Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	V	W	L	N	R	Y	P	A	D	V	P	T	E	I	N	P	D	R	Y	Q	S	L	V	D	M	F	E	Q	S	V	A	R	Y	A	D	Q	P	A	F	V	N	M	G	E	V	M	T	F	R	K	L	E	E	R	S	R	A
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	A	A	Y	L	Q	Q	G	L	G	L	K	K	G	D	R	V	A	L	M	M	P	N	L	L	Q	Y	P	V	A	L	F	G	I	L	R	A	G	M	I	V	V	N	V	N	P	L	Y	T	P	R	E	L	E	H	Q	L	N	D	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	S	A	I	V	I	V	S	N	F	A	H	T	L	E	K	V	V	D	K	T	A	V	Q	H	V	I	L	T	R	M	G	D	Q	L	S	T	A	K	G	T	V	V	N	F	V	V	K	Y	I	K	R	L	V	P	K	Y	H	L
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?			?				?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	D	A	I	S	F	R	S	A	L	H	N	G	Y	R	M	Q	Y	V	K	P	E	L	V	P	E	D	L	A	F	L	Q	Y	T	G	G	T	T	G	V	A	K	G	A	M	L	T	H	R	N	M	L	A	N	L	E	Q	V	N	A
Secondary structure
SS confidence
Disorder															?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	Y	G	P	L	L	H	P	G	K	E	L	V	V	T	A	L	P	L	Y	H	I	F	A	L	T	I	N	C	L	L	F	I	E	L	G	G	Q	N	L	L	I	T	N	P	R	D	I	P	G	L	V	K	E	L	A	K	Y	P	F
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	A	I	T	G	V	N	T	L	F	N	A	L	L	N	N	K	E	F	Q	Q	L	D	F	S	S	L	H	L	S	A	G	G	G	M	P	V	Q	Q	V	V	A	E	R	W	V	K	L	T	G	Q	Y	L	L	E	G	Y	G	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	C	A	P	L	V	S	V	N	P	Y	D	I	D	Y	H	S	G	S	I	G	L	P	V	P	S	T	E	A	K	L	V	D	D	D	D	N	E	V	P	P	G	Q	P	G	E	L	C	V	K	G	P	Q	V	M	L	G	Y	W	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		R	P	D	A	T	D	E	I	I	K	N	G	W	L	H	T	G	D	I	A	V	M	D	E	E	G	F	L	R	I	V	D	R	K	K	D	M	I	L	V	S	G	F	N	V	Y	P	N	E	I	E	D	V	V	M	Q	H	P	G	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Q	E	V	A	A	V	G	V	P	S	G	S	S	G	E	A	V	K	I	F	V	V	K	K	D	P	S	L	T	E	E	S	L	V	T	F	C	R	R	Q	L	T	G	Y	K	V	P	K	L	V	E	F	R	D	E	L	P	K	S	N
Secondary structure
SS confidence
Disorder																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.
