Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ47013
DateThu Jan 5 12:36:09 GMT 2012
Unique Job IDb31bfff916f3524d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1euva_
Top template information
Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
Confidence and coverage
Confidence: 97.9% Coverage: 29%
117 residues ( 29% of your sequence) have been modelled with 97.9% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MMVTVVSNYCQLSQTQLSQTFAEKFTVTEELLQSLKKTALSGDEESIELLHNIALGYDKF
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Disorder  ???????
















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???
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   .........70.........80.........90.........100.........110.........120
Sequence  GKEAEDILYHIVRTPTNETLSIIRLIKNACLKLYNLAHIATNSPLKSHDSDDLLFKKLFS
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   .........130.........140.........150.........160.........170.........180
Sequence  PSKLMTIIGDEIPLISEKQSLSKVLLNDENNELSDGTNFWDKNRQLTTDEIACYLQKIAA
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   .........190.........200.........210.........220.........230.........240
Sequence  NAKNTQVNYPTGLYVPYSTRTHLEDALNENIKSDPSWPNEVQLFPINTGGHWILVSLQKI
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   .........250.........260.........270.........280.........290.........300
Sequence  VNKKNNKLQIKCVIFNSLRALGYDKENSLKRVINSFNSELMGEMSNNNIKVHLNEPEIIF
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   .........310.........320.........330.........340.........350.........360
Sequence  LHADLQQYLSQSCGAFVCMAAQEVIEQRESNSDSAPYTLLKNHADRFKKYSAEEQYEIDF
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   .........370.........380.........390.........400...
Sequence  QHRLANRNCYLDKYGDANINHYYRNLEIKHSQPKNRASGKRVS
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???????????????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1euv chain A

3D model

Region: 210 - 343
Aligned: 117
Modelled: 134
Confidence: 97.9%
Identity: 19%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 2g4d chain A domain 1

3D model

Region: 212 - 343
Aligned: 116
Modelled: 132
Confidence: 97.6%
Identity: 19%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 2bkr chain A domain 1

3D model

Region: 204 - 350
Aligned: 125
Modelled: 147
Confidence: 97.5%
Identity: 18%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 2oix chain A

3D model

Region: 215 - 324
Aligned: 86
Modelled: 96
Confidence: 97.3%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:xanthomonas outer protein d;
PDBTitle: xanthomonas xopd c470a mutant

Phyre2

PDB 3eay chain A

3D model

Region: 215 - 356
Aligned: 138
Modelled: 142
Confidence: 97.2%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:sentrin-specific protease 7;
PDBTitle: crystal structure of the human senp7 catalytic domain

Phyre2

PDB 1th0 chain A

3D model

Region: 212 - 343
Aligned: 120
Modelled: 132
Confidence: 97.0%
Identity: 18%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 2iy1 chain A domain 1

3D model

Region: 205 - 343
Aligned: 125
Modelled: 139
Confidence: 96.8%
Identity: 18%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 1nln chain A

3D model

Region: 216 - 319
Aligned: 87
Modelled: 104
Confidence: 68.5%
Identity: 26%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Adenain-like

Phyre2

PDB 1xd3 chain A

3D model

Region: 274 - 354
Aligned: 74
Modelled: 81
Confidence: 58.4%
Identity: 16%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Ubiquitin carboxyl-terminal hydrolase UCH-L

Phyre2

PDB 2cpq chain A domain 1

3D model

Region: 16 - 41
Aligned: 26
Modelled: 26
Confidence: 56.6%
Identity: 38%
Fold: Eukaryotic type KH-domain (KH-domain type I)
Superfamily: Eukaryotic type KH-domain (KH-domain type I)
Family: Eukaryotic type KH-domain (KH-domain type I)

Phyre2

PDB 2etl chain A domain 1

3D model

Region: 277 - 354
Aligned: 71
Modelled: 78
Confidence: 55.7%
Identity: 18%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Ubiquitin carboxyl-terminal hydrolase UCH-L

Phyre2

PDB 2wdt chain A

3D model

Region: 306 - 354
Aligned: 46
Modelled: 46
Confidence: 46.9%
Identity: 22%
PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase l3;
PDBTitle: crystal structure of plasmodium falciparum uchl3 in complex2 with the suicide inhibitor ubvme

