Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	S	P	I	C	H	L	F	S	A	I	N	S	S	P	F	K	I	A	P	E	K	E	Q	D	L	K	T	I	V	D	D	K	K	I	I	I	S	V	V	S	E	P	G	F	N	I	R	V	R	K	N	E	S	N	N	S	H	E
Secondary structure
SS confidence
Disorder		?	?	?	?																		?																											?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	V	L	T	V	A	S	L	E	Y	I	W	A	F	S	N	F	F	W	V	F	T	Q	E	Y	S	K	S	Q	K	N	N	D	E	H	F	D	L	T	G	K	N	R	L	K	K	S	D	E	L	L	K	W	A	R	K	N	L	Q	T
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	G	C	E	S	W	P	K	K	C	P	K	P	E	A	Y	L	Q	G	S	E	D	S	Q	V	A	S	E	I	F	L	C	A	I	A	W	I	L	H	H	E	I	S	H	V	V	L	Q	H	P	L	V	T	T	A	F	S	T	Q	E
Secondary structure
SS confidence
Disorder			?	?											?	?	?	?	?	?	?	?	?																															?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	R	E	A	D	S	H	A	T	K	W	I	L	G	N	L	Y	E	S	A	P	E	L	K	K	R	A	L	G	I	A	T	A	V	L	C	I	Q	S	L	E	V	E	N	Y	F	C	L	Q	N	T	H	P	A	A	Y	E	R	I	Y
Secondary structure
SS confidence
Disorder																			?	?	?	?								?											?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.
Sequence		S	N	I	S	C	Y	P	V	G	N	E	E	L	I	E	A	L	C	T	V	M	L	Q	Y	L	F	H	G	K	N	I	N	V	N	L	D	G	E	S	F	S	S	I	L	G	D	L	L	C	D	I	S	R	L	T	S	N
Secondary structure
SS confidence
Disorder					?	?	?	?	?																			?							?				?																	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3c37 chain B Region: 154 - 242 Aligned: 70 Modelled: 89 Confidence: 97.4% Identity: 41% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 3dtk chain A Region: 155 - 192 Aligned: 38 Modelled: 38 Confidence: 91.3% Identity: 32% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 3cqb chain B Region: 154 - 171 Aligned: 18 Modelled: 16 Confidence: 69.2% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 3k7l chain A Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 36.1% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 2e3x chain A Region: 151 - 165 Aligned: 15 Modelled: 15 Confidence: 35.0% Identity: 40% PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase Phyre2 PDB 2erp chain A Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 34.3% Identity: 29% PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) Phyre2 PDB 2l0r chain A Region: 157 - 166 Aligned: 10 Modelled: 10 Confidence: 32.3% Identity: 40% PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center Phyre2 PDB 4aig chain A Region: 153 - 165 Aligned: 13 Modelled: 13 Confidence: 31.1% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1atl chain A Region: 153 - 165 Aligned: 13 Modelled: 13 Confidence: 31.0% Identity: 23% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 2dw1 chain B Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 31.0% Identity: 36% PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) Phyre2 PDB 2rjp chain C Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 27.1% Identity: 33% PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound Phyre2 PDB 1r55 chain A Region: 153 - 165 Aligned: 13 Modelled: 13 Confidence: 27.0% Identity: 38% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1q0q chain A domain 1 Region: 144 - 201 Aligned: 58 Modelled: 58 Confidence: 26.7% Identity: 19% Fold: Left-handed superhelix Superfamily: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Phyre2 PDB 2v4b chain B Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 25.3% Identity: 42% PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) Phyre2 PDB 3b8z chain B Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 25.1% Identity: 42% PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) Phyre2 PDB 1qua chain A Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 24.1% Identity: 33% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1vpr chain A domain 1 Region: 126 - 141 Aligned: 16 Modelled: 16 Confidence: 23.7% Identity: 25% Fold: Lipocalins Superfamily: Lipocalins Family: Dinoflagellate luciferase repeat Phyre2 PDB 1r0k chain A domain 1 Region: 144 - 198 Aligned: 55 Modelled: 55 Confidence: 23.5% Identity: 22% Fold: Left-handed superhelix Superfamily: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Phyre2 PDB 2rjq chain A Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 22.7% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound Phyre2 PDB 1yp1 chain A Region: 154 - 165 Aligned: 12 Modelled: 12 Confidence: 22.5% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus Phyre2 1 c3c37B_ 2 c3dtkA_ 3 c3cqbB_ 4 c3k7lA_ 5 c2e3xA_ 6 c2erpA_ 7 c2l0rA_ 8 d4aiga_ 9 d1atla_ 10 c2dw1B_ 11 c2rjpC_ 12 d1r55a_ 13 d1q0qa1 14 c2v4bB_ 15 c3b8zB_ 16 d1quaa_ 17 d1vpra1 18 d1r0ka1 19 c2rjqA_ 20 c1yp1A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3c37B_ 97.4 41 PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a 2 c3dtkA_ 91.3 32 PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae 3 c3cqbB_ 69.2 28 PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 4 c3k7lA_ 36.1 29 PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 5 c2e3xA_ 35.0 40 PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase 6 c2erpA_ 34.3 29 PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) 7 c2l0rA_ 32.3 40 PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center 8 d4aiga_ 31.1 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 9 d1atla_ 31.0 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 10 c2dw1B_ 31.0 36 PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) 11 c2rjpC_ 27.1 33 PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound 12 d1r55a_ 27.0 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 13 d1q0qa1 26.7 19 Fold:Left-handed superhelix Superfamily:1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family:1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 14 c2v4bB_ 25.3 42 PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) 15 c3b8zB_ 25.1 42 PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) 16 d1quaa_ 24.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 17 d1vpra1 23.7 25 Fold:Lipocalins Superfamily:Lipocalins Family:Dinoflagellate luciferase repeat 18 d1r0ka1 23.5 22 Fold:Left-handed superhelix Superfamily:1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain Family:1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 19 c2rjqA_ 22.7 42 PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound 20 c1yp1A_ 22.5 33 PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus 21 d1hfca_ not modelled 22.5 30 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 22 d1eaka2 not modelled 22.3 27 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 23 d1j7na2 not modelled 22.2 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Anthrax toxin lethal factor, N- and C-terminal domains 24 d1nd1a_ not modelled 22.0 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 25 d1bswa_ not modelled 21.9 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 26 d1wnia_ not modelled 21.7 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 27 d2i47a1 not modelled 21.6 21 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TNF-alpha converting enzyme, TACE, catalytic domain 28 d1qiba_ not modelled 21.3 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 29 d1cxva_ not modelled 21.2 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 30 d1y93a1 not modelled 21.2 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 31 d1cgla_ not modelled 20.7 30 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 32 c2i47A_ not modelled 20.7 25 PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor 33 d1hova_ not modelled 19.9 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 34 c2xs4A_ not modelled 19.9 44 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 35 d1xuca1 not modelled 19.8 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 36 d1g9ka2 not modelled 19.4 50 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 37 d1hy7a_ not modelled 19.3 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 38 d1i76a_ not modelled 19.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 39 d1kufa_ not modelled 18.9 27 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 40 d1hv5a_ not modelled 18.8 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 41 c3k7nA_ not modelled 18.6 27 PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 42 d1k7ia2 not modelled 18.3 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 43 d2ovxa1 not modelled 18.1 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 44 d1mmqa_ not modelled 17.9 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 45 d1t3ta7 not modelled 17.7 10 Fold:PurM C-terminal domain-like Superfamily:PurM C-terminal domain-like Family:PurM C-terminal domain-like 46 d1sata2 not modelled 17.5 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 47 d1fbla2 not modelled 17.2 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 48 d1bqqm_ not modelled 17.2 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 49 c3b4rB_ not modelled 17.1 24 PDB header:hydrolase Chain: B: PDB Molecule:putative zinc metalloprotease mj0392; PDBTitle: site-2 protease from methanocaldococcus jannaschii 50 c2jsdA_ not modelled 17.0 33 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-20; PDBTitle: solution structure of mmp20 complexed with nngh 51 d1rm8a_ not modelled 17.0 25 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 52 d1q3aa_ not modelled 15.9 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 53 c3sksA_ not modelled 15.7 36 PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames 54 c1slmA_ not modelled 15.3 38 PDB header:hydrolase Chain: A: PDB Molecule:stromelysin-1; PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme 55 c2h1jA_ not modelled 15.1 36 PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding 56 c3phzA_ not modelled 14.6 29 PDB header:sugar binding protein Chain: A: PDB Molecule:ricin b-related lectin; PDBTitle: crystal structure analysis of polyporus squamosus lectin bound to2 human-type influenza-binding epitope neu5aca2-6galb1-4glcnac 57 c3ce2A_ not modelled 14.6 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus 58 c3g5cA_ not modelled 14.0 25 PDB header:membrane protein Chain: A: PDB Molecule:adam 22; PDBTitle: structural and biochemical studies on the ectodomain of human adam22 59 d1kapp2 not modelled 13.5 50 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 60 c2vqxA_ not modelled 12.4 21 PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. 