Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	N	K	P	F	H	Y	Q	A	P	F	P	L	K	K	D	D	T	E	Y	Y	L	L	T	S	E	H	V	S	V	S	E	F	E	G	Q	E	I	L	K	V	A	P	E	A	L	T	L	L	A	R	Q	A	F	H	D	A	S	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?												?					?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	L	R	P	A	H	Q	Q	Q	V	A	D	I	L	R	D	P	E	A	S	E	N	D	K	Y	V	A	L	Q	F	L	R	N	S	D	I	A	A	K	G	V	L	P	T	C	Q	D	T	G	T	A	I	I	V	G	K	K	G	Q	R
Secondary structure
SS confidence
Disorder																	?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	W	T	G	G	G	D	E	A	A	L	A	R	G	V	Y	N	T	Y	I	E	D	N	L	R	Y	S	Q	N	A	P	L	D	M	Y	K	E	V	N	T	G	T	N	L	P	A	Q	I	D	L	Y	A	V	D	G	D	E	Y	K	F
Secondary structure
SS confidence
Disorder																																	?		?				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	C	I	A	K	G	G	G	S	A	N	K	T	Y	L	Y	Q	E	T	K	A	L	L	T	P	G	K	L	K	N	Y	L	V	E	K	M	R	T	L	G	T	A	A	C	P	P	Y	H	I	A	F	V	I	G	G	T	S	A	E	T
Secondary structure
SS confidence
Disorder																					?	?	?	?																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	L	K	T	V	K	L	A	S	A	K	Y	Y	D	E	L	P	T	E	G	N	E	H	G	Q	A	F	R	D	V	E	L	E	K	E	L	L	I	E	A	Q	N	L	G	L	G	A	Q	F	G	G	K	Y	F	A	H	D	I	R	V
Secondary structure
SS confidence
Disorder															?	?			?	?	?	?	?	?	?		?																	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	R	L	P	R	H	G	A	S	C	P	V	G	M	G	V	S	C	S	A	D	R	N	I	K	A	K	I	N	R	Q	G	I	W	I	E	K	L	E	H	N	P	G	K	Y	I	P	E	E	L	R	K	A	G	E	G	E	A	V	R
Secondary structure
SS confidence
Disorder																																																						?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	D	L	N	R	P	M	K	E	I	L	A	Q	L	S	Q	Y	P	V	S	T	R	L	S	L	N	G	T	I	I	V	G	R	D	I	A	H	A	K	L	K	E	R	M	D	N	G	E	G	L	P	Q	Y	I	K	D	H	P	I	Y
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Y	A	G	P	A	K	T	P	E	G	Y	A	S	G	S	L	G	P	T	T	A	G	R	M	D	S	Y	V	D	Q	L	Q	A	Q	G	G	S	M	I	M	L	A	K	G	N	R	S	Q	Q	V	T	D	A	C	K	K	H	G	G	F
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Y	L	G	S	I	G	G	P	A	A	V	L	A	Q	G	S	I	K	S	L	E	C	V	E	Y	P	E	L	G	M	E	A	I	W	K	I	E	V	E	D	F	P	A	F	I	L	V	D	D	K	G	N	D	F	F	Q	Q	I	Q	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		T	Q	C	T	R	C	V	K
Secondary structure
SS confidence
Disorder						?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2isb chain A domain 1 Region: 360 - 536 Aligned: 173 Modelled: 177 Confidence: 100.0% Identity: 29% Fold: The "swivelling" beta/beta/alpha domain Superfamily: FumA C-terminal domain-like Family: FumA C-terminal domain-like Phyre2 PDB 2qv6 chain D Region: 187 - 249 Aligned: 53 Modelled: 63 Confidence: 87.6% Identity: 15% PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions Phyre2 PDB 4a1o chain B Region: 446 - 484 Aligned: 39 Modelled: 39 Confidence: 63.6% Identity: 26% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 1pkx chain A domain 2 Region: 446 - 486 Aligned: 40 Modelled: 41 Confidence: 61.2% Identity: 23% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 3p2o chain A Region: 190 - 283 Aligned: 84 Modelled: 91 Confidence: 59.8% Identity: 20% PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni Phyre2 PDB 1ed7 chain A Region: 377 - 393 Aligned: 17 Modelled: 17 Confidence: 58.6% Identity: 18% Fold: WW domain-like Superfamily: Carbohydrate binding domain Family: Carbohydrate binding domain Phyre2 PDB 1zcz chain A Region: 446 - 484 Aligned: 39 Modelled: 39 Confidence: 57.7% Identity: 21% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 3l07 chain B Region: 193 - 283 Aligned: 84 Modelled: 91 