What's new in version 2.2?
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Phyre2.2 has a number of new features:
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- Fold library now based on unique UniProt entries rather than built on
SCOP entries
- Using HHBlits instead of HHSearch for HMM-HMM matching
- Top results ordered by individual domains
- Build models for both apo- and holo- structures
- One-to-one threading using AlphaFold DB
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What was new in version 2?
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Phyre2 has been totally overhauled with a variety of new
features:
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- Weekly updated fold library
- Automatic handling of multi-domain proteins
- Multi-template
modelling for higher accuracy
- New interface
- BackPhyre:
scan a user-supplied structure against a range of
genomes
- One to one
threading: submit a sequence AND a template structure
and build a model of your sequence based on that template
- Phyre
Alarm: Haven't found a good confident hit? Add your sequence
to your phyre alarm account and it will be automatically scanned
against new entries to our fold library every week and you will be
notified of any new confident hits.
- Batch
processing: Submit multiple sequences at once and have them
processed by Phyre2 automatically
- User accounts: sign up for a user
account to use advanced
features such as those above.
- Increased longevity of results to 1 month.
- View and renew past jobs in the job manager
- Fold
library browser: track all updates, view
information on all newly added structures, search for PDB codes and
auto-search for close homologues
- Hi-res ray-traced model images, publication ready
- Binding site prediction via 3DLigandSite
- Transmembrane helix prediction by
Memsat_svm
- ab initio modelling of missing
regions or whole proteins via Poing. Warning:
Treat results with extreme caution.
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