Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	E	Q	R	V	V	V	M	G	L	G	N	L	L	W	A	D	E	G	F	G	V	R	V	A	E	R	L	Y	A	H	Y	H	W	P	E	Y	V	E	I	V	D	G	G	T	Q	G	L	N	L	L	G	Y	V	E	S	A	S	H
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	I	L	D	A	I	D	Y	G	L	E	P	G	T	L	R	T	Y	A	G	E	R	I	P	A	Y	L	S	A	K	K	M	S	L	H	Q	N	S	F	S	E	V	L	A	L	A	D	I	R	G	H	L	P	A	H	I	A	L	V
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	Q	P	A	M	L	D	D	Y	G	G	S	L	S	E	L	A	R	E	Q	L	P	A	A	E	Q	A	A	L	A	Q	L	A	A	W	G	I	V	P	Q	P	A	N	E	S	R	C	L	N	Y	D	C	L	S	M	E	N	Y	E
Secondary structure
SS confidence
Disorder																																					?			?	?	?	?	?	?	?	?	?	?	?	?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.
Sequence		G	V	R	L	R	Q	Y	R	M	T	Q	E	E	Q	G
Secondary structure
SS confidence
Disorder		?	?		?	?		?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1cfz chain A Region: 5 - 166 Aligned: 160 Modelled: 162 Confidence: 100.0% Identity: 38% Fold: Phosphorylase/hydrolase-like Superfamily: HybD-like Family: Hydrogenase maturating endopeptidase HybD Phyre2 PDB 2e85 chain B Region: 2 - 164 Aligned: 154 Modelled: 163 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:hydrogenase 3 maturation protease; PDBTitle: crystal structure of the hydrogenase 3 maturation protease Phyre2 PDB 3pu6 chain A Region: 5 - 156 Aligned: 131 Modelled: 147 Confidence: 100.0% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of an uncharacterized protein from wolinella2 succinogenes Phyre2 PDB 1c8b chain A Region: 2 - 75 Aligned: 74 Modelled: 74 Confidence: 96.9% Identity: 28% Fold: Phosphorylase/hydrolase-like Superfamily: HybD-like Family: Germination protease Phyre2 PDB 3fvw chain A Region: 4 - 155 Aligned: 148 Modelled: 152 Confidence: 90.1% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative nad(p)h-dependent fmn reductase; PDBTitle: crystal structure of the q8dwd8_strmu protein from2 streptococcus mutans. northeast structural genomics3 consortium target smr99. Phyre2 PDB 9ldt chain A domain 1 Region: 1 - 43 Aligned: 35 Modelled: 43 Confidence: 85.1% Identity: 23% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 PDB 2z2j chain A Region: 1 - 36 Aligned: 35 Modelled: 36 Confidence: 84.2% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: crystal structure of peptidyl-trna hydrolase from mycobacterium2 tuberculosis Phyre2 PDB 2cuk chain C Region: 1 - 63 Aligned: 53 Modelled: 60 Confidence: 83.4% Identity: 21% PDB header:oxidoreductase Chain: C: PDB Molecule:glycerate dehydrogenase/glyoxylate reductase; PDBTitle: crystal structure of tt0316 protein from thermus thermophilus hb8 Phyre2 PDB 1fmf chain A Region: 1 - 70 Aligned: 63 Modelled: 70 Confidence: 81.7% Identity: 11% Fold: Flavodoxin-like Superfamily: Cobalamin (vitamin B12)-binding domain Family: Cobalamin (vitamin B12)-binding domain Phyre2 PDB 2ph5 chain A Region: 2 - 68 Aligned: 60 Modelled: 67 Confidence: 80.2% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:homospermidine synthase; PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54 Phyre2 PDB 1a9x chain A domain 3 Region: 1 - 63 Aligned: 58 Modelled: 63 Confidence: 79.8% Identity: 16% Fold: PreATP-grasp domain Superfamily: PreATP-grasp domain Family: BC N-terminal domain-like Phyre2 PDB 2ldx chain A domain 1 Region: 1 - 43 Aligned: 35 Modelled: 43 Confidence: 78.9% Identity: 26% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 PDB 2vhy chain B Region: 1 - 78 Aligned: 68 Modelled: 75 Confidence: 78.2% Identity: 25% PDB header:oxidoreductase Chain: B: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of apo l-alanine dehydrogenase from2 mycobacterium tuberculosis Phyre2 PDB 1i0z chain A domain 1 Region: 1 - 43 Aligned: 35 Modelled: 43 Confidence: 77.9% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 PDB 1jf8 chain A Region: 3 - 48 Aligned: 39 Modelled: 46 Confidence: 77.2% Identity: 15% Fold: Phosphotyrosine protein phosphatases I-like Superfamily: Phosphotyrosine