Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	R	F	I	I	A	D	A	T	K	C	I	G	C	R	T	C	E	V	A	C	A	V	S	H	H	E	N	Q	D	C	A	A	L	S	P	D	E	F	I	S	R	I	R	V	I	K	D	H	C	W	T	T	A	V	A	C	H	Q
Secondary structure
SS confidence
Disorder		?	?	?																											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	E	D	A	P	C	A	N	V	C	P	V	D	A	I	S	R	E	H	G	H	I	F	V	E	Q	T	R	C	I	G	C	K	S	C	M	L	A	C	P	F	G	A	M	E	V	V	S	S	R	K	K	A	R	A	I	K	C	D	L
Secondary structure
SS confidence
Disorder																																																			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.
Sequence		C	W	H	R	E	T	G	P	A	C	V	E	A	C	P	T	K	A	L	Q	C	M	D	V	E	K	V	Q	R	H	R	L	R	Q	Q	P	V
Secondary structure
SS confidence
Disorder																																			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ti2 chain F Region: 1 - 155 Aligned: 153 Modelled: 155 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: F: PDB Molecule:pyrogallol hydroxytransferase small subunit; PDBTitle: crystal structure of pyrogallol-phloroglucinol2 transhydroxylase from pelobacter acidigallici Phyre2 PDB 1kqf chain B Region: 2 - 154 Aligned: 151 Modelled: 153 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: B: PDB Molecule:formate dehydrogenase, nitrate-inducible, iron-sulfur PDBTitle: formate dehydrogenase n from e. coli Phyre2 PDB 2vpy chain B Region: 1 - 154 Aligned: 153 Modelled: 154 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: B: PDB Molecule:nrfc protein; PDBTitle: polysulfide reductase with bound quinone inhibitor,2 pentachlorophenol (pcp) Phyre2 PDB 1kqf chain B domain 1 Region: 1 - 154 Aligned: 152 Modelled: 154 Confidence: 100.0% Identity: 27% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 1h0h chain B Region: 2 - 154 Aligned: 151 Modelled: 153 Confidence: 100.0% Identity: 22% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 2ivf chain B Region: 2 - 153 Aligned: 150 Modelled: 152 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: B: PDB Molecule:ethylbenzene dehydrogenase beta-subunit; PDBTitle: ethylbenzene dehydrogenase from aromatoleum aromaticum Phyre2 PDB 1vlf chain N domain 2 Region: 1 - 154 Aligned: 152 Modelled: 154 Confidence: 100.0% Identity: 22% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 1y5i chain B domain 1 Region: 1 - 155 Aligned: 153 Modelled: 155 Confidence: 100.0% Identity: 22% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 1blu chain A Region: 83 - 155 Aligned: 73 Modelled: 73 Confidence: 99.7% Identity: 23% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Short-chain ferredoxins Phyre2 PDB 1rgv chain A Region: 83 - 155 Aligned: 73 Modelled: 73 Confidence: 99.7% Identity: 21% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Short-chain ferredoxins Phyre2 PDB 2fgo chain A Region: 81 - 155 Aligned: 74 Modelled: 75 Confidence: 99.6% Identity: 22% PDB header:electron transport Chain: A: PDB Molecule:ferredoxin; PDBTitle: structure of the 2[4fe-4s] ferredoxin from pseudomonas2 aeruginosa Phyre2 PDB 2zvs chain B Region: 83 - 151 Aligned: 69 Modelled: 69 Confidence: 99.6% Identity: 23% PDB header:electron transport Chain: B: PDB Molecule:uncharacterized ferredoxin-like protein yfhl; PDBTitle: crystal structure of the 2[4fe-4s] ferredoxin from escherichia coli Phyre2 PDB 1xer chain A Region: 73 - 143 Aligned: 71 Modelled: 71 Confidence: 99.6% Identity: 21% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Archaeal ferredoxins Phyre2 PDB 2fug chain 9 domain 1 Region: 84 - 143 Aligned: 60 Modelled: 60 Confidence: 99.5% Identity: 32% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 2fug chain G Region: 84 - 143 Aligned: 60 Modelled: 60 Confidence: 99.5% Identity: 32% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase chain 9; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus Phyre2 PDB 1gth