Phyre2

PDB 3a7s chain A

3D model

Region: 306 - 354
Aligned: 43
Modelled: 49
Confidence: 24.6%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase isozyme l5;
PDBTitle: catalytic domain of uch37

Phyre2

PDB 3mst chain A

3D model

Region: 308 - 361
Aligned: 48
Modelled: 49
Confidence: 17.5%
Identity: 23%
PDB header:transport protein
Chain: A: PDB Molecule:putative nitrate transport protein;
PDBTitle: crystal structure of a putative nitrate transport protein (tvn0104)2 from thermoplasma volcanium at 1.35 a resolution

Phyre2

PDB 3ihr chain A

3D model

Region: 306 - 354
Aligned: 43
Modelled: 48
Confidence: 15.9%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase isozyme l5;
PDBTitle: crystal structure of uch37

Phyre2

PDB 1cja chain A

3D model

Region: 59 - 84
Aligned: 26
Modelled: 26
Confidence: 15.0%
Identity: 15%
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Family: Actin-fragmin kinase, catalytic domain

Phyre2

PDB 3zrh chain A

3D model

Region: 161 - 217
Aligned: 52
Modelled: 57
Confidence: 13.8%
Identity: 23%
PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin thioesterase zranb1;
PDBTitle: crystal structure of the lys29, lys33-linkage-specific trabid otu2 deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding3 domain (ankubd)

Phyre2

PDB 3dcy chain A

3D model

Region: 213 - 262
Aligned: 47
Modelled: 50
Confidence: 13.4%
Identity: 17%
PDB header:apoptosis regulator
Chain: A: PDB Molecule:regulator protein;
PDBTitle: crystal structure a tp53-induced glycolysis and apoptosis2 regulator protein from homo sapiens.

Phyre2

PDB 2qqp chain D

3D model

Region: 74 - 88
Aligned: 15
Modelled: 15
Confidence: 13.0%
Identity: 27%
PDB header:virus
Chain: D: PDB Molecule:small capsid protein;
PDBTitle: crystal structure of authentic providence virus

Phyre2

PDB 2of6 chain C

3D model

Region: 311 - 316
Aligned: 6
Modelled: 6
Confidence: 10.7%
Identity: 50%
PDB header:virus
Chain: C: PDB Molecule:envelope glycoprotein e;
PDBTitle: structure of immature west nile virus

Phyre2
1

d1euva_
2

d2g4da1
3

d2bkra1
4

c2oixA_
5

c3eayA_
6

d1th0a_
7

d2iy1a1
8

d1nlna_
9

d1xd3a_
10

d2cpqa1
11

d2etla1
12

c2wdtA_
13

c3a7sA_
14

c3mstA_
15

c3ihrA_
16

d1cjaa_
17

c3zrhA_
18

c3dcyA_
19

c2qqpD_
20

c2of6C_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



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41



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55



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57



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62






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1euva_



97.9 19 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
2d2g4da1



97.6 19 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
3d2bkra1



97.5 18 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
4c2oixA_



97.3 15 PDB header:hydrolase
Chain: A: PDB Molecule:xanthomonas outer protein d;
PDBTitle: xanthomonas xopd c470a mutant
5c3eayA_



97.2 13 PDB header:hydrolase
Chain: A: PDB Molecule:sentrin-specific protease 7;
PDBTitle: crystal structure of the human senp7 catalytic domain
6d1th0a_



97.0 18 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
7d2iy1a1



96.8 18 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
8d1nlna_



68.5 26 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Adenain-like
9d1xd3a_



58.4 16 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Ubiquitin carboxyl-terminal hydrolase UCH-L
10d2cpqa1



56.6 38 Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
11d2etla1



55.7 18 Fold:Cysteine proteinases
Superfamily:Cysteine proteinases
Family:Ubiquitin carboxyl-terminal hydrolase UCH-L
12c2wdtA_



46.9 22 PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase l3;
PDBTitle: crystal structure of plasmodium falciparum uchl3 in complex2 with the suicide inhibitor ubvme
13c3a7sA_



24.6 12 PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase isozyme l5;
PDBTitle: catalytic domain of uch37
14c3mstA_



17.5 23 PDB header:transport protein
Chain: A: PDB Molecule:putative nitrate transport protein;
PDBTitle: crystal structure of a putative nitrate transport protein (tvn0104)2 from thermoplasma volcanium at 1.35 a resolution
15c3ihrA_



