Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	K	L	K	L	L	A	L	G	V	L	I	A	T	S	A	G	V	A	H	A	E	G	K	F	S	L	G	A	G	V	G	V	V	E	H	P	Y	K	D	Y	D	T	D	V	Y	P	V	P	V	I	N	Y	E	G	D	N	F	W
Secondary structure
SS confidence
Disorder		?	?	?												?	?	?	?	?	?	?	?	?	?												?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	R	G	L	G	G	G	Y	Y	L	W	N	D	A	T	D	K	L	S	I	T	A	Y	W	S	P	L	Y	F	K	A	K	D	S	G	D	H	Q	M	R	H	L	D	D	R	K	S	T	M	M	A	G	L	S	Y	A	H	F	T	Q
Secondary structure
SS confidence
Disorder																?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	G	Y	L	R	T	T	L	A	G	D	T	L	D	N	S	N	G	I	V	W	D	M	A	W	L	Y	R	Y	T	N	G	G	L	T	V	T	P	G	I	G	V	Q	W	N	S	E	N	Q	N	E	Y	Y	Y	G	V	S	R	K	E
Secondary structure
SS confidence
Disorder												?				?	?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	A	R	S	G	L	R	G	Y	N	P	N	D	S	W	S	P	Y	L	E	L	S	A	S	Y	N	F	L	G	D	W	S	V	Y	G	T	A	R	Y	T	R	L	S	D	E	V	T	D	S	P	M	V	D	K	S	W	T	G	L	I
Secondary structure
SS confidence
Disorder			?	?	?			?	?			?																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		S	T	G	I	T	Y	K	F
Secondary structure
SS confidence
Disorder								?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2x27 chain X Region: 18 - 248 Aligned: 194 Modelled: 201 Confidence: 98.9% Identity: 17% PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa Phyre2 PDB 2f1t chain B Region: 72 - 248 Aligned: 164 Modelled: 170 Confidence: 98.8% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw Phyre2 PDB 2k0l chain A Region: 72 - 248 Aligned: 166 Modelled: 177 Confidence: 98.7% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. Phyre2 PDB 1g90 chain A Region: 72 - 248 Aligned: 157 Modelled: 164 Confidence: 98.3% Identity: 14% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1p4t chain A Region: 104 - 248 Aligned: 128 Modelled: 132 Confidence: 98.3% Identity: 12% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1qjp chain A Region: 101 - 248 Aligned: 119 Modelled: 132 Confidence: 98.2% Identity: 18% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 2x4m chain D Region: 64 - 248 Aligned: 161 Modelled: 174 Confidence: 98.0% Identity: 17% PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla Phyre2 PDB 3nb3 chain C Region: 104 - 248 Aligned: 116 Modelled: 129 Confidence: 97.9% Identity: 18% PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components Phyre2 PDB 2jmm chain A Region: 70 - 248 Aligned: 144 Modelled: 163 Confidence: 97.8% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein Phyre2 PDB 2lhf chain A Region: 103 - 248 Aligned: 135 Modelled: 146 Confidence: 97.7% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles Phyre2 PDB 3qra chain A Region: 100 - 248 Aligned: 125 Modelled: 135 Confidence: 97.7% Identity: 14% PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis Phyre2 PDB 2iwv chain D Region: 23 - 248 Aligned: 180 Modelled: 186 Confidence: 97.4% Identity: 23% PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation Phyre2 PDB 1i78 chain A Region: 57 - 248 Aligned: 164 Modelled: 171 Confidence: 97.3% Identity: 17% Fold: Transmembrane beta-barrels Superfamily: OMPT-like Family: Outer membrane protease OMPT Phyre2 PDB 1qj8 chain A Region: 103 - 248 Aligned: 122 Modelled: 133 Confidence: 97.0% Identity: 13% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 3slj chain A Region: 58 - 248 Aligned: 154 Modelled: 168 Confidence: 95.8% Identity: 10% PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant Phyre2 PDB 2wjq chain A Region: 80 - 248 Aligned: 127 Modelled: 128 Confidence: 95.2% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. Phyre2 PDB 3aeh chain B Region: 52 - 248 Aligned: 167 Modelled: 177 Confidence: 94.1% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp Phyre2 PDB 2qom chain B Region: 61 - 248 Aligned: 176 Modelled: 188 Confidence: 93.1% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. Phyre2 PDB 3kvn chain A Region: 8 - 248 Aligned: 220 Modelled: 239 Confidence: 91.6% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa Phyre2 PDB 3dwo chain X Region: 58 - 248 Aligned: 183 Modelled: 191 Confidence: 89.0% Identity: 13% PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue Phyre2 1 c2x27X_ 2 c2f1tB_ 3 c2k0lA_ 4 d1g90a_ 5 d1p4ta_ 6 d1qjpa_ 7 c2x4mD_ 8 c3nb3C_ 9 c2jmmA_ 10 c2lhfA_ 11 c3qraA_ 12 c2iwvD_ 13 d1i78a_ 14 d1qj8a_ 15 c3sljA_ 16 c2wjqA_ 17 c3aehB_ 18 c2qomB_ 19 c3kvnA_ 20 c3dwoX_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2x27X_ 98.9 17 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa 2 c2f1tB_ 98.8 14 PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw 3 c2k0lA_ 98.7 16 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. 4 d1g90a_ 98.3 14 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 5 d1p4ta_ 98.3 12 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 6 d1qjpa_ 98.2 18 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 7 c2x4mD_ 98.0 17 PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla 8 c3nb3C_ 97.9 18 PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components 9 c2jmmA_ 97.8 19 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein 10 c2lhfA_ 97.7 15 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles 11 c3qraA_ 97.7 14 PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis 12 c2iwvD_ 97.4 23 PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation 13 d1i78a_ 97.3 17 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane protease OMPT 14 d1qj8a_ 97.0 13 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 15 c3sljA_ 95.8 10 PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant 16 c2wjqA_ 95.2 16 PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. 