Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	Q	V	F	F	Q	E	T	E	F	L	N	S	V	I	D	Y	D	H	K	V	E	T	E	N	L	C	L	D	I	A	Y	G	T	D	K	N	F	L	F	G	C	G	I	S	I	A	S	I	L	K	Y	N	E	G	S	R	L	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	H	I	F	T	D	Y	F	G	D	D	D	R	K	Y	F	D	A	L	A	L	Q	Y	K	T	R	I	K	I	Y	L	I	N	G	D	R	L	R	S	L	P	S	T	K	N	W	T	H	A	I	Y	F	R	F	V	I	A	D	Y	F
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	N	K	A	P	K	V	L	Y	L	D	A	D	I	I	C	Q	G	T	I	E	P	L	I	N	F	S	F	P	D	D	K	V	A	M	V	V	T	E	G	Q	A	D	W	W	E	K	R	A	H	S	L	G	V	A	G	I	A	K	G
Secondary structure
SS confidence
Disorder																																																?	?									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	F	N	S	G	F	L	L	I	N	T	A	Q	W	A	A	Q	Q	V	S	A	R	A	I	A	M	L	N	E	P	E	I	I	K	K	I	T	H	P	D	Q	D	V	L	N	M	L	L	A	D	K	L	I	F	A	D	I	K	Y	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	Q	F	S	L	N	Y	Q	L	K	E	S	F	I	N	P	V	T	N	D	T	I	F	I	H	Y	I	G	P	T	K	P	W	H	D	W	A	W	D	Y	P	V	S	Q	A	F	M	E	A	K	N	A	S	P	W	K	N	T	A	L
Secondary structure
SS confidence
Disorder																																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.
Sequence		L	K	P	N	N	S	N	Q	L	R	Y	S	A	K	H	M	L	K	K	H	R	Y	L	K	G	F	S	N	Y	L	F	Y	F	I	E	K	I	K	H
Secondary structure
SS confidence
Disorder			?	?		?	?												?	?	?	?															?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ga8 chain A Region: 30 - 299 Aligned: 264 Modelled: 270 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:galactosyl transferase lgtc; PDBTitle: crystal structure of galacosyltransferase lgtc in complex2 with donor and acceptor sugar analogs. Phyre2 PDB 1ga8 chain A Region: 30 - 299 Aligned: 264 Modelled: 270 Confidence: 100.0% Identity: 20% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Galactosyltransferase LgtC Phyre2 PDB 3tzt chain B Region: 31 - 295 Aligned: 220 Modelled: 231 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:glycosyl transferase family 8; PDBTitle: the structure of a protein in glycosyl transferase family 8 from2 anaerococcus prevotii. Phyre2 PDB 1zcy chain A Region: 31 - 293 Aligned: 228 Modelled: 246 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:glycogenin-1; PDBTitle: apo form of a mutant of glycogenin in which asp159 is replaced by ser Phyre2 PDB 1ll2 chain A Region: 31 - 294 Aligned: 229 Modelled: 247 Confidence: 100.0% Identity: 17% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Glycogenin Phyre2 PDB 1zct chain B Region: 31 - 293 Aligned: 228 Modelled: 246 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:glycogenin-1; PDBTitle: structure of glycogenin truncated at residue 270 in a2 complex with udp Phyre2 PDB 1xhb chain A Region: 27 - 196 Aligned: 157 Modelled: 170 Confidence: 97.2% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 1; PDBTitle: the crystal structure of udp-galnac: polypeptide alpha-n-2 acetylgalactosaminyltransferase-t1 Phyre2 PDB 2ffu chain A Region: 27 - 196 Aligned: 153 Modelled: 170 Confidence: 96.2% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 2; PDBTitle: crystal structure of human ppgalnact-2 complexed with udp2 and ea2 Phyre2 PDB 2d7i chain A Region: 27 - 157 Aligned: 118 Modelled: 131 Confidence: 95.8% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 10; PDBTitle: crsytal structure of pp-galnac-t10 with udp, galnac and mn2+ Phyre2 PDB 1o7q chain A Region: 23 - 241 Aligned: 198 Modelled: 219 Confidence: 94.9% Identity: 13% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: alpha-1,3-galactosyltransferase-like Phyre2 PDB 2z86 chain D Region: 31 - 156 Aligned: 110 Modelled: 114 Confidence: 92.3% Identity: 