Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	S	L	T	T	A	L	E	N	L	L	R	H	L	S	Q	E	I	P	A	T	P	G	I	R	V	I	D	I	P	F	P	L	K	D	A	F	D	A	L	S	W	L	A	S	Q	Q	T	Y	P	Q	F	Y	W	Q	Q	R	N	G
Secondary structure
SS confidence
Disorder		?	?	?															?	?				?		?								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	E	E	A	V	V	L	G	A	I	T	R	F	T	S	L	D	Q	A	Q	R	F	L	R	Q	H	P	E	H	A	D	L	R	I	W	G	L	N	A	F	D	P	S	Q	G	N	L	L	L	P	R	L	E	W	R	R	C	G	G	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	T	L	R	L	T	L	F	S	E	S	S	L	Q	H	D	A	I	Q	A	K	E	F	I	A	T	L	V	S	I	K	P	L	P	G	L	H	L	T	T	T	R	E	Q	H	W	P	D	K	T	G	W	T	Q	L	I	E	L	A	T
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	T	I	A	E	G	E	L	D	K	V	V	L	A	R	A	T	D	L	H	F	A	S	P	V	N	A	A	A	M	M	A	A	S	R	R	L	N	L	N	C	Y	H	F	Y	M	A	F	D	G	E	N	A	F	L	G	S	S	P	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	L	W	R	R	R	D	K	A	L	R	T	E	A	L	A	G	T	V	A	N	N	P	D	D	K	Q	A	Q	Q	L	G	E	W	L	M	A	D	D	K	N	Q	R	E	N	M	L	V	V	E	D	I	C	Q	R	L	Q	A	D	T
Secondary structure
SS confidence
Disorder																								?												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	T	L	D	V	L	P	P	Q	V	L	R	L	R	K	V	Q	H	L	R	R	C	I	W	T	S	L	N	K	A	D	D	V	I	C	L	H	Q	L	Q	P	T	A	A	V	A	G	L	P	R	D	L	A	R	Q	F	I	A	R	H
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	P	F	T	R	E	W	Y	A	G	S	A	G	Y	L	S	L	Q	Q	S	E	F	C	V	S	L	R	S	A	K	I	S	G	N	V	V	R	L	Y	A	G	A	G	I	V	R	G	S	D	P	E	Q	E	W	Q	E	I	D	N	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.
Sequence		A	A	G	L	R	T	L	L	Q	M	E
Secondary structure
SS confidence
Disorder									?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3bzn chain A domain 1 Region: 2 - 429 Aligned: 428 Modelled: 428 Confidence: 100.0% Identity: 100% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3gse chain A Region: 3 - 424 Aligned: 419 Modelled: 422 Confidence: 100.0% Identity: 53% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 3hwo chain B Region: 45 - 430 Aligned: 361 Modelled: 362 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 2g5f chain A domain 1 Region: 29 - 430 Aligned: 385 Modelled: 396 Confidence: 100.0% Identity: 23% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1qdl chain A Region: 29 - 431 Aligned: 382 Modelled: 386 Confidence: 100.0% Identity: 23% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3os6 chain A Region: 42 - 431 Aligned: 355 Modelled: 354 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 2fn0 chain A domain 1 Region: 28 - 430 Aligned: 367 Modelled: 371 Confidence: 100.0% Identity: 25% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i1q chain A Region: 22 - 430 Aligned: 404 Modelled: 409 Confidence: 100.0% Identity: 21% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i7q chain A Region: 21 - 430 Aligned: 405 Modelled: 409 Confidence: 100.0% Identity: 22% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2i6y chain A Region: 31 - 428 Aligned: 369 Modelled: 396 Confidence: 100.0% Identity: 24% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 3h9m chain A Region: 39 - 429 Aligned: 348 Modelled: 372 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase,2 component i from cytophaga hutchinsonii Phyre2 PDB 3r74 chain B Region: 39 - 431 Aligned: 374 Modelled: 393 Confidence: 100.0% Identity: 19% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 1k0g chain A Region: 23 - 429 Aligned: 365 Modelled: 381 Confidence: 100.0% Identity: 19% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3nqk chain A Region: 366 - 401 Aligned: 36 Modelled: 36 Confidence: 30.8% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 1eyb chain A Region: 247 - 264 Aligned: 18 Modelled: 18 Confidence: 19.2% Identity: 11% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: Homogentisate dioxygenase Phyre2 PDB 1ey2 chain A Region: 247 - 264 Aligned: 18 Modelled: 18 Confidence: 19.2% Identity: 11% PDB header:oxidoreductase Chain: A: PDB Molecule:homogentisate 1,2-dioxygenase; PDBTitle: human homogentisate dioxygenase with fe(ii) Phyre2 PDB 1hxr chain A Region: 370 - 386 Aligned: 17 Modelled: 17 Confidence: 18.7% Identity: 29% Fold: Mss4-like Superfamily: Mss4-like Family: RabGEF Mss4 Phyre2 PDB 2fu5 chain A domain 1 Region: 370 - 386 Aligned: 17 Modelled: 17 Confidence: 17.9% Identity: 29% Fold: Mss4-like Superfamily: Mss4-like Family: RabGEF Mss4 Phyre2 PDB 2ffc chain A domain 1 Region: 343 - 428 Aligned: 82 Modelled: 81 Confidence: 17.0% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Decarboxylase Phyre2 PDB 3fuy chain C Region: 384 - 431 Aligned: 44 Modelled: 48 Confidence: 14.2% Identity: 36% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:putative integron gene cassette protein; PDBTitle: structure from the mobile metagenome of cole harbour salt2 marsh: integron cassette protein hfx_cass1 Phyre2 1 d3bzna1 2 c3gseA_ 3 c3hwoB_ 4 d2g5fa1 5 d1qdla_ 6 c3os6A_ 7 d2fn0a1 8 d1i1qa_ 9 d1i7qa_ 10 c2i6yA_ 11 c3h9mA_ 12 c3r74B_ 13 d1k0ga_ 14 c3nqkA_ 15 d1eyba_ 16 c1ey2A_ 17 d1hxra_ 18 d2fu5a1 19 d2ffca1 20 c3fuyC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d3bzna1 100.0 100 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 2 c3gseA_ 100.0 53 PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 3 c3hwoB_ 100.0 26 PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate 4 d2g5fa1 100.0 23 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 5 d1qdla_ 100.0 23 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 6 c3os6A_ 100.0 26 PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. 7 d2fn0a1 100.0 25 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 8 d1i1qa_ 100.0 21 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 9 d1i7qa_ 100.0 22 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 10 c2i6yA_ 100.0 24 PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti 11 c3h9mA_ 100.0 19 PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase,2 component i from cytophaga hutchinsonii 12 c3r74B_ 100.0 19 PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 13 d1k0ga_ 100.0 19 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 14 c3nqkA_ 30.8 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution 15 d1eyba_ 19.2 11 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:Homogentisate dioxygenase 16 c1ey2A_ 19.2 11 PDB header:oxidoreductase Chain: A: PDB Molecule:homogentisate 1,2-dioxygenase; PDBTitle: human homogentisate dioxygenase with fe(ii) 17 d1hxra_ 18.7 29 Fold:Mss4-like Superfamily:Mss4-like Family:RabGEF Mss4 18 d2fu5a1 17.9 29 Fold:Mss4-like Superfamily:Mss4-like Family:RabGEF Mss4 19 d2ffca1 17.0 17 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Decarboxylase 20 c3fuyC_ 14.2 36 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:putative integron gene cassette protein; PDBTitle: structure from the mobile metagenome of cole harbour salt2 marsh: integron cassette protein hfx_cass1 21 d2nwua1 not modelled 12.7 12 Fold:RL5-like Superfamily:RL5-like Family:SSO1042-like 22 d1d5ta2 not modelled 11.6 36 Fold:FAD-linked reductases, C-terminal domain Superfamily:FAD-linked reductases, C-terminal domain Family:GDI-like 23 c3ci9B_ not modelled 10.3 26 PDB header:transcription Chain: B: PDB Molecule:heat shock factor-binding protein 1; PDBTitle: crystal structure of the human hsbp1 24 d1ji8a_ not modelled 9.7 26 Fold:DsrC, the gamma subunit of dissimilatory sulfite reductase Superfamily:DsrC, the gamma subunit of dissimilatory sulfite reductase Family:DsrC, the gamma subunit of dissimilatory sulfite reductase 25 c1wxnA_ not modelled 9.2 46 PDB header:toxin Chain: A: PDB Molecule:toxin apetx2; PDBTitle: solution structure of apetx2, a specific peptide inhibitor2 of asic3 proton-gated channels 26 c2km1A_ not modelled 8.7 17 PDB