Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	Y	I	K	S	I	T	Q	Q	K	L	S	F	L	L	A	I	Y	I	G	L	F	M	N	G	A	V	F	Y	R	R	F	G	S	Y	A	H	D	F	T	V	W	K	G	I	S	A	V	V	E	L	A	A	T	V	L	V	T	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	L	L	R	L	L	S	L	F	G	R	R	S	W	R	I	L	A	S	L	V	V	L	F	S	A	G	A	S	Y	Y	M	T	F	L	N	V	V	I	G	Y	G	I	I	A	S	V	M	T	T	D	I	D	L	S	K	E	V	V	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	N	F	I	L	W	L	I	A	V	S	A	L	P	L	I	L	I	W	N	N	R	C	R	Y	T	L	L	R	Q	L	R	T	P	G	Q	R	I	R	S	L	A	V	V	V	L	A	G	I	M	V	W	A	P	I	R	L	L	D	I
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?	?	?	?																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	Q	K	K	V	E	R	A	T	G	V	D	L	P	S	Y	G	G	V	V	A	N	S	Y	L	P	S	N	W	L	S	A	L	G	L	Y	A	W	A	R	V	D	E	S	S	D	N	N	S	L	L	N	P	A	K	K	F	T	Y	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?		?										?	?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	P	Q	N	V	D	D	T	Y	V	V	F	I	I	G	E	T	T	R	W	D	H	M	G	I	F	G	Y	E	R	N	T	T	P	K	L	A	Q	E	K	N	L	A	A	F	R	G	Y	S	C	D	T	A	T	K	L	S	L	R	C
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		M	F	V	R	Q	G	G	A	E	D	N	P	Q	R	T	L	K	E	Q	N	I	F	A	V	L	K	Q	L	G	F	S	S	D	L	Y	A	M	Q	S	E	M	W	F	Y	S	N	T	M	A	D	N	I	A	Y	R	E	Q	I	G	A
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																					?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	P	R	N	R	G	K	P	V	D	D	M	L	L	V	D	E	M	Q	Q	S	L	G	R	N	P	D	G	K	H	L	I	I	L	H	T	K	G	S	H	F	N	Y	T	Q	R	Y	P	R	S	F	A	Q	W	K	P	E	C	I	G
Secondary structure
SS confidence
Disorder		?			?																																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	D	S	G	C	T	K	A	Q	M	I	N	S	Y	D	N	S	V	T	Y	V	D	H	F	I	S	S	V	I	D	Q	V	R	D	K	K	A	I	V	F	Y	A	A	D	H	G	E	S	I	N	E	R	E	H	L	H	G	T	P	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																													?	?	?	?	?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		E	L	A	P	P	E	Q	F	R	V	P	M	M	V	W	M	S	D	K	Y	L	E	N	P	A	N	A	Q	A	F	A	Q	L	K	K	E	A	D	M	K	V	P	R	R	H	V	E	L	Y	D	T	I	M	G	C	L	G	Y	T	S
Secondary structure
SS confidence
Disorder		?	?																	?	?	?	?	?	?			?			?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.