protein phosphatases I Family: Low-molecular-weight phosphotyrosine protein phosphatases Phyre2 PDB 5pnt chain A Region: 2 - 50 Aligned: 47 Modelled: 49 Confidence: 76.9% Identity: 19% Fold: Phosphotyrosine protein phosphatases I-like Superfamily: Phosphotyrosine protein phosphatases I Family: Low-molecular-weight phosphotyrosine protein phosphatases Phyre2 PDB 5ldh chain A domain 1 Region: 1 - 43 Aligned: 35 Modelled: 36 Confidence: 76.3% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 PDB 1dg9 chain A Region: 1 - 46 Aligned: 43 Modelled: 45 Confidence: 76.0% Identity: 19% Fold: Phosphotyrosine protein phosphatases I-like Superfamily: Phosphotyrosine protein phosphatases I Family: Low-molecular-weight phosphotyrosine protein phosphatases Phyre2 PDB 2c42 chain A domain 3 Region: 1 - 123 Aligned: 116 Modelled: 123 Confidence: 75.4% Identity: 15% Fold: TK C-terminal domain-like Superfamily: TK C-terminal domain-like Family: Pyruvate-ferredoxin oxidoreductase, PFOR, domain II Phyre2 PDB 1i10 chain A domain 1 Region: 1 - 43 Aligned: 35 Modelled: 43 Confidence: 74.1% Identity: 23% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 1 d1cfza_ 2 c2e85B_ 3 c3pu6A_ 4 d1c8ba_ 5 c3fvwA_ 6 d9ldta1 7 c2z2jA_ 8 c2cukC_ 9 d1fmfa_ 10 c2ph5A_ 11 d1a9xa3 12 d2ldxa1 13 c2vhyB_ 14 d1i0za1 15 d1jf8a_ 16 d5pnta_ 17 d5ldha1 18 d1dg9a_ 19 d2c42a3 20 d1i10a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1cfza_ 100.0 38 Fold:Phosphorylase/hydrolase-like Superfamily:HybD-like Family:Hydrogenase maturating endopeptidase HybD 2 c2e85B_ 100.0 21 PDB header:hydrolase Chain: B: PDB Molecule:hydrogenase 3 maturation protease; PDBTitle: crystal structure of the hydrogenase 3 maturation protease 3 c3pu6A_ 100.0 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of an uncharacterized protein from wolinella2 succinogenes 4 d1c8ba_ 96.9 28 Fold:Phosphorylase/hydrolase-like Superfamily:HybD-like Family:Germination protease 5 c3fvwA_ 90.1 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative nad(p)h-dependent fmn reductase; PDBTitle: crystal structure of the q8dwd8_strmu protein from2 streptococcus mutans. northeast structural genomics3 consortium target smr99. 6 d9ldta1 85.1 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 7 c2z2jA_ 84.2 34 PDB header:hydrolase Chain: A: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: crystal structure of peptidyl-trna hydrolase from mycobacterium2 tuberculosis 8 c2cukC_ 83.4 21 PDB header:oxidoreductase Chain: C: PDB Molecule:glycerate dehydrogenase/glyoxylate reductase; PDBTitle: crystal structure of tt0316 protein from thermus thermophilus hb8 9 d1fmfa_ 81.7 11 Fold:Flavodoxin-like Superfamily:Cobalamin (vitamin B12)-binding domain Family:Cobalamin (vitamin B12)-binding domain 10 c2ph5A_ 80.2 15 PDB header:transferase Chain: A: PDB Molecule:homospermidine synthase; PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54 11 d1a9xa3 79.8 16 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 12 d2ldxa1 78.9 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 13 c2vhyB_ 78.2 25 PDB header:oxidoreductase Chain: B: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of apo l-alanine dehydrogenase from2 mycobacterium tuberculosis 14 d1i0za1 77.9 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 15 d1jf8a_ 77.2 15 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 16 d5pnta_ 76.9 19 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 17 d5ldha1 76.3 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 18 d1dg9a_ 76.0 19 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 19 d2c42a3 75.4 15 Fold:TK C-terminal domain-like Superfamily:TK C-terminal domain-like Family:Pyruvate-ferredoxin oxidoreductase, PFOR, domain II 20 d1i10a1 74.1 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 21 c3d0oA_ not modelled 73.3 29 PDB header:oxidoreductase Chain: A: PDB Molecule:l-lactate dehydrogenase 