Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	D	N	D	N	S	L	N	K	R	P	T	F	K	R	A	L	R	N	I	S	M	T	S	I	F	I	T	M	M	L	I	W	L	L	L	S	V	T	S	V	L	T	L	K	Q	Y	A	Q	K	N	L	A	L	T	A	A	T	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	Y	S	L	E	A	A	V	V	F	A	D	G	P	A	A	T	E	T	L	A	A	L	G	Q	Q	G	Q	F	S	T	A	E	V	R	D	K	Q	Q	N	I	L	A	S	W	H	Y	T	R	K	D	P	G	D	T	F	S	N	F	I
Secondary structure
SS confidence
Disorder		?	?		?																				?	?		?																				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	H	W	L	F	P	A	P	I	I	Q	P	I	R	H	N	G	E	T	I	G	E	V	R	L	T	A	R	D	S	S	I	S	H	F	I	W	F	S	L	A	V	L	T	G	C	I	L	L	A	S	G	I	A	I	T	L	T	R	H
Secondary structure
SS confidence
Disorder			?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	H	N	G	L	V	E	A	L	K	N	I	T	D	V	V	H	D	V	R	S	N	R	N	F	S	R	R	V	S	E	E	R	I	A	E	F	H	R	F	A	L	D	F	N	S	L	L	D	E	M	E	E	W	Q	L	R	L	Q	A
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	N	A	Q	L	L	R	T	A	L	H	D	P	L	T	G	L	A	N	R	A	A	F	R	S	G	I	N	T	L	M	N	N	S	D	A	R	K	T	S	A	L	L	F	L	D	G	D	N	F	K	Y	I	N	D	T	W	G	H	A
Secondary structure
SS confidence
Disorder																																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	G	D	R	V	L	I	E	I	A	K	R	L	A	E	F	G	G	L	R	H	K	A	Y	R	L	G	G	D	E	F	A	M	V	L	Y	D	V	Q	S	E	S	E	V	Q	Q	I	C	S	A	L	T	Q	I	F	N	L	P	F	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.
Sequence		L	H	N	G	H	Q	T	T	M	T	L	S	I	G	Y	A	M	T	I	E	H	A	S	A	E	K	L	Q	E	L	A	D	H	N	M	Y	Q	A	K	H	Q	R	A	E	K	L	V	R
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1w25 chain B Region: 236 - 407 Aligned: 171 Modelled: 172 Confidence: 100.0% Identity: 31% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 3ezu chain A Region: 236 - 407 Aligned: 162 Modelled: 172 Confidence: 100.0% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution Phyre2 PDB 3i5a chain A Region: 231 - 407 Aligned: 175 Modelled: 175 Confidence: 100.0% Identity: 30% PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae Phyre2 PDB 3bre chain A Region: 230 - 407 Aligned: 176 Modelled: 178 Confidence: 100.0% Identity: 32% PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 Phyre2 PDB 3ign chain A Region: 247 - 407 Aligned: 160 Modelled: 157 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a Phyre2 PDB 3icl chain A Region: 251 - 407 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 30% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c Phyre2 PDB 3hva chain A Region: 248 - 406 Aligned: 158 Modelled: 159 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa Phyre2 PDB 3qyy chain B Region: 244 - 408 Aligned: 154 Modelled: 155 Confidence: 100.0% Identity: 33% PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp Phyre2 PDB 1w25 chain A domain 3 Region: 254 - 407 Aligned: 153 Modelled: 154 Confidence: 100.0% Identity: 32% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: GGDEF domain Phyre2 PDB 3i5c chain A Region: 224 - 407 Aligned: 183 Modelled: 184 Confidence: 100.0% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa Phyre2 PDB 3i5b chain A Region: 247 - 407 Aligned: 160 Modelled: 161 Confidence: 100.0% Identity: 29% PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa Phyre2 PDB 3mtk chain A Region: 244 - 407 Aligned: 155 Modelled: 164 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c Phyre2 PDB 3hvw chain A Region: 258 - 404 Aligned: 144 Modelled: 147 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c Phyre2 PDB 3pjw chain A Region: 236 - 407 Aligned: 170 Modelled: 172 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 Phyre2 PDB 3gfz chain B Region: 244 - 407 Aligned: 133 Modelled: 135 Confidence: 99.7% Identity: 11% PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex Phyre2 PDB 3p7n chain B Region: 236 - 305 Aligned: 70 Modelled: 70 Confidence: 98.4% Identity: 16% PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis Phyre2 PDB 2qv6 chain D Region: 276 - 404 Aligned: 113 Modelled: 129 Confidence: 97.7% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions Phyre2 PDB 3lnr chain A Region: 176 - 240 Aligned: 64 Modelled: 65 Confidence: 95.9% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 3uvj chain C Region: 273 - 377 Aligned: 105 Modelled: 105 Confidence: 95.7% Identity: 17% PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. Phyre2 PDB 1cjk chain A Region: 275 - 378 Aligned: 104 Modelled: 104 Confidence: 95.6% Identity: 13% PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn Phyre2 PDB 3pjv chain D Region: 38 - 161 Aligned: 122 Modelled: 120 Confidence: 94.7% Identity: 13% PDB header:lyase Chain: D: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd periplasmic domain Phyre2 PDB 2asx chain A domain 1 Region: 184 - 236 Aligned: 52 Modelled: 52 Confidence: 94.6% Identity: 12% Fold: HAMP domain-like Superfamily: HAMP domain-like Family: HAMP domain Phyre2 PDB 1p0z chain A Region: 47 - 152 Aligned: 106 Modelled: 106 Confidence: 93.9% Identity: 13% Fold: Profilin-like Superfamily: Sensory domain-like Family: Sensory domain of two-component sensor kinase Phyre2 PDB 3by8 chain A domain 1 Region: 45 - 157 Aligned: 113 Modelled: 113 Confidence: 93.3% Identity: 13% Fold: Profilin-like Superfamily: Sensory domain-like Family: Sensory domain of two-component sensor kinase Phyre2 1 c1w25B_ 2 c3ezuA_ 3 c3i5aA_ 4 c3breA_ 5 c3ignA_ 6 c3iclA_ 7 c3hvaA_ 8 c3qyyB_ 9 d1w25a3 10 c3i5cA_ 11 c3i5bA_ 12 c3mtkA_ 13 c3hvwA_ 14 c3pjwA_ 15 c3gfzB_ 16 c3p7nB_ 17 c2qv6D_ 18 c3lnrA_ 19 c3uvjC_ 20 c1cjkA_ 21 22 23 24 c3pjvD_ 25 26 d2asxa1 27 28 d1p0za_ 29 d3by8a1 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1w25B_ 100.0 31 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 2 c3ezuA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution 3 c3i5aA_ 100.0 30 PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae 4 c3breA_ 100.0 32 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 5 c3ignA_ 100.0 26 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a 6 c3iclA_ 100.0 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c 7 c3hvaA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa 8 c3qyyB_ 100.0 33 PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp 9 d1w25a3 100.0 32 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:GGDEF domain 10 c3i5cA_ 100.0 27 PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa 11 c3i5bA_ 100.0 29 PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa 12 c3mtkA_ 100.0 26 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c 13 c3hvwA_ 100.0 16 PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c 14 c3pjwA_ 100.0 22 PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 15 c3gfzB_ 99.7 11 PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex 16 c3p7nB_ 98.4 16 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 17 c2qv6D_ 97.7 19 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 18 c3lnrA_ 95.9 13 PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 19 c3uvjC_ 95.7 17 PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. 20 c1cjkA_ 95.6 13 PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn 21 d1azsa_ not modelled 95.3 13 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 22 d1fx2a_ not modelled 95.3 18 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 23 c3mr7B_ not modelled 95.1 10 PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi 24 c3pjvD_ 94.7 13 PDB header:lyase Chain: D: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd periplasmic domain 25 d1wc1a_ not modelled 94.7 13 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 26 d2asxa1 94.6 12 Fold:HAMP domain-like Superfamily:HAMP domain-like Family:HAMP domain 27 c1wc6B_ not modelled 94.2 13 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate 28 d1p0za_ 93.9 13 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 29 d3by8a1 93.3 13 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 30 c1yk9A_ not modelled 91.8 16 PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c 31 c1ybuA_ not modelled 91.3 10 PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. 32 c1y10C_ not modelled 89.6 13 PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state 33 c3et6A_ not modelled 89.4 9 PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase 34 d1fx4a_ not modelled 88.7 14 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 35 c2aq4A_ not modelled 86.9 17 PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. 36 c2rm8A_ not modelled 84.9 7 PDB header:signaling protein Chain: A: PDB Molecule:sensory rhodopsin ii transducer; PDBTitle: the solution structure of phototactic transducer protein2 htrii linker region from natronomonas pharaonis 37 c2w01C_ not modelled 83.9 15 PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 38 c3b47A_ not modelled 79.6 12 PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: periplasmic sensor domain of chemotaxis protein gsu0582 39 c3zrwB_ not modelled 78.2 11 PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant 40 c2wz1B_ not modelled 77.2 11 PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble2 guanylate cyclase 1 beta 3. 