15.9 14 PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase isozyme l5;
PDBTitle: crystal structure of uch37
16d1cjaa_



15.0 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Actin-fragmin kinase, catalytic domain
17c3zrhA_



13.8 23 PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin thioesterase zranb1;
PDBTitle: crystal structure of the lys29, lys33-linkage-specific trabid otu2 deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding3 domain (ankubd)
18c3dcyA_



13.4 17 PDB header:apoptosis regulator
Chain: A: PDB Molecule:regulator protein;
PDBTitle: crystal structure a tp53-induced glycolysis and apoptosis2 regulator protein from homo sapiens.
19c2qqpD_



13.0 27 PDB header:virus
Chain: D: PDB Molecule:small capsid protein;
PDBTitle: crystal structure of authentic providence virus
20c2of6C_



10.7 50 PDB header:virus
Chain: C: PDB Molecule:envelope glycoprotein e;
PDBTitle: structure of immature west nile virus
21d1s2xa_



not modelled 10.7 47 Fold:STAT-like
Superfamily:Cag-Z
Family:Cag-Z
22c1s2xA_



not modelled 10.7 47 PDB header:unknown function
Chain: A: PDB Molecule:cag-z;
PDBTitle: crystal structure of cag-z from helicobacter pylori
23d1z21a1



not modelled 10.6 21 Fold:Type III secretion system domain
Superfamily:Type III secretion system domain
Family:YopR Core
24c2i3eA_



not modelled 10.3 20 PDB header:hydrolase
Chain: A: PDB Molecule:g-rich;
PDBTitle: solution structure of catalytic domain of goldfish rich2 protein
25d1aina_



not modelled 10.0 23 Fold:Annexin
Superfamily:Annexin
Family:Annexin
26c1uzgA_



not modelled 9.9 50 PDB header:viral protein
Chain: A: PDB Molecule:major envelope protein e;
PDBTitle: crystal structure of the dengue type 3 virus envelope2 protein
27d1u7za_



not modelled 9.9 15 Fold:Ribokinase-like
Superfamily:CoaB-like
Family:CoaB-like
28c2ka2A_



not modelled 9.8 43 PDB header:membrane protein
Chain: A: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting
PDBTitle: solution nmr structure of bnip3 transmembrane peptide dimer2 in detergent micelles with his173-ser172 intermonomer3 hydrogen bond restraints
29c2ka1B_



not modelled 9.8 43 PDB header:membrane protein
Chain: B: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting
PDBTitle: solution nmr structure of bnip3 transmembrane peptide dimer2 in detergent micelles
30d1zrua3



not modelled 9.7 27 Fold:Pseudo beta-prism
Superfamily:Bacteriophage trimeric proteins domain
Family:Lactophage receptor-binding protein N-terminal domain
31c2ka2B_



not modelled 9.3 43 PDB header:membrane protein
Chain: B: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting
PDBTitle: solution nmr structure of bnip3 transmembrane peptide dimer2 in detergent micelles with his173-ser172 intermonomer3 hydrogen bond restraints
32c2ka1A_



not modelled 9.3 43 PDB header:membrane protein
Chain: A: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting
PDBTitle: solution nmr structure of bnip3 transmembrane peptide dimer2 in detergent micelles
33d2arha1



not modelled 9.1 41 Fold:Acyl-CoA N-acyltransferases (Nat)
Superfamily:Acyl-CoA N-acyltransferases (Nat)
Family:Aq 1966-like
34d1svba2



not modelled 9.0 50 Fold:Viral glycoprotein, central and dimerisation domains
Superfamily:Viral glycoprotein, central and dimerisation domains
Family:Viral glycoprotein, central and dimerisation domains
35c3lcnC_



not modelled 8.8 46 PDB header:nuclear protein
Chain: C: PDB Molecule:mrna transport factor gfd1;
PDBTitle: nab2:gfd1 complex
36c3lcnD_



not modelled 8.5 46 PDB header:nuclear protein
Chain: D: PDB Molecule:mrna transport factor gfd1;
PDBTitle: nab2:gfd1 complex
37d1sjpa2



not modelled 8.3 28 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:GroEL apical domain-like
Family:GroEL-like chaperone, apical domain
38c2f9jP_



not modelled 8.2 27 PDB header:rna binding protein
Chain: P: PDB Molecule:splicing factor 3b subunit 1;
PDBTitle: 3.0 angstrom resolution structure of a y22m mutant of the spliceosomal2 protein p14 bound to a region of sf3b155
39d1ok8a2