Sequence		V	G	K	I	L	R	R	E	L	R	D	E	A	R	G	K	V	D	N	K	A
Secondary structure
SS confidence
Disorder																			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1pg4 chain A Region: 5 - 558 Aligned: 543 Modelled: 554 Confidence: 100.0% Identity: 21% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 1mdb chain A Region: 3 - 558 Aligned: 526 Modelled: 531 Confidence: 100.0% Identity: 24% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 1ry2 chain A Region: 5 - 556 Aligned: 533 Modelled: 534 Confidence: 100.0% Identity: 23% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 2vsq chain A Region: 11 - 560 Aligned: 503 Modelled: 511 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a2 nonribosomal peptide synthetase termination module Phyre2 PDB 3e7w chain A Region: 24 - 559 Aligned: 493 Modelled: 495 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: crystal structure of dlta: implications for the reaction2 mechanism of non-ribosomal peptide synthetase (nrps)3 adenylation domains Phyre2 PDB 3cw9 chain A domain 1 Region: 23 - 553 Aligned: 494 Modelled: 498 Confidence: 100.0% Identity: 26% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 3eyn chain B Region: 5 - 553 Aligned: 514 Modelled: 521 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: B: PDB Molecule:acyl-coenzyme a synthetase acsm2a; PDBTitle: crystal structure of human acyl-coa synthetase medium-chain2 family member 2a (l64p mutation) in a complex with coa Phyre2 PDB 3ni2 chain A Region: 2 - 552 Aligned: 517 Modelled: 518 Confidence: 100.0% Identity: 29% PDB header:ligase Chain: A: PDB Molecule:4-coumarate:coa ligase; PDBTitle: crystal structures and enzymatic mechanisms of a populus tomentosa 4-2 coumarate:coa ligase Phyre2 PDB 3etc chain B Region: 1 - 538 Aligned: 515 Modelled: 520 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: B: PDB Molecule:amp-binding protein; PDBTitle: 2.1 a structure of acyl-adenylate synthetase from methanosarcina2 acetivorans containing a link between lys256 and cys298 Phyre2 PDB 2d1t chain A Region: 14 - 557 Aligned: 523 Modelled: 527 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:luciferin 4-monooxygenase; PDBTitle: crystal structure of the thermostable japanese firefly2 luciferase red-color emission s286n mutant complexed with3 high-energy intermediate analogue Phyre2 PDB 1amu chain A Region: 2 - 552 Aligned: 494 Modelled: 507 Confidence: 100.0% Identity: 20% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 2v7b chain B Region: 24 - 551 Aligned: 484 Modelled: 492 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: B: PDB Molecule:benzoate-coenzyme a ligase; PDBTitle: crystal structures of a benzoate coa ligase from2 burkholderia xenovorans lb400 Phyre2 PDB 1amu chain B Region: 15 - 551 Aligned: 482 Modelled: 492 Confidence: 100.0% Identity: 20% PDB header:peptide synthetase Chain: B: PDB Molecule:gramicidin synthetase 1; PDBTitle: phenylalanine activating domain of gramicidin synthetase 12 in a complex with amp and phenylalanine Phyre2 PDB 3gqw chain B Region: 13 - 557 Aligned: 502 Modelled: 508 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: B: PDB Molecule:fatty acid amp ligase; PDBTitle: crystal structure of a fatty acid amp ligase from e. coli with an acyl2 adenylate product bound Phyre2 PDB 3dhv chain A Region: 25 - 555 Aligned: 484 Modelled: 492 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:d-alanine-poly(phosphoribitol) ligase; PDBTitle: crystal structure of dlta protein in complex with d-alanine2 adenylate Phyre2 PDB 1lci chain A Region: 14 - 552 Aligned: 505 Modelled: 517 Confidence: 100.0% Identity: 26% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 3kxw chain A Region: 21 - 559 Aligned: 500 Modelled: 501 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:saframycin mx1 synthetase b; PDBTitle: the crystal structure of fatty acid amp ligase from legionella2 pneumophila Phyre2 PDB 3tsy chain A Region: 9 - 557 Aligned: 521 Modelled: 521 Confidence: 100.0% Identity: 24% PDB header:ligase, transferase Chain: A: PDB