Sequence		P	D	G	G	I	N	E	N	N	N	W	C	H	I	P	Q	A	K	E	A	A	A	N
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?		?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2w8d chain B Region: 219 - 563 Aligned: 319 Modelled: 329 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:processed glycerol phosphate lipoteichoic acid synthase 2; PDBTitle: distinct and essential morphogenic functions for wall- and2 lipo-teichoic acids in bacillus subtilis Phyre2 PDB 2w5t chain A Region: 220 - 563 Aligned: 318 Modelled: 328 Confidence: 100.0% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:processed glycerol phosphate lipoteichoic acid PDBTitle: structure-based mechanism of lipoteichoic acid synthesis by2 staphylococcus aureus ltas. Phyre2 PDB 3lxq chain B Region: 212 - 559 Aligned: 308 Modelled: 320 Confidence: 100.0% Identity: 15% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein vp1736; PDBTitle: the crystal structure of a protein in the alkaline2 phosphatase superfamily from vibrio parahaemolyticus to3 1.95a Phyre2 PDB 3ed4 chain A Region: 247 - 561 Aligned: 302 Modelled: 315 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:arylsulfatase; PDBTitle: crystal structure of putative arylsulfatase from escherichia coli Phyre2 PDB 1fsu chain A Region: 245 - 563 Aligned: 293 Modelled: 306 Confidence: 100.0% Identity: 13% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 2qzu chain A Region: 239 - 561 Aligned: 307 Modelled: 322 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative sulfatase yidj; PDBTitle: crystal structure of the putative sulfatase yidj from bacteroides2 fragilis. northeast structural genomics consortium target bfr123 Phyre2 PDB 1auk chain A Region: 246 - 561 Aligned: 284 Modelled: 286 Confidence: 100.0% Identity: 12% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 3b5q chain B Region: 246 - 563 Aligned: 301 Modelled: 307 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:putative sulfatase yidj; PDBTitle: crystal structure of a putative sulfatase (np_810509.1)2 from bacteroides thetaiotaomicron vpi-5482 at 2.40 a3 resolution Phyre2 PDB 1hdh chain A Region: 246 - 563 Aligned: 300 Modelled: 305 Confidence: 100.0% Identity: 19% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 2vqr chain A Region: 247 - 562 Aligned: 297 Modelled: 316 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative sulfatase; PDBTitle: crystal structure of a phosphonate monoester hydrolase2 from rhizobium leguminosarum: a new member of the3 alkaline phosphatase superfamily Phyre2 PDB 1p49 chain A Region: 244 - 561 Aligned: 288 Modelled: 302 Confidence: 100.0% Identity: 13% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 1o98 chain A domain 2 Region: 247 - 552 Aligned: 258 Modelled: 265 Confidence: 100.0% Identity: 14% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain Phyre2 PDB 2i09 chain A domain 1 Region: 245 - 547 Aligned: 237 Modelled: 236 Confidence: 100.0% Identity: 12% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: DeoB catalytic domain-like Phyre2 PDB 2zkt chain B Region: 247 - 537 Aligned: 277 Modelled: 291 Confidence: 99.9% Identity: 13% PDB header:isomerase Chain: B: PDB Molecule:2,3-bisphosphoglycerate-independent phosphoglycerate PDBTitle: structure of ph0037 protein from pyrococcus horikoshii Phyre2 PDB 3m8y chain C Region: 246 - 551 Aligned: 256 Modelled: 284 Confidence: 99.9% Identity: 15% PDB header:isomerase Chain: C: PDB Molecule:phosphopentomutase; PDBTitle: phosphopentomutase from bacillus cereus after glucose-1,6-bisphosphate2 activation Phyre2 PDB 2gso chain B Region: 247 - 556 Aligned: 256 Modelled: 273 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:phosphodiesterase-nucleotide pyrophosphatase; PDBTitle: structure of xac nucleotide2 pyrophosphatase/phosphodiesterase in complex with vanadate Phyre2 PDB 2i09 chain A Region: 316 - 547 Aligned: 171 Modelled: 181 Confidence: 99.9% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:phosphopentomutase; PDBTitle: crystal structure of putative phosphopentomutase from streptococcus2 mutans Phyre2 PDB 3q3q chain A Region: 238 - 545 Aligned: 269 Modelled: 269 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:alkaline phosphatase; PDBTitle: crystal structure of spap: an novel alkaline phosphatase from2 bacterium sphingomonas sp. strain bsar-1 Phyre2 PDB 3szz chain A Region: 241 - 533 Aligned: 254 Modelled: 254 Confidence: 99.8% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:phosphonoacetate hydrolase; PDBTitle: crystal structure of phosphonoacetate hydrolase from sinorhizobium2 meliloti 1021 in complex with acetate Phyre2 PDB 1ei6 chain A Region: 246 - 534 Aligned: 248 Modelled: 249 Confidence: 99.8% Identity: 15% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Phosphonoacetate hydrolase Phyre2 1 c2w8dB_ 2 c2w5tA_ 3 c3lxqB_ 4 c3ed4A_ 5 d1fsua_ 6 c2qzuA_ 7 d1auka_ 8 c3b5qB_ 9 d1hdha_ 10 c2vqrA_ 11 d1p49a_ 12 d1o98a2 13 d2i09a1 14 c2zktB_ 15 c3m8yC_ 16 c2gsoB_ 17 c2i09A_ 18 c3q3qA_ 19 c3szzA_ 20 d1ei6a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2w8dB_ 100.0 13 PDB header:transferase Chain: B: PDB Molecule:processed glycerol phosphate lipoteichoic acid synthase 2; PDBTitle: distinct and essential morphogenic functions for wall- and2 lipo-teichoic acids in bacillus subtilis 2 c2w5tA_ 100.0 12 PDB header:transferase Chain: A: PDB Molecule:processed glycerol phosphate lipoteichoic acid PDBTitle: structure-based mechanism of lipoteichoic acid synthesis by2 staphylococcus aureus ltas. 3 c3lxqB_ 100.0 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein vp1736; PDBTitle: the crystal structure of a protein in the alkaline2 phosphatase superfamily from vibrio parahaemolyticus to3 1.95a 4 c3ed4A_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:arylsulfatase; PDBTitle: crystal structure of putative arylsulfatase from escherichia coli 5 d1fsua_ 100.0 13 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Arylsulfatase 6 c2qzuA_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:putative sulfatase yidj; PDBTitle: crystal structure of the putative sulfatase yidj from bacteroides2 fragilis. northeast structural genomics consortium target bfr123 7 d1auka_ 100.0 12 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Arylsulfatase 8 c3b5qB_ 100.0 13 PDB header:hydrolase Chain: B: PDB Molecule:putative sulfatase yidj; PDBTitle: crystal structure of a putative sulfatase (np_810509.1)2 from bacteroides thetaiotaomicron vpi-5482 at 2.40 a3 resolution 9 d1hdha_ 100.0 19 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Arylsulfatase 10 c2vqrA_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:putative sulfatase; PDBTitle: crystal structure of a phosphonate monoester hydrolase2 from rhizobium leguminosarum: a new member of the3 alkaline phosphatase superfamily 11 d1p49a_ 100.0 13 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Arylsulfatase 12 d1o98a2 100.0 14 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain 13 d2i09a1 100.0 12 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:DeoB catalytic domain-like 14 c2zktB_ 99.9 13 PDB header:isomerase Chain: B: PDB Molecule:2,3-bisphosphoglycerate-independent phosphoglycerate PDBTitle: structure of ph0037 protein from pyrococcus horikoshii 15 c3m8yC_ 99.9 15 PDB header:isomerase Chain: C: PDB Molecule:phosphopentomutase; PDBTitle: phosphopentomutase from bacillus cereus after glucose-1,6-bisphosphate2 activation 16 c2gsoB_ 99.9 17 PDB header:hydrolase Chain: B: PDB Molecule:phosphodiesterase-nucleotide pyrophosphatase; PDBTitle: structure of xac nucleotide2 pyrophosphatase/phosphodiesterase in complex with vanadate 17 c2i09A_ 99.9 16 PDB header:isomerase Chain: A: PDB Molecule:phosphopentomutase; PDBTitle: crystal structure of putative phosphopentomutase from streptococcus2 mutans 18 c3q3qA_ 99.9 18 PDB header:hydrolase Chain: A: PDB Molecule:alkaline phosphatase; PDBTitle: crystal structure of spap: an novel alkaline phosphatase from2 bacterium sphingomonas sp. strain bsar-1 19 c3szzA_ 99.8 12 PDB header:hydrolase Chain: A: PDB