Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	L	Q	N	E	K	N	S	R	Y	L	L	R	D	W	K	P	E	N	P	A	F	W	E	N	K	G	K	H	I	A	R	R	N	L	W	I	S	V	S	C	L	L	L	A	F	C	V	W	M	L	F	S	A	V	T	V	N	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?								?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	K	I	G	F	N	F	T	T	D	Q	L	F	L	L	T	A	L	P	S	V	S	G	A	L	L	R	V	P	Y	S	F	M	V	P	I	F	G	G	R	R	W	T	V	F	S	T	A	I	L	I	I	P	C	V	W	L	G	I	A
Secondary structure
SS confidence
Disorder			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	Q	N	P	N	T	P	F	G	I	F	I	V	I	A	L	L	C	G	F	A	G	A	N	F	A	S	S	M	G	N	I	S	F	F	F	P	K	A	K	Q	G	S	A	L	G	I	N	G	G	L	G	N	L	G	V	S	V	M	Q
Secondary structure
SS confidence
Disorder			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	V	A	P	L	V	I	F	V	P	V	F	A	F	L	G	V	N	G	V	P	Q	A	D	G	S	V	M	S	L	A	N	A	A	W	I	W	V	P	L	L	A	I	A	T	I	A	A	W	S	G	M	N	D	I	A	S	S	R	A
Secondary structure
SS confidence
Disorder																																															?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	I	A	D	Q	L	P	V	L	Q	R	L	H	L	W	L	L	S	L	L	Y	L	A	T	F	G	S	F	I	G	F	S	A	G	F	A	M	L	A	K	T	Q	F	P	D	V	N	I	L	R	L	A	F	F	G	P	F	I	G	A
Secondary structure
SS confidence
Disorder		?																																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	A	R	S	V	G	G	A	I	S	D	K	F	G	G	V	R	V	T	L	I	N	F	I	F	M	A	I	F	S	A	L	L	F	L	T	L	P	G	T	G	S	G	N	F	I	A	F	Y	A	V	F	M	G	L	F	L	T	A	G
Secondary structure
SS confidence
Disorder																																								?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	G	S	G	S	T	F	Q	M	I	A	V	I	F	R	Q	I	T	I	Y	R	V	K	M	K	G	G	S	D	E	Q	A	H	K	E	A	V	T	E	T	A	A	A	L	G	F	I	S	A	I	G	A	V	G	G	F	F	I	P	Q
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
Sequence		A	F	G	M	S	L	N	M	T	G	S	P	V	G	A	M	K	V	F	L	I	F	Y	I	V	C	V	L	L	T	W	L	V	Y	G	R	R	K	F	S	Q	K
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1pw4 chain A Region: 15 - 462 Aligned: 420 Modelled: 423 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 3o7p chain A Region: 34 - 452 Aligned: 389 Modelled: 394 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 1pv7 chain A Region: 29 - 462 Aligned: 406 Modelled: 409 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 2gfp chain A Region: 36 - 449 Aligned: 372 Modelled: 374 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 2xut chain C Region: 37 - 449 Aligned: 409 Modelled: 413 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. Phyre2 PDB 3b9y chain A Region: 21 - 257 Aligned: 225 Modelled: 237 Confidence: 55.5% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter family rh-like protein; PDBTitle: crystal structure of the nitrosomonas europaea rh protein Phyre2 PDB 2bbj chain B Region: 391 - 458 Aligned: 68 Modelled: 68 Confidence: 34.2% Identity: 10% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 3obh chain A Region: 5 - 22 Aligned: 18 Modelled: 18 Confidence: 26.4% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: x-ray crystal structure of protein sp_0782 (7-79) from streptococcus2 pneumoniae. northeast structural genomics consortium target spr104 Phyre2 PDB 3db3 chain A Region: 4 - 24 Aligned: 21 Modelled: 21 Confidence: 26.1% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase uhrf1; PDBTitle: crystal structure of the tandem tudor domains of the e3 ubiquitin-2 protein ligase uhrf1 in complex with trimethylated histone h3-k93 peptide Phyre2 PDB 3met chain B Region: 5 - 31 Aligned: 27 Modelled: 27 Confidence: 23.6% Identity: 11% PDB header:transcription Chain: B: PDB Molecule:saga-associated factor 29 homolog; PDBTitle: crystal structure of sgf29 in complex with h3k4me2 Phyre2 PDB 2l92 chain A Region: 16 - 33 Aligned: 18 Modelled: 18 Confidence: 20.6% Identity: 22% PDB header:dna binding protein Chain: A: PDB Molecule:histone family protein nucleoid-structuring protein h-ns; PDBTitle: solution structure of the c-terminal domain of h-ns like protein bv3f Phyre2 PDB 3pm7 chain A Region: 5 - 22 Aligned: 18 Modelled: 18 Confidence: 18.6% Identity: 28% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of ef_3132 protein from enterococcus faecalis at the2 resolution 2a, northeast structural genomics consortium target efr184 Phyre2 PDB 1hw4 chain A Region: 3 - 20 Aligned: 18 Modelled: 18 Confidence: 17.2% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors Phyre2 PDB 1hw3 chain A Region: 3 - 20 Aligned: 18 Modelled: 18 Confidence: 14.6% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors Phyre2 PDB 2knc chain A Region: 432 - 462 Aligned: 31 Modelled: 31 Confidence: 14.6% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3hd6 chain A Region: 18 - 237 Aligned: 211 Modelled: 220 Confidence: 12.3% Identity: 13% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 2kz7 chain C Region: 3 - 35 Aligned: 33 Modelled: 33 Confidence: 11.9% Identity: 27% PDB header:protein binding Chain: C: PDB Molecule:leucine-rich repeat-containing protein 16a; PDBTitle: solution structure of the carmil cah3a/b domain bound to capping2 protein (cp) Phyre2 PDB 2iub chain A domain 2 Region: 436 - 458 Aligned: 23 Modelled: 23 Confidence: 11.6% Identity: 17% Fold: Transmembrane helix hairpin Superfamily: Magnesium transport protein CorA, transmembrane region Family: Magnesium transport protein CorA, transmembrane region Phyre2 PDB 2g9p chain A Region: 89 - 102 Aligned: 14 Modelled: 14 Confidence: 11.5% Identity: 14% PDB header:antimicrobial protein Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a; PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom Phyre2 PDB 3dgp chain B Region: 5 - 19 Aligned: 15 Modelled: 15 Confidence: 8.4% Identity: 20% PDB header:transcription Chain: B: PDB Molecule:rna polymerase ii transcription factor b subunit 5; PDBTitle: crystal structure of the complex between tfb5 and the c-terminal2 domain of tfb2 Phyre2 1 d1pw4a_ 2 c3o7pA_ 3 d1pv7a_ 4 c2gfpA_ 5 c2xutC_ 6 c3b9yA_ 7 c2bbjB_ 8 c3obhA_ 9 c3db3A_ 10 c3metB_ 11 c2l92A_ 12 c3pm7A_ 13 c1hw4A_ 14 c1hw3A_ 15 c2kncA_ 16 c3hd6A_ 17 c2kz7C_ 18 d2iuba2 19 c2g9pA_ 20 c3dgpB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1pw4a_ 100.0 12 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:Glycerol-3-phosphate transporter 2 c3o7pA_ 100.0 12 PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) 3 d1pv7a_ 100.0 12 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:LacY-like proton/sugar symporter 4 c2gfpA_ 100.0 10 PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli 5 c2xutC_ 99.9 13 PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. 6 c3b9yA_ 55.5 13 PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter family rh-like protein; PDBTitle: crystal structure of the nitrosomonas europaea rh protein 7 c2bbjB_ 34.2 10 PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter 8 c3obhA_ 26.4 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: x-ray crystal structure of protein sp_0782 (7-79) from streptococcus2 pneumoniae. northeast structural genomics consortium target spr104 9 c3db3A_ 26.1 19 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase uhrf1; PDBTitle: crystal structure of the tandem tudor domains of the e3 ubiquitin-2 protein ligase uhrf1 in complex with trimethylated histone h3-k93 peptide 10 c3metB_ 23.6 11 PDB header:transcription Chain: B: PDB Molecule:saga-associated factor 29 homolog; PDBTitle: crystal structure of sgf29 in complex with h3k4me2 11 c2l92A_ 20.6 22 PDB header:dna binding protein Chain: A: PDB Molecule:histone family protein nucleoid-structuring protein h-ns; PDBTitle: solution structure of the c-terminal domain of h-ns like protein bv3f 12 c3pm7A_ 18.6 28 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of ef_3132 protein from enterococcus faecalis at the2 resolution 2a, northeast structural genomics consortium target efr184 13 c1hw4A_ 17.2 17 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors 14 c1hw3A_ 14.6 17 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors 15 c2kncA_ 14.6 10 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 16 c3hd6A_ 12.3 13 PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg 17 c2kz7C_ 11.9 27 PDB header:protein binding Chain: C: PDB Molecule:leucine-rich repeat-containing protein 16a; PDBTitle: solution structure of the carmil cah3a/b domain bound to capping2 protein (cp) 18 d2iuba2 11.6 17 Fold:Transmembrane helix hairpin Superfamily:Magnesium transport protein CorA, transmembrane region Family:Magnesium transport protein CorA, transmembrane region 19 c2g9pA_ 11.5 14 PDB header:antimicrobial protein Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a; PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom 20 c3dgpB_ 8.4 20 PDB header:transcription Chain: B: PDB Molecule:rna polymerase ii transcription factor b subunit 5; PDBTitle: crystal structure of the complex between tfb5 