41 c3gqcB_ not modelled 74.9 16 PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex 42 c3b42B_ not modelled 65.5 12 PDB header:signaling protein Chain: B: PDB Molecule:methyl-accepting chemotaxis protein, putative; PDBTitle: periplasmic sensor domain of chemotaxis protein gsu0935 43 d1azsb_ not modelled 64.6 10 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 44 c1k1qA_ not modelled 61.7 16 PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus 45 c1s97D_ not modelled 61.0 18 PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch 46 d1im4a_ not modelled 60.2 16 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 47 d1k1sa2 not modelled 54.5 16 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 48 d1yhta1 not modelled 45.7 22 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 49 d1jx4a2 not modelled 43.4 18 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 50 d1vr6a1 not modelled 32.1 10 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I DAHP synthetase 51 d1xxaa_ not modelled 26.9 18 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 52 c3l7xA_ not modelled 26.8 17 PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 53 c3k30B_ not modelled 24.5 18 PDB header:oxidoreductase Chain: B: PDB Molecule:histamine dehydrogenase; PDBTitle: histamine dehydrogenase from nocardiodes simplex 54 c3hf3A_ not modelled 22.6 14 PDB header:oxidoreductase Chain: A: PDB Molecule:chromate reductase; PDBTitle: old yellow enzyme from thermus scotoductus sa-01 55 c3nuiA_ not modelled 21.6 12 PDB header:transferase Chain: A: PDB Molecule:pyruvate transaminase; PDBTitle: crystal structure of omega-transferase from vibrio fluvialis js17 56 c2kseA_ not modelled 20.2 17 PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor qsec, center for structures of3 membrane proteins (csmp) target 4311c 57 c3i24B_ not modelled 19.3 14 PDB header:hydrolase Chain: B: PDB Molecule:hit family hydrolase; PDBTitle: crystal structure of a hit family hydrolase protein from2 vibrio fischeri. northeast structural genomics consortium3 target id vfr176 58 c3oheA_ not modelled 17.3 14 PDB header:hydrolase Chain: A: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad protein (maqu_1709) from2 marinobacter aquaeolei vt8 at 1.20 a resolution 59 c2ylaA_ not modelled 16.2 14 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: inhibition of the pneumococcal virulence factor strh and2 molecular insights into n-glycan recognition and3 hydrolysis 60 c3fosA_ not modelled 15.7 11 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of two-component sensor histidine kinase domain from2 bacillus subtilis subsp. subtilis str. 168 61 d1szwa_ not modelled 15.3 25 Fold:Pseudouridine synthase Superfamily:Pseudouridine synthase Family:tRNA pseudouridine synthase TruD 62 d1jiha2 not modelled 15.2 24 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 63 c1qgeE_ not modelled 15.1 23 PDB header:hydrolase Chain: E: PDB Molecule:protein (triacylglycerol hydrolase); PDBTitle: new crystal form of pseudomonas glumae (formerly chromobacterium2 viscosum atcc 6918) lipase 64 c1sb7A_ not modelled 14.1 26 PDB header:lyase Chain: A: PDB Molecule:trna pseudouridine synthase d; PDBTitle: crystal structure of the e.coli pseudouridine synthase trud 65 d1wdia_ not modelled 13.3 19 Fold:QueA-like Superfamily:QueA-like Family:QueA-like 66 c3iyuY_ not modelled 13.3 20 PDB header:virus Chain: Y: PDB Molecule:outer capsid protein vp4; PDBTitle: atomic model of an infectious rotavirus particle 67 d1w6ta1 not modelled 12.7 14 Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:Enolase 68 d2c0ra1 not modelled 12.6 18 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 69 d1ps9a1 not modelled 12.5 22 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 70 c1t3nB_ not modelled 12.2 29 PDB header:replication/dna Chain: B: PDB Molecule:polymerase (dna directed) iota; PDBTitle: structure of the catalytic core of dna polymerase iota in2 complex with dna and dttp 71 c3nrdB_ not modelled 12.1 17 PDB header:nucleotide binding protein Chain: B: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad (hit) protein (smc02904) from2 sinorhizobium meliloti 1021 at 2.06 a resolution 72 c1ps9A_ not modelled 11.8 24 PDB header:oxidoreductase Chain: A: PDB Molecule:2,4-dienoyl-coa reductase; PDBTitle: the crystal structure and reaction mechanism of e. coli 2,4-2 dienoyl coa reductase 73 c3onqB_ not modelled 11.5 13 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:regulator of polyketide synthase expression; PDBTitle: crystal structure of regulator of polyketide synthase expression2 