Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	P	M	L	N	I	A	V	R	A	A	R	K	A	G	N	L	I	A	K	N	Y	E	T	P	D	A	V	E	A	S	Q	K	G	S	N	D	F	V	T	N	V	D	K	A	A	E	A	V	I	I	D	T	I	R	K	S	Y	P
Secondary structure
SS confidence
Disorder		?	?																									?	?	?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	H	T	I	I	T	E	E	S	G	E	L	E	G	T	D	Q	D	V	Q	W	V	I	D	P	L	D	G	T	T	N	F	I	K	R	L	P	H	F	A	V	S	I	A	V	R	I	K	G	R	T	E	V	A	V	V	Y	D	P	M
Secondary structure
SS confidence
Disorder												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	N	E	L	F	T	A	T	R	G	Q	G	A	Q	L	N	G	Y	R	L	R	G	S	T	A	R	D	L	D	G	T	I	L	A	T	G	F	P	F	K	A	K	Q	Y	A	T	T	Y	I	N	I	V	G	K	L	F	N	E	C	A
Secondary structure
SS confidence
Disorder																								?	?	?															?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	F	R	R	T	G	S	A	A	L	D	L	A	Y	V	A	A	G	R	V	D	G	F	F	E	I	G	L	R	P	W	D	F	A	A	G	E	L	L	V	R	E	A	G	G	I	V	S	D	F	T	G	G	H	N	Y	M	L	T	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.
Sequence		N	I	V	A	G	N	P	R	V	V	K	A	M	L	A	N	M	R	D	E	L	S	D	A	L	K	R
Secondary structure
SS confidence
Disorder																										?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2qfl chain A Region: 1 - 262 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of suhb: inositol monophosphatase and extragenic2 suppressor from e. coli Phyre2 PDB 2p3n chain B Region: 1 - 263 Aligned: 252 Modelled: 257 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: thermotoga maritima impase tm1415 Phyre2 PDB 3luz chain A Region: 3 - 259 Aligned: 237 Modelled: 257 Confidence: 100.0% Identity: 44% PDB header:hydrolase Chain: A: PDB Molecule:extragenic suppressor protein suhb; PDBTitle: crystal structure of extragenic suppressor protein suhb from2 bartonella henselae, via combined iodide sad molecular replacement Phyre2 PDB 2hhm chain A Region: 2 - 258 Aligned: 256 Modelled: 257 Confidence: 100.0% Identity: 32% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2czh chain B Region: 2 - 258 Aligned: 240 Modelled: 244 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: crystal structure of human myo-inositol monophosphatase 22 (impa2) with phosphate ion (orthorhombic form) Phyre2 PDB 2fvz chain B Region: 2 - 257 Aligned: 240 Modelled: 242 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: human inositol monophosphosphatase 2 Phyre2 PDB 2pcr chain A Region: 1 - 260 Aligned: 233 Modelled: 236 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983)2 from aquifex aeolicus vf5 Phyre2 PDB 1g0h chain A Region: 3 - 257 Aligned: 242 Modelled: 255 Confidence: 100.0% Identity: 25% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2q74 chain B Region: 1 - 259 Aligned: 233 Modelled: 241 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: mycobacterium tuberculosis suhb Phyre2 PDB 1jp4 chain A Region: 1 - 266 Aligned: 265 Modelled: 266 Confidence: 100.0% Identity: 19% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1ka1 chain A Region: 1 - 263 Aligned: 258 Modelled: 263 Confidence: 100.0% Identity: 28% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1vdw chain A Region: 1 - 259 Aligned: 239 Modelled: 243 Confidence: 100.0% Identity: 31% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1xi6 chain A Region: 1 - 254 Aligned: 225 Modelled: 225 Confidence: 100.0% Identity: 29% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1lbv chain A Region: 2 - 258 Aligned: 236 Modelled: 237 Confidence: 100.0% Identity: 31% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 3b8b chain A Region: 1 - 246 Aligned: 240 Modelled: 246 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:cysq, sulfite synthesis pathway protein; PDBTitle: crystal structure of cysq from bacteroides thetaiotaomicron, a2 bacterial member of the inositol monophosphatase family Phyre2 PDB 1inp chain A Region: 1 - 261 Aligned: 255 Modelled: 261 Confidence: 100.0% Identity: 24% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 3uks chain B Region: 2 - 260 