not modelled 8.2 50 Fold:Viral glycoprotein, central and dimerisation domains
Superfamily:Viral glycoprotein, central and dimerisation domains
Family:Viral glycoprotein, central and dimerisation domains
40c2j5dA_



not modelled 7.9 50 PDB header:membrane protein
Chain: A: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting
PDBTitle: nmr structure of bnip3 transmembrane domain in lipid2 bicelles
41c1p58C_



not modelled 7.8 50 PDB header:virus
Chain: C: PDB Molecule:major envelope protein e;
PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction
42c3uajA_



not modelled 7.8 50 PDB header:viral protein/immune system
Chain: A: PDB Molecule:envelope protein;
PDBTitle: crystal structure of the envelope glycoprotein ectodomain from dengue2 virus serotype 4 in complex with the fab fragment of the chimpanzee3 monoclonal antibody 5h2
43d1f74a_



not modelled 7.7 21 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
44c1urzC_



not modelled 7.7 50 PDB header:virus/viral protein
Chain: C: PDB Molecule:envelope protein;
PDBTitle: low ph induced, membrane fusion conformation of the2 envelope protein of tick-borne encephalitis virus
45d1o22a_



not modelled 7.3 70 Fold:Hypothetical protein TM0875
Superfamily:Hypothetical protein TM0875
Family:Hypothetical protein TM0875
46d1ufwa_



not modelled 7.1 23 Fold:Ferredoxin-like
Superfamily:RNA-binding domain, RBD
Family:Canonical RBD
47d1rmka_



not modelled 6.8 83 Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:omega toxin-like
Family:Conotoxin
48c3dxeC_



not modelled 6.7 24 PDB header:protein binding
Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member
PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2
49c3c6dB_



not modelled 6.6 50 PDB header:virus
Chain: B: PDB Molecule:polyprotein;
PDBTitle: the pseudo-atomic structure of dengue immature virus
50c3siiA_



not modelled 6.5 35 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:poly(adp-ribose) glycohydrolase;
PDBTitle: the x-ray crystal structure of poly(adp-ribose) glycohydrolase bound2 to the inhibitor adp-hpd from thermomonospora curvata
51c3ogzA_



not modelled 6.1 20 PDB header:transferase
Chain: A: PDB Molecule:udp-sugar pyrophosphorylase;
PDBTitle: protein structure of usp from l. major in apo-form
52d1dm5a_



not modelled 6.1 23 Fold:Annexin
Superfamily:Annexin
Family:Annexin
53d1srva_



not modelled 5.9 31 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:GroEL apical domain-like
Family:GroEL-like chaperone, apical domain
54d2ptza1



not modelled 5.8 16 Fold:TIM beta/alpha-barrel
Superfamily:Enolase C-terminal domain-like
Family:Enolase
55c1bmxA_



not modelled 5.8 32 PDB header:viral protein
Chain: A: PDB Molecule:human immunodeficiency virus type 1 capsid;
PDBTitle: hiv-1 capsid protein major homology region peptide analog,2 nmr, 8 structures
56d1vlya1



not modelled 5.7 15 Fold:Elongation factor/aminomethyltransferase common domain
Superfamily:Aminomethyltransferase beta-barrel domain
Family:Aminomethyltransferase beta-barrel domain
57c2vc6A_



not modelled 5.4 22 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: structure of mosa from s. meliloti with pyruvate bound
58d1sx5a_



not modelled 5.3 21 Fold:Restriction endonuclease-like
Superfamily:Restriction endonuclease-like
Family:Restriction endonuclease EcoRV
59c1gp8A_



not modelled 5.2 13 PDB header:viral protein
Chain: A: PDB Molecule:protein (scaffolding protein);
PDBTitle: nmr solution structure of the coat protein-binding domain2 of bacteriophage p22 scaffolding protein
60d1t6t1_



not modelled 5.2 8 Fold:Toprim domain
Superfamily:Toprim domain
Family:Toprim domain
61d1k8ga2



not modelled 5.2 23 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:Single strand DNA-binding domain, SSB
62c1w9zB_



not modelled 5.1 35 PDB header:virus coat protein
Chain: B: PDB Molecule:vp9;
PDBTitle: structure of bannavirus vp9

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0