1; PDBTitle: crystal structure of lactate dehydrogenase from2 staphylococcus aureus 22 d1pjca1 not modelled 72.5 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 23 d2gv8a1 not modelled 69.0 20 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 24 c3ggpA_ not modelled 68.6 26 PDB header:oxidoreductase Chain: A: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from a. aeolicus in2 complex with hydroxyphenyl propionate and nad+ 25 c4a26B_ not modelled 67.1 32 PDB header:oxidoreductase Chain: B: PDB Molecule:putative c-1-tetrahydrofolate synthase, cytoplasmic; PDBTitle: the crystal structure of leishmania major n5,n10-2 methylenetetrahydrofolate dehydrogenase/cyclohydrolase 26 c1wwkA_ not modelled 67.0 17 PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoglycerate dehydrogenase; PDBTitle: crystal structure of phosphoglycerate dehydrogenase from pyrococcus2 horikoshii ot3 27 c3b1fA_ not modelled 66.9 20 PDB header:oxidoreductase Chain: A: PDB Molecule:putative prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from streptococcus2 mutans 28 d2jfga1 not modelled 66.8 24 Fold:MurCD N-terminal domain Superfamily:MurCD N-terminal domain Family:MurCD N-terminal domain 29 c3gucB_ not modelled 66.0 20 PDB header:transferase Chain: B: PDB Molecule:ubiquitin-like modifier-activating enzyme 5; PDBTitle: human ubiquitin-activating enzyme 5 in complex with amppnp 30 d2dlda1 not modelled 64.8 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 31 c2gi4A_ not modelled 64.6 19 PDB header:hydrolase Chain: A: PDB Molecule:possible phosphotyrosine protein phosphatase; PDBTitle: solution structure of the low molecular weight protein2 tyrosine phosphatase from campylobacter jejuni. 32 d1gdha1 not modelled 64.5 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 33 c1d4fD_ not modelled 63.6 21 PDB header:hydrolase Chain: D: PDB Molecule:s-adenosylhomocysteine hydrolase; PDBTitle: crystal structure of recombinant rat-liver d244e mutant s-2 adenosylhomocysteine hydrolase 34 d1qp8a1 not modelled 62.6 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 35 c3dapB_ not modelled 62.0 29 PDB header:oxidoreductase Chain: B: PDB Molecule:diaminopimelic acid dehydrogenase; PDBTitle: c. glutamicum dap dehydrogenase in complex with nadp+ and2 the inhibitor 5s-isoxazoline 36 c2rirA_ not modelled 60.7 25 PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase, a chain; PDBTitle: crystal structure of dipicolinate synthase, a chain, from bacillus2 subtilis 37 c2yxbA_ not modelled 60.6 16 PDB header:isomerase Chain: A: PDB Molecule:coenzyme b12-dependent mutase; PDBTitle: crystal structure of the methylmalonyl-coa mutase alpha-subunit from2 aeropyrum pernix 38 d1wu2a3 not modelled 60.4 15 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MoeA central domain-like 39 d1np3a2 not modelled 60.0 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 40 c1gdhA_ not modelled 60.0 17 PDB header:oxidoreductase(choh (d)-nad(p)+ (a)) Chain: A: PDB Molecule:d-glycerate dehydrogenase; PDBTitle: crystal structure of a nad-dependent d-glycerate2 dehydrogenase at 2.4 angstroms resolution 41 c3tovB_ not modelled 59.3 18 PDB header:transferase Chain: B: PDB Molecule:glycosyl transferase family 9; PDBTitle: the crystal structure of the glycosyl transferase family 9 from2 veillonella parvula dsm 2008 42 c1ez4B_ not modelled 59.0 37 PDB header:oxidoreductase Chain: B: PDB Molecule:lactate dehydrogenase; PDBTitle: crystal structure of non-allosteric l-lactate dehydrogenase2 from lactobacillus pentosus at 2.3 angstrom resolution 43 d1ygya1 not modelled 58.8 32 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 44 c3gvxA_ not modelled 58.3 19 PDB header:oxidoreductase Chain: A: PDB Molecule:glycerate dehydrogenase related protein; PDBTitle: crystal structure of glycerate dehydrogenase related2 protein from thermoplasma acidophilum 45 d1hyha1 not modelled 57.7 30 