bad_0249 from bifidobacterium adolescentis 74 c3nvtA_ not modelled 11.5 17 PDB header:transferase/isomerase Chain: A: PDB Molecule:3-deoxy-d-arabino-heptulosonate 7-phosphate synthase; PDBTitle: 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7-2 phosphoheptulonate synthase/chorismate mutase (aroa) from listeria3 monocytogenes egd-e 75 d2incc1 not modelled 10.9 21 Fold:beta-Grasp (ubiquitin-like) Superfamily:TmoB-like Family:TmoB-like 76 d2p7ja2 not modelled 10.8 14 Fold:Profilin-like Superfamily:Sensory domain-like Family:YkuI C-terminal domain-like 77 d2o5aa1 not modelled 10.7 19 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 78 c3rpmA_ not modelled 10.4 14 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetyl-hexosaminidase; PDBTitle: crystal structure of the first gh20 domain of a novel beta-n-acetyl-2 hexosaminidase strh from streptococcus pneumoniae r6 79 c3v4gA_ not modelled 10.3 16 PDB header:dna binding protein Chain: A: PDB Molecule:arginine repressor; PDBTitle: 1.60 angstrom resolution crystal structure of an arginine repressor2 from vibrio vulnificus cmcp6 80 c2h90A_ not modelled 10.2 22 PDB header:oxidoreductase Chain: A: PDB Molecule:xenobiotic reductase a; PDBTitle: xenobiotic reductase a in complex with coumarin 81 d1j27a_ not modelled 10.2 14 Fold:Ferredoxin-like Superfamily:Hypothetical protein TT1725 Family:Hypothetical protein TT1725 82 c3p0tB_ not modelled 10.2 11 PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an hit-like protein from mycobacterium2 paratuberculosis 83 c3imiB_ not modelled 9.9 19 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hit family protein; PDBTitle: 2.01 angstrom resolution crystal structure of a hit family protein2 from bacillus anthracis str. 'ames ancestor' 84 c2zztA_ not modelled 9.7 9 PDB header:transport protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the cytosolic domain of the cation2 diffusion facilitator family protein 85 c3i5tB_ not modelled 9.3 12 PDB header:transferase Chain: B: PDB Molecule:aminotransferase; PDBTitle: crystal structure of aminotransferase prk07036 from rhodobacter2 sphaeroides kd131 86 d1b4ba_ not modelled 9.0 11 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 87 c3hmuA_ not modelled 8.3 14 PDB header:transferase Chain: A: PDB Molecule:aminotransferase, class iii; PDBTitle: crystal structure of a class iii aminotransferase from2 silicibacter pomeroyi 88 c1yy3A_ not modelled 8.3 19 PDB header:isomerase Chain: A: PDB Molecule:s-adenosylmethionine:trna ribosyltransferase- PDBTitle: structure of s-adenosylmethionine:trna ribosyltransferase-2 isomerase (quea) 89 d1zpda1 not modelled 8.2 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 90 c1t94B_ not modelled 7.7 24 PDB header:replication Chain: B: PDB Molecule:polymerase (dna directed) kappa; PDBTitle: crystal structure of the catalytic core of human dna2 polymerase kappa 91 c3v4cB_ not modelled 7.4 15 PDB header:oxidoreductase Chain: B: PDB Molecule:aldehyde dehydrogenase (nadp+); PDBTitle: crystal structure of a semialdehyde dehydrogenase from sinorhizobium2 meliloti 1021 92 c2ordA_ not modelled 7.3 10 PDB header:transferase Chain: A: PDB Molecule:acetylornithine aminotransferase; PDBTitle: crystal structure of acetylornithine aminotransferase (ec 2.6.1.11)2 (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution 93 c3i82A_ not modelled 7.2 13 PDB header:structural protein Chain: A: PDB Molecule:ethanolamine utilization protein eutl; PDBTitle: ethanolamine utilization microcompartment shell subunit, eutl closed2 form 94 c2zomC_ not modelled 6.9 8 PDB header:unknown function Chain: C: PDB Molecule:protein cuta, chloroplast, putative, expressed; PDBTitle: crystal structure of cuta1 from oryza sativa 95 c3dhhC_ not modelled 6.9 17 PDB header:oxidoreductase Chain: C: PDB Molecule:toluene 4-monooxygenase hydroxylase gamma PDBTitle: crystal structure of resting state toluene 4-monoxygenase2 hydroxylase complexed with effector protein 96 c2pfcA_ not modelled 6.7 17 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein rv0098/mt0107; PDBTitle: structure of mycobacterium tuberculosis rv0098 97 d1lxna_ not modelled 6.6 12 Fold:Ferredoxin-like Superfamily:MTH1187/YkoF-like Family:MTH1187-like 98 c3nx3A_ not modelled 6.3 6 PDB header:transferase Chain: A: PDB Molecule:acetylornithine aminotransferase; PDBTitle: crystal structure of acetylornithine aminotransferase (argd) from2 campylobacter jejuni 99 d1s0aa_ not modelled 6.3 11 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0