and the c-terminal2 domain of tfb2 21 c3ke2A_ not modelled 8.1 20 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein yp_928783.1; PDBTitle: crystal structure of a duf2131 family protein (sama_2911) from2 shewanella amazonensis sb2b at 2.50 a resolution 22 c3mkuA_ not modelled 7.9 10 PDB header:transport protein Chain: A: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter 23 d1sv0c_ not modelled 7.7 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Pointed domain 24 d1sxda_ not modelled 7.5 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Pointed domain 25 c2dkxA_ not modelled 7.2 18 PDB header:signaling protein Chain: A: PDB Molecule:sam pointed domain-containing ets transcription PDBTitle: solution structure of the sam_pnt-domain of ets2 transcription factor pdef (prostate ets) 26 d1hnra_ not modelled 7.1 18 Fold:H-NS histone-like proteins Superfamily:H-NS histone-like proteins Family:H-NS histone-like proteins 27 d1bcoa1 not modelled 7.0 7 Fold:mu transposase, C-terminal domain Superfamily:mu transposase, C-terminal domain Family:mu transposase, C-terminal domain 28 d1sv0a_ not modelled 6.1 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Pointed domain 29 c1y6gB_ not modelled 6.1 33 PDB header:transferase/dna Chain: B: PDB Molecule:dna alpha-glucosyltransferase; PDBTitle: alpha-glucosyltransferase in complex with udp and a 13_mer2 dna containing a hmu base at 2.8 a resolution 30 d1vbva1 not modelled 6.1 22 Fold:SH3-like barrel Superfamily:YccV-like Family:YccV-like 31 d1bqva_ not modelled 5.9 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Pointed domain 32 d1jb0a_ not modelled 5.9 20 Fold:Photosystem I subunits PsaA/PsaB Superfamily:Photosystem I subunits PsaA/PsaB Family:Photosystem I subunits PsaA/PsaB 33 d2z15a1 not modelled 5.7 50 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 34 d3e9va1 not modelled 5.6 50 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 35 c2h31A_ not modelled 5.6 12 PDB header:ligase, lyase Chain: A: PDB Molecule:multifunctional protein ade2; PDBTitle: crystal structure of human paics, a bifunctional carboxylase and2 synthetase in purine biosynthesis 36 d1jb0b_ not modelled 5.5 16 Fold:Photosystem I subunits PsaA/PsaB Superfamily:Photosystem I subunits PsaA/PsaB Family:Photosystem I subunits PsaA/PsaB 37 c2k9pA_ not modelled 5.5 15 PDB header:membrane protein Chain: A: PDB Molecule:pheromone alpha factor receptor; PDBTitle: structure of tm1_tm2 in lppg micelles 38 c2o8kA_ not modelled 5.5 21 PDB header:transcription/dna Chain: A: PDB Molecule:rna polymerase sigma factor rpon; PDBTitle: nmr structure of the sigma-54 rpon domain bound to the-242 promoter element 39 c2yh6C_ not modelled 5.5 25 PDB header:lipid binding protein Chain: C: PDB Molecule:lipoprotein 34; PDBTitle: structure of the n-terminal domain of bamc from e. coli 40 c3hftA_ not modelled 5.5 20 PDB header:hydrolase Chain: A: PDB Molecule:wbms, polysaccharide deacetylase involved in o-antigen PDBTitle: crystal structure of a putative polysaccharide deacetylase involved in2 o-antigen biosynthesis (wbms, bb0128) from bordetella bronchiseptica3 at 1.90 a resolution 41 c3ehuC_ not modelled 5.4 27 PDB header:membrane protein Chain: C: PDB Molecule:corticoliberin; PDBTitle: crystal structure of the extracellular domain of human corticotropin2 releasing factor receptor type 1 (crfr1) in complex with crf 42 c3ehuD_ not modelled 5.4 27 PDB header:membrane protein Chain: D: PDB Molecule:corticoliberin; PDBTitle: crystal structure of the extracellular domain of human corticotropin2 releasing factor receptor type 1 (crfr1) in complex with crf 43 c3jyvT_ not modelled 5.4 16 PDB header:ribosome Chain: T: PDB Molecule:s19e protein; PDBTitle: structure of the 40s rrna and proteins and p/e trna for eukaryotic2 ribosome based on cryo-em map of thermomyces lanuginosus ribosome at3 8.9a resolution 44 d1sxea_ not modelled 5.2 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Pointed domain 45 d1hdmb2 not modelled 5.2 29 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 46 c2ytuA_ not modelled 5.1 19 PDB header:signaling protein Chain: A: PDB Molecule:friend leukemia integration 1 transcription PDBTitle: solution structure of the sam_pnt-domain of the human2 friend leukemiaintegration 1 transcription factor

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0