header:protein binding Chain: A: PDB Molecule:protein dre2; PDBTitle: solution structure of the n-terminal domain of the yeast protein dre2 27 c3c66B_ not modelled 8.7 23 PDB header:transferase Chain: B: PDB Molecule:poly(a) polymerase; PDBTitle: yeast poly(a) polymerase in complex with fip1 residues 80-105 28 d1aopa2 not modelled 8.7 13 Fold:Ferredoxin-like Superfamily:Nitrite/Sulfite reductase N-terminal domain-like Family:Duplicated SiR/NiR-like domains 1 and 3 29 c3ol4B_ not modelled 8.6 38 PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium smegmatis, an ortholog of rv0543c 30 d2ch5a2 not modelled 8.5 13 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:BadF/BadG/BcrA/BcrD-like 31 c2z1tA_ not modelled 7.9 19 PDB header:lyase Chain: A: PDB Molecule:hydrogenase expression/formation protein hype; PDBTitle: crystal structure of hydrogenase maturation protein hype 32 c1wqkA_ not modelled 7.9 54 PDB header:toxin Chain: A: PDB Molecule:toxin apetx1; PDBTitle: solution structure of apetx1, a specific peptide inhibitor2 of human ether-a-go-go-related gene potassium channels3 from the venom of the sea anemone anthopleura4 elegantissima: a new fold for an herg toxin 33 c2zkrf_ not modelled 7.4 20 PDB header:ribosomal protein/rna Chain: F: PDB Molecule:rna expansion segment es7 part iii; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 34 c3rpdB_ not modelled 7.0 19 PDB header:transferase Chain: B: PDB Molecule:methionine synthase (b12-independent); PDBTitle: the structure of a b12-independent methionine synthase from shewanella2 sp. w3-18-1 in complex with selenomethionine. 35 c1s1iG_ not modelled 6.9 16 PDB header:ribosome Chain: G: PDB Molecule:60s ribosomal protein l8-a; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from2 yeast obtained by docking atomic models for rna and protein3 components into a 11.7 a cryo-em map. this file, 1s1i,4 contains 60s subunit. the 40s ribosomal subunit is in file5 1s1h. 36 d2bcgg3 not modelled 6.8 21 Fold:FAD-linked reductases, C-terminal domain Superfamily:FAD-linked reductases, C-terminal domain Family:GDI-like 37 c3izcH_ not modelled 6.1 16 PDB header:ribosome Chain: H: PDB Molecule:60s ribosomal protein rpl8 (l7ae); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 38 c3rrrB_ not modelled 6.0 45 PDB header:viral protein Chain: B: PDB Molecule:fusion glycoprotein f0; PDBTitle: structure of the rsv f protein in the post-fusion conformation 39 c3t6mA_ not modelled 6.0 7 PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of the catalytic domain of dape protein from2 v.cholerea in the zn bound form 40 c4a1eF_ not modelled 5.7 22 PDB header:ribosome Chain: F: PDB Molecule:rpl7a; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna, 5.8s rrna3 and proteins of molecule 1 41 d2c1wa1 not modelled 5.6 50 Fold:EndoU-like Superfamily:EndoU-like Family:Eukaryotic EndoU ribonuclease 42 c3dwlG_ not modelled 5.6 14 PDB header:structural protein Chain: G: PDB Molecule:actin-related protein 2/3 complex subunit 5; PDBTitle: crystal structure of fission yeast arp2/3 complex lacking the arp22 subunit 43 c3fhdA_ not modelled 5.5 13 PDB header:hydrolase Chain: A: PDB Molecule:orf 37; PDBTitle: crystal structure of the shutoff and exonuclease protein from kaposis2 sarcoma associated herpesvirus 44 d2fkia1 not modelled 5.5 14 Fold:Secretion chaperone-like Superfamily:YjbR-like Family:YjbR-like 45 d1ydua1 not modelled 5.1 7 Fold:At5g01610-like Superfamily:At5g01610-like Family:At5g01610-like 46 c2kvcA_ not modelled 5.1 24 PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution structure of the mycobacterium tuberculosis protein rv0543c,2 a member of the duf3349 superfamily. seattle structural genomics3 center for infectious disease target mytud.17112.a

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0