Molecule:phosphonoacetate hydrolase; PDBTitle: crystal structure of phosphonoacetate hydrolase from sinorhizobium2 meliloti 1021 in complex with acetate 20 d1ei6a_ 99.8 15 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Phosphonoacetate hydrolase 21 c2xrgA_ not modelled 99.8 16 PDB header:hydrolase Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family PDBTitle: crystal structure of autotaxin (enpp2) in complex with the2 ha155 boronic acid inhibitor 22 c2xr9A_ not modelled 99.7 17 PDB header:hydrolase Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family PDBTitle: crystal structure of autotaxin (enpp2) 23 c1o98A_ not modelled 99.7 20 PDB header:isomerase Chain: A: PDB Molecule:2,3-bisphosphoglycerate-independent PDBTitle: 1.4a crystal structure of phosphoglycerate mutase from2 bacillus stearothermophilus complexed with3 2-phosphoglycerate 24 c3igzB_ not modelled 99.6 12 PDB header:isomerase Chain: B: PDB Molecule:cofactor-independent phosphoglycerate mutase; PDBTitle: crystal structures of leishmania mexicana phosphoglycerate2 mutase at low cobalt concentration 25 c2iucB_ not modelled 99.1 15 PDB header:hydrolase Chain: B: PDB Molecule:alkaline phosphatase; PDBTitle: structure of alkaline phosphatase from the antarctic2 bacterium tab5 26 c2d1gB_ not modelled 99.0 14 PDB header:hydrolase Chain: B: PDB Molecule:acid phosphatase; PDBTitle: structure of francisella tularensis acid phosphatase a (acpa) bound to2 orthovanadate 27 c1ew2A_ not modelled 98.8 12 PDB header:hydrolase Chain: A: PDB Molecule:phosphatase; PDBTitle: crystal structure of a human phosphatase 28 d1zeda1 not modelled 98.8 12 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase 29 d1k7ha_ not modelled 98.7 15 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase 30 d1y6va1 not modelled 98.7 15 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase 31 c2w0yB_ not modelled 98.5 15 PDB header:hydrolase Chain: B: PDB Molecule:alkaline phosphatase; PDBTitle: h.salinarum alkaline phosphatase 32 c2x98A_ not modelled 98.3 14 PDB header:hydrolase Chain: A: PDB Molecule:alkaline phosphatase; PDBTitle: h.salinarum alkaline phosphatase 33 c3e2dB_ not modelled 98.2 15 PDB header:hydrolase Chain: B: PDB Molecule:alkaline phosphatase; PDBTitle: the 1.4 a crystal structure of the large and cold-active2 vibrio sp. alkaline phosphatase 34 c3a52A_ not modelled 98.0 17 PDB header:hydrolase Chain: A: PDB Molecule:cold-active alkaline phosphatase; PDBTitle: crystal structure of cold-active alkailne phosphatase from2 psychrophile shewanella sp. 35 c3iddA_ not modelled 92.1 21 PDB header:isomerase Chain: A: PDB Molecule:2,3-bisphosphoglycerate-independent PDBTitle: cofactor-independent phosphoglycerate mutase from2 thermoplasma acidophilum dsm 1728 36 c3uoaB_ not modelled 70.1 8 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:mucosa-associated lymphoid tissue lymphoma translocation PDBTitle: crystal structure of the malt1 paracaspase (p21 form) 37 c3bijC_ not modelled 62.8 9 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein gsu0716; PDBTitle: crystal structure of protein gsu0716 from geobacter2 sulfurreducens. northeast structural genomics target gsr13 38 d1b4ub_ not modelled 60.0 17 Fold:Phosphorylase/hydrolase-like Superfamily:LigB-like Family:LigB-like 39 d1s1qa_ not modelled 59.0 21 Fold:UBC-like Superfamily:UBC-like Family:UEV domain 40 c2xmoB_ not modelled 45.9 19 PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 41 d1l5oa_ not modelled 24.0 46 Fold:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Superfamily:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Family:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) 42 d2hkja2 not modelled 19.2 14 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:DNA gyrase/MutL, second domain 43 c3t1iC_ not modelled 18.2 10 PDB header:hydrolase Chain: C: PDB Molecule:double-strand break repair protein mre11a; PDBTitle: crystal structure of human mre11: understanding tumorigenic mutations 44 c3dufD_ not modelled 18.0 13 PDB