chain D Region: 72 - 144 Aligned: 68 Modelled: 73 Confidence: 99.5% Identity: 16% PDB header:oxidoreductase Chain: D: PDB Molecule:dihydropyrimidine dehydrogenase; PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil Phyre2 PDB 1hfe chain L domain 2 Region: 71 - 142 Aligned: 68 Modelled: 72 Confidence: 99.5% Identity: 19% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 2gmh chain A Region: 84 - 145 Aligned: 62 Modelled: 62 Confidence: 99.4% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:electron transfer flavoprotein-ubiquinone PDBTitle: structure of porcine electron transfer flavoprotein-2 ubiquinone oxidoreductase in complexed with ubiquinone Phyre2 PDB 3gyx chain J Region: 82 - 146 Aligned: 62 Modelled: 65 Confidence: 99.4% Identity: 27% PDB header:oxidoreductase Chain: J: PDB Molecule:adenylylsulfate reductase; PDBTitle: crystal structure of adenylylsulfate reductase from2 desulfovibrio gigas Phyre2 PDB 3c8y chain A domain 3 Region: 2 - 108 Aligned: 73 Modelled: 73 Confidence: 99.4% Identity: 25% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 1 c1ti2F_ 2 c1kqfB_ 3 c2vpyB_ 4 d1kqfb1 5 d1h0hb_ 6 c2ivfB_ 7 d1vlfn2 8 d1y5ib1 9 d1blua_ 10 d1rgva_ 11 c2fgoA_ 12 c2zvsB_ 13 d1xera_ 14 d2fug91 15 c2fugG_ 16 c1gthD_ 17 d1hfel2 18 c2gmhA_ 19 c3gyxJ_ 20 d3c8ya3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1ti2F_ 100.0 22 PDB header:oxidoreductase Chain: F: PDB Molecule:pyrogallol hydroxytransferase small subunit; PDBTitle: crystal structure of pyrogallol-phloroglucinol2 transhydroxylase from pelobacter acidigallici 2 c1kqfB_ 100.0 28 PDB header:oxidoreductase Chain: B: PDB Molecule:formate dehydrogenase, nitrate-inducible, iron-sulfur PDBTitle: formate dehydrogenase n from e. coli 3 c2vpyB_ 100.0 27 PDB header:oxidoreductase Chain: B: PDB Molecule:nrfc protein; PDBTitle: polysulfide reductase with bound quinone inhibitor,2 pentachlorophenol (pcp) 4 d1kqfb1 100.0 27 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 5 d1h0hb_ 100.0 22 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 6 c2ivfB_ 100.0 30 PDB header:oxidoreductase Chain: B: PDB Molecule:ethylbenzene dehydrogenase beta-subunit; PDBTitle: ethylbenzene dehydrogenase from aromatoleum aromaticum 7 d1vlfn2 100.0 22 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 8 d1y5ib1 100.0 22 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 9 d1blua_ 99.7 23 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 10 d1rgva_ 99.7 21 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 11 c2fgoA_ 99.6 22 PDB header:electron transport Chain: A: PDB Molecule:ferredoxin; PDBTitle: structure of the 2[4fe-4s] ferredoxin from pseudomonas2 aeruginosa 12 c2zvsB_ 99.6 23 PDB header:electron transport Chain: B: PDB Molecule:uncharacterized ferredoxin-like protein yfhl; PDBTitle: crystal structure of the 2[4fe-4s] ferredoxin from escherichia coli 13 d1xera_ 99.6 21 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Archaeal ferredoxins 14 d2fug91 99.5 32 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 15 c2fugG_ 99.5 32 PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase chain 9; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus 16 c1gthD_ 99.5 16 PDB header:oxidoreductase Chain: D: PDB Molecule:dihydropyrimidine dehydrogenase; PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil 17 d1hfel2 99.5 19 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 18 c2gmhA_ 99.4 16 PDB header:oxidoreductase Chain: A: PDB Molecule:electron transfer flavoprotein-ubiquinone PDBTitle: structure of porcine electron transfer flavoprotein-2 ubiquinone oxidoreductase in complexed with ubiquinone 19 c3gyxJ_ 99.4 27 PDB header:oxidoreductase Chain: J: PDB Molecule:adenylylsulfate reductase; PDBTitle: crystal structure of adenylylsulfate reductase from2 