Phyre 2 Results for P0CK95

Email	l.a.kelley@imperial.ac.uk
Description	P0CK95
Date	Wed Jan 25 15:20:37 GMT 2012
Unique Job ID	6ba547f08901501c

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3b37A_

Top template information

PDB header:hydrolase
Chain: A: PDB Molecule:aminopeptidase n;
PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine

Confidence and coverage

Confidence:

88.4%

Coverage:

14%

209 residues ( 14% of your sequence) have been modelled with 88.4% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Please note: You must be registered and logged in to use Phyrealarm.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M N K K F K Y K K S L L A A I L S A T L L A G C D G G G S G S S S D T P P V D S G T G S L P E V K P D P T P N P E P T P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence E P T P D P E P T P E P I P D P E P T P E P E P E P V P T K T G Y L T L G G S Q R V T G A T C N G E S S D G F T F K P G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence E D V T C V A G N T T I A T F N T Q S E A A R S L R A V E K V S F S L E D A Q E L A G S D D K K S N A V S L V T S S N S

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ?
? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence C P A N T E Q V C L T F S S V I E S K R F D S L Y K Q I D L A P E E F K K L V N E E V E N N A A T D K A P S T H T S P V

Secondary structure

SS confidence

Disorder ? ? ?
?
?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence V P V T T P G T K P D L N A S F V S A N A E Q F Y Q Y Q P T E I I L S E G R L V D S Q G Y G V A G V N Y Y T N S G R G V

Secondary structure

SS confidence

Disorder
? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence T G E N G E F S F S W G E T I S F G I D T F E L G S V R G N K S T I A L T E L G D E V R G A N I D Q L I H R Y S T T G Q

Secondary structure

SS confidence

Disorder ? ? ?
?
?
?
?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence N N T R V V P D D V R K V F A E Y P N V I N E I I N L S L S N G A T L G E G E Q V V N L P N E F I E Q F N T G Q A K E I

Secondary structure

SS confidence

Disorder ?
? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence D T A I C A K T D G C N E A R W F S L T T R N V N D G Q I Q G V I N K L W G V D T N Y K S V S K F H V F H D S T N F Y G

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence S T G N A R G Q A V V N I S N A A F P I L M A R N D K N Y W L A F G E K R A W D K N E L A Y I T E A P S L V E P E N V T

Secondary structure

SS confidence

Disorder ?
?
?
? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence R D T A T F N L P F I S L G Q V G E G K L M V I G N P H Y N S I L R C P N G Y S W N G G V N K D G Q C T L N S D P D D M

Secondary structure

SS confidence

Disorder ? ?
? ?
?
? ? ? ?
?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence K N F M E N V L R Y L S D D K W K P D A K A S M T V G T N L D T V Y F K R H G Q V T G N S A A F D F H P D F A G I S V E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence H L S S Y G D L D P Q E M P L L I L N G F E Y V T Q V G N D P Y A I P L R A D T S K P K L T Q Q D V T D L I A Y L N K G

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?
?
?
? ? ? ? ? ? ?
?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence G S V L I M E N V M S N L K E E S A S G F V R L L D A A G L S M A L N K S V V N N D P Q G Y P N R V R Q Q R A T G I W V

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?
?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Y E R Y P A V D G A L P Y T I D S K T G E V K W K Y Q V E N K P D D K P K L E V A S W L E D V D G K Q E T R Y A F I D E

Secondary structure

SS confidence

Disorder
? ?
? ?
?
? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence A D H K T E D S L K A A K E K I F A A F P G L K E C T N P A Y H Y E V N C L E Y R P G T G V P V T G G M Y V P Q Y T Q L

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence S L N A D T A K A M V Q A A D L G T N I Q R L Y Q H E L Y F R T N G R K G E R L S S V D L E R L Y Q N M S V W L W N D T

Secondary structure

SS confidence

Disorder
?
? ?
? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence S Y R Y E E G K N D E L G F K T F T E F L N C Y A N D A Y A G G T K C S A D L K K S L V D N N M I Y G D G S S K A G M M

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
? ? ?
?
? ? ?
? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence N P S Y P L N Y M E K P L T R L M L G R S W W D L N I K V D V E K Y P G A V S E E G Q N V T E T I S L Y S N P T K W F A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence G N M Q S T G L W A P A Q K E V T I K S N A N V P V T V T V A L A D D L T G R E K H E V A L N R P P R V T K T Y S L D A