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 46 d2ptha_ not modelled 57.4 20 Fold:Phosphorylase/hydrolase-like Superfamily:Peptidyl-tRNA hydrolase-like Family:Peptidyl-tRNA hydrolase-like 47 d1n1ea2 not modelled 56.1 28 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 48 c2g5cD_ not modelled 56.1 24 PDB header:oxidoreductase Chain: D: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from aquifex aeolicus 49 d1mx3a1 not modelled 56.1 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 50 c3vh1A_ not modelled 55.7 31 PDB header:metal binding protein Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of saccharomyces cerevisiae atg7 (1-595) 51 d1f0ya2 not modelled 55.3 33 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 52 c1m6vE_ not modelled 55.3 15 PDB header:ligase Chain: E: PDB Molecule:carbamoyl phosphate synthetase large chain; PDBTitle: crystal structure of the g359f (small subunit) point mutant of2 carbamoyl phosphate synthetase 53 c3d64A_ not modelled 55.2 27 PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from2 burkholderia pseudomallei 54 c3d1lB_ not modelled 55.2 28 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nadp oxidoreductase bf3122; PDBTitle: crystal structure of putative nadp oxidoreductase bf3122 from2 bacteroides fragilis 55 c3fi9B_ not modelled 55.0 17 PDB header:oxidoreductase Chain: B: PDB Molecule:malate dehydrogenase; PDBTitle: crystal structure of malate dehydrogenase from porphyromonas2 gingivalis 56 c3neaA_ not modelled 54.3 17 PDB header:hydrolase Chain: A: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: crystal structure of peptidyl-trna hydrolase from francisella2 tularensis 57 c3v2iA_ not modelled 54.3 20 PDB header:hydrolase Chain: A: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: structure of a peptidyl-trna hydrolase (pth) from burkholderia2 thailandensis 58 c2g76A_ not modelled 54.2 23 PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: crystal structure of human 3-phosphoglycerate dehydrogenase 59 c2dbqA_ not modelled 54.1 13 PDB header:oxidoreductase Chain: A: PDB Molecule:glyoxylate reductase; PDBTitle: crystal structure of glyoxylate reductase (ph0597) from pyrococcus2 horikoshii ot3, complexed with nadp (i41) 60 c1np3B_ not modelled 54.1 23 PDB header:oxidoreductase Chain: B: PDB Molecule:ketol-acid reductoisomerase; PDBTitle: crystal structure of class i acetohydroxy acid isomeroreductase from2 pseudomonas aeruginosa 61 c3d4oA_ not modelled 54.1 23 PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution 62 d1a9xa4 not modelled 53.8 14 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 63 d2ftsa3 not modelled 53.7 18 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MoeA central domain-like 64 c2fnzA_ not modelled 53.6 21 PDB header:oxidoreductase Chain: A: PDB Molecule:lactate dehydrogenase; PDBTitle: crystal structure of the lactate dehydrogenase from cryptosporidium2 parvum complexed with cofactor (b-nicotinamide adenine dinucleotide)3 and inhibitor (oxamic acid) 65 c3h9gA_ not modelled 53.4 24 PDB header:transferase/antibiotic Chain: A: PDB Molecule:mccb protein; PDBTitle: crystal structure of e. coli mccb + mcca-n7isoasn 66 d1f06a1 not modelled 52.2 35 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 67 d1e5qa1 not modelled 52.1 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 68 c3vh3A_ not modelled 51.7 17 PDB header:metal binding protein/protein transport Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of atg7ctd-atg8 complex 69 c2ldxA_ not modelled 51.7 26 PDB header:oxidoreductase(choh(d)-nad(a)) Chain: A: PDB Molecule:apo-lactate dehydrogenase; PDBTitle: characterization of the antigenic sites on the refined 3-2 angstroms resolution structure of mouse testicular lactate3 dehydrogenase c4 70 c3ktdC_ not modelled 51.4 26 PDB header:oxidoreductase Chain: C: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of a putative