desulfovibrio gigas 20 d3c8ya3 99.4 25 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 21 d1jnrb_ not modelled 99.4 27 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 22 d1jb0c_ not modelled 99.4 30 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:7-Fe ferredoxin 23 d7fd1a_ not modelled 99.4 24 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:7-Fe ferredoxin 24 c1hfeL_ not modelled 99.4 18 PDB header:hydrogenase Chain: L: PDB Molecule:protein (fe-only hydrogenase (e.c.1.18.99.1) PDBTitle: 1.6 a resolution structure of the fe-only hydrogenase from2 desulfovibrio desulfuricans 25 c2c3yA_ not modelled 99.4 23 PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate-ferredoxin oxidoreductase; PDBTitle: crystal structure of the radical form of2 pyruvate:ferredoxin oxidoreductase from desulfovibrio3 africanus 26 d1gtea5 not modelled 99.4 16 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 27 d2fug34 not modelled 99.4 20 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 28 d2c42a5 not modelled 99.3 21 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 29 d2fdna_ not modelled 99.3 30 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 30 d1dura_ not modelled 99.3 28 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 31 d1iqza_ not modelled 99.3 19 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Single 4Fe-4S cluster ferredoxin 32 d1fcaa_ not modelled 99.3 33 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 33 d1bc6a_ not modelled 99.3 25 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:7-Fe ferredoxin 34 c1gx7A_ not modelled 99.3 24 PDB header:oxidoreductase Chain: A: PDB Molecule:periplasmic [fe] hydrogenase large subunit; PDBTitle: best model of the electron transfer complex between2 cytochrome c3 and [fe]-hydrogenase 35 d2gmha3 not modelled 99.2 14 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:ETF-QO domain-like 36 d1h98a_ not modelled 99.2 27 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:7-Fe ferredoxin 37 d1clfa_ not modelled 99.2 25 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Short-chain ferredoxins 38 d1sj1a_ not modelled 99.2 21 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Single 4Fe-4S cluster ferredoxin 39 d1vjwa_ not modelled 99.2 23 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Single 4Fe-4S cluster ferredoxin 40 c1c4cA_ not modelled 99.2 22 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (fe-only hydrogenase); PDBTitle: binding of exogenously added carbon monoxide at the active2 site of the fe-only hydrogenase (cpi) from clostridium3 pasteurianum 41 c2v2kB_ not modelled 99.1 24 PDB header:electron transport Chain: B: PDB Molecule:ferredoxin; PDBTitle: the crystal structure of fdxa, a 7fe ferredoxin from2 mycobacterium smegmatis 42 d1fxra_ not modelled 99.0 26 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Single 4Fe-4S cluster ferredoxin 43 d3c7bb1 not modelled 99.0 22 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 44 c1dwlA_ not modelled 98.9 26 PDB header:electron transfer Chain: A: PDB Molecule:ferredoxin i; PDBTitle: the ferredoxin-cytochrome complex using heteronuclear nmr2 and docking simulation 45 c3c7bE_ not modelled 98.9 13 PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit beta; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus 46 c2fugC_ not modelled 98.9 20 PDB header:oxidoreductase Chain: C: PDB Molecule:nadh-quinone oxidoreductase chain 3; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus 47 c2v4jE_ not modelled 98.7 10 PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit PDBTitle: the crystal structure of desulfovibrio vulgaris2 dissimilatory sulfite reductase bound to dsrc provides3 novel insights into the mechanism of sulfate respiration 48 c2v4jA_ not modelled 98.4 16 PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase, dissimilatory-type subunit PDBTitle: the crystal structure of desulfovibrio vulgaris2 dissimilatory sulfite reductase bound to dsrc provides3 novel insights into the mechanism of sulfate respiration 49 c3c7bA_ not modelled 98.4 19 PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase, dissimilatory-type subunit alpha; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus 50 c3bk7A_ not modelled 98.4 20 PDB header:hydrolyase/translation Chain: A: PDB Molecule:abc transporter atp-binding protein; PDBTitle: structure of the complete abce1/rnaase-l inhibitor protein2 from pyrococcus abysii 51 d2bs2b1 not modelled 98.2 17 Fold:Globin-like Superfamily:alpha-helical ferredoxin Family:Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain 52 d1kf6b1 not modelled 98.1 13 Fold:Globin-like Superfamily:alpha-helical ferredoxin Family:Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain 53 d1nekb1 not modelled 98.0 17 Fold:Globin-like Superfamily:alpha-helical ferredoxin Family:Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain 54 c1nekB_ not modelled 98.0 18 PDB header:oxidoreductase/electron transport Chain: B: PDB Molecule:succinate dehydrogenase iron-sulfur protein; PDBTitle: complex ii (succinate dehydrogenase) from e. coli with2 ubiquinone bound 55 c2bs2E_ not modelled 98.0 25 PDB header:oxidoreductase Chain: E: PDB Molecule:quinol-fumarate reductase iron-sulfur subunit b; PDBTitle: quinol:fumarate reductase from wolinella succinogenes 56 c2h89B_ not modelled 97.7 18 PDB header:oxidoreductase Chain: B: PDB Molecule:succinate dehydrogenase ip subunit; PDBTitle: avian respiratory complex ii with malonate bound 57 c2b76N_ not modelled 97.5 21 PDB header:oxidoreductase Chain: N: PDB Molecule:fumarate reductase iron-sulfur protein; PDBTitle: e. coli quinol fumarate reductase frda e49q mutation 58 c3cf4A_ not modelled 96.7 30 PDB header:oxidoreductase Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex 59 d2v4jb1 not modelled 95.2 17 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 60 d3c7ba1 not modelled 94.3 32 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 61 d2v4ja1 not modelled 94.1 29 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Ferredoxin domains from multidomain proteins 62 d1fxda_ not modelled 91.2 24 Fold:Ferredoxin-like Superfamily:4Fe-4S ferredoxins Family:Single 4Fe-4S cluster ferredoxin 63 c2vdcI_ not modelled 91.1 18 PDB header:oxidoreductase Chain: I: PDB Molecule:glutamate synthase [nadph] small chain; PDBTitle: the 9.5 a resolution structure of glutamate synthase from2 cryo-electron microscopy and its oligomerization behavior3 in solution: functional implications. 64 d1gtea1 not modelled 60.6 15 Fold:Globin-like Superfamily:alpha-helical ferredoxin Family:Dihydropyrimidine dehydrogenase, N-terminal domain 65 c3ktbD_ not modelled 11.8 22 PDB header:transcription regulator Chain: D: PDB Molecule:arsenical resistance operon trans-acting repressor; PDBTitle: crystal structure of arsenical resistance operon trans-acting2 repressor from bacteroides vulgatus atcc 8482 66 d1g8ka2 not modelled 10.7 11 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 67 d1djqa3 not modelled 8.4 40 Fold:Nucleotide-binding domain Superfamily:Nucleotide-binding domain Family:N-terminal domain of adrenodoxin reductase-like 68 c2eqpA_ not modelled 7.3 45 PDB header:transcription Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily PDBTitle: solution structure of the stn_tnfrsf12a_tnfr domain of2 tumor necrosis factor receptor superfamily member 12a3 precursor 69 c2kn0A_ not modelled 7.0 45 PDB header:apoptosis Chain: A: PDB Molecule:fn14; PDBTitle: solution nmr structure of xenopus fn14

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0