Secondary structure

SS confidence

Disorder ?
? ? ?
? ? ? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence S G T V K F K V P Y G G L I Y I K G N S S T N E S A S F T F T G V V K A P F Y K D G A W K N D L N S P A P L G E L E S D

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence A F V Y T T P K K N L N A S N Y T G G L E Q F A N D L D T F A S S M N D F Y G R D S E D G K H R M F T Y K N L P G H K H

Secondary structure

SS confidence

Disorder
?
? ?
?
?
?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence R F T N D V Q I S I G D A H S G Y P V M N S S F S P N S T T L P T T P L N D W L I W H E V G H N A A E T P L T V P G A T

Secondary structure

SS confidence

Disorder
? ?
? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence E V A N N V L A L Y M Q D R Y L G K M N R V A D D I T V A P E Y L E E S N N Q A W A R G G A G D R L L M Y A Q L K E W A

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ?
?
? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence E K N F D I K K W Y P D G T P L P E F Y S E R E G M K G W N L F Q L M H R K A R G D E V S N D K F G G K N Y C A E S N G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence N A A D T L M L C A S W V A Q T D L S E F F K K W N P G A N A Y Q L P G A S E M S F E G G V S Q S A Y N T L A S L D L P

Secondary structure

SS confidence

Disorder
? ? ?
?
?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520

Sequence K P E Q G P E T I N Q V T E H K M S A E

Secondary structure

SS confidence

Disorder ?
? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3b37 chain A

Region: 1215 - 1465
Aligned: 209
Modelled: 237
Confidence: 88.4%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:aminopeptidase n;
PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine

Phyre2

PDB 3ebh chain A

Region: 1215 - 1465
Aligned: 209
Modelled: 237
Confidence: 85.6%
Identity: 12%
PDB header:hydrolase inhibitor
Chain: A: PDB Molecule:m1 family aminopeptidase;
PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin

Phyre2

PDB 2boy chain C

Region: 245 - 309
Aligned: 65
Modelled: 65
Confidence: 84.8%
Identity: 26%
PDB header:oxidoreductase
Chain: C: PDB Molecule:3-chlorocatechol 1,2-dioxygenase;
PDBTitle: crystal structure of 3-chlorocatechol 1,2-dioxygenase from2 rhodococcus opacus 1cp

Phyre2

PDB 2xsu chain A

Region: 245 - 309
Aligned: 65
Modelled: 65
Confidence: 82.9%
Identity: 23%
PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2 dioxygenase;
PDBTitle: crystal structure of the a72g mutant of acinetobacter2 radioresistens catechol 1,2 dioxygenase

Phyre2

PDB 2xdt chain A

Region: 1215 - 1465
Aligned: 215
Modelled: 249
Confidence: 82.6%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1;
PDBTitle: crystal structure of the soluble domain of human2 endoplasmic reticulum aminopeptidase 1 erap1

Phyre2

PDB 1s9a chain A

Region: 234 - 309
Aligned: 76
Modelled: 76
Confidence: 81.1%
Identity: 24%
Fold: Prealbumin-like
Superfamily: Aromatic compound dioxygenase
Family: Aromatic compound dioxygenase

Phyre2

PDB 3rht chain B

Region: 692 - 726
Aligned: 35
Modelled: 33
Confidence: 79.5%
Identity: 14%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:(gatase1)-like protein;
PDBTitle: crystal structure of type 1 glutamine amidotransferase (gatase1)-like2 protein from planctomyces limnophilus

Phyre2

PDB 2gtq chain A

Region: 1215 - 1465
Aligned: 210
Modelled: 247
Confidence: 79.2%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:aminopeptidase n;
PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis

Phyre2

PDB 3pcc chain M

Region: 271 - 309
Aligned: 39
Modelled: 39
Confidence: 76.6%
Identity: 41%
Fold: Prealbumin-like
Superfamily: Aromatic compound dioxygenase
Family: Aromatic compound dioxygenase

