Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Y	R	Y	L	S	I	A	A	V	V	L	S	A	A	F	S	G	P	A	L	A	E	G	I	N	S	F	S	Q	A	K	A	A	A	V	K	V	H	A	D	A	P	G	T	F	Y	C	G	C	K	I	N	W	Q	G	K	K	G	V
Secondary structure
SS confidence
Disorder		?	?	?															?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	D	L	Q	S	C	G	Y	Q	V	R	K	N	E	N	R	A	S	R	V	E	W	E	H	V	V	P	A	W	Q	F	G	H	Q	R	Q	C	W	Q	D	G	G	R	K	N	C	A	K	D	P	V	Y	R	K	M	E	S	D	M	H
Secondary structure
SS confidence
Disorder								?	?			?	?	?	?	?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	L	Q	P	S	V	G	E	V	N	G	D	R	G	N	F	M	Y	S	Q	W	N	G	G	E	G	Q	Y	G	Q	C	A	M	K	V	D	F	K	E	K	A	A	E	P	P	A	R	A	R	G	A	I	A	R	T	Y	F	Y	M	R
Secondary structure
SS confidence
Disorder																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Sequence		D	Q	Y	N	L	T	L	S	R	Q	Q	T	Q	L	F	N	A	W	N	K	M	Y	P	V	T	D	W	E	C	E	R	D	E	R	I	A	K	V	Q	G	N	H	N	P	Y	V	Q	R	A	C	Q	A	R	K	S
Secondary structure
SS confidence
Disorder																								?																													?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ouo chain A Region: 23 - 230 Aligned: 208 Modelled: 207 Confidence: 100.0% Identity: 63% Fold: His-Me finger endonucleases Superfamily: His-Me finger endonucleases Family: Endonuclease I Phyre2 PDB 2qgp chain A Region: 46 - 141 Aligned: 50 Modelled: 50 Confidence: 93.5% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:hnh endonuclease; PDBTitle: x-ray structure of the nhn endonuclease from geobacter2 metallireducens. northeast structural genomics consortium3 target gmr87. Phyre2 PDB 2ebf chain X domain 3 Region: 203 - 227 Aligned: 19 Modelled: 25 Confidence: 29.5% Identity: 47% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: PMT C-terminal domain like Phyre2 PDB 2e72 chain A Region: 92 - 117 Aligned: 26 Modelled: 26 Confidence: 29.2% Identity: 38% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pogo transposable element with znf domain; PDBTitle: solution structure of the zinc finger domain of human2 kiaa0461 Phyre2 PDB 3c4r chain C Region: 171 - 209 Aligned: 38 Modelled: 39 Confidence: 23.4% Identity: 24% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein encoded by2 cryptic prophage Phyre2 PDB 2ebf chain X domain 1 Region: 171 - 204 Aligned: 34 Modelled: 34 Confidence: 20.9% Identity: 12% Fold: PMT central region-like Superfamily: PMT central region-like Family: PMT central region-like Phyre2 PDB 2lmd chain A Region: 176 - 198 Aligned: 23 Modelled: 23 Confidence: 18.9% Identity: 22% PDB header:transcription Chain: A: PDB Molecule:prospero homeobox protein 1; PDBTitle: minimal constraints solution nmr structure of prospero homeobox2 protein 1 from homo sapiens, northeast structural genomics consortium3 target hr4660b Phyre2 PDB 1mij chain A Region: 176 - 198 Aligned: 23 Modelled: 21 Confidence: 15.7% Identity: 17% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Homeodomain Phyre2 PDB 3gqe chain A Region: 108 - 139 Aligned: 31 Modelled: 32 Confidence: 15.4% Identity: 16% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of venezuelan equine encephalitis2 virus Phyre2 PDB 2evr chain A domain 1 Region: 96 - 126 Aligned: 16 Modelled: 16 Confidence: 14.7% Identity: 38% Fold: SH3-like barrel Superfamily: Prokaryotic SH3-related domain Family: Spr N-terminal domain-like Phyre2 PDB 1tr8 chain A Region: 166 - 177 Aligned: 12 Modelled: 11 Confidence: 13.7% Identity: 17% PDB header:chaperone Chain: A: PDB Molecule:conserved protein (mth177); PDBTitle: crystal structure of archaeal nascent polypeptide-associated complex2 (aenac) Phyre2 PDB 2ec5 chain B Region: 171 - 204 Aligned: 34 Modelled: 34 Confidence: 11.2% Identity: 12% PDB header:toxin Chain: B: PDB Molecule:dermonecrotic toxin; PDBTitle: crystal structures reveal a thiol-protease like catalytic triad in the2 c-terminal region of pasteurella multocida toxin Phyre2 PDB 1em8 chain B Region: 29 - 47 Aligned: 19 Modelled: 19 Confidence: 11.1% Identity: 21% Fold: DNA polymerase III psi subunit Superfamily: DNA polymerase III psi subunit Family: DNA polymerase III psi subunit Phyre2 PDB 1m8o chain B Region: 194 - 229 Aligned: 34 Modelled: 36 Confidence: 10.6% Identity: 26% PDB header:membrane protein Chain: B: PDB Molecule:platele integrin beta3 subunit: cytoplasmic PDBTitle: platelet integrin alfaiib-beta3 cytoplasmic domain Phyre2 PDB 3gpq chain A Region: 110 - 139 Aligned: 29 Modelled: 30 