Phyre 2 Results for O13577

Email	l.a.kelley@imperial.ac.uk
Description	O13577
Date	Mon Jul 2 19:10:19 BST 2012
Unique Job ID	087cb74d2e7f16c5

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2zxcA_

Top template information

PDB header:hydrolase
Chain: A: PDB Molecule:neutral ceramidase;
PDBTitle: seramidase complexed with c2

Confidence and coverage

Confidence:

22.6%

Coverage:

20%

26 residues ( 20% of your sequence) have been modelled with 22.6% confidence by the single highest scoring template.

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Warning: 57% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M D A Q L E W A S S L V P K R Q L Q Q Q Q Q Q Q E Q Q Q Q Q Q Q D F H K D Q L M T V G M R I R Q R V D Q G Y A S R T P S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?
?
? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence T S D A S L Q P G V I R D Y S S V I V P Q F T R S P L P T A N S L P P M L I N Q R T M S T E A S S L E K W D V A E P A A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 130 . . .

Sequence E H E T M V N G S K R R L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2zxc chain A

Region: 40 - 69
Aligned: 26
Modelled: 30
Confidence: 22.6%
Identity: 31%
PDB header:hydrolase
Chain: A: PDB Molecule:neutral ceramidase;
PDBTitle: seramidase complexed with c2

Phyre2

PDB 1pgy chain A

Region: 26 - 51
Aligned: 26
Modelled: 26
Confidence: 19.8%
Identity: 19%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2

PDB 2z4l chain C

Region: 114 - 132
Aligned: 16
Modelled: 19
Confidence: 17.7%
Identity: 19%
PDB header:ribosome
Chain: C: PDB Molecule:50s ribosomal protein l2;
PDBTitle: crystal structure of the bacterial ribosome from escherichia2 coli in complex with paromomycin and ribosome recycling3 factor (rrf). this file contains the 50s subunit of the4 first 70s ribosome, with paromomycin and rrf bound. the5 entire crystal structure contains two 70s ribosomes and is6 described in remark 400.

Phyre2

PDB 2qam chain C domain 1

Region: 114 - 132
Aligned: 16
Modelled: 19
Confidence: 15.8%
Identity: 19%
Fold: SH3-like barrel
Superfamily: Translation proteins SH3-like domain
Family: C-terminal domain of ribosomal protein L2

Phyre2

PDB 1of5 chain B

Region: 73 - 123
Aligned: 47
Modelled: 51
Confidence: 14.9%
Identity: 17%
Fold: Cystatin-like
Superfamily: NTF2-like
Family: NTF2-like

Phyre2

PDB 1sid chain A

Region: 56 - 114
Aligned: 46
Modelled: 59
Confidence: 14.4%
Identity: 20%
Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily: Group I dsDNA viruses
Family: Papovaviridae-like VP

Phyre2

PDB 2gya chain A

Region: 114 - 132
Aligned: 16
Modelled: 19
Confidence: 12.9%
Identity: 19%
PDB header:ribosome
Chain: A: PDB Molecule:50s ribosomal protein l2;
PDBTitle: structure of the 50s subunit of a pre-translocational e.2 coli ribosome obtained by fitting atomic models for rna and3 protein components into cryo-em map emd-1056

Phyre2

PDB 1vps chain A

Region: 56 - 114
Aligned: 46
Modelled: 59
Confidence: 12.2%
Identity: 20%
Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily: Group I dsDNA viruses
Family: Papovaviridae-like VP

Phyre2

PDB 1qhm chain A

Region: 46 - 87
Aligned: 31
Modelled: 42
Confidence: 10.6%
Identity: 26%
Fold: PFL-like glycyl radical enzymes
Superfamily: PFL-like glycyl radical enzymes
Family: PFL-like

Phyre2

PDB 1vqo chain A domain 1

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 9.5%
Identity: 36%
Fold: SH3-like barrel
Superfamily: Translation proteins SH3-like domain
Family: C-terminal domain of ribosomal protein L2

Phyre2

PDB 2zjr chain A domain 1

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 8.8%
Identity: 18%
Fold: SH3-like barrel
Superfamily: Translation proteins SH3-like domain
Family: C-terminal domain of ribosomal protein L2

Phyre2

PDB 1hc1 chain A domain 2

Region: 34 - 54
Aligned: 21
Modelled: 21
Confidence: 8.8%
Identity: 33%
Fold: Di-copper centre-containing domain
Superfamily: Di-copper centre-containing domain
Family: Hemocyanin middle domain

Phyre2

PDB 1h16 chain A

Region: 46 - 87
Aligned: 31
Modelled: 42
Confidence: 8.6%
Identity: 23%
Fold: PFL-like glycyl radical enzymes
Superfamily: PFL-like glycyl radical enzymes
Family: PFL-like

Phyre2

PDB 4drb chain C

Region: 81 - 131
Aligned: 46
Modelled: 51
Confidence: 7.8%
Identity: 20%
PDB header:dna binding protein/protein binding
Chain: C: PDB Molecule:fanconi anemia group m protein;
PDBTitle: the crystal structure of fancm bound mhf complex

Phyre2

PDB 1m45 chain B

Region: 43 - 52
Aligned: 10
Modelled: 10
Confidence: 7.8%
Identity: 60%
PDB header:cell cycle protein
Chain: B: PDB Molecule:iq2 motif from myo2p, a class v myosin;
PDBTitle: crystal structure of mlc1p bound to iq2 of myo2p, a class v2 myosin

Phyre2

PDB 1kqs chain A

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 6.9%
Identity: 36%
PDB header:ribosome
Chain: A: PDB Molecule:ribosomal protein l2;
PDBTitle: the haloarcula marismortui 50s complexed with a2 pretranslocational intermediate in protein synthesis

Phyre2

PDB 2j01 chain D domain 1

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 6.8%
Identity: 18%
Fold: SH3-like barrel
Superfamily: Translation proteins SH3-like domain
Family: C-terminal domain of ribosomal protein L2

Phyre2

PDB 1lla chain A domain 2

Region: 33 - 54
Aligned: 22
Modelled: 22
Confidence: 6.0%
Identity: 23%
Fold: Di-copper centre-containing domain
Superfamily: Di-copper centre-containing domain
Family: Hemocyanin middle domain

Phyre2

PDB 2b66 chain D

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 5.9%
Identity: 36%
PDB header:ribosome
Chain: D: PDB Molecule:50s ribosomal protein l2;
PDBTitle: 50s ribosomal subunit from a crystal structure of release factor rf1,2 trnas and mrna bound to the ribosome. this file contains the 50s3 subunit from a crystal structure of release factor rf1, trnas and4 mrna bound to the ribosome and is described in remark 400

Phyre2

PDB 4a1c chain A

Region: 114 - 124
Aligned: 11
Modelled: 11
Confidence: 5.6%
Identity: 27%
PDB header:ribosome
Chain: A: PDB Molecule:rpl8;
PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4.

Phyre2