Confidence: 51.7% Identity: 20% PDB header:oxidoreductase,hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate2 cyclohydrolase, putative bifunctional protein fold from francisella3 tularensis. Phyre2 PDB 3fpn chain A Region: 364 - 419 Aligned: 56 Modelled: 56 Confidence: 51.7% Identity: 20% PDB header:dna binding protein Chain: A: PDB Molecule:geobacillus stearothermophilus uvra interaction PDBTitle: crystal structure of uvra-uvrb interaction domains Phyre2 PDB 3p2o chain B Region: 205 - 283 Aligned: 72 Modelled: 79 Confidence: 45.7% Identity: 21% PDB header:oxidoreductase, hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni Phyre2 PDB 1g8m chain A domain 2 Region: 446 - 484 Aligned: 39 Modelled: 39 Confidence: 45.3% Identity: 18% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 12as chain A Region: 465 - 507 Aligned: 40 Modelled: 43 Confidence: 43.5% Identity: 23% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain Phyre2 PDB 1thz chain A Region: 446 - 484 Aligned: 39 Modelled: 39 Confidence: 43.3% Identity: 18% PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Phyre2 PDB 1k98 chain A Region: 339 - 419 Aligned: 80 Modelled: 81 Confidence: 40.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:methionine synthase; PDBTitle: adomet complex of meth c-terminal fragment Phyre2 PDB 1yqe chain A domain 1 Region: 107 - 143 Aligned: 37 Modelled: 37 Confidence: 39.8% Identity: 8% Fold: Phosphorylase/hydrolase-like Superfamily: AF0625-like Family: AF0625-like Phyre2 PDB 3p9z chain A Region: 429 - 478 Aligned: 42 Modelled: 50 Confidence: 39.6% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:uroporphyrinogen iii cosynthase (hemd); PDBTitle: crystal structure of uroporphyrinogen-iii synthetase from helicobacter2 pylori 26695 Phyre2 PDB 1zcz chain A domain 2 Region: 446 - 484 Aligned: 39 Modelled: 39 Confidence: 38.5% Identity: 21% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1ei5 chain A domain 2 Region: 312 - 327 Aligned: 16 Modelled: 16 Confidence: 36.8% Identity: 25% Fold: Streptavidin-like Superfamily: D-aminopeptidase, middle and C-terminal domains Family: D-aminopeptidase, middle and C-terminal domains Phyre2 PDB 2vdc chain I Region: 189 - 247 Aligned: 57 Modelled: 59 Confidence: 36.8% Identity: 18% PDB header:oxidoreductase Chain: I: PDB Molecule:glutamate synthase [nadph] small chain; PDBTitle: the 9.5 a resolution structure of glutamate synthase from2 cryo-electron microscopy and its oligomerization behavior3 in solution: functional implications. Phyre2 PDB 2xmo chain B Region: 367 - 406 Aligned: 39 Modelled: 40 Confidence: 36.8% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 Phyre2 1 d2isba1 2 c2qv6D_ 3 c4a1oB_ 4 d1pkxa2 5 c3p2oA_ 6 d1ed7a_ 7 c1zczA_ 8 c3l07B_ 9 c3fpnA_ 10 c3p2oB_ 11 d1g8ma2 12 d12asa_ 13 c1thzA_ 14 c1k98A_ 15 d1yqea1 16 c3p9zA_ 17 d1zcza2 18 d1ei5a2 19 c2vdcI_ 20 c2xmoB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2isba1 100.0 29 Fold:The "swivelling" beta/beta/alpha domain Superfamily:FumA C-terminal domain-like Family:FumA C-terminal domain-like 2 c2qv6D_ 87.6 15 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 3 c4a1oB_ 63.6 26 PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. 