12% PDB header:transferase Chain: D: PDB Molecule:chondroitin synthase; PDBTitle: crystal structure of chondroitin polymerase from2 escherichia coli strain k4 (k4cp) complexed with udp-glcua3 and udp Phyre2 PDB 1xhb chain A domain 2 Region: 24 - 157 Aligned: 122 Modelled: 124 Confidence: 88.4% Identity: 12% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain Phyre2 PDB 1qg8 chain A Region: 31 - 156 Aligned: 116 Modelled: 126 Confidence: 84.9% Identity: 15% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Spore coat polysaccharide biosynthesis protein SpsA Phyre2 PDB 2p73 chain A Region: 60 - 271 Aligned: 185 Modelled: 204 Confidence: 76.0% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:putative glycosyltransferase (mannosyltransferase) involved PDBTitle: crystal structure of a glycosyltransferase involved in the2 glycosylation of the major capsid of pbcv-1 Phyre2 PDB 1fo8 chain A Region: 31 - 145 Aligned: 112 Modelled: 115 Confidence: 75.6% Identity: 10% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: N-acetylglucosaminyltransferase I Phyre2 PDB 1lzi chain A Region: 23 - 241 Aligned: 187 Modelled: 197 Confidence: 74.1% Identity: 14% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: alpha-1,3-galactosyltransferase-like Phyre2 PDB 2py5 chain A domain 2 Region: 108 - 137 Aligned: 30 Modelled: 30 Confidence: 68.6% Identity: 17% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: DNA polymerase I Phyre2 PDB 1s4n chain A Region: 19 - 229 Aligned: 204 Modelled: 210 Confidence: 67.4% Identity: 12% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Glycolipid 2-alpha-mannosyltransferase Phyre2 PDB 2ex3 chain I Region: 108 - 139 Aligned: 32 Modelled: 32 Confidence: 55.2% Identity: 16% PDB header:transferase/replication Chain: I: PDB Molecule:dna polymerase; PDBTitle: bacteriophage phi29 dna polymerase bound to terminal protein Phyre2 PDB 1omz chain A Region: 31 - 155 Aligned: 106 Modelled: 125 Confidence: 54.8% Identity: 11% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Exostosin Phyre2 1 c1ga8A_ 2 d1ga8a_ 3 c3tztB_ 4 c1zcyA_ 5 d1ll2a_ 6 c1zctB_ 7 c1xhbA_ 8 c2ffuA_ 9 c2d7iA_ 10 d1o7qa_ 11 c2z86D_ 12 d1xhba2 13 d1qg8a_ 14 c2p73A_ 15 d1fo8a_ 16 d1lzia_ 17 d2py5a2 18 d1s4na_ 19 c2ex3I_ 20 d1omza_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1ga8A_ 100.0 20 PDB header:transferase Chain: A: PDB Molecule:galactosyl transferase lgtc; PDBTitle: crystal structure of galacosyltransferase lgtc in complex2 with donor and acceptor sugar analogs. 2 d1ga8a_ 100.0 20 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Galactosyltransferase LgtC 3 c3tztB_ 100.0 21 PDB header:transferase Chain: B: PDB Molecule:glycosyl transferase family 8; PDBTitle: the structure of a protein in glycosyl transferase family 8 from2 anaerococcus prevotii. 4 c1zcyA_ 100.0 18 PDB header:transferase Chain: A: PDB Molecule:glycogenin-1; PDBTitle: apo form of a mutant of glycogenin in which asp159 is replaced by ser 5 d1ll2a_ 100.0 17 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Glycogenin 6 c1zctB_ 100.0 18 PDB header:transferase Chain: B: PDB Molecule:glycogenin-1; PDBTitle: structure of glycogenin truncated at residue 270 in a2 complex with udp 7 c1xhbA_ 97.2 13 PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 1; PDBTitle: the crystal structure of udp-galnac: polypeptide alpha-n-2 acetylgalactosaminyltransferase-t1 8 c2ffuA_ 96.2 16 PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 2; PDBTitle: crystal structure of human ppgalnact-2 complexed with udp2 and ea2 9 c2d7iA_ 95.8 13 PDB