prephenate dehydrogenase (cgl0226)2 from corynebacterium glutamicum atcc 13032 at 2.60 a resolution 71 d1sc6a1 not modelled 50.6 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 72 c1vqwB_ not modelled 50.4 19 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein with similarity to flavin-containing PDBTitle: crystal structure of a protein with similarity to flavin-2 containing monooxygenases and to mammalian dimethylalanine3 monooxygenases 73 c3k96B_ not modelled 50.4 23 PDB header:oxidoreductase Chain: B: PDB Molecule:glycerol-3-phosphate dehydrogenase [nad(p)+]; PDBTitle: 2.1 angstrom resolution crystal structure of glycerol-3-phosphate2 dehydrogenase (gpsa) from coxiella burnetii 74 d1li4a1 not modelled 50.3 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 75 c2xdoC_ not modelled 50.1 24 PDB header:oxidoreductase Chain: C: PDB Molecule:tetx2 protein; PDBTitle: structure of the tetracycline degrading monooxygenase tetx2 from2 bacteroides thetaiotaomicron 76 d1ez4a1 not modelled 49.6 34 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 77 d1j4aa1 not modelled 49.4 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 78 c3gznB_ not modelled 49.3 27 PDB header:protein binding/ligase Chain: B: PDB Molecule:nedd8-activating enzyme e1 catalytic subunit; PDBTitle: structure of nedd8-activating enzyme in complex with nedd82 and mln4924 79 c3kboB_ not modelled 49.1 28 PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate/hydroxypyruvate reductase a; PDBTitle: 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from2 salmonella typhimurium in complex with nadp 80 c2eklA_ not modelled 48.9 15 PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: structure of st1218 protein from sulfolobus tokodaii 81 c3n58D_ not modelled 48.8 23 PDB header:hydrolase Chain: D: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from brucella2 melitensis in ternary complex with nad and adenosine, orthorhombic3 form 82 c2q1uA_ not modelled 48.7 16 PDB header:sugar binding protein Chain: A: PDB Molecule:putative nucleotide sugar epimerase/ dehydratase; PDBTitle: crystal structure of the bordetella bronchiseptica enzyme wbmf in2 complex with nad+ and udp 83 c2cwdA_ not modelled 48.1 20 PDB header:hydrolase Chain: A: PDB Molecule:low molecular weight phosphotyrosine protein phosphatase; PDBTitle: crystal structure of tt1001 protein from thermus thermophilus hb8 84 c3n7uD_ not modelled 47.5 17 PDB header:oxidoreductase Chain: D: PDB Molecule:formate dehydrogenase; PDBTitle: nad-dependent formate dehydrogenase from higher-plant arabidopsis2 thaliana in complex with nad and azide 85 d2g5ca2 not modelled 47.1 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 86 d1ryba_ not modelled 46.9 23 Fold:Phosphorylase/hydrolase-like Superfamily:Peptidyl-tRNA hydrolase-like Family:Peptidyl-tRNA hydrolase-like 87 d1dxya1 not modelled 46.7 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 88 c2uyyD_ not modelled 46.7 28 PDB header:cytokine Chain: D: PDB Molecule:n-pac protein; PDBTitle: structure of the cytokine-like nuclear factor n-pac 89 c2x2oA_ not modelled 46.6 27 PDB header:flavoprotein Chain: A: PDB Molecule:nrdi protein; PDBTitle: the flavoprotein nrdi from bacillus cereus with the2 initially oxidized fmn cofactor in an intermediate3 radiation reduced state 90 c1hyhA_ not modelled 46.3 31 PDB header:oxidoreductase (choh(d)-nad+(a)) Chain: A: PDB Molecule:l-2-hydroxyisocaproate dehydrogenase; PDBTitle: crystal structure of l-2-hydroxyisocaproate dehydrogenase from2 lactobacillus confusus at 2.2 angstroms resolution-an example of3 strong asymmetry between subunits 91 d1rlja_ not modelled 46.3 23 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Flavoprotein NrdI 92 c1j4aA_ not modelled 45.6 21 PDB header:oxidoreductase Chain: A: PDB Molecule:d-lactate dehydrogenase; PDBTitle: insights into domain closure, substrate specificity and2 catalysis