Phyre2

PDB 1z5h chain B

Region: 1303 - 1465
Aligned: 141
Modelled: 142
Confidence: 75.7%
Identity: 13%
PDB header:hydrolase
Chain: B: PDB Molecule:tricorn protease interacting factor f3;
PDBTitle: crystal structures of the tricorn interacting factor f32 from thermoplasma acidophilum

Phyre2

PDB 2azq chain A

Region: 241 - 309
Aligned: 69
Modelled: 69
Confidence: 74.9%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2-dioxygenase;
PDBTitle: crystal structure of catechol 1,2-dioxygenase from pseudomonas arvilla2 c-1

Phyre2

PDB 2bur chain B domain 1

Region: 237 - 309
Aligned: 73
Modelled: 73
Confidence: 74.3%
Identity: 25%
Fold: Prealbumin-like
Superfamily: Aromatic compound dioxygenase
Family: Aromatic compound dioxygenase

Phyre2

PDB 3n9t chain A

Region: 226 - 309
Aligned: 76
Modelled: 84
Confidence: 71.8%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:pnpc;
PDBTitle: cryatal structure of hydroxyquinol 1,2-dioxygenase from pseudomonas2 putida dll-e4

Phyre2

PDB 1v06 chain A

Region: 1129 - 1184
Aligned: 51
Modelled: 56
Confidence: 70.2%
Identity: 18%
PDB header:dna-binding protein
Chain: A: PDB Molecule:hmg box-containing protein 1;
PDBTitle: axh domain of the transcription factor hbp1 from m.musculus

Phyre2

PDB 3hj8 chain A

Region: 247 - 309
Aligned: 63
Modelled: 62
Confidence: 60.6%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2-dioxygenase;
PDBTitle: crystal structure determination of catechol 1,2-dioxygenase from2 rhodococcus opacus 1cp in complex with 4-chlorocatechol

Phyre2

PDB 3se6 chain A

Region: 1215 - 1465
Aligned: 215
Modelled: 237
Confidence: 58.7%
Identity: 11%
PDB header:hydrolase
Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2;
PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2

Phyre2

PDB 2bur chain A domain 1

Region: 268 - 309
Aligned: 42
Modelled: 42
Confidence: 58.1%
Identity: 33%
Fold: Prealbumin-like
Superfamily: Aromatic compound dioxygenase
Family: Aromatic compound dioxygenase

Phyre2

PDB 1tmx chain A

Region: 247 - 309
Aligned: 63
Modelled: 63
Confidence: 56.8%
Identity: 19%
PDB header:oxidoreductase
Chain: A: PDB Molecule:hydroxyquinol 1,2-dioxygenase;
PDBTitle: crystal structure of hydroxyquinol 1,2-dioxygenase from2 nocardioides simplex 3e

Phyre2

PDB 1yqe chain A domain 1

Region: 842 - 913
Aligned: 58
Modelled: 58
Confidence: 55.5%
Identity: 19%
Fold: Phosphorylase/hydrolase-like
Superfamily: AF0625-like
Family: AF0625-like

Phyre2

PDB 1bqb chain A

Region: 1227 - 1307
Aligned: 66
Modelled: 81
Confidence: 51.7%
Identity: 21%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Thermolysin-like