61 d1npca_ not modelled 12.3 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 62 c1y791_ not modelled 11.7 36 PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor 63 d2ilxa1 not modelled 11.7 24 Fold:LigT-like Superfamily:LigT-like Family:2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain 64 c3nqxA_ not modelled 11.7 29 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family 65 c3dl1A_ not modelled 11.0 9 PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent hydrolase; PDBTitle: crystal structure of a putative metal-dependent hydrolase2 (yp_001336084.1) from klebsiella pneumoniae subsp. pneumoniae mgh3 78578 at 2.20 a resolution 66 d1kjpa_ not modelled 10.4 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 67 c1jiwP_ not modelled 10.4 50 PDB header:hydrolase/hyrolase inhibitor Chain: P: PDB Molecule:alkaline metalloproteinase; PDBTitle: crystal structure of the apr-aprin complex 68 d1bqba_ not modelled 10.3 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 69 c3ac6A_ not modelled 9.0 16 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylformylglycinamidine synthase 2; PDBTitle: crystal structure of purl from thermus thermophilus 70 c3nqzB_ not modelled 8.6 29 PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation 71 c3ba0A_ not modelled 8.6 33 PDB header:hydrolase Chain: A: PDB Molecule:macrophage metalloelastase; PDBTitle: crystal structure of full-length human mmp-12 72 c2cltB_ not modelled 8.5 22 PDB header:hydrolase Chain: B: PDB Molecule:interstitial collagenase; PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase. 73 d1pyta_ not modelled 8.2 14 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 74 d1t1ra3 not modelled 8.0 33 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 75 d1i1ip_ not modelled 8.0 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 76 d2ejqa1 not modelled 7.9 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 77 d1tx3a1 not modelled 7.8 21 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Restriction endonuclease HincII 78 d1c7ka_ not modelled 7.6 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Zinc protease 79 d1x7va_ not modelled 7.3 15 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:PA3566-like 80 c2fb0A_ not modelled 7.2 0 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of conserved protein of unknown function from2 bacteroides thetaiotaomicron vpi-5482 at 2.10 a resolution, possible3 oxidoreductase 81 d1jqga2 not modelled 7.1 7 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 82 d1t06a_ not modelled 6.7 28 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:BC3264-like 83 d1ayea2 not modelled 6.6 18 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 84 d2boaa2 not modelled 6.6 14 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 85 d1u4ga_ not modelled 6.5 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 86 d1o6xa_ not modelled 6.4 18 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 87 d1nsaa2 not modelled 6.3 11 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 88 c1l6jA_ not modelled 6.1 54 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-9; PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b). 89 d1s4bp_ not modelled 6.0 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 90 d1v54m_ not modelled 6.0 28 Fold:Single transmembrane helix Superfamily:Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) Family:Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) 91 c2omoC_ not modelled 5.9 15 PDB header:oxidoreductase Chain: C: PDB Molecule:duf176; PDBTitle: putative antibiotic biosynthesis monooxygenase from nitrosomonas2 europaea 92 d1pbaa_ not modelled 5.9 11 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 93 d2ajfa1 not modelled 5.8 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 94 c3p1vB_ not modelled 5.7 27 PDB header:hydrolase Chain: B: PDB Molecule:metallo-endopeptidase; PDBTitle: crystal structure of a metallo-endopeptidases (bacova_00663) from2 bacteroides ovatus at 1.93 a resolution 95 c1su3A_ not modelled 5.6 26 PDB header:hydrolase Chain: A: PDB Molecule:interstitial collagenase; PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action 96 d2ihoa2 not modelled 5.6 9 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:MOA C-terminal domain-like 97 c1om8A_ not modelled 5.5 50 PDB header:hydrolase Chain: A: PDB Molecule:serralysin; PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta 98 d1kwma2 not modelled 5.5 11 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 99 d2cpwa1 not modelled 5.1 33 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:UBA domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0