Confidence: 10.6% Identity: 21% PDB header:viral protein/rna Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of chikungunya virus in complex with2 rna Phyre2 PDB 1yc6 chain 1 domain 1 Region: 61 - 87 Aligned: 25 Modelled: 27 Confidence: 9.7% Identity: 28% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Bromoviridae-like VP Phyre2 PDB 2bpb chain B Region: 165 - 198 Aligned: 30 Modelled: 34 Confidence: 9.6% Identity: 10% PDB header:oxidoreductase Chain: B: PDB Molecule:sulfite\:cytochrome c oxidoreductase subunit b; PDBTitle: sulfite dehydrogenase from starkeya novella Phyre2 PDB 3g9w chain C Region: 193 - 229 Aligned: 35 Modelled: 37 Confidence: 9.1% Identity: 20% PDB header:cell adhesion Chain: C: PDB Molecule:integrin beta-1d; PDBTitle: crystal structure of talin2 f2-f3 in complex with the integrin beta1d2 cytoplasmic tail Phyre2 PDB 2bcg chain G domain 3 Region: 85 - 124 Aligned: 26 Modelled: 26 Confidence: 8.4% Identity: 42% Fold: FAD-linked reductases, C-terminal domain Superfamily: FAD-linked reductases, C-terminal domain Family: GDI-like Phyre2 PDB 3t4a chain G Region: 27 - 41 Aligned: 15 Modelled: 15 Confidence: 8.0% Identity: 33% PDB header:immune system Chain: G: PDB Molecule:fibrinogen-binding protein; PDBTitle: structure of a truncated form of staphylococcal complement inhibitor b2 bound to human c3c at 3.4 angstrom resolution Phyre2 1 d1ouoa_ 2 c2qgpA_ 3 d2ebfx3 4 c2e72A_ 5 c3c4rC_ 6 d2ebfx1 7 c2lmdA_ 8 d1mija_ 9 c3gqeA_ 10 d2evra1 11 c1tr8A_ 12 c2ec5B_ 13 d1em8b_ 14 c1m8oB_ 15 c3gpqA_ 16 d1yc611 17 c2bpbB_ 18 c3g9wC_ 19 d2bcgg3 20 c3t4aG_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1ouoa_ 100.0 63 Fold:His-Me finger endonucleases Superfamily:His-Me finger endonucleases Family:Endonuclease I 2 c2qgpA_ 93.5 32 PDB header:hydrolase Chain: A: PDB Molecule:hnh endonuclease; PDBTitle: x-ray structure of the nhn endonuclease from geobacter2 metallireducens. northeast structural genomics consortium3 target gmr87. 3 d2ebfx3 29.5 47 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:PMT C-terminal domain like 4 c2e72A_ 29.2 38 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pogo transposable element with znf domain; PDBTitle: solution structure of the zinc finger domain of human2 kiaa0461 5 c3c4rC_ 23.4 24 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein encoded by2 cryptic prophage 6 d2ebfx1 20.9 12 Fold:PMT central region-like Superfamily:PMT central region-like Family:PMT central region-like 7 c2lmdA_ 18.9 22 PDB header:transcription Chain: A: PDB Molecule:prospero homeobox protein 1; PDBTitle: minimal constraints solution nmr structure of prospero homeobox2 protein 1 from homo sapiens, northeast structural genomics consortium3 target hr4660b 8 d1mija_ 15.7 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Homeodomain 9 c3gqeA_ 15.4 16 PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of venezuelan equine encephalitis2 virus 10 d2evra1 14.7 38 Fold:SH3-like barrel Superfamily:Prokaryotic SH3-related domain Family:Spr N-terminal domain-like 11 c1tr8A_ 13.7 17 PDB header:chaperone Chain: A: PDB Molecule:conserved protein (mth177); PDBTitle: crystal structure of archaeal nascent polypeptide-associated complex2 (aenac) 12 c2ec5B_ 11.2 12 PDB header:toxin Chain: B: PDB Molecule:dermonecrotic toxin; PDBTitle: crystal structures reveal a thiol-protease like catalytic triad in the2 c-terminal region of pasteurella multocida toxin 13 d1em8b_ 11.1 21 Fold:DNA polymerase III psi subunit Superfamily:DNA polymerase III psi subunit Family:DNA polymerase III psi subunit 14 c1m8oB_ 10.6 26 PDB header:membrane protein Chain: B: PDB Molecule:platele integrin beta3 subunit: cytoplasmic PDBTitle: platelet integrin alfaiib-beta3 cytoplasmic domain 15 c3gpqA_ 10.6 21 PDB header:viral protein/rna Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of chikungunya virus in complex with2 rna 16 d1yc611 9.7 28 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Bromoviridae-like VP 17 c2bpbB_ 9.6 10 PDB header:oxidoreductase Chain: B: PDB Molecule:sulfite\:cytochrome c oxidoreductase subunit b; PDBTitle: sulfite dehydrogenase from starkeya novella 18 c3g9wC_ 9.1 20 PDB header:cell adhesion Chain: C: PDB Molecule:integrin beta-1d; PDBTitle: crystal structure of talin2 f2-f3 in complex with the integrin beta1d2 cytoplasmic tail 19 d2bcgg3 8.4 42 