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	N	K	K	F	K	Y	K	K	S	L	L	A	A	I	L	S	A	T	L	L	A	G	C	D	G	G	G	S	G	S	S	S	D	T	P	P	V	D	S	G	T	G	S	L	P	E	V	K	P	D	P	T	P	N	P	E	P	T	P
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?																?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	E	P	T	P	D	P	E	P	T	P	E	P	I	P	D	P	E	P	T	P	E	P	E	P	E	P	V	P	T	K	T	G	Y	L	T	L	G	G	S	Q	R	V	T	G	A	T	C	N	G	E	S	S	D	G	F	T	F	K	P	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	E	D	V	T	C	V	A	G	N	T	T	I	A	T	F	N	T	Q	S	E	A	A	R	S	L	R	A	V	E	K	V	S	F	S	L	E	D	A	Q	E	L	A	G	S	D	D	K	K	S	N	A	V	S	L	V	T	S	S	N	S
Secondary structure
SS confidence
Disorder												?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?			?	?	?	?		?	?	?										?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	C	P	A	N	T	E	Q	V	C	L	T	F	S	S	V	I	E	S	K	R	F	D	S	L	Y	K	Q	I	D	L	A	P	E	E	F	K	K	L	V	N	E	E	V	E	N	N	A	A	T	D	K	A	P	S	T	H	T	S	P	V
Secondary structure
SS confidence
Disorder	?	?	?													?										?				?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	V	P	V	T	T	P	G	T	K	P	D	L	N	A	S	F	V	S	A	N	A	E	Q	F	Y	Q	Y	Q	P	T	E	I	I	L	S	E	G	R	L	V	D	S	Q	G	Y	G	V	A	G	V	N	Y	Y	T	N	S	G	R	G	V
Secondary structure
SS confidence
Disorder							?	?	?		?	?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	T	G	E	N	G	E	F	S	F	S	W	G	E	T	I	S	F	G	I	D	T	F	E	L	G	S	V	R	G	N	K	S	T	I	A	L	T	E	L	G	D	E	V	R	G	A	N	I	D	Q	L	I	H	R	Y	S	T	T	G	Q
Secondary structure
SS confidence
Disorder	?	?	?																									?											?		?		?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	N	N	T	R	V	V	P	D	D	V	R	K	V	F	A	E	Y	P	N	V	I	N	E	I	I	N	L	S	L	S	N	G	A	T	L	G	E	G	E	Q	V	V	N	L	P	N	E	F	I	E	Q	F	N	T	G	Q	A	K	E	I
Secondary structure
SS confidence
Disorder	?																														?	?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	D	T	A	I	C	A	K	T	D	G	C	N	E	A	R	W	F	S	L	T	T	R	N	V	N	D	G	Q	I	Q	G	V	I	N	K	L	W	G	V	D	T	N	Y	K	S	V	S	K	F	H	V	F	H	D	S	T	N	F	Y	G
Secondary structure
SS confidence
Disorder				?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?																?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	S	T	G	N	A	R	G	Q	A	V	V	N	I	S	N	A	A	F	P	I	L	M	A	R	N	D	K	N	Y	W	L	A	F	G	E	K	R	A	W	D	K	N	E	L	A	Y	I	T	E	A	P	S	L	V	E	P	E	N	V	T
Secondary structure
SS confidence
Disorder	?																																					?		?											?	?	?	?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	R	D	T	A	T	F	N	L	P	F	I	S	L	G	Q	V	G	E	G	K	L	M	V	I	G	N	P	H	Y	N	S	I	L	R	C	P	N	G	Y	S	W	N	G	G	V	N	K	D	G	Q	C	T	L	N	S	D	P	D	D	M
Secondary structure
SS confidence
Disorder	?	?										?	?		?																										?	?	?	?			?		?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	K	N	F	M	E	N	V	L	R	Y	L	S	D	D	K	W	K	P	D	A	K	A	S	M	T	V	G	T	N	L	D	T	V	Y	F	K	R	H	G	Q	V	T	G	N	S	A	A	F	D	F	H	P	D	F	A	G	I	S	V	E
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?		?												?	?	?	?	?	?	?	?	?	?													?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	H	L	S	S	Y	G	D	L	D	P	Q	E	M	P	L	L	I	L	N	G	F	E	Y	V	T	Q	V	G	N	D	P	Y	A	I	P	L	R	A	D	T	S	K	P	K	L	T	Q	Q	D	V	T	D	L	I	A	Y	L	N	K	G
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?		?									?			?	?	?	?	?	?	?			?							?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	G	S	V	L	I	M	E	N	V	M	S	N	L	K	E	E	S	A	S	G	F	V	R	L	L	D	A	A	G	L	S	M	A	L	N	K	S	V	V	N	N	D	P	Q	G	Y	P	N	R	V	R	Q	Q	R	A	T	G	I	W	V