header:oxidoreductase/transferase Chain: D: PDB Molecule:pyruvate dehydrogenase e1 component subunit beta; PDBTitle: snapshots of catalysis in the e1 subunit of the pyruvate2 dehydrogenase multi-enzyme complex 45 c1ni4D_ not modelled 16.0 6 PDB header:oxidoreductase Chain: D: PDB Molecule:pyruvate dehydrogenase e1 component: beta PDBTitle: human pyruvate dehydrogenase 46 d1j33a_ not modelled 15.7 36 Fold:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Superfamily:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Family:Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) 47 d2h6fb1 not modelled 12.0 15 Fold:alpha/alpha toroid Superfamily:Terpenoid cyclases/Protein prenyltransferases Family:Protein prenyltransferases 48 c2bp7F_ not modelled 11.9 15 PDB header:oxidoreductase Chain: F: PDB Molecule:2-oxoisovalerate dehydrogenase beta subunit; PDBTitle: new crystal form of the pseudomonas putida branched-chain2 dehydrogenase (e1) 49 c3q7aB_ not modelled 11.1 15 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:farnesyltransferase beta subunit; PDBTitle: cryptococcus neoformans protein farnesyltransferase in complex with2 fpp and l-778,123 50 d2nxfa1 not modelled 11.1 7 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:ADPRibase-Mn-like 51 c2xokG_ not modelled 10.7 24 PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: refined structure of yeast f1c10 atpase complex to 3 a2 resolution 52 d1w85b1 not modelled 10.1 13 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:Branched-chain alpha-keto acid dehydrogenase Pyr module 53 c2pr7A_ not modelled 10.1 7 PDB header:hydrolase Chain: A: PDB Molecule:haloacid dehalogenase/epoxide hydrolase family; PDBTitle: crystal structure of uncharacterized protein (np_599989.1) from2 corynebacterium glutamicum atcc 13032 kitasato at 1.44 a resolution 54 d1pv7a_ not modelled 10.0 14 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:LacY-like proton/sugar symporter 55 d1oz9a_ not modelled 9.8 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 56 d1xo1a2 not modelled 9.6 8 Fold:PIN domain-like Superfamily:PIN domain-like Family:5' to 3' exonuclease catalytic domain 57 c3e37B_ not modelled 9.6 17 PDB header:transferase Chain: B: PDB Molecule:protein farnesyltransferase subunit beta; PDBTitle: protein farnesyltransferase complexed with bisubstrate2 ethylenediamine scaffold inhibitor 5 58 d1ma3a_ not modelled 9.2 14 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 59 d1a9xa3 not modelled 8.8 14 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 60 d2pw6a1 not modelled 8.7 9 Fold:Phosphorylase/hydrolase-like Superfamily:LigB-like Family:LigB-like 61 c2zbkB_ not modelled 8.7 14 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 62 c3mk7F_ not modelled 8.6 5 PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase 63 c1xaxA_ not modelled 8.4 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical upf0054 protein hi0004; PDBTitle: nmr structure of hi0004, a putative essential gene product2 from haemophilus influenzae 64 d1fs0g_ not modelled 8.4 16 Fold:Pyruvate kinase C-terminal domain-like Superfamily:ATP synthase (F1-ATPase), gamma subunit Family:ATP synthase (F1-ATPase), gamma subunit 65 d1tfra2 not modelled 8.3 17 Fold:PIN domain-like Superfamily:PIN domain-like Family:5' to 3' exonuclease catalytic domain 66 d2ozlb1 not modelled 8.0 6 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:Branched-chain alpha-keto acid dehydrogenase Pyr module 67 c1cn3F_ not modelled 7.9 18 PDB header:viral protein Chain: F: PDB Molecule:fragment of coat protein vp2; PDBTitle: interaction of polyomavirus internal protein vp2 with major2 capsid protein vp1 and implications for participation of3 vp2 in viral entry 68 d1xm5a_ not modelled 7.9 25 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 69 c1mx0D_ not modelled 7.8 14 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 70 d1usha2 not modelled 7.6 23 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain 71 c2fphX_ not modelled 7.5 13 PDB header:dna binding protein Chain: X: PDB Molecule:ylmh; PDBTitle: cell division protein ylmh from streptococcus pneumoniae 72 d1umdb1 not modelled 7.5 13 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:Branched-chain alpha-keto acid dehydrogenase Pyr module 73 c2w6jG_ not modelled 7.5 33 PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: low resolution structures of bovine mitochondrial f1-atpase2 during controlled dehydration: hydration state 5. 