Aligned: 258 Modelled: 258 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:sedoheptulose-1,7 bisphosphatase, putative; PDBTitle: 1.85 angstrom crystal structure of putative sedoheptulose-1,72 bisphosphatase from toxoplasma gondii Phyre2 PDB 1d9q chain A Region: 5 - 257 Aligned: 248 Modelled: 252 Confidence: 99.9% Identity: 19% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1nuw chain A Region: 1 - 260 Aligned: 258 Modelled: 260 Confidence: 99.6% Identity: 16% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2fhy chain L Region: 2 - 260 Aligned: 252 Modelled: 259 Confidence: 99.6% Identity: 12% PDB header:hydrolase Chain: L: PDB Molecule:fructose-1,6-bisphosphatase 1; PDBTitle: structure of human liver fpbase complexed with a novel2 benzoxazole as allosteric inhibitor Phyre2 1 c2qflA_ 2 c2p3nB_ 3 c3luzA_ 4 d2hhma_ 5 c2czhB_ 6 c2fvzB_ 7 c2pcrA_ 8 d1g0ha_ 9 c2q74B_ 10 d1jp4a_ 11 d1ka1a_ 12 d1vdwa_ 13 d1xi6a_ 14 d1lbva_ 15 c3b8bA_ 16 d1inpa_ 17 c3uksB_ 18 d1d9qa_ 19 d1nuwa_ 20 c2fhyL_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2qflA_ 100.0 100 PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of suhb: inositol monophosphatase and extragenic2 suppressor from e. coli 2 c2p3nB_ 100.0 36 PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: thermotoga maritima impase tm1415 3 c3luzA_ 100.0 44 PDB header:hydrolase Chain: A: PDB Molecule:extragenic suppressor protein suhb; PDBTitle: crystal structure of extragenic suppressor protein suhb from2 bartonella henselae, via combined iodide sad molecular replacement 4 d2hhma_ 100.0 32 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 5 c2czhB_ 100.0 33 PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: crystal structure of human myo-inositol monophosphatase 22 (impa2) with phosphate ion (orthorhombic form) 6 c2fvzB_ 100.0 33 PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: human inositol monophosphosphatase 2 7 c2pcrA_ 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983)2 from aquifex aeolicus vf5 8 d1g0ha_ 100.0 25 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 9 c2q74B_ 100.0 35 PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: mycobacterium tuberculosis suhb 10 d1jp4a_ 100.0 19 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 11 d1ka1a_ 100.0 28 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 12 d1vdwa_ 100.0 31 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 13 d1xi6a_ 100.0 29 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 14 d1lbva_ 100.0 31 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 15 c3b8bA_ 100.0 25 PDB header:hydrolase Chain: A: PDB Molecule:cysq, sulfite synthesis pathway protein; PDBTitle: crystal structure of cysq from bacteroides thetaiotaomicron, a2 bacterial member of the inositol monophosphatase family 16 d1inpa_ 100.0 24 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 17 c3uksB_ 99.9 18 PDB header:hydrolase Chain: B: PDB Molecule:sedoheptulose-1,7 bisphosphatase, putative; PDBTitle: 1.85 angstrom crystal structure of putative sedoheptulose-1,72 bisphosphatase from toxoplasma gondii 18 d1d9qa_ 99.9 19 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 19 d1nuwa_ 99.6 16 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 20 c2fhyL_ 99.6 12 PDB header:hydrolase Chain: L: PDB Molecule:fructose-1,6-bisphosphatase 1; PDBTitle: structure of human liver fpbase complexed with a novel2 benzoxazole as allosteric inhibitor 21 d1ftaa_ not modelled 99.5 15 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 22 d1bk4a_ not modelled 99.4 15 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 23 c2gq1A_ not modelled 99.3 18 PDB header:hydrolase Chain: A: PDB Molecule:fructose-1,6-bisphosphatase; PDBTitle: crystal structure of recombinant type i fructose-1,6-bisphosphatase2 from escherichia coli complexed with sulfate ions 24 d1spia_ not modelled 99.1 19 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:Inositol