Email l.a.kelley@imperial.ac.uk Description P0ABQ4 Date Thu Jan 5 11:16:05 GMT 2012 Unique Job ID 6bc08d06dbd532de

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1ra9a_ 100.0 99 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 2 c3tq8A_ 100.0 43 PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim 3 c3ia5A_ 100.0 55 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: moritella profunda dihydrofolate reductase (dhfr) 4 c3e0bA_ 100.0 40 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: bacillus anthracis dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) 5 c3f0uX_ 100.0 35 PDB header:oxidoreductase Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase; PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase2 complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-3 phenylphenyl)but-1-ynyl]-6-methylpyrimidine 6 c1zdrB_ 100.0 39 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: dhfr from bacillus stearothermophilus 7 c3k2hA_ 100.0 34 PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp 8 c2oipE_ 100.0 34 PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis 9 d3dfra_ 100.0 28 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 10 c3cseA_ 100.0 30 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) 11 c3ix9B_ 100.0 35 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant 12 d8dfra_ 100.0 32 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 13 d1aoea_ 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 14 c3jsuA_ 100.0 35 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump 15 d1kmva_ 100.0 32 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 16 d1j3ka_ 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 17 d2fzia1 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 18 c3dg8B_ 100.0 35 PDB header:oxidoreductase, transferase Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium2 falciparum dihydrofolate reductase-thymidylate synthase3 (pfdhfr-ts) complexed with rjf670, nadph, and dump 19 c3rg9A_ 100.0 32 PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase; PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210 20 d1df7a_ 100.0 36 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 21 c2blcA_ not modelled 100.0 29 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: sp21 double mutant p. vivax dihydrofolate reductase in2 complex with des-chloropyrimethamine 22 d1vdra_ not modelled 100.0 33 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 23 c3clbA_ not modelled 100.0 37 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq 24 d1seja1 not modelled 100.0 33 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 25 d1juva_ not modelled 100.0 22 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 26 d1d1ga_ not modelled 100.0 26 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 27 c3jtwB_ not modelled 99.9 19 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution 28 c2gd9A_ not modelled 99.8 17 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution 29 c2xw7A_ not modelled 99.8 16 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308 30 c3ky8B_ not modelled 99.6 18 PDB header:biosynthetic protein Chain: B: PDB Molecule:putative riboflavin biosynthesis protein; PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution 31 d2hxva1 not modelled 99.5 20 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 32 c3kgyA_ not modelled 99.4 19 PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution 33 d2azna1 not modelled 99.4 16 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 34 d2b3za1 not modelled 99.4 15 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 35 c2hxvA_ not modelled 99.3 20 PDB header:biosynthetic protein Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5- PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution 36 c2o7pA_ not modelled 99.2 15 PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain 37 c2d5nB_ not modelled 99.2 16 PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis 38 c2p4gA_ not modelled 98.8 17 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution 39 d1aoga2 not modelled 66.2 13 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 40 d1q1ra2 not modelled 47.6 19 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 41 d1gesa2 not modelled 38.5 21 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 42 d1gera2 not modelled 33.9 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 43 d3grsa2 not modelled 32.9 10 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 44 d1onfa2 not modelled 28.4 17 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 45 d1m6ia2 not modelled 27.4 27 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 46 d1feca2 not modelled 22.3 17 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 47 d1nhpa2 not modelled 21.2 27 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 48 d1gv4a2 not modelled 20.3 33 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 49 c3fq6A_ not modelled 20.1 17 PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the crystal structure of a methyltransferase domain from bacteroides2 thetaiotaomicron vpi 50 d1h6va2 not modelled 18.3 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 51 c3ihtB_ not modelled 16.7 11 PDB header:transferase Chain: B: PDB Molecule:s-adenosyl-l-methionine methyl transferase; PDBTitle: crystal structure of s-adenosyl-l-methionine methyl transferase2 (yp_165822.1) from silicibacter pomeroyi dss-3 at 1.80 a resolution 52 d1rm6b2 not modelled 16.2 11 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CO dehydrogenase flavoprotein N-terminal domain-like 53 d1udxa3 not modelled 15.8 18 Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain 54 c3q3vA_ not modelled 15.7 13 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from campylobacter2 jejuni. 