17 c3aehB_ 94.1 14 PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp 18 c2qomB_ 93.1 16 PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. 19 c3kvnA_ 91.6 18 PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa 20 c3dwoX_ 89.0 13 PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue 21 d1uynx_ not modelled 87.6 16 Fold:Transmembrane beta-barrels Superfamily:Autotransporter Family:Autotransporter 22 c3qq2C_ not modelled 86.7 16 PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka 23 d2fgqx1 not modelled 86.6 14 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 24 c3dzmB_ not modelled 86.2 17 PDB header:unknown function Chain: B: PDB Molecule:hypothetical conserved protein; PDBTitle: crystal structure of a major outer membrane protein from thermus2 thermophilus hb27 25 d1t16a_ not modelled 85.9 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Outer membrane protein transport protein 26 c2iahA_ not modelled 75.1 14 PDB header:membrane protein Chain: A: PDB Molecule:ferripyoverdine receptor; PDBTitle: crystal structure of the ferripyoverdine receptor of the outer2 membrane of pseudomonas aeruginosa bound to ferripyoverdine. 27 c3a2rX_ not modelled 74.6 16 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein ii; PDBTitle: crystal structure of outer membrane protein porb from neisseria2 meningitidis 28 c3brzA_ not modelled 69.0 13 PDB header:transport protein Chain: A: PDB Molecule:todx; PDBTitle: crystal structure of the pseudomonas putida toluene2 transporter todx 29 d2zfga1 not modelled 64.5 11 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 30 d1osma_ not modelled 47.8 17 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 31 c3bryB_ not modelled 45.0 8 PDB header:transport protein Chain: B: PDB Molecule:tbux; PDBTitle: crystal structure of the ralstonia pickettii toluene2 transporter tbux 32 c3efmA_ not modelled 42.3 10 PDB header:membrane protein Chain: A: PDB Molecule:ferric alcaligin siderophore receptor; PDBTitle: structure of the alcaligin outer membrane recepteur faua from2 bordetella pertussis 33 d1tlya_ not modelled 36.3 14 Fold:Transmembrane beta-barrels Superfamily:Tsx-like channel Family:Tsx-like channel 34 c3nsgA_ not modelled 31.4 16 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein f; PDBTitle: crystal structure of ompf, an outer membrane protein from salmonella2 typhi 35 c1xkhC_ not modelled 31.3 15 PDB header:membrane protein Chain: C: PDB Molecule:ferripyoverdine receptor; PDBTitle: pyoverdine outer membrane receptor fpva from pseudomonas aeruginosa2 pao1 bound to pyoverdine 36 d1a0tp_ not modelled 26.1 16 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like 37 c3cslB_ not modelled 25.2 12 PDB header:membrane protein/heme binding protein Chain: B: PDB Molecule:hasr protein; PDBTitle: structure of the serratia marcescens hemophore receptor hasr in2 complex with its hemophore hasa and heme 38 d2gufa1 not modelled 24.8 13 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 39 d3prna_ not modelled 21.3 19 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 40 c3qlbA_ not modelled 12.4 9 PDB header:metal transport Chain: A: PDB Molecule:enantio-pyochelin receptor; PDBTitle: enantiopyochelin outer membrane tonb-dependent transporter from2 pseudomonas fluorescens bound to the ferri-enantiopyochelin 41 d2vdfa1 not modelled 11.1 14 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane adhesin/invasin OpcA 42 c2gr7C_ not modelled 9.7 17 PDB header:membrane protein Chain: C: PDB Molecule:adhesin; PDBTitle: hia 992-1098 43 d2gr7a1 not modelled 9.7 17 Fold:Pili subunits Superfamily:Pili subunits Family:YadA C-terminal domain-like 44 c2c4iA_ not modelled 9.3 27 PDB header:glycoprotein Chain: A: PDB Molecule:avidin; PDBTitle: crystal structure of engineered avidin 45 c3oiqB_ not modelled 8.8 55 PDB header:protein binding Chain: B: PDB Molecule:dna polymerase alpha catalytic subunit a; PDBTitle: crystal structure of yeast telomere protein cdc13 ob1 and the2 catalytic subunit of dna polymerase alpha pol1 46 d1phoa_ not modelled 8.3 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 47 c2grxB_ not modelled 5.9 15 PDB header:metal transport Chain: B: PDB Molecule:ferrichrome-iron receptor; PDBTitle: crystal structure of tonb in complex with fhua, e. coli2 outer membrane receptor for ferrichrome 48 c2hdiA_ not modelled 5.9 15 PDB header:protein transport,antimicrobial protein Chain: A: PDB Molecule:colicin i receptor; PDBTitle: crystal structure of the colicin i receptor cir from e.coli in complex2 with receptor binding domain of colicin ia.

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0