Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	S	P	K	V	K	F	L	T	I	F	T	F	C	I	F	I	T	K	M	S	F	A	S	N	S	C	S	N	E	A	G	T	M	F	R	I	E	P	N	L	I	K	A	I	A	L	V	E	S	N	L	K	K	D	S	I	G	K
Secondary structure
SS confidence
Disorder		?	?	?																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	R	D	K	N	N	N	I	K	S	L	D	Y	W	L	M	Q	I	N	Q	M	H	I	P	L	L	K	K	R	G	I	I	K	D	E	R	D	L	L	D	N	P	C	L	N	I	K	I	G	T	E	I	L	Y	N	H	F	S	R	C
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.
Sequence		G	V	T	W	Q	C	L	G	T	Y	N	A	G	F	A	M	D	N	Q	K	K	R	Q	Q	Y	A	P	K	Y	I	L	Y	I	P	G	L	M	N
Secondary structure
SS confidence
Disorder																	?	?	?																			?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1sly chain A Region: 17 - 154 Aligned: 129 Modelled: 129 Confidence: 100.0% Identity: 22% PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a Phyre2 PDB 1qsa chain A domain 2 Region: 24 - 154 Aligned: 122 Modelled: 131 Confidence: 100.0% Identity: 22% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 2y8p chain A Region: 24 - 158 Aligned: 126 Modelled: 135 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli Phyre2 PDB 3mgw chain A Region: 24 - 154 Aligned: 111 Modelled: 111 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme Phyre2 PDB 3gxk chain B Region: 24 - 156 Aligned: 121 Modelled: 122 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 Phyre2 PDB 1gbs chain A Region: 24 - 156 Aligned: 113 Modelled: 124 Confidence: 99.9% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: G-type lysozyme Phyre2 PDB 3bkh chain A Region: 26 - 119 Aligned: 86 Modelled: 91 Confidence: 98.4% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 Phyre2 PDB 1qus chain A Region: 24 - 116 Aligned: 92 Modelled: 93 Confidence: 98.4% Identity: 13% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 1gd6 chain A Region: 29 - 83 Aligned: 50 Modelled: 55 Confidence: 98.0% Identity: 34% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1iiz chain A Region: 29 - 83 Aligned: 51 Modelled: 55 Confidence: 97.9% Identity: 27% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2fbd chain B Region: 29 - 83 Aligned: 51 Modelled: 55 Confidence: 97.9% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. Phyre2 PDB 1hhl chain A Region: 29 - 83 Aligned: 49 Modelled: 55 Confidence: 97.7% Identity: 29% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2vb1 chain A domain 1 Region: 29 - 83 Aligned: 49 Modelled: 55 Confidence: 97.7% Identity: 29% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1ghl chain A Region: 29 - 83 Aligned: 49 Modelled: 55 Confidence: 97.6% Identity: 29% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1lsg chain A domain 1 Region: 46 - 83 Aligned: 33 Modelled: 38 Confidence: 97.6% Identity: 36% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2eql chain A Region: 46 - 83 Aligned: 34 Modelled: 38 Confidence: 97.5% Identity: 35% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1jse chain A Region: 46 - 83 Aligned: 33 Modelled: 38 Confidence: 97.4% Identity: 36% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2goi chain C Region: 29 - 80 Aligned: 46 Modelled: 52 Confidence: 97.4% Identity: 15% PDB header:cell adhesion, sugar binding protein Chain: C: PDB Molecule:sperm lysozyme-like protein 1; PDBTitle: crystal structure of mouse sperm c-type lysozyme-like2 protein 1 Phyre2 PDB 1lmq chain A Region: 46 - 80 Aligned: 30 Modelled: 35 Confidence: 97.4% Identity: 33% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1jug chain A Region: 29 - 80 Aligned: 46 Modelled: 52 Confidence: 97.3% Identity: 28% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 1 c1slyA_ 2 d1qsaa2 3 c2y8pA_ 4 c3mgwA_ 5 c3gxkB_ 6 d1gbsa_ 7 c3bkhA_ 8 d1qusa_ 9 d1gd6a_ 10 d1iiza_ 11 c2fbdB_ 12 d1hhla_ 13 d2vb1a1 14 d1ghla_ 15 d1lsga1 16 d2eqla_ 17 d1jsea_ 18 c2goiC_ 19 d1lmqa_ 20 d1juga_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1slyA_ 100.0 22 PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a 2 d1qsaa2 100.0 22 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 3 c2y8pA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli 4 c3mgwA_ 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme 5 c3gxkB_ 99.9 19 PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 6 d1gbsa_ 99.9 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:G-type lysozyme 7 c3bkhA_ 98.4 17 PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 8 d1qusa_ 98.4 13 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 9 d1gd6a_ 98.0 34 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 10 d1iiza_ 97.9 27 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 11 c2fbdB_ 97.9 24 PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. 