monophosphatase/fructose-1,6-bisphosphatase-like 25 d1ni9a_ not modelled 93.5 22 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:GlpX-like bacterial fructose-1,6-bisphosphatase 26 d1o12a1 not modelled 58.1 36 Fold:Composite domain of metallo-dependent hydrolases Superfamily:Composite domain of metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA 27 c3fhkF_ not modelled 49.2 8 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:upf0403 protein yphp; PDBTitle: crystal structure of apc1446, b.subtilis yphp disulfide2 isomerase 28 d1mdah_ not modelled 32.2 20 Fold:7-bladed beta-propeller Superfamily:YVTN repeat-like/Quinoprotein amine dehydrogenase Family:Methylamine dehydrogenase, H-chain 29 d1r89a1 not modelled 17.0 33 Fold:PAP/OAS1 substrate-binding domain Superfamily:PAP/OAS1 substrate-binding domain Family:Archaeal tRNA CCA-adding enzyme substrate-binding domain 30 c3mx7A_ not modelled 16.2 20 PDB header:apoptosis Chain: A: PDB Molecule:fas apoptotic inhibitory molecule 1; PDBTitle: crystal structure analysis of human faim-ntd 31 c1ikqA_ not modelled 14.3 40 PDB header:transferase Chain: A: PDB Molecule:exotoxin a; PDBTitle: pseudomonas aeruginosa exotoxin a, wild type 32 d2ns0a1 not modelled 14.1 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:RHA1 ro06458-like 33 d3pmga4 not modelled 12.6 13 Fold:TBP-like Superfamily:Phosphoglucomutase, C-terminal domain Family:Phosphoglucomutase, C-terminal domain 34 c2o7jA_ not modelled 11.5 21 PDB header:sugar binding protein Chain: A: PDB Molecule:oligopeptide abc transporter, periplasmic PDBTitle: the x-ray crystal structure of a thermophilic cellobiose2 binding protein bound with cellopentaose 35 d2dsqg1 not modelled 11.2 20 Fold:Thyroglobulin type-1 domain Superfamily:Thyroglobulin type-1 domain Family:Thyroglobulin type-1 domain 36 c2pncB_ not modelled 9.8 23 PDB header:oxidoreductase Chain: B: PDB Molecule:copper amine oxidase, liver isozyme; PDBTitle: crystal structure of bovine plasma copper-containing amine oxidase in2 complex with clonidine 37 d2j9ga2 not modelled 9.7 23 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 38 c3g5uB_ not modelled 9.3 20 PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding 39 d1icfi_ not modelled 8.9 23 Fold:Thyroglobulin type-1 domain Superfamily:Thyroglobulin type-1 domain Family:Thyroglobulin type-1 domain 40 d2g5gx1 not modelled 8.7 18 Fold:EreA/ChaN-like Superfamily:EreA/ChaN-like Family:ChaN-like 41 d1w96a2 not modelled 7.9 19 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 42 c3b5xB_ not modelled 7.5 16 PDB header:membrane protein Chain: B: PDB Molecule:lipid a export atp-binding/permease protein msba; PDBTitle: crystal structure of msba from vibrio cholerae 43 c3equB_ not modelled 7.5 20 PDB header:biosynthetic protein Chain: B: PDB Molecule:penicillin-binding protein 2; PDBTitle: crystal structure of penicillin-binding protein 2 from neisseria2 gonorrhoeae 44 d1kfia4 not modelled 7.4 38 Fold:TBP-like Superfamily:Phosphoglucomutase, C-terminal domain Family:Phosphoglucomutase, C-terminal domain 45 c2hydB_ not modelled 7.3 18 PDB header:transport protein Chain: B: PDB Molecule:abc transporter homolog; PDBTitle: multidrug abc transporter sav1866 46 c1sz1A_ not modelled 6.9 27 PDB header:transferase/rna Chain: A: PDB Molecule:trna nucleotidyltransferase; PDBTitle: mechanism of cca-adding enzymes specificity revealed by crystal2 structures of ternary complexes 47 d1l0wa2 not modelled 6.8 32 Fold:DCoH-like Superfamily:GAD domain-like Family:GAD domain 48 d1g4ma1 not modelled 6.5 23 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Arrestin/Vps26-like 49 c2h7tA_ not modelled 6.1 19 PDB header:protein binding Chain: A: PDB Molecule:insulin-like growth factor-binding protein 2; PDBTitle: solution structure of the c-terminal domain of insulin-like2 growth factor binding protein 2 (igfbp-2)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0