header:transferase Chain: A: PDB Molecule:polypeptide n-acetylgalactosaminyltransferase 10; PDBTitle: crsytal structure of pp-galnac-t10 with udp, galnac and mn2+ 10 d1o7qa_ 94.9 13 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:alpha-1,3-galactosyltransferase-like 11 c2z86D_ 92.3 12 PDB header:transferase Chain: D: PDB Molecule:chondroitin synthase; PDBTitle: crystal structure of chondroitin polymerase from2 escherichia coli strain k4 (k4cp) complexed with udp-glcua3 and udp 12 d1xhba2 88.4 12 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain 13 d1qg8a_ 84.9 15 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Spore coat polysaccharide biosynthesis protein SpsA 14 c2p73A_ 76.0 12 PDB header:transferase Chain: A: PDB Molecule:putative glycosyltransferase (mannosyltransferase) involved PDBTitle: crystal structure of a glycosyltransferase involved in the2 glycosylation of the major capsid of pbcv-1 15 d1fo8a_ 75.6 10 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:N-acetylglucosaminyltransferase I 16 d1lzia_ 74.1 14 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:alpha-1,3-galactosyltransferase-like 17 d2py5a2 68.6 17 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:DNA polymerase I 18 d1s4na_ 67.4 12 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Glycolipid 2-alpha-mannosyltransferase 19 c2ex3I_ 55.2 16 PDB header:transferase/replication Chain: I: PDB Molecule:dna polymerase; PDBTitle: bacteriophage phi29 dna polymerase bound to terminal protein 20 d1omza_ 54.8 11 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:Exostosin 21 c2npiB_ not modelled 51.9 16 PDB header:transcription Chain: B: PDB Molecule:protein clp1; PDBTitle: clp1-atp-pcf11 complex 22 c3ckvA_ not modelled 49.0 15 PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a mycobacterial protein 23 d1w7pd2 not modelled 39.5 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Vacuolar sorting protein domain 24 c1omxB_ not modelled 30.6 9 PDB header:transferase Chain: B: PDB Molecule:alpha-1,4-n-acetylhexosaminyltransferase extl2; PDBTitle: crystal structure of mouse alpha-1,4-n-2 acetylhexosaminyltransferase (extl2) 25 c3ew8A_ not modelled 24.8 25 PDB header:hydrolase Chain: A: PDB Molecule:histone deacetylase 8; PDBTitle: crystal structure analysis of human hdac8 d101l variant 26 c3maxB_ not modelled 20.4 30 PDB header:hydrolase Chain: B: PDB Molecule:histone deacetylase 2; PDBTitle: crystal structure of human hdac2 complexed with an n-(2-aminophenyl)2 benzamide 27 c3bcvA_ not modelled 20.0 15 PDB header:transferase Chain: A: PDB Molecule:putative glycosyltransferase protein; PDBTitle: crystal structure of a putative glycosyltransferase from bacteroides2 fragilis 28 d1ibia1 not modelled 20.0 55 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 29 d1t64a_ not modelled 19.9 25 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Histone deacetylase, HDAC 30 d1v9fa_ not modelled 18.9 12 Fold:Pseudouridine synthase Superfamily:Pseudouridine synthase Family:Pseudouridine synthase RsuA/RluD 31 c1v9fA_ not modelled 18.9 12 PDB header:lyase Chain: A: PDB Molecule:ribosomal large subunit pseudouridine synthase d; PDBTitle: crystal structure of catalytic domain of pseudouridine2 synthase rlud from escherichia coli 32 c1qyuA_ not modelled 17.2 12 PDB header:lyase Chain: A: PDB Molecule:ribosomal large subunit pseudouridine synthase d; PDBTitle: structure of the catalytic domain of 23s rrna pseudouridine2 synthase rlud 33 c4a69A_ not modelled 16.0 40 PDB header:transcription Chain: A: PDB Molecule:histone deacetylase 3,; PDBTitle: structure of hdac3 bound to corepressor and inositol tetraphosphate 34 c3lmaC_ not modelled 14.7 11 PDB header:membrane protein Chain: C: PDB Molecule:stage v sporulation protein ad (spovad); PDBTitle: crystal structure of the stage v sporulation protein ad2 (spovad) from bacillus licheniformis. northeast structural3 genomics consortium target bir6. 