Molecule:fusion protein 4-coumarate--coa ligase 1, resveratrol PDBTitle: 4-coumaroyl-coa ligase::stilbene synthase fusion protein Phyre2 PDB 3ite chain B Region: 24 - 550 Aligned: 480 Modelled: 491 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: B: PDB Molecule:sidn siderophore synthetase; PDBTitle: the third adenylation domain of the fungal sidn non-2 ribosomal peptide synthetase Phyre2 PDB 1v25 chain A Region: 15 - 525 Aligned: 469 Modelled: 483 Confidence: 100.0% Identity: 25% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 1 d1pg4a_ 2 d1mdba_ 3 d1ry2a_ 4 c2vsqA_ 5 c3e7wA_ 6 d3cw9a1 7 c3eynB_ 8 c3ni2A_ 9 c3etcB_ 10 c2d1tA_ 11 d1amua_ 12 c2v7bB_ 13 c1amuB_ 14 c3gqwB_ 15 c3dhvA_ 16 d1lcia_ 17 c3kxwA_ 18 c3tsyA_ 19 c3iteB_ 20 d1v25a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1pg4a_ 100.0 21 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 2 d1mdba_ 100.0 24 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 3 d1ry2a_ 100.0 23 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 4 c2vsqA_ 100.0 23 PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a2 nonribosomal peptide synthetase termination module 5 c3e7wA_ 100.0 19 PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: crystal structure of dlta: implications for the reaction2 mechanism of non-ribosomal peptide synthetase (nrps)3 adenylation domains 6 d3cw9a1 100.0 26 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 7 c3eynB_ 100.0 24 PDB header:ligase Chain: B: PDB Molecule:acyl-coenzyme a synthetase acsm2a; PDBTitle: crystal structure of human acyl-coa synthetase medium-chain2 family member 2a (l64p mutation) in a complex with coa 8 c3ni2A_ 100.0 29 PDB header:ligase Chain: A: PDB Molecule:4-coumarate:coa ligase; PDBTitle: crystal structures and enzymatic mechanisms of a populus tomentosa 4-2 coumarate:coa ligase 9 c3etcB_ 100.0 23 PDB header:ligase Chain: B: PDB Molecule:amp-binding protein; PDBTitle: 2.1 a structure of acyl-adenylate synthetase from methanosarcina2 acetivorans containing a link between lys256 and cys298 10 c2d1tA_ 100.0 27 PDB header:oxidoreductase Chain: A: PDB Molecule:luciferin 4-monooxygenase; PDBTitle: crystal structure of the thermostable japanese firefly2 luciferase red-color emission s286n mutant complexed with3 high-energy intermediate analogue 11 d1amua_ 100.0 20 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 12 c2v7bB_ 100.0 26 PDB header:ligase Chain: B: PDB Molecule:benzoate-coenzyme a ligase; PDBTitle: crystal structures of a benzoate coa ligase from2 burkholderia xenovorans lb400 13 c1amuB_ 100.0 20 PDB header:peptide synthetase Chain: B: PDB Molecule:gramicidin synthetase 1; PDBTitle: phenylalanine activating domain of gramicidin synthetase 12 in a complex with amp and phenylalanine 14 c3gqwB_ 100.0 22 PDB header:ligase Chain: B: PDB Molecule:fatty acid amp ligase; PDBTitle: crystal structure of a fatty acid amp ligase from e. coli with an acyl2 adenylate product bound 15 c3dhvA_ 100.0 19 PDB header:ligase Chain: A: PDB Molecule:d-alanine-poly(phosphoribitol) ligase; PDBTitle: crystal structure of dlta protein in complex with d-alanine2 adenylate 16 d1lcia_ 100.0 26 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 17 c3kxwA_ 100.0 22 PDB header:ligase Chain: A: PDB Molecule:saframycin mx1 synthetase b; PDBTitle: the crystal structure of fatty acid amp ligase from legionella2 pneumophila 18 c3tsyA_ 100.0 24 PDB header:ligase, transferase Chain: A: PDB Molecule:fusion protein 4-coumarate--coa ligase 1, resveratrol PDBTitle: 4-coumaroyl-coa ligase::stilbene synthase fusion protein 19 c3iteB_ 100.0 20 PDB header:ligase Chain: B: PDB Molecule:sidn siderophore synthetase; PDBTitle: the third adenylation domain of the fungal sidn non-2 ribosomal peptide synthetase 20 d1v25a_ 100.0 25 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 21 c3l8cA_ not modelled 100.0 20 PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: structure of probable d-alanine--poly(phosphoribitol) ligase2 subunit-1 from streptococcus pyogenes 22 c3iplB_ not modelled 100.0 24 PDB