4 d1pkxa2 61.2 23 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 5 c3p2oA_ 59.8 20 PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni 6 d1ed7a_ 58.6 18 Fold:WW domain-like Superfamily:Carbohydrate binding domain Family:Carbohydrate binding domain 7 c1zczA_ 57.7 21 PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution 8 c3l07B_ 51.7 20 PDB header:oxidoreductase,hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate2 cyclohydrolase, putative bifunctional protein fold from francisella3 tularensis. 9 c3fpnA_ 51.7 20 PDB header:dna binding protein Chain: A: PDB Molecule:geobacillus stearothermophilus uvra interaction PDBTitle: crystal structure of uvra-uvrb interaction domains 10 c3p2oB_ 45.7 21 PDB header:oxidoreductase, hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni 11 d1g8ma2 45.3 18 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 12 d12asa_ 43.5 23 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 13 c1thzA_ 43.3 18 PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening 14 c1k98A_ 40.0 21 PDB header:transferase Chain: A: PDB Molecule:methionine synthase; PDBTitle: adomet complex of meth c-terminal fragment 15 d1yqea1 39.8 8 Fold:Phosphorylase/hydrolase-like Superfamily:AF0625-like Family:AF0625-like 16 c3p9zA_ 39.6 24 PDB header:ligase Chain: A: PDB Molecule:uroporphyrinogen iii cosynthase (hemd); PDBTitle: crystal structure of uroporphyrinogen-iii synthetase from helicobacter2 pylori 26695 17 d1zcza2 38.5 21 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 18 d1ei5a2 36.8 25 Fold:Streptavidin-like Superfamily:D-aminopeptidase, middle and C-terminal domains Family:D-aminopeptidase, middle and C-terminal domains 19 c2vdcI_ 36.8 18 PDB header:oxidoreductase Chain: I: PDB Molecule:glutamate synthase [nadph] small chain; PDBTitle: the 9.5 a resolution structure of glutamate synthase from2 cryo-electron microscopy and its oligomerization behavior3 in solution: functional implications. 20 c2xmoB_ 36.8 18 PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 21 c2c2xB_ not modelled 34.8 14 PDB header:oxidoreductase Chain: B: PDB Molecule:methylenetetrahydrofolate dehydrogenase- PDBTitle: three dimensional structure of bifunctional2 methylenetetrahydrofolate dehydrogenase-cyclohydrolase3 from mycobacterium tuberculosis 22 d1a4ia2 not modelled 34.8 16 Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Tetrahydrofolate dehydrogenase/cyclohydrolase 23 d3bula2 not modelled 31.8 25 Fold:Flavodoxin-like Superfamily:Cobalamin (vitamin B12)-binding domain Family:Cobalamin (vitamin B12)-binding domain 24 c2gfqC_ not modelled 30.4 9 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:upf0204 protein ph0006; PDBTitle: structure of protein of unknown function ph0006 from pyrococcus2 horikoshii 25 c1jr2A_ not modelled 30.0 24 PDB header:lyase Chain: A: PDB Molecule:uroporphyrinogen-iii synthase; PDBTitle: structure of uroporphyrinogen iii synthase 26 d1jr2a_ not modelled 30.0 24 Fold:HemD-like Superfamily:HemD-like Family:HemD-like 27 c1a4iB_ not modelled 29.2 17 PDB header:oxidoreductase Chain: B: PDB Molecule:methylenetetrahydrofolate dehydrogenase / PDBTitle: human tetrahydrofolate dehydrogenase / cyclohydrolase 28 c2d49A_ not modelled 29.0 24 PDB header:hydrolase Chain: A: PDB Molecule:chitinase c; PDBTitle: solution structure of the chitin-binding domain of2 streptomyces griseus chitinase c 29 d1edza2 not modelled 28.5 8 Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Tetrahydrofolate dehydrogenase/cyclohydrolase 30 c3q3vA_ not modelled 27.6 22 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from campylobacter2 jejuni. 