55 c1jb9A_ not modelled 15.1 16 PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin-nadp reductase; PDBTitle: crystal structure of the ferredoxin:nadp+ reductase from maize root at2 1.7 angstroms 56 c1zmrA_ not modelled 14.3 18 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of the e. coli phosphoglycerate kinase 57 d1d7ya2 not modelled 14.0 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 58 d1vjda_ not modelled 13.9 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 59 d1hdia_ not modelled 13.5 20 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 60 d1fw8a_ not modelled 13.3 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 61 d1vdca2 not modelled 13.2 22 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 62 c3cqyA_ not modelled 12.5 30 PDB header:transferase Chain: A: PDB Molecule:anhydro-n-acetylmuramic acid kinase; PDBTitle: crystal structure of a functionally unknown protein (so_1313) from2 shewanella oneidensis mr-1 63 d1ojta2 not modelled 11.8 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 64 c1rm6E_ not modelled 11.7 11 PDB header:oxidoreductase Chain: E: PDB Molecule:4-hydroxybenzoyl-coa reductase beta subunit; PDBTitle: structure of 4-hydroxybenzoyl-coa reductase from thauera2 aromatica 65 d1qpga_ not modelled 11.5 21 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 66 d1ebda2 not modelled 11.3 20 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 67 d2b4ya1 not modelled 11.1 20 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 68 d1lvla2 not modelled 11.1 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 69 c3okfA_ not modelled 10.9 11 PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase2 (arob) from vibrio cholerae 70 d1jeoa_ not modelled 10.7 27 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 71 d1gg4a1 not modelled 10.5 21 Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain 72 d1ltka_ not modelled 10.3 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 73 d1dxla2 not modelled 9.0 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 74 d16pka_ not modelled 8.7 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 75 d1xhca2 not modelled 8.5 19 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 76 d1phpa_ not modelled 8.5 26 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 77 c2jraB_ not modelled 8.5 28 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein rpa2121; PDBTitle: a novel domain-swapped solution nmr structure of protein rpa2121 from2 rhodopseudomonas palustris. northeast structural genomics target rpt6 78 d1vpea_ not modelled 8.4 21 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 79 d2gs5a1 not modelled 8.1 12 Fold:VC0467-like Superfamily:VC0467-like Family:VC0467-like 80 c2hjhB_ not modelled 8.1 23 PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase 81 c1xahA_ not modelled 8.0 9 PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: crystal structure of staphlyococcus aureus 3-dehydroquinate2 synthase (dhqs) in complex with zn2+ and nad+ 82 d1v6sa_ not modelled 7.8 19 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 83 d2i14a2 not modelled 7.7 20 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 84 c2cunA_ not modelled 7.5 24 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from pyrococcus2 horikoshii ot3 85 c3hl0B_ not modelled 7.3 20 PDB header:oxidoreductase Chain: B: PDB Molecule:maleylacetate reductase; PDBTitle: crystal structure of maleylacetate reductase from agrobacterium2 tumefaciens 86 c3ce9A_ not modelled 6.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:glycerol dehydrogenase; PDBTitle: crystal structure of glycerol dehydrogenase (np_348253.1) from2 clostridium acetobutylicum at 2.37 a resolution 87 c3f3mA_ not modelled 6.6 25 PDB header:transferase Chain: A: PDB Molecule:phosphopantetheine adenylyltransferase; PDBTitle: six crystal structures of two phosphopantetheine2 adenylyltransferases reveal an alternative ligand binding3 mode and an associated structural change 88 d1krha2 not modelled 6.5 13 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Aromatic dioxygenase reductase-like 89 c1kyqC_ not modelled 6.5 38 PDB header:oxidoreductase, lyase Chain: C: PDB Molecule:siroheme biosynthesis protein met8; PDBTitle: met8p: a bifunctional nad-dependent dehydrogenase and2 ferrochelatase involved in siroheme synthesis. 90 d1kyqa1 not modelled 6.4 38 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Siroheme synthase N-terminal domain-like 91 d2h3ka1 not modelled 6.3 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:NEAT domain-like Family:NEAT domain 92 d1fcda1 not modelled 6.3 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 93 d1jb9a2 not modelled 6.3 16 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 94 c3dfzB_ not modelled 6.3 18 PDB header:oxidoreductase Chain: B: PDB Molecule:precorrin-2 dehydrogenase; PDBTitle: sirc, precorrin-2 dehydrogenase 95 d1fl2a2 not modelled 6.1 29 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 96 c3hrdC_ not modelled 6.0 18 PDB header:oxidoreductase Chain: C: PDB Molecule:nicotinate dehydrogenase fad-subunit; PDBTitle: crystal structure of nicotinate dehydrogenase 97 d1ddga2 not modelled 6.0 22 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:NADPH-cytochrome p450 reductase-like 98 d1up7a1 not modelled 5.8 43 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 99 d1v59a2 not modelled 5.8 24 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains