Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	A	L	L	L	E	K	L	E	G	Q	L	A	T	L	R	Q	R	C	A	P	V	S	Q	F	A	T	L	S	A	R	F	D	R	H	L	F	Q	T	R	A	T	T	L	Q	A	C	L	D	E	A	G	D	N	L	A	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?																					?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	H	A	V	E	Q	Q	Q	L	P	Q	V	A	W	L	A	E	H	L	A	A	Q	L	E	A	I	A	R	E	A	S	A	W	S	L	R	E	W	D	S	A	P	P	K	I	A	R	W	Q	R	K	R	I	Q	H	Q	D	F	E	R
Secondary structure
SS confidence
Disorder					?	?	?	?	?																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.
Sequence		R	L	R	E	M	V	A	E	R	R	A	R	L	A	R	V	T	D	L	V	E	Q	Q	T	L	H	R	E	V	E	A	Y	E	A	R	L	A	R	C	R	H	A	L	E	K	I	E	N	R	L	A	R	L	T	R
Secondary structure
SS confidence
Disorder																?	?	?	?																																			?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2osz chain A Region: 145 - 171 Aligned: 27 Modelled: 27 Confidence: 57.0% Identity: 33% PDB header:structural protein Chain: A: PDB Molecule:nucleoporin p58/p45; PDBTitle: structure of nup58/45 suggests flexible nuclear pore diameter by2 intermolecular sliding Phyre2 PDB 1ei3 chain C Region: 52 - 170 Aligned: 112 Modelled: 114 Confidence: 27.9% Identity: 10% PDB header: PDB COMPND: Phyre2 PDB 1deq chain F Region: 48 - 170 Aligned: 109 Modelled: 123 Confidence: 17.6% Identity: 9% PDB header: PDB COMPND: Phyre2 PDB 3oja chain B Region: 40 - 174 Aligned: 130 Modelled: 130 Confidence: 17.0% Identity: 16% PDB header:protein binding Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein PDBTitle: crystal structure of lrim1/apl1c complex Phyre2 PDB 3u59 chain C Region: 77 - 174 Aligned: 95 Modelled: 98 Confidence: 15.3% Identity: 7% PDB header:contractile protein Chain: C: PDB Molecule:tropomyosin beta chain; PDBTitle: n-terminal 98-aa fragment of smooth muscle tropomyosin beta Phyre2 PDB 1deq chain O Region: 110 - 174 Aligned: 63 Modelled: 65 Confidence: 14.4% Identity: 11% PDB header: PDB COMPND: Phyre2 PDB 2wuk chain D Region: 23 - 70 Aligned: 48 Modelled: 48 Confidence: 14.3% Identity: 6% PDB header:cell cycle Chain: D: PDB Molecule:septum site-determining protein diviva; PDBTitle: diviva n-terminal domain, f17a mutant Phyre2 PDB 2xus chain A Region: 153 - 173 Aligned: 21 Modelled: 21 Confidence: 13.5% Identity: 24% PDB header:protein binding Chain: A: PDB Molecule:breast cancer metastasis-suppressor 1; PDBTitle: crystal structure of the brms1 n-terminal region Phyre2 PDB 1k1f chain A Region: 149 - 172 Aligned: 24 Modelled: 24 Confidence: 13.0% Identity: 21% Fold: Bcr-Abl oncoprotein oligomerization domain Superfamily: Bcr-Abl oncoprotein oligomerization domain Family: Bcr-Abl oncoprotein oligomerization domain Phyre2 PDB 3cwg chain A Region: 41 - 175 Aligned: 129 Modelled: 135 Confidence: 10.9% Identity: 7% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 2efr chain B Region: 7 - 175 Aligned: 151 Modelled: 154 Confidence: 10.3% Identity: 11% PDB header:contractile protein Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain; PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution Phyre2 PDB 3plt chain B Region: 78 - 175 Aligned: 94 Modelled: 98 Confidence: 10.2% Identity: 14% PDB header:structural protein Chain: B: PDB Molecule:sphingolipid long chain base-responsive protein lsp1; PDBTitle: crystal structure of lsp1 from saccharomyces cerevisiae Phyre2 PDB 2gl2 chain B Region: 79 - 174 Aligned: 93 Modelled: 96 Confidence: 9.2% Identity: 13% PDB header:cell adhesion Chain: B: PDB Molecule:adhesion a; PDBTitle: crystal structure of the tetra muntant (t66g,r67g,f68g,2 y69g) of bacterial adhesin fada Phyre2 PDB 2gts chain A domain 1 Region: 7 - 52 Aligned: 46 Modelled: 46 Confidence: 7.7% Identity: 24% Fold: Ferritin-like Superfamily: HP0062-like Family: HP0062-like Phyre2 PDB 1ykh chain B domain 1 Region: 40 - 139 Aligned: 96 Modelled: 