header:ligase Chain: B: PDB Molecule:2-succinylbenzoate--coa ligase; PDBTitle: crystal structure of o-succinylbenzoic acid-coa ligase from2 staphylococcus aureus subsp. aureus mu50 23 c3nyrA_ not modelled 100.0 26 PDB header:ligase Chain: A: PDB Molecule:malonyl-coa ligase; PDBTitle: malonyl-coa ligase ternary product complex with malonyl-coa and amp2 bound 24 c3g7sA_ not modelled 100.0 28 PDB header:ligase Chain: A: PDB Molecule:long-chain-fatty-acid--coa ligase (fadd-1); PDBTitle: crystal structure of a long-chain-fatty-acid-coa ligase2 (fadd1) from archaeoglobus fulgidus 25 c3o82B_ not modelled 100.0 20 PDB header:ligase Chain: B: PDB Molecule:peptide arylation enzyme; PDBTitle: structure of base n-terminal domain from acinetobacter baumannii bound2 to 5'-o-[n-(2,3-dihydroxybenzoyl)sulfamoyl] adenosine 26 c3o82A_ not modelled 100.0 20 PDB header:ligase Chain: A: PDB Molecule:peptide arylation enzyme; PDBTitle: structure of base n-terminal domain from acinetobacter baumannii bound2 to 5'-o-[n-(2,3-dihydroxybenzoyl)sulfamoyl] adenosine 27 c3ivrA_ not modelled 100.0 22 PDB header:ligase Chain: A: PDB Molecule:putative long-chain-fatty-acid coa ligase; PDBTitle: crystal structure of putative long-chain-fatty-acid coa ligase from2 rhodopseudomonas palustris cga009 28 c3e53A_ not modelled 100.0 25 PDB header:ligase Chain: A: PDB Molecule:fatty-acid-coa ligase fadd28; PDBTitle: crystal structure of n-terminal domain of a fatty acyl amp2 ligase faal28 from mycobacterium tuberculosis 29 c2y4oA_ not modelled 100.0 17 PDB header:ligase Chain: A: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of paak2 in complex with phenylacetyl adenylate 30 c3qovD_ not modelled 100.0 14 PDB header:ligase Chain: D: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of a hypothetical acyl-coa ligase (bt_0428) from2 bacteroides thetaiotaomicron vpi-5482 at 2.20 a resolution 31 c2y27B_ not modelled 100.0 15 PDB header:ligase Chain: B: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of paak1 in complex with atp from2 burkholderia cenocepacia 32 c3laxA_ not modelled 99.5 17 PDB header:ligase Chain: A: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: the crystal structure of a domain of phenylacetate-coenzyme2 a ligase from bacteroides vulgatus atcc 8482 33 c3hguB_ not modelled 99.4 15 PDB header:biosynthetic protein Chain: B: PDB Molecule:ehpf; PDBTitle: structure of phenazine antibiotic biosynthesis protein 34 d2ayia1 not modelled 86.2 20 Fold:Thermophilic metalloprotease-like Superfamily:Thermophilic metalloprotease-like Family:Thermophilic metalloprotease (M29) 35 d1f06a2 not modelled 53.2 31 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Dihydrodipicolinate reductase-like 36 d1pl8a2 not modelled 52.1 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 37 d1p0fa2 not modelled 50.6 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 38 d1d1ta2 not modelled 48.9 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 39 d1e3ia2 not modelled 47.5 5 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 40 d1zjca1 not modelled 44.7 18 Fold:Thermophilic metalloprotease-like Superfamily:Thermophilic metalloprotease-like Family:Thermophilic metalloprotease (M29) 41 d2jhfa2 not modelled 44.5 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 42 c2ywiA_ not modelled 42.9 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical conserved protein; PDBTitle: crystal structure of uncharacterized conserved protein from2 geobacillus kaustophilus 43 d1ykfa2 not modelled 39.4 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 44 d1e3ja2 not modelled 36.7 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 45 c1vs3B_ not modelled 34.6 13 PDB header:isomerase Chain: B: PDB Molecule:trna pseudouridine synthase a; PDBTitle: crystal structure of the trna pseudouridine synthase trua from thermus2 thermophilus hb8 46 d1piwa2 not modelled 33.3 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 47 d1u3wa2 not modelled 33.3 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 48 c3smaD_ not modelled 32.9 