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?																				?				?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Y	E	R	Y	P	A	V	D	G	A	L	P	Y	T	I	D	S	K	T	G	E	V	K	W	K	Y	Q	V	E	N	K	P	D	D	K	P	K	L	E	V	A	S	W	L	E	D	V	D	G	K	Q	E	T	R	Y	A	F	I	D	E
Secondary structure
SS confidence
Disorder																												?	?		?	?										?		?	?		?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	A	D	H	K	T	E	D	S	L	K	A	A	K	E	K	I	F	A	A	F	P	G	L	K	E	C	T	N	P	A	Y	H	Y	E	V	N	C	L	E	Y	R	P	G	T	G	V	P	V	T	G	G	M	Y	V	P	Q	Y	T	Q	L
Secondary structure
SS confidence
Disorder		?	?	?	?																																								?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	S	L	N	A	D	T	A	K	A	M	V	Q	A	A	D	L	G	T	N	I	Q	R	L	Y	Q	H	E	L	Y	F	R	T	N	G	R	K	G	E	R	L	S	S	V	D	L	E	R	L	Y	Q	N	M	S	V	W	L	W	N	D	T
Secondary structure
SS confidence
Disorder																?															?	?		?	?	?	?	?	?	?	?				?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	S	Y	R	Y	E	E	G	K	N	D	E	L	G	F	K	T	F	T	E	F	L	N	C	Y	A	N	D	A	Y	A	G	G	T	K	C	S	A	D	L	K	K	S	L	V	D	N	N	M	I	Y	G	D	G	S	S	K	A	G	M	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																		?	?	?	?	?	?	?	?	?	?		?	?	?		?		?	?	?		?	?	?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	N	P	S	Y	P	L	N	Y	M	E	K	P	L	T	R	L	M	L	G	R	S	W	W	D	L	N	I	K	V	D	V	E	K	Y	P	G	A	V	S	E	E	G	Q	N	V	T	E	T	I	S	L	Y	S	N	P	T	K	W	F	A
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?									?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	G	N	M	Q	S	T	G	L	W	A	P	A	Q	K	E	V	T	I	K	S	N	A	N	V	P	V	T	V	T	V	A	L	A	D	D	L	T	G	R	E	K	H	E	V	A	L	N	R	P	P	R	V	T	K	T	Y	S	L	D	A
Secondary structure
SS confidence
Disorder	?																						?	?	?													?	?	?	?	?	?		?	?												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	S	G	T	V	K	F	K	V	P	Y	G	G	L	I	Y	I	K	G	N	S	S	T	N	E	S	A	S	F	T	F	T	G	V	V	K	A	P	F	Y	K	D	G	A	W	K	N	D	L	N	S	P	A	P	L	G	E	L	E	S	D
Secondary structure
SS confidence
Disorder		?																			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	A	F	V	Y	T	T	P	K	K	N	L	N	A	S	N	Y	T	G	G	L	E	Q	F	A	N	D	L	D	T	F	A	S	S	M	N	D	F	Y	G	R	D	S	E	D	G	K	H	R	M	F	T	Y	K	N	L	P	G	H	K	H
Secondary structure
SS confidence
Disorder													?																															?	?		?		?			?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	R	F	T	N	D	V	Q	I	S	I	G	D	A	H	S	G	Y	P	V	M	N	S	S	F	S	P	N	S	T	T	L	P	T	T	P	L	N	D	W	L	I	W	H	E	V	G	H	N	A	A	E	T	P	L	T	V	P	G	A	T
Secondary structure
SS confidence
Disorder																									?	?						?	?		?	?																?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	E	V	A	N	N	V	L	A	L	Y	M	Q	D	R	Y	L	G	K	M	N	R	V	A	D	D	I	T	V	A	P	E	Y	L	E	E	S	N	N	Q	A	W	A	R	G	G	A	G	D	R	L	L	M	Y	A	Q	L	K	E	W	A
Secondary structure
SS confidence
Disorder																?	?	?	?		?	?	?	?		?									?	?	?	?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	E	K	N	F	D	I	K	K	W	Y	P	D	G	T	P	L	P	E	F	Y	S	E	R	E	G	M	K	G	W	N	L	F	Q	L	M	H	R	K	A	R	G	D	E	V	S	N	D	K	F	G	G	K	N	Y	C	A	E	S	N	G
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?	?					?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	N	A	A	D	T	L	M	L	C	A	S	W	V	A	Q	T	D	L	S	E	F	F	K	K	W	N	P	G	A	N	A	Y	Q	L	P	G	A	S	E	M	S	F	E	G	G	V	S	Q	S	A	Y	N	T	L	A	S	L	D	L	P
Secondary structure
SS confidence
Disorder																																	?	?	?				?																					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520
Sequence	K	P	E	Q	G	P	E	T	I	N	Q	V	T	E	H	K	M	S	A	E
Secondary structure
SS confidence
Disorder	?												?	?	?	?	?	?	?	?
Disorder confidence