100 Confidence: 6.2% Identity: 13% Fold: Mediator hinge subcomplex-like Superfamily: Mediator hinge subcomplex-like Family: CSE2-like Phyre2 PDB 2x6p chain B Region: 143 - 167 Aligned: 25 Modelled: 25 Confidence: 5.9% Identity: 32% PDB header:de novo protein Chain: B: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c Phyre2 PDB 2x6p chain A Region: 143 - 167 Aligned: 25 Modelled: 25 Confidence: 5.9% Identity: 32% PDB header:de novo protein Chain: A: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c Phyre2 PDB 1sdi chain A Region: 1 - 49 Aligned: 46 Modelled: 46 Confidence: 5.7% Identity: 9% Fold: YcfC-like Superfamily: YcfC-like Family: YcfC-like Phyre2 PDB 2x6p chain C Region: 143 - 168 Aligned: 26 Modelled: 26 Confidence: 5.5% Identity: 31% PDB header:de novo protein Chain: C: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c Phyre2 PDB 1gs9 chain A Region: 5 - 134 Aligned: 129 Modelled: 130 Confidence: 5.3% Identity: 15% Fold: Four-helical up-and-down bundle Superfamily: Apolipoprotein Family: Apolipoprotein Phyre2 1 c2oszA_ 2 c1ei3C_ 3 c1deqF_ 4 c3ojaB_ 5 c3u59C_ 6 c1deqO_ 7 c2wukD_ 8 c2xusA_ 9 d1k1fa_ 10 c3cwgA_ 11 c2efrB_ 12 c3pltB_ 13 c2gl2B_ 14 d2gtsa1 15 d1ykhb1 16 c2x6pB_ 17 c2x6pA_ 18 d1sdia_ 19 c2x6pC_ 20 d1gs9a_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2oszA_ 57.0 33 PDB header:structural protein Chain: A: PDB Molecule:nucleoporin p58/p45; PDBTitle: structure of nup58/45 suggests flexible nuclear pore diameter by2 intermolecular sliding 2 c1ei3C_ 27.9 10 PDB header: PDB COMPND: 3 c1deqF_ 17.6 9 PDB header: PDB COMPND: 4 c3ojaB_ 17.0 16 PDB header:protein binding Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein PDBTitle: crystal structure of lrim1/apl1c complex 5 c3u59C_ 15.3 7 PDB header:contractile protein Chain: C: PDB Molecule:tropomyosin beta chain; PDBTitle: n-terminal 98-aa fragment of smooth muscle tropomyosin beta 6 c1deqO_ 14.4 11 PDB header: PDB COMPND: 7 c2wukD_ 14.3 6 PDB header:cell cycle Chain: D: PDB Molecule:septum site-determining protein diviva; PDBTitle: diviva n-terminal domain, f17a mutant 8 c2xusA_ 13.5 24 PDB header:protein binding Chain: A: PDB Molecule:breast cancer metastasis-suppressor 1; PDBTitle: crystal structure of the brms1 n-terminal region 9 d1k1fa_ 13.0 21 Fold:Bcr-Abl oncoprotein oligomerization domain Superfamily:Bcr-Abl oncoprotein oligomerization domain Family:Bcr-Abl oncoprotein oligomerization domain 10 c3cwgA_ 10.9 7 PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment 11 c2efrB_ 10.3 11 PDB header:contractile protein Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain; PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution 12 c3pltB_ 10.2 14 PDB header:structural protein Chain: B: PDB Molecule:sphingolipid long chain base-responsive protein lsp1; PDBTitle: crystal structure of lsp1 from saccharomyces cerevisiae 13 c2gl2B_ 9.2 13 PDB header:cell adhesion Chain: B: PDB Molecule:adhesion a; PDBTitle: crystal structure of the tetra muntant (t66g,r67g,f68g,2 y69g) of bacterial adhesin fada 14 d2gtsa1 7.7 24 Fold:Ferritin-like Superfamily:HP0062-like Family:HP0062-like 15 d1ykhb1 6.2 13 Fold:Mediator hinge subcomplex-like Superfamily:Mediator hinge subcomplex-like Family:CSE2-like 16 c2x6pB_ 5.9 32 PDB header:de novo protein Chain: B: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c 17 c2x6pA_ 5.9 32 PDB header:de novo protein Chain: A: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c 18 d1sdia_ 5.7 9 Fold:YcfC-like Superfamily:YcfC-like Family:YcfC-like 19 c2x6pC_ 5.5 31 PDB header:de novo protein Chain: C: PDB Molecule:coil ser l19c; PDBTitle: crystal structure of coil ser l19c 20 d1gs9a_ 5.3 15 Fold:Four-helical up-and-down bundle Superfamily:Apolipoprotein Family:Apolipoprotein

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0