Fold:FAD-linked reductases, C-terminal domain Superfamily:FAD-linked reductases, C-terminal domain Family:GDI-like 20 c3t4aG_ 8.0 33 PDB header:immune system Chain: G: PDB Molecule:fibrinogen-binding protein; PDBTitle: structure of a truncated form of staphylococcal complement inhibitor b2 bound to human c3c at 3.4 angstrom resolution 21 d1js9c_ not modelled 7.8 28 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Bromoviridae-like VP 22 d1i5za1 not modelled 7.8 20 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:CAP C-terminal domain-like 23 d1qbaa2 not modelled 7.7 18 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Carbohydrate-binding domain Family:Bacterial chitobiase, n-terminal domain 24 d2dk1a1 not modelled 7.6 18 Fold:WW domain-like Superfamily:WW domain Family:WW domain 25 c2a45L_ not modelled 7.5 25 PDB header:hydrolase/hydrolase inhibitor Chain: L: PDB Molecule:fibrinogen gamma chain; PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin 26 c3gnzP_ not modelled 7.5 50 PDB header:toxin Chain: P: PDB Molecule:25 kda protein elicitor; PDBTitle: toxin fold for microbial attack and plant defense 27 c3bunB_ not modelled 7.3 24 PDB header:ligase/signaling protein Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl; PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4 28 c2cblA_ not modelled 7.0 24 PDB header:complex (proto-oncogene/peptide) Chain: A: PDB Molecule:proto-oncogene cbl; PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70 29 d1yy9a4 not modelled 6.9 30 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Growth factor receptor domain Family:Growth factor receptor domain 30 c2qffA_ not modelled 6.8 27 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of staphylococcal complement inhibitor 31 d1cwpa_ not modelled 6.7 56 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Bromoviridae-like VP 32 c3st1A_ not modelled 6.3 40 PDB header:toxin Chain: A: PDB Molecule:necrosis-and ethylene-inducing protein; PDBTitle: crystal structure of necrosis and ethylene inducing protein 2 from the2 causal agent of cocoa's witches broom disease 33 c3nzqB_ not modelled 6.2 32 PDB header:lyase Chain: B: PDB Molecule:biosynthetic arginine decarboxylase; PDBTitle: crystal structure of biosynthetic arginine decarboxylase adc (spea)2 from escherichia coli, northeast structural genomics consortium3 target er600 34 c2kncB_ not modelled 6.1 27 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 35 c2y69S_ not modelled 6.0 43 PDB header:electron transport Chain: S: PDB Molecule:cytochrome c oxidase subunit 5b; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular2 oxygen 36 d1d5ta2 not modelled 6.0 35 Fold:FAD-linked reductases, C-terminal domain Superfamily:FAD-linked reductases, C-terminal domain Family:GDI-like 37 d3buxb2 not modelled 6.0 17 Fold:N-cbl like Superfamily:N-terminal domain of cbl (N-cbl) Family:N-terminal domain of cbl (N-cbl) 38 d2gaua1 not modelled 5.9 20 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:CAP C-terminal domain-like 39 c2yqfA_ not modelled 5.9 23 PDB header:protein binding Chain: A: PDB Molecule:ankyrin-1; PDBTitle: solution structure of the death domain of ankyrin-1 40 d1cwva5 not modelled 5.8 22 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Invasin/intimin cell-adhesion fragment, C-terminal domain 41 c1cwpB_ not modelled 5.7 56 PDB header:virus/rna Chain: B: PDB Molecule:coat protein; PDBTitle: structures of the native and swollen forms of cowpea2 chlorotic mottle virus determined by x-ray crystallography3 and cryo-electron microscopy 42 c1hp9A_ not modelled 5.7 60 PDB header:toxin Chain: A: PDB Molecule:kappa-hefutoxin 1; PDBTitle: kappa-hefutoxins: a novel class of potassium channel toxins2 from scorpion venom 43 d1pbya1 not modelled 5.3 13 Fold:Cytochrome c Superfamily:Cytochrome c Family:Quinohemoprotein amine dehydrogenase A chain, domains 1 and 2 44 c3rnvA_ not modelled 5.2 13 PDB header:hydrolase Chain: A: PDB Molecule:helper component proteinase; PDBTitle: structure of the autocatalytic cysteine protease domain of potyvirus2 helper-component proteinase 45 c2q4pA_ not modelled 5.0 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:protein rs21-c6; PDBTitle: ensemble refinement of the crystal structure of protein from mus2 musculus mm.29898

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0