74 d2r7ka1 not modelled 7.4 19 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:PurP N-terminal domain-like 75 d1yc5a1 not modelled 7.3 11 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 76 d1nw9b_ not modelled 7.1 10 Fold:Caspase-like Superfamily:Caspase-like Family:Caspase catalytic domain 77 d1j3ma_ not modelled 7.1 6 Fold:TBP-like Superfamily:TT1751-like Family:TT1751-like 78 c3k35D_ not modelled 7.0 13 PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 79 c1um9D_ not modelled 7.0 13 PDB header:oxidoreductase Chain: D: PDB Molecule:2-oxo acid dehydrogenase beta subunit; PDBTitle: branched-chain 2-oxo acid dehydrogenase (e1) from thermus2 thermophilus hb8 in apo-form 80 d1tvia_ not modelled 6.9 25 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 81 c3ib7A_ not modelled 6.9 17 PDB header:hydrolase Chain: A: PDB Molecule:icc protein; PDBTitle: crystal structure of full length rv0805 82 d2p0va1 not modelled 6.8 32 Fold:alpha/alpha toroid Superfamily:Six-hairpin glycosidases Family:CPF0428-like 83 c2p0vA_ not modelled 6.8 32 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein bt3781; PDBTitle: crystal structure of bt3781 protein from bacteroides2 thetaiotaomicron, northeast structural genomics target3 btr58 84 d1v8za1 not modelled 6.7 8 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 85 c3auzA_ not modelled 6.5 18 PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11 with manganese 86 c3e4cB_ not modelled 6.4 8 PDB header:hydrolase Chain: B: PDB Molecule:caspase-1; PDBTitle: procaspase-1 zymogen domain crystal strucutre 87 d1uf3a_ not modelled 6.4 5 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:TT1561-like 88 d1q9ua_ not modelled 6.3 13 Fold:TBP-like Superfamily:TT1751-like Family:TT1751-like 89 c2fp3A_ not modelled 6.3 17 PDB header:hydrolysis/apoptosis Chain: A: PDB Molecule:caspase nc; PDBTitle: crystal structure of the drosophila initiator caspase dronc 90 d1szpb1 not modelled 6.2 14 Fold:SAM domain-like Superfamily:Rad51 N-terminal domain-like Family:DNA repair protein Rad51, N-terminal domain 91 d1iq0a1 not modelled 6.2 27 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 92 c3qfnA_ not modelled 6.1 14 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of streptococcal asymmetric ap4a hydrolase and2 phosphodiesterase spr1479/saph in complex with inorganic phosphate 93 c2hy1A_ not modelled 6.1 20 PDB header:hydrolase Chain: A: PDB Molecule:rv0805; PDBTitle: crystal structure of rv0805 94 d2hy1a1 not modelled 6.1 20 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:GpdQ-like 95 c2qe7G_ not modelled 6.1 22 PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma; PDBTitle: crystal structure of the f1-atpase from the thermoalkaliphilic2 bacterium bacillus sp. ta2.a1 96 d2b8ea1 not modelled 6.1 5 Fold:HAD-like Superfamily:HAD-like Family:Meta-cation ATPase, catalytic domain P 97 d2axti1 not modelled 6.1 17 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein I, PsbI Family:PsbI-like 98 d2jdig1 not modelled 6.0 33 Fold:Pyruvate kinase C-terminal domain-like Superfamily:ATP synthase (F1-ATPase), gamma subunit Family:ATP synthase (F1-ATPase), gamma subunit 99 c3qspB_ not modelled 5.9 32 PDB header:hydrolase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: analysis of a new family of widely distributed metal-independent alpha2 mannosidases provides unique insight into the processing of n-linked3 glycans, streptococcus pneumoniae sp_2144 non-productive substrate4 complex with alpha-1,6-mannobiose

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0