31 c3ibgF_ not modelled 27.5 17 PDB header:hydrolase Chain: F: PDB Molecule:atpase, subunit of the get complex; PDBTitle: crystal structure of aspergillus fumigatus get3 with bound2 adp 32 d2gqba1 not modelled 26.9 35 Fold:RPA2825-like Superfamily:RPA2825-like Family:RPA2825-like 33 d1sf8a_ not modelled 26.0 23 Fold:HSP90 C-terminal domain Superfamily:HSP90 C-terminal domain Family:HSP90 C-terminal domain 34 d1b8aa1 not modelled 25.9 6 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Anticodon-binding domain 35 d1aiwa_ not modelled 25.8 7 Fold:WW domain-like Superfamily:Carbohydrate binding domain Family:Carbohydrate binding domain 36 d1o6aa_ not modelled 25.8 15 Fold:Surface presentation of antigens (SPOA) Superfamily:Surface presentation of antigens (SPOA) Family:Surface presentation of antigens (SPOA) 37 d2gfqa1 not modelled 23.8 9 Fold:Phosphorylase/hydrolase-like Superfamily:AF0625-like Family:AF0625-like 38 d1xmpa_ not modelled 23.5 10 Fold:Flavodoxin-like Superfamily:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Family:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) 39 d2piaa1 not modelled 23.2 0 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like 40 c3trhI_ not modelled 22.6 14 PDB header:lyase Chain: I: PDB Molecule:phosphoribosylaminoimidazole carboxylase PDBTitle: structure of a phosphoribosylaminoimidazole carboxylase catalytic2 subunit (pure) from coxiella burnetii 41 c3cr8C_ not modelled 22.5 30 PDB header:transferase Chain: C: PDB Molecule:sulfate adenylyltranferase, adenylylsulfate PDBTitle: hexameric aps kinase from thiobacillus denitrificans 42 d1goia1 not modelled 22.0 18 Fold:WW domain-like Superfamily:Carbohydrate binding domain Family:Carbohydrate binding domain 43 d1stza2 not modelled 21.5 6 Fold:Profilin-like Superfamily:GAF domain-like Family:HrcA C-terminal domain-like 44 c2iheA_ not modelled 21.3 15 PDB header:dna binding protein Chain: A: PDB Molecule:single-stranded dna-binding protein; PDBTitle: crystal structure of wild-type single-stranded dna binding protein2 from thermus aquaticus 45 d1fnda1 not modelled 21.2 21 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like 46 c4a5oB_ not modelled 20.5 17 PDB header:oxidoreductase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of pseudomonas aeruginosa n5, n10-2 methylenetetrahydrofolate dehydrogenase-cyclohydrolase (fold) 47 d1ni9a_ not modelled 20.4 25 Fold:Carbohydrate phosphatase Superfamily:Carbohydrate phosphatase Family:GlpX-like bacterial fructose-1,6-bisphosphatase 48 d1whka_ not modelled 20.0 17 Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain 49 c3o59X_ not modelled 19.9 46 PDB header:transferase Chain: X: PDB Molecule:dna polymerase ii large subunit; PDBTitle: dna polymerase d large subunit dp2(1-300) from pyrococcus horikoshii 50 c3orsD_ not modelled 19.8 18 PDB header:isomerase,biosynthetic protein Chain: D: PDB Molecule:n5-carboxyaminoimidazole ribonucleotide mutase; PDBTitle: crystal structure of n5-carboxyaminoimidazole ribonucleotide mutase2 from staphylococcus aureus 51 d1v58a1 not modelled 19.7 11 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:DsbC/DsbG C-terminal domain-like 52 c3hjbA_ not modelled 19.6 30 PDB header:isomerase Chain: A: PDB Molecule:glucose-6-phosphate isomerase; PDBTitle: 1.5 angstrom crystal structure of glucose-6-phosphate isomerase from2 vibrio cholerae. 