Phyre 2 Results for Q1WWC9

Email	l.a.kelley@imperial.ac.uk
Description	Q1WWC9
Date	Tue Jan 22 11:33:30 GMT 2013
Unique Job ID	a2110206f2ccec96

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2khnA_

Top template information

PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Confidence and coverage

Confidence:

99.9%

Coverage:

102 residues ( 9% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

335 residues ( 31%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M N S A V D A W A V T P R E R L K Y Q E Q F R A L Q P Q A G F V T G A Q A K G F F L Q S Q L P P L I L G Q I W A L A D T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence D S D G K M N I N E F S I A C K L I N L K L R G M D V P K V L P P S L L S S L T G D V P S M T P R G S T S S L S P L D P

Secondary structure

SS confidence

Disorder
? ? ? ?
?
?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence L K G I V P A V A P V V P V V A P P V A V A T V I S P P G V S V P S G P T P P T S N P P S R H T S I S E R A P S I E S V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence N Q G E W A V Q A A Q K R K Y T Q V F N A N D R T R S G Y L T G S Q A R G V L V Q S K L P Q V T L A Q I W T L S D I D G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence D G R L N C D E F I L A M F L C E K A M A G E K I P V T L P Q E W V P P N L R K I K S R P G S V S G V V S R P G S Q P A

Secondary structure

SS confidence

Disorder ? ?
?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence S R H A S V S S Q S G V G V V D A D P T A G L P G Q T S F E D K R K E N Y V K G Q A E L D R R R K I M E D Q Q R K E R E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E R E R K E R E E A D K R E K A R L E A E R K Q Q E E L E R Q L Q R Q R E I E M E K E E Q R K R E L E A K E A A R K E L

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence E K Q R Q Q E W E Q A R I A E M N A Q K E R E Q E R V L K Q K A H N T Q L N V E L S T L N E K I K E L S Q R I C D T R A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence G V T N V K T V I D G M R T Q R D T S M S E M S Q L K A R I K E Q N A K L L Q L T Q E R A K W E A K S K A S G A A L G G

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence E N A Q Q E Q L N A A F A H K Q L I I N Q I K D K V E N I S K E I E S K K E D I N T N D V Q M S E L K A E L S A L I T K

Secondary structure

SS confidence

Disorder ?
? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence C E D L Y K E Y D V Q R T S V L E L K Y N R K N E T S V S S A W D T G S S S A W E E T G T T V T D P Y A V A S N D I S A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence L A A P A V D L G G P A P E G F V K Y Q A V Y E F N A R N A E E I T F V P G D I I L V P L E Q N A E P G W L A G E I N G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence H T G W F P E S Y V E K L E V G E V A P V A A V E A P V D A Q V A T V A D T Y N D N I N T S S I P A A S A D L T A A G D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence V E Y Y I A A Y P Y E S A E E G D L S F S A G E M V M V I K K E G E W W T G T I G S R T G M F P S N Y V Q K A D V G T A

Secondary structure

SS confidence

Disorder ?
? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence S T A A A E P V E S L D Q T T L N G N A A Y T A A P V E A Q E Q V Y Q P L P V Q E P S E Q P I S S P G V G A E E A H E D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence L D T E V S Q I N T Q S K T Q S S E P A E S Y S R P M S R T S S M T P G M R A K R S E I A Q V I A P Y E A T S T E Q L S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence L T R G Q L I M I R K K T D S G W W E G E L Q A K G R R R Q I G W F P A T Y V K V L Q G G R N S G R N T P V S G S R I E

Secondary structure

SS confidence

Disorder ? ?
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence M T E Q I L D K V I A L Y P Y K A Q N D D E L S F D K D D I I S V L G R D E P E W W R G E L N G L S G L F P S N Y V G P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . .

Sequence F V T S G K P A K A N G T T K K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2khn chain A

Region: 1 - 102
Aligned: 102
Modelled: 102
Confidence: 99.9%
Identity: 49%
PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Phyre2

PDB 2jq6 chain A

Region: 1 - 102
Aligned: 101
Modelled: 102
Confidence: 99.9%
Identity: 39%
PDB header:metal binding protein
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of eh-domain of ehd1

Phyre2

PDB 3fia chain A

Region: 1 - 96
Aligned: 96
Modelled: 96
Confidence: 99.9%
Identity: 51%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.

Phyre2

PDB 1gri chain A

Region: 783 - 1081
Aligned: 206
Modelled: 216
Confidence: 99.9%
Identity: 25%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2lqn chain A

Region: 919 - 1085
Aligned: 163
Modelled: 167
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2kfh chain A

Region: 1 - 102
Aligned: 101
Modelled: 102
Confidence: 99.9%
Identity: 40%
PDB header:protein binding
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of the c-terminal domain of ehd1 with fnyestgpftak

Phyre2

PDB 2eyz chain A

Region: 913 - 1085
Aligned: 169
Modelled: 173
Confidence: 99.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 1ng2 chain A

Region: 943 - 1096
Aligned: 140
Modelled: 149
Confidence: 99.9%
Identity: 24%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 2jxc chain A domain 1

Region: 7 - 101
Aligned: 95
Modelled: 95
Confidence: 99.8%
Identity: 39%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1ov3 chain A

Region: 935 - 1079
Aligned: 131
Modelled: 145
Confidence: 99.8%
Identity: 27%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 2l3s chain A

Region: 943 - 1079
Aligned: 133
Modelled: 137
Confidence: 99.8%
Identity: 23%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2qpt chain A

Region: 3 - 103
Aligned: 100
Modelled: 101
Confidence: 99.8%
Identity: 36%
PDB header:endocytosis
Chain: A: PDB Molecule:eh domain-containing protein-2;
PDBTitle: crystal structure of an ehd atpase involved in membrane remodelling

Phyre2

PDB 2kgr chain A

Region: 3 - 110
Aligned: 108
Modelled: 108
Confidence: 99.8%
Identity: 36%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: solution structure of protein itsn1 from homo sapiens.2 northeast structural genomics consortium target hr5524a

Phyre2

PDB 1iq3 chain A

Region: 4 - 98
Aligned: 95
Modelled: 95
Confidence: 99.8%
Identity: 39%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1mv3 chain A

Region: 904 - 1081
Aligned: 178
Modelled: 178
Confidence: 99.8%
Identity: 17%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 1fi6 chain A

Region: 8 - 97
Aligned: 90
Modelled: 90
Confidence: 99.8%
Identity: 42%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1c07 chain A

Region: 7 - 99
Aligned: 93
Modelled: 93
Confidence: 99.8%
Identity: 39%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1udl chain A

Region: 985 - 1088
Aligned: 94
Modelled: 104
Confidence: 99.6%
Identity: 46%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1ng2 chain A domain 2

Region: 1014 - 1095
Aligned: 82
Modelled: 82
Confidence: 99.6%
Identity: 20%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1qjt chain A

Region: 12 - 100
Aligned: 89
Modelled: 89
Confidence: 99.6%
Identity: 30%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

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