of d-lactate dehydrogenase from lactobacillus3 bulgaricus 93 d1uz5a3 not modelled 45.3 16 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MoeA central domain-like 94 d2vapa1 not modelled 44.9 27 Fold:Tubulin nucleotide-binding domain-like Superfamily:Tubulin nucleotide-binding domain-like Family:Tubulin, GTPase domain 95 d1p8aa_ not modelled 44.6 27 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 96 d2qwxa1 not modelled 44.2 13 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Quinone reductase 97 d1llca1 not modelled 43.9 29 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 98 c3dzbA_ not modelled 43.4 25 PDB header:biosynthetic protein Chain: A: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from streptococcus2 thermophilus 99 d2hmva1 not modelled 43.1 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Potassium channel NAD-binding domain 100 d1leha1 not modelled 42.5 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 101 d1b0aa1 not modelled 42.4 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 102 d1t0ia_ not modelled 42.2 10 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:NADPH-dependent FMN reductase 103 d1uxja1 not modelled 41.8 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 104 d1a4ia1 not modelled 41.6 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 105 d1v8ba1 not modelled 41.6 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 106 d1hdoa_ not modelled 41.6 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 107 d2bkaa1 not modelled 41.0 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 108 d1d4aa_ not modelled 41.0 17 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Quinone reductase 109 c2g1uA_ not modelled 40.8 29 PDB header:transport protein Chain: A: PDB Molecule:hypothetical protein tm1088a; PDBTitle: crystal structure of a putative transport protein (tm1088a) from2 thermotoga maritima at 1.50 a resolution 110 c3gviB_ not modelled 40.8 18 PDB header:oxidoreductase Chain: B: PDB Molecule:malate dehydrogenase; PDBTitle: crystal structure of lactate/malate dehydrogenase from2 brucella melitensis in complex with adp 111 c2omeA_ not modelled 40.7 23 PDB header:oxidoreductase Chain: A: PDB Molecule:c-terminal-binding protein 2; PDBTitle: crystal structure of human ctbp2 dehydrogenase complexed with nad(h) 112 d1jl3a_ not modelled 40.5 13 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 113 c3nklA_ not modelled 40.1 26 PDB header:oxidoreductase/lyase Chain: A: PDB Molecule:udp-d-quinovosamine 4-dehydrogenase; PDBTitle: crystal structure of udp-d-quinovosamine 4-dehydrogenase from vibrio2 fischeri 114 c3lcmB_ not modelled 40.0 13 PDB header:oxidoreductase Chain: B: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of smu.1420 from streptococcus mutans ua159 115 c2gcgB_ not modelled 40.0 17 PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate reductase/hydroxypyruvate reductase; PDBTitle: ternary crystal structure of human glyoxylate2 reductase/hydroxypyruvate reductase 116 c3oetF_ not modelled 38.9 25 PDB header:oxidoreductase Chain: F: PDB Molecule:erythronate-4-phosphate dehydrogenase; PDBTitle: d-erythronate-4-phosphate dehydrogenase complexed with nad 117 c2j6iC_ not modelled 38.7 21 PDB header:oxidoreductase Chain: C: PDB Molecule:formate dehydrogenase; PDBTitle: candida boidinii formate dehydrogenase (fdh) c-terminal2 mutant 118 c3jviA_ not modelled 38.6 20 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase; PDBTitle: product state mimic crystal structure of protein tyrosine phosphatase2 from entamoeba histolytica 119 d1fcda1 not modelled 38.4 29 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 120 c1cjcA_ not modelled 38.3 26 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (adrenodoxin reductase); PDBTitle: structure of adrenodoxin reductase of mitochondrial p4502 systems

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0