53 d1vkza2 not modelled 19.3 23 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 54 d2cp6a1 not modelled 19.3 15 Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain 55 d2oz4a1 not modelled 19.2 29 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C2 set domains 56 d2eyqa1 not modelled 18.9 6 Fold:SH3-like barrel Superfamily:CarD-like Family:CarD-like 57 d2coza1 not modelled 18.8 16 Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain 58 d1fyba1 not modelled 18.5 13 Fold:Plant proteinase inhibitors Superfamily:Plant proteinase inhibitors Family:Plant proteinase inhibitors 59 c2o2cB_ not modelled 17.9 25 PDB header:isomerase Chain: B: PDB Molecule:glucose-6-phosphate isomerase, glycosomal; PDBTitle: crystal structure of phosphoglucose isomerase from t. brucei2 containing glucose-6-phosphate in the active site 60 d1q50a_ not modelled 17.9 30 Fold:SIS domain Superfamily:SIS domain Family:Phosphoglucose isomerase, PGI 61 c3c00B_ not modelled 17.9 12 PDB header:membrane protein, protein transport Chain: B: PDB Molecule:escu; PDBTitle: crystal structural of the mutated g247t escu/spas c-terminal domain 62 c3t1iC_ not modelled 17.8 26 PDB header:hydrolase Chain: C: PDB Molecule:double-strand break repair protein mre11a; PDBTitle: crystal structure of human mre11: understanding tumorigenic mutations 63 c1t10A_ not modelled 17.8 30 PDB header:isomerase Chain: A: PDB Molecule:glucose-6-phosphate isomerase; PDBTitle: phosphoglucose isomerase from leishmania mexicana in complex with2 substrate d-fructose-6-phosphate 64 c3pr3B_ not modelled 17.7 35 PDB header:isomerase Chain: B: PDB Molecule:glucose-6-phosphate isomerase; PDBTitle: crystal structure of plasmodium falciparum glucose-6-phosphate2 isomerase (pf14_0341) in complex with fructose-6-phosphate 65 c3nbuC_ not modelled 17.6 30 PDB header:isomerase Chain: C: PDB Molecule:glucose-6-phosphate isomerase; PDBTitle: crystal structure of pgi glucosephosphate isomerase 66 c3lerA_ not modelled 17.6 8 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168 67 d2gc6a1 not modelled 17.4 15 Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:Folylpolyglutamate synthetase, C-terminal domain 68 d2buna1 not modelled 17.2 18 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 69 d4sgbi_ not modelled 17.2 19 Fold:Plant proteinase inhibitors Superfamily:Plant proteinase inhibitors Family:Plant proteinase inhibitors 70 d1yrxa1 not modelled 17.1 18 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 71 c3en2A_ not modelled 17.1 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:probable primosomal replication protein n; PDBTitle: three-dimensional structure of the protein prib from2 ralstonia solanacearum at the resolution 2.3a. northeast3 structural genomics consortium target rsr213c. 72 c2crvA_ not modelled 16.9 14 PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-2; PDBTitle: solution structure of c-terminal domain of mitochondrial2 translational initiationfactor 2 73 c2jmbA_ not modelled 16.8 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein atu4866; PDBTitle: solution structure of the protein atu4866 from agrobacterium2 tumefaciens 74 d1wlfa2 not modelled 16.8 15 Fold:Double psi beta-barrel Superfamily:ADC-like Family:Cdc48 N-terminal domain-like 75 d1y1la_ not modelled 16.8 31 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:Phosphotyrosine protein phosphatases I Family:Low-molecular-weight phosphotyrosine protein phosphatases 76 c3fmxX_ not modelled 16.6 22 PDB header:oxidoreductase Chain: X: PDB Molecule:tartrate