20 PDB header:transferase Chain: D: PDB Molecule:frbf; PDBTitle: a new n-acetyltransferase fold in the structure and mechanism of the2 phosphonate biosynthetic enzyme frbf 49 d1l9xa_ not modelled 32.9 24 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:Class I glutamine amidotransferases (GAT) 50 c1l9xA_ not modelled 32.9 24 PDB header:hydrolase Chain: A: PDB Molecule:gamma-glutamyl hydrolase; PDBTitle: structure of gamma-glutamyl hydrolase 51 d1cdoa2 not modelled 32.1 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 52 d2fzwa2 not modelled 31.0 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 53 c3nnkC_ not modelled 28.7 10 PDB header:transferase Chain: C: PDB Molecule:ureidoglycine-glyoxylate aminotransferase; PDBTitle: biochemical and structural characterization of a ureidoglycine2 aminotransferase in the klebsiella pneumoniae uric acid catabolic3 pathway 54 d1j7ja_ not modelled 27.7 7 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 55 d1i1ga2 not modelled 25.5 16 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Lrp/AsnC-like transcriptional regulator C-terminal domain 56 d1g9sa_ not modelled 24.9 9 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 57 c3ippA_ not modelled 23.4 8 PDB header:transferase Chain: A: PDB Molecule:putative thiosulfate sulfurtransferase ynje; PDBTitle: crystal structure of sulfur-free ynje 58 d1ja1a1 not modelled 23.1 31 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:NADPH-cytochrome p450 reductase FAD-binding domain-like 59 c1uarA_ not modelled 22.9 13 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: crystal structure of rhodanese from thermus thermophilus hb8 60 c3bcxA_ not modelled 22.4 29 PDB header:transferase Chain: A: PDB Molecule:cdp-6-deoxy-l-threo-d-glycero-4-hexulose-3- PDBTitle: e1 dehydrase 61 c3ewbX_ not modelled 22.0 9 PDB header:transferase Chain: X: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of n-terminal domain of putative 2-2 isopropylmalate synthase from listeria monocytogenes 62 c3islA_ not modelled 21.8 9 PDB header:transferase Chain: A: PDB Molecule:purine catabolism protein pucg; PDBTitle: crystal structure of ureidoglycine-glyoxylate aminotransferase (pucg)2 from bacillus subtilis 63 c1c4kA_ not modelled 21.5 17 PDB header:lyase Chain: A: PDB Molecule:protein (ornithine decarboxylase); PDBTitle: ornithine decarboxylase mutant (gly121tyr) 64 d1f20a1 not modelled 21.3 22 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:NADPH-cytochrome p450 reductase FAD-binding domain-like 65 d1z7wa1 not modelled 20.8 11 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 66 d2ch1a1 not modelled 20.6 12 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 67 c2jwlB_ not modelled 20.6 5 PDB header:membrane protein Chain: B: PDB Molecule:protein tolr; PDBTitle: solution structure of periplasmic domain of tolr from h.2 influenzae with saxs data 68 d2nyga1 not modelled 20.5 27 Fold:TTHA0583/YokD-like Superfamily:TTHA0583/YokD-like Family:Aminoglycoside 3-N-acetyltransferase-like 69 d1iz0a2 not modelled 20.4 12 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 70 c2cw6B_ not modelled 19.8 11 PDB header:lyase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial; PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria 71 d1llua2 not modelled 19.3 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 72 c3e4fB_ not modelled 18.2 27 PDB header:transferase Chain: B: PDB Molecule:aminoglycoside n3-acetyltransferase; PDBTitle: crystal structure of ba2930- a putative aminoglycoside n3-2 acetyltransferase from bacillus anthracis 73 c2pfuA_ not modelled 17.5 7 PDB header:transport protein Chain: A: PDB Molecule:biopolymer transport exbd protein; PDBTitle: nmr strcuture determination of the periplasmic domain of exbd from2 e.coli 74 c3eegB_ not modelled 17.3 15 PDB header:transferase Chain: B: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of a 2-isopropylmalate synthase from2 cytophaga hutchinsonii 75 c3hjtB_ not modelled 16.9 13 PDB header:cell adhesion, transport protein Chain: B: PDB Molecule:lmb; PDBTitle: structure of laminin binding protein (lmb) of streptococcus2 agalactiae a bifunctional protein with adhesin and metal3 transporting activity 76 c2zy3A_ not modelled 16.8 24 PDB header:lyase Chain: A: PDB Molecule:l-aspartate beta-decarboxylase; PDBTitle: dodecameric l-aspartate beta-decarboxylase 77 c1ydnA_ not modelled 16.6 12 PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of the hmg-coa lyase from brucella melitensis,2 northeast structural genomics target lr35. 