12 d1hhla_ 97.7 29 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 13 d2vb1a1 97.7 29 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 14 d1ghla_ 97.6 29 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 15 d1lsga1 97.6 36 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 16 d2eqla_ 97.5 35 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 17 d1jsea_ 97.4 36 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 18 c2goiC_ 97.4 15 PDB header:cell adhesion, sugar binding protein Chain: C: PDB Molecule:sperm lysozyme-like protein 1; PDBTitle: crystal structure of mouse sperm c-type lysozyme-like2 protein 1 19 d1lmqa_ 97.4 33 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 20 d1juga_ 97.3 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 21 d1qqya_ not modelled 97.3 32 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 22 c2z2fA_ not modelled 97.2 23 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme c-2; PDBTitle: x-ray crystal structure of bovine stomach lysozyme 23 d1ivma_ not modelled 97.2 26 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 24 c3ct5A_ not modelled 96.9 13 PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail 25 d2nwdx1 not modelled 96.9 35 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 26 d1b9oa_ not modelled 96.7 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 27 d1fkqa_ not modelled 96.7 45 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 28 d1f6sa_ not modelled 96.7 41 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 29 d1yroa1 not modelled 96.6 34 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 30 d1hfxa_ not modelled 96.6 34 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 31 d1alca_ not modelled 96.5 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 32 c1xsfA_ not modelled 96.4 15 PDB header:cell cycle, hydrolase Chain: A: PDB Molecule:probable resuscitation-promoting factor rpfb; PDBTitle: solution structure of a resuscitation promoting factor2 domain from mycobacterium tuberculosis 33 d1xsfa1 not modelled 95.9 15 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:RPF-like 34 c3fi7A_ not modelled 94.8 21 PDB header:hydrolase Chain: A: PDB Molecule:lmo1076 protein; PDBTitle: crystal structure of the autolysin auto (lmo1076) from listeria2 monocytogenes, catalytic domain 35 c2zycA_ not modelled 93.9 14 PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan hydrolase flgj; PDBTitle: crystal structure of peptidoglycan hydrolase from2 sphingomonas sp. a1 36 c3eo5A_ not modelled 93.7 15 PDB header:cell adhesion Chain: A: PDB Molecule:resuscitation-promoting factor rpfb; PDBTitle: crystal structure of the resuscitation promoting factor rpfb 37 c2dqaA_ not modelled 90.1 17 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of tapes japonica lysozyme 38 c3ab6A_ not modelled 87.8 14 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of nag3 bound lysozyme from meretrix lusoria 39 c3csqC_ not modelled 81.8 14 PDB header:hydrolase Chain: C: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall2 degrading enzyme in the bacteriophage phi29 tail 40 c3aq8A_ not modelled 45.4 19 PDB header:oxygen binding Chain: A: PDB Molecule:group 1 truncated hemoglobin; PDBTitle: crystal structure of truncated hemoglobin from tetrahymena pyriformis,2 q46e mutant, fe(iii) form 41 d1idra_ not modelled 45.4 19 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 42 d1dlwa_ not modelled 43.2 14 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 43 c1dlyA_ not modelled 40.7 13 PDB header:oxygen storage/transport Chain: A: PDB Molecule:hemoglobin; PDBTitle: x-ray crystal structure of hemoglobin from the green2 unicellular alga chlamydomonas eugametos 44 d1dlya_ not modelled 40.7 13 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 45 c3k1tA_ not modelled 36.4 20 PDB header:ligase Chain: A: PDB Molecule:glutamate--cysteine ligase gsha; PDBTitle: crystal structure of putative gamma-glutamylcysteine synthetase2 (yp_546622.1) from methylobacillus