	L	N	P	A	G	L	S	Y	T	Y	Q	Y	E	K	D	R	I	T	I	T	D	S	L	D	R	R	E	V	L	H	T	Q	G	E	A	G	L	K	R	V	V	K	K	E	H	A	D	G	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	T	Q	S	Q	F	D	A	V	G	R	L	R	A	Q	T	D	A	A	G	R	T	T	E	Y	S	P	D	V	V	T	G	L	I	T	R	I	T	T	P	D	G	R	A	S	A	F	Y	Y	N	H	H	N	Q	L	T	S	A	T	G	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	D	G	L	E	L	R	R	E	Y	D	E	L	G	R	L	I	Q	E	T	A	P	D	G	D	I	T	R	Y	R	Y	D	N	P	H	S	D	L	P	C	A	T	E	D	A	T	G	S	R	K	T	M	T	W	S	R	Y	G	Q	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	F	T	D	C	S	G	Y	V	T	R	Y	D	H	D	R	F	G	Q	M	T	A	V	H	R	E	E	G	L	S	Q	Y	R	A	Y	D	S	R	G	Q	L	I	A	V	K	D	T	Q	G	H	E	T	R	Y	E	Y	N	I	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	D	L	T	A	V	I	A	P	D	G	S	R	N	G	T	Q	Y	D	A	W	G	K	A	V	R	T	T	Q	G	G	L	T	R	S	M	E	Y	D	A	A	G	R	V	I	R	L	T	S	E	N	G	S	H	T	T	F	R	Y	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	L	D	R	L	I	Q	E	T	G	F	D	G	R	T	Q	R	Y	H	H	D	L	T	G	K	L	I	R	S	E	D	E	G	L	V	T	H	W	H	Y	D	E	A	D	R	L	T	H	R	T	V	K	G	E	T	A	E	R	W	Q	Y
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	D	E	R	G	W	L	T	D	I	S	H	I	S	E	G	H	R	V	A	V	H	Y	R	Y	D	E	K	G	R	L	T	G	E	R	Q	T	V	H	H	P	Q	T	E	A	L	L	W	Q	H	E	T	R	H	A	Y	N	A	Q	G	L
Secondary structure
SS confidence
Disorder												?																								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	A	N	R	C	I	P	D	S	L	P	A	V	E	W	L	T	Y	G	S	G	Y	L	A	G	M	K	L	G	D	T	P	L	V	E	Y	T	R	D	R	L	H	R	E	T	L	R	S	F	G	R	Y	E	L	T	T	A	Y	T	P	A
Secondary structure
SS confidence
Disorder							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	G	Q	L	Q	S	Q	H	L	N	S	L	L	S	D	R	D	Y	T	W	N	D	N	G	E	L	I	R	I	S	S	P	R	Q	T	R	S	Y	S	Y	S	T	T	G	R	L	T	G	V	H	T	T	A	A	N	L	D	I	R	I	P
Secondary structure
SS confidence
Disorder									?	?	?																				?																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	Y	A	T	D	P	A	G	N	R	L	P	D	P	E	L	H	P	D	S	T	L	S	M	W	P	D	N	R	I	A	R	D	A	H	Y	L	Y	R	Y	D	R	H	G	R	L	T	E	K	T	D	L	I	P	E	G	V	I	R	T	D
Secondary structure
SS confidence
Disorder																																																			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	D	E	R	T	H	R	Y	H	Y	D	S	Q	H	R	L	V	H	Y	T	R	T	Q	Y	E	E	P	L	V	E	S	R	Y	L	Y	D	P	L	G	R	R	V	A	K	R	V	W	R	R	E	R	D	L	T	G	W	M	S	L	S	R
Secondary structure
SS confidence
Disorder																					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	K	P	Q	V	T	W	Y	G	W	D	G	D	R	L	T	T	I	Q	N	D	R	T	R	I	Q	T	I	Y	Q	P	G	S	F	T	P	L	I	R	V	E	T	A	T	G	E	L	A	K	T	Q	R	R	S	L	A	D	A	L	Q	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	G	G	E	D	G	G	S	V	V	F	P	P	V	L	V	Q	M	L	D	R	L	E	S	E	I	L	A	D	R	V	S	E	E	S	R	R	W	L	A	S	C	G	L	T	V	E	Q	M	Q	N	Q	M	D	P	V	Y	T	P	A
Secondary structure
SS confidence
Disorder																																																			?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	R	K	I	H	L	Y	H	C	D	H	R	G	L	P	L	A	L	I	S	K	E	G	T	T	E	W	C	A	E	Y	D	E	W	G	N	L	L	N	E	E	N	P	H	Q	L	Q	Q	L	I	R	L	P	G	Q	Q	Y	D	E	E	S
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	G	L	Y	Y	N	R	H	R	Y	Y	D	P	L	Q	G	R	Y	I	T	Q	D	P	I	G	L	K	G	G	W	N	F	Y	Q	Y	P	L	N	P	V	T	N	T	D	P	L	G	L	E	V	F	P	R	P	F	P	L	P	I	P	W
Secondary structure
SS confidence
Disorder																									?																										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	P	K	S	P	A	Q	Q	Q	A	D	D	N	A	A	K	A	L	T	K	W	W	N	D	T	A	S	Q	R	I	F	D	S	L	I	L	N	N	P	G	L	A	L	D	I	T	M	I	A	S	R	G	N	V	A	D	T	G	I	T	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.
Sequence	R	V	N	D	I	I	N	D	R	F	W	S	D	G	K	K	P	D	R	C	D	V	L	Q	E	L	I	D	C	G	D	I	S	A	K	D	A	K	S	T	Q	K	A	W	N	C	R	H	S	R	Q	S	N	D	K	K	R
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?		?											?	?	?	?			?	?	?	?	?	?										?	?	?	?	?	?	?	?	?
Disorder confidence