dehydrogenase/decarboxylase; PDBTitle: crystal structure of tartrate dehydrogenase from pseudomonas2 putida complexed with nadh 77 d2cnda1 not modelled 16.6 25 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like 78 d2byca1 not modelled 16.4 8 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 79 d1hm5a_ not modelled 16.2 35 Fold:SIS domain Superfamily:SIS domain Family:Phosphoglucose isomerase, PGI 80 c4a26B_ not modelled 16.2 15 PDB header:oxidoreductase Chain: B: PDB Molecule:putative c-1-tetrahydrofolate synthase, cytoplasmic; PDBTitle: the crystal structure of leishmania major n5,n10-2 methylenetetrahydrofolate dehydrogenase/cyclohydrolase 81 d1whha_ not modelled 15.9 30 Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain 82 d2al3a1 not modelled 15.9 13 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:UBX domain 83 d1iata_ not modelled 15.8 35 Fold:SIS domain Superfamily:SIS domain Family:Phosphoglucose isomerase, PGI 84 d1pjua1 not modelled 15.8 20 Fold:Plant proteinase inhibitors Superfamily:Plant proteinase inhibitors Family:Plant proteinase inhibitors 85 d1gzda_ not modelled 15.7 35 Fold:SIS domain Superfamily:SIS domain Family:Phosphoglucose isomerase, PGI 86 c1fybA_ not modelled 15.6 17 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:proteinase inhibitor; PDBTitle: solution structure of c1-t1, a two-domain proteinase2 inhibitor derived from the circular precursor protein na-3 propi from nicotiana alata 87 c3k1rA_ not modelled 15.4 17 PDB header:structural protein Chain: A: PDB Molecule:harmonin; PDBTitle: structure of harmonin npdz1 in complex with the sam-pbm of2 sans 88 d1u0fa_ not modelled 15.4 35 Fold:SIS domain Superfamily:SIS domain Family:Phosphoglucose isomerase, PGI 89 c3cyyA_ not modelled 15.1 19 PDB header:peptide binding protein Chain: A: PDB Molecule:tight junction protein zo-1; PDBTitle: the crystal structure of zo-1 pdz2 in complex with the cx43 peptide 90 d1qx4a1 not modelled 15.1 14 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like 91 c2e4hA_ not modelled 15.0 24 PDB header:structural protein Chain: A: PDB Molecule:restin; PDBTitle: solution structure of cytoskeletal protein in complex with2 tubulin tail 92 d1n0ua3 not modelled 15.0 10 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Translational machinery components 93 c2wu8A_ not modelled 14.8 30 PDB header:isomerase Chain: A: PDB Molecule:glucose-6-phosphate isomerase; PDBTitle: structural studies of phosphoglucose isomerase from2 mycobacterium tuberculosis h37rv 94 d1u11a_ not modelled 14.7 19 Fold:Flavodoxin-like Superfamily:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Family:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) 95 c2jlhA_ not modelled 14.7 15 PDB header:protein transport Chain: A: PDB Molecule:yop proteins translocation protein u; PDBTitle: crystal structure of the cytoplasmic domain of yersinia2 pestis yscu n263a mutant 96 d2ix0a3 not modelled 14.5 13 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 97 c3ijfX_ not modelled 14.3 22 PDB header:hydrolase Chain: X: PDB Molecule:cytidine deaminase; PDBTitle: crystal structure of cytidine deaminase from mycobacterium2 tuberculosis 98 d1sm4a1 not modelled 14.2 14 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like 99 d1krha1 not modelled 14.1 21 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:Ferredoxin reductase FAD-binding domain-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0