flagellatus kt at 1.90 a3 resolution 46 c2bmmA_ not modelled 28.2 8 PDB header:oxygen storage/transport Chain: A: PDB Molecule:thermostable hemoglobin from thermobifida fusca; PDBTitle: x-ray structure of a novel thermostable hemoglobin from the2 actinobacterium thermobifida fusca 47 d1nvma1 not modelled 18.0 10 Fold:RuvA C-terminal domain-like Superfamily:post-HMGL domain-like Family:DmpG/LeuA communication domain-like 48 c2kscA_ not modelled 17.6 12 PDB header:unknown function Chain: A: PDB Molecule:cyanoglobin; PDBTitle: solution structure of synechococcus sp. pcc 7002 hemoglobin 49 c2xykB_ not modelled 16.1 15 PDB header:oxygen storage/transport Chain: B: PDB Molecule:2-on-2 hemoglobin; PDBTitle: group ii 2-on-2 hemoglobin from the plant pathogen2 agrobacterium tumefaciens 50 c2k53A_ not modelled 14.1 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:a3dk08 protein; PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9 51 c2yusA_ not modelled 13.7 11 PDB header:transcription Chain: A: PDB Molecule:swi/snf-related matrix-associated actin- PDBTitle: solution structure of the sant domain of human swi/snf-2 related matrix-associated actin-dependent regulator of3 chromatin subfamily c member 1 52 d2coba1 not modelled 13.5 8 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Psq domain 53 d1ux8a_ not modelled 13.3 19 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 54 c2k5eA_ not modelled 13.1 6 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of putative uncharacterized protein2 gsu1278 from methanocaldococcus jannaschii, northeast3 structural genomics consortium (nesg) target gsr195 55 d1bw6a_ not modelled 12.8 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Centromere-binding 56 d2ahra1 not modelled 12.6 14 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:ProC C-terminal domain-like 57 d1yt3a2 not modelled 12.1 17 Fold:SAM domain-like Superfamily:HRDC-like Family:RNase D C-terminal domains 58 d1t56a2 not modelled 11.4 12 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 59 d1s69a_ not modelled 10.9 19 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 60 d1yqga1 not modelled 8.5 13 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:ProC C-terminal domain-like 61 d2jn6a1 not modelled 7.2 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Cgl2762-like 62 d1i36a1 not modelled 7.0 13 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:Conserved hypothetical protein MTH1747 63 c2rn7A_ not modelled 6.8 6 PDB header:unknown function Chain: A: PDB Molecule:is629 orfa; PDBTitle: nmr solution structure of tnpe protein from shigella2 flexneri. northeast structural genomics target sfr125 64 c2elkA_ not modelled 6.8 26 PDB header:transcription Chain: A: PDB Molecule:spcc24b10.08c protein; PDBTitle: solution structure of the sant domain of fission yeast2 spcc24b10.08c protein 65 d1qdva_ not modelled 6.6 6 Fold:POZ domain Superfamily:POZ domain Family:Tetramerization domain of potassium channels 66 d1t1da_ not modelled 6.5 10 Fold:POZ domain Superfamily:POZ domain Family:Tetramerization domain of potassium channels 67 d1hlva1 not modelled 6.2 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Centromere-binding 68 d2cvza1 not modelled 6.2 7 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain 69 d1riqa1 not modelled 6.0 24 Fold:Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Superfamily:Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Family:Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 70 c1yx5A_ not modelled 5.8 42 PDB header:hydrolase Chain: A: PDB Molecule:26s proteasome non-atpase regulatory subunit 4; PDBTitle: solution structure of s5a uim-1/ubiquitin complex 71 c3hbhA_ not modelled 5.7 11 PDB header:hydrolase Chain: A: PDB Molecule:class iv chitinase chia4-pa2; PDBTitle: class iv chitinase structure from picea abies at 2.25a 72 d1ynja1 not modelled 5.7 18 Fold:DCoH-like Superfamily:RBP11-like subunits of RNA polymerase Family:RNA polymerase alpha subunit dimerisation domain 73 d1wj9a2 not modelled 5.3 20 Fold:Ferredoxin-like Superfamily:CRISPR-associated protein Family:CRISPR-associated protein 74 d1smya1 not modelled 5.2 23 Fold:DCoH-like Superfamily:RBP11-like subunits of RNA polymerase Family:RNA polymerase alpha subunit dimerisation domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0