78 d1kola2 not modelled 16.6 11 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 79 d1vj0a2 not modelled 16.1 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 80 d1s6ua_ not modelled 15.9 23 Fold:Ferredoxin-like Superfamily:HMA, heavy metal-associated domain Family:HMA, heavy metal-associated domain 81 d1jqba2 not modelled 15.6 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 82 c2vycA_ not modelled 15.3 25 PDB header:lyase Chain: A: PDB Molecule:biodegradative arginine decarboxylase; PDBTitle: crystal structure of acid induced arginine decarboxylase2 from e. coli 83 c2ofhX_ not modelled 15.3 21 PDB header:hydrolase, membrane protein Chain: X: PDB Molecule:zinc-transporting atpase; PDBTitle: solution structure of the n-terminal domain of the zinc(ii) atpase2 ziaa in its apo form 84 d1jvba2 not modelled 14.9 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 85 c1y3kA_ not modelled 14.8 21 PDB header:hydrolase Chain: A: PDB Molecule:copper-transporting atpase 1; PDBTitle: solution structure of the apo form of the fifth domain of2 menkes protein 86 d2vqca1 not modelled 14.7 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:F112-like 87 c2vqcA_ not modelled 14.7 17 PDB header:dna-binding protein Chain: A: PDB Molecule:hypothetical 13.2 kda protein; PDBTitle: structure of a dna binding winged-helix protein, f-112,2 from sulfolobus spindle-shaped virus 1. 88 d2okga1 not modelled 14.4 8 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:SorC sugar-binding domain-like 89 c2zbcH_ not modelled 14.1 20 PDB header:transcription Chain: H: PDB Molecule:83aa long hypothetical transcriptional regulator asnc; PDBTitle: crystal structure of sts042, a stand-alone ram module protein, from2 hyperthermophilic archaeon sulfolobus tokodaii strain7. 90 d1udxa3 not modelled 14.0 23 Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain 91 d1ddga1 not modelled 13.8 21 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:NADPH-cytochrome p450 reductase FAD-binding domain-like 92 d1pn0a3 not modelled 13.8 13 Fold:FAD-linked reductases, C-terminal domain Superfamily:FAD-linked reductases, C-terminal domain Family:PHBH-like 93 c2ps3A_ not modelled 13.6 13 PDB header:metal transport Chain: A: PDB Molecule:high-affinity zinc uptake system protein znua; PDBTitle: structure and metal binding properties of znua, a2 periplasmic zinc transporter from escherichia coli 94 d2cg4a2 not modelled 13.4 11 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Lrp/AsnC-like transcriptional regulator C-terminal domain 95 c3bleA_ not modelled 13.2 8 PDB header:transferase Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans; PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate 96 c2l66B_ not modelled 13.1 27 PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, abrb family; PDBTitle: the dna-recognition fold of sso7c4 suggests a new member of spovt-abrb2 superfamily from archaea. 97 c3olhA_ not modelled 13.0 8 PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: human 3-mercaptopyruvate sulfurtransferase 98 c2ga7A_ not modelled 12.8 22 PDB header:hydrolase Chain: A: PDB Molecule:copper-transporting atpase 1; PDBTitle: solution structure of the copper(i) form of the third metal-2 binding domain of atp7a protein (menkes disease protein) 99 c3g23A_ not modelled 12.5 14 PDB header:hydrolase Chain: A: PDB Molecule:ld-carboxypeptidase a; PDBTitle: crystal structure of a ld-carboxypeptidase a (saro_1426) from2 novosphingobium aromaticivorans dsm at 1.89 a resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0