35 c1hf2A_ not modelled 14.7 17 PDB header:cell division protein Chain: A: PDB Molecule:septum site-determining protein minc; PDBTitle: crystal structure of the bacterial cell-division inhibitor2 minc from t. maritima 36 c2w3zA_ not modelled 14.5 10 PDB header:hydrolase Chain: A: PDB Molecule:putative deacetylase; PDBTitle: structure of a streptococcus mutans ce4 esterase 37 d1c3pa_ not modelled 13.5 24 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Histone deacetylase, HDAC 38 c3lznA_ not modelled 12.9 20 PDB header:transport protein Chain: A: PDB Molecule:p19 protein; PDBTitle: crystal structure analysis of the apo p19 protein from campylobacter2 jejuni at 1.59 a at ph 9 39 d1hf2a1 not modelled 11.4 17 Fold:Single-stranded right-handed beta-helix Superfamily:Cell-division inhibitor MinC, C-terminal domain Family:Cell-division inhibitor MinC, C-terminal domain 40 d1u5tb1 not modelled 11.1 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Vacuolar sorting protein domain 41 c3menC_ not modelled 9.9 25 PDB header:hydrolase Chain: C: PDB Molecule:acetylpolyamine aminohydrolase; PDBTitle: crystal structure of acetylpolyamine aminohydrolase from burkholderia2 pseudomallei, iodide soak 42 c3kk1B_ not modelled 8.9 16 PDB header:transferase/dna Chain: B: PDB Molecule:reverse transcriptase p51 subunit; PDBTitle: hiv-1 reverse transcriptase-dna complex with nuceotide inhibitor gs-2 9148-diphosphate bound in nucleotide site 43 d2f5ka1 not modelled 8.6 53 Fold:SH3-like barrel Superfamily:Chromo domain-like Family:Chromo barrel domain 44 c3m9qA_ not modelled 8.0 20 PDB header:dna binding protein Chain: A: PDB Molecule:protein male-specific lethal-3; PDBTitle: drosophila msl3 chromodomain 45 d2g3ra2 not modelled 7.8 33 Fold:SH3-like barrel Superfamily:Tudor/PWWP/MBT Family:Tudor domain 46 d1vhib_ not modelled 7.7 12 Fold:Ferredoxin-like Superfamily:Viral DNA-binding domain Family:Viral DNA-binding domain 47 d2c71a1 not modelled 7.6 10 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:NodB-like polysaccharide deacetylase 48 c2o6dB_ not modelled 7.4 27 PDB header:membrane protein, protein binding Chain: B: PDB Molecule:34 kda membrane antigen; PDBTitle: structure of native rtp34 from treponema pallidum 49 c3m9pA_ not modelled 6.8 33 PDB header:dna binding protein/dna Chain: A: PDB Molecule:male-specific lethal 3 homolog; PDBTitle: human msl3 chromodomain bound to dna and h4k20me1 peptide 50 d1xbta1 not modelled 6.1 14 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Type II thymidine kinase 51 d1ny1a_ not modelled 6.0 13 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:NodB-like polysaccharide deacetylase 52 d1b3ta_ not modelled 6.0 12 Fold:Ferredoxin-like Superfamily:Viral DNA-binding domain Family:Viral DNA-binding domain 53 c2rffA_ not modelled 5.7 4 PDB header:transferase Chain: A: PDB Molecule:putative nucleotidyltransferase; PDBTitle: crystal structure of a putative nucleotidyltransferase2 (np_343093.1) from sulfolobus solfataricus at 1.40 a3 resolution 54 d2buda1 not modelled 5.1 27 Fold:SH3-like barrel Superfamily:Chromo domain-like Family:Chromo barrel domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0