Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	L	R	W	F	A	F	L	I	V	L	L	A	G	C	S	S	K	H	D	Y	T	N	P	P	W	N	A	K	V	P	V	Q	R	A	M	Q	W	M	P	I	S	Q	K	A	G	A	A	W	G	V	D	P	Q	L	I	T	A	I
Secondary structure
SS confidence
Disorder		?	?	?																?	?							?	?	?	?	?		?	?																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	A	I	E	S	G	G	N	P	N	A	V	S	K	S	N	A	I	G	L	M	Q	L	K	A	S	T	S	G	R	D	V	Y	R	R	M	G	W	S	G	E	P	T	T	S	E	L	K	N	P	E	R	N	I	S	M	G	A	A	Y
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	N	I	L	E	T	G	P	L	A	G	I	E	D	P	K	V	L	Q	Y	A	L	V	V	S	Y	A	N	G	A	G	A	L	L	R	T	F	S	S	D	R	K	K	A	I	S	K	I	N	D	L	D	A	D	E	F	L	E	H	V
Secondary structure
SS confidence
Disorder										?		?	?																												?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.
Sequence		A	R	N	H	P	A	P	Q	A	P	R	Y	I	Y	K	L	E	Q	A	L	D	A	M
Secondary structure
SS confidence
Disorder																							?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2y8p chain A Region: 19 - 203 Aligned: 185 Modelled: 185 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli Phyre2 PDB 1sly chain A Region: 39 - 200 Aligned: 143 Modelled: 155 Confidence: 100.0% Identity: 22% PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a Phyre2 PDB 1qsa chain A domain 2 Region: 38 - 201 Aligned: 145 Modelled: 157 Confidence: 100.0% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 3mgw chain A Region: 29 - 201 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme Phyre2 PDB 1gbs chain A Region: 28 - 201 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: G-type lysozyme Phyre2 PDB 3gxk chain B Region: 29 - 201 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 Phyre2 PDB 1qus chain A Region: 25 - 123 Aligned: 95 Modelled: 99 Confidence: 99.1% Identity: 24% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 3bkh chain A Region: 41 - 168 Aligned: 127 Modelled: 128 Confidence: 99.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 Phyre2 PDB 1xsf chain A Region: 51 - 122 Aligned: 67 Modelled: 72 Confidence: 97.4% Identity: 21% PDB header:cell cycle, hydrolase Chain: A: PDB Molecule:probable resuscitation-promoting factor rpfb; PDBTitle: solution structure of a resuscitation promoting factor2 domain from mycobacterium tuberculosis Phyre2 PDB 1xsf chain A domain 1 Region: 52 - 122 Aligned: 66 Modelled: 71 Confidence: 97.2% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: RPF-like Phyre2 PDB 3eo5 chain A Region: 58 - 122 Aligned: 60 Modelled: 65 Confidence: 96.6% Identity: 22% PDB header:cell adhesion Chain: A: PDB Molecule:resuscitation-promoting factor rpfb; PDBTitle: crystal structure of the resuscitation promoting factor rpfb Phyre2 PDB 2fbd chain B Region: 43 - 83 Aligned: 41 Modelled: 41 Confidence: 96.2% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. Phyre2 PDB 1gd6 chain A Region: 43 - 83 Aligned: 41 Modelled: 41 Confidence: 96.1% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1iiz chain A Region: 43 - 83 Aligned: 41 Modelled: 41 Confidence: 96.1% Identity: 24% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1hhl chain A Region: 43 - 83 Aligned: 40 Modelled: 41 Confidence: 95.6% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2vb1 chain A domain 1 Region: 43 - 83 Aligned: 40 Modelled: 41 Confidence: 95.6% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1ghl chain A Region: 43 - 83 Aligned: 40 Modelled: 41 Confidence: 95.5% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 3fi7 chain A Region: 34 - 67 Aligned: 34 Modelled: 34 Confidence: 95.3% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:lmo1076 protein; PDBTitle: crystal structure of the autolysin auto (lmo1076) from listeria2 monocytogenes, catalytic domain Phyre2 PDB 2zyc chain A Region: 33 - 73 Aligned: 41 Modelled: 41 Confidence: 95.2% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan hydrolase flgj; PDBTitle: crystal structure of peptidoglycan hydrolase from2 sphingomonas sp. a1 Phyre2 PDB 1jse chain A Region: 43 - 83 Aligned: 40 Modelled: 41 Confidence: 95.1% Identity: 23% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 1 c2y8pA_ 2 c1slyA_ 3 d1qsaa2 4 c3mgwA_ 5 d1gbsa_ 6 c3gxkB_ 7 d1qusa_ 8 c3bkhA_ 9 c1xsfA_ 10 d1xsfa1 11 c3eo5A_ 12 c2fbdB_ 13 d1gd6a_ 14 d1iiza_ 15 d1hhla_ 16 d2vb1a1 17 d1ghla_ 18 c3fi7A_ 19 c2zycA_ 20 d1jsea_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2y8pA_ 100.0 100 PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli 2 c1slyA_ 100.0 22 PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a 3 d1qsaa2 100.0 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 4 c3mgwA_ 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme 5 d1gbsa_ 100.0 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:G-type lysozyme 6 c3gxkB_ 100.0 18 PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 7 d1qusa_ 99.1 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 8 c3bkhA_ 99.0 20 PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 9 c1xsfA_ 97.4 21 PDB header:cell cycle, hydrolase Chain: A: PDB Molecule:probable resuscitation-promoting factor rpfb; PDBTitle: solution structure of a resuscitation promoting factor2 domain from mycobacterium tuberculosis 10 d1xsfa1 97.2 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:RPF-like 11 c3eo5A_ 96.6 22 PDB header:cell adhesion Chain: A: PDB Molecule:resuscitation-promoting factor rpfb; PDBTitle: crystal structure of the resuscitation promoting factor rpfb 12 c2fbdB_ 96.2 32 PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. 13 d1gd6a_ 96.1 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 14 d1iiza_ 96.1 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 15 d1hhla_ 95.6 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 16 d2vb1a1 95.6 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 17 d1ghla_ 95.5 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 18 c3fi7A_ 95.3 15 PDB header:hydrolase Chain: A: PDB Molecule:lmo1076 protein; PDBTitle: crystal structure of the autolysin auto (lmo1076) from listeria2 monocytogenes, catalytic domain 19 c2zycA_ 95.2 22 PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan hydrolase flgj; PDBTitle: crystal structure of peptidoglycan hydrolase from2 sphingomonas sp. a1 20 d1jsea_ 95.1 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 21 c3ct5A_ not modelled 95.1 17 PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail 22 d1lmqa_ not modelled 95.1 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 23 c2goiC_ not modelled 95.0 30 PDB header:cell adhesion, sugar binding protein Chain: C: PDB Molecule:sperm lysozyme-like protein 1; PDBTitle: crystal structure of mouse sperm c-type lysozyme-like2 protein 1 24 d1qqya_ not modelled 94.9 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 25 d1juga_ not modelled 94.8 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 26 c2z2fA_ not modelled 94.7 20 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme c-2; PDBTitle: x-ray crystal structure of bovine stomach lysozyme 27 d1lsga1 not modelled 94.5 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 28 d1ivma_ not modelled 94.5 18 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 29 d2nwdx1 not modelled 93.8 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 30 d1f6sa_ not modelled 92.5 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 31 d2eqla_ not modelled 92.5 34 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 32 d1b9oa_ not modelled 92.3 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 33 d1yroa1 not modelled 91.9 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 34 d1hfxa_ not modelled 91.9 38 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 35 d1fkqa_ not modelled 91.3 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 36 d1alca_ not modelled 90.3 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 37 c3csqC_ not modelled 80.4 18 PDB header:hydrolase Chain: C: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall2 degrading enzyme in the bacteriophage phi29 tail 38 d1nvma1 not modelled 34.0 15 Fold:RuvA C-terminal domain-like Superfamily:post-HMGL domain-like Family:DmpG/LeuA communication domain-like 39 d1idra_ not modelled 29.8 16 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 40 d1yt3a2 not modelled 21.8 4 Fold:SAM domain-like Superfamily:HRDC-like Family:RNase D C-terminal domains 41 d2coba1 not modelled 15.0 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Psq domain 42 c3aq8A_ not modelled 9.2 14 PDB header:oxygen binding Chain: A: PDB Molecule:group 1 truncated hemoglobin; PDBTitle: crystal structure of truncated hemoglobin from tetrahymena pyriformis,2 q46e mutant, fe(iii) form 43 c2l5qA_ not modelled 9.0 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of bvu_3817 from bacteroides vulgatus,2 northeast structural genomics consortium target bvr159 44 d2cvza1 not modelled 8.7 22 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain 45 d1dlwa_ not modelled 8.3 19 Fold:Globin-like Superfamily:Globin-like Family:Truncated hemoglobin 46 c1mgtA_ not modelled 7.1 16 PDB header:transferase Chain: A: PDB Molecule:protein (o6-methylguanine-dna methyltransferase); PDBTitle: crystal structure of o6-methylguanine-dna methyltransferase from2 hyperthermophilic archaeon pyrococcus kodakaraensis strain kod1 47 d1a5za1 not modelled 6.7 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 48 d2fnoa1 not modelled 6.2 32 Fold:GST C-terminal domain-like Superfamily:GST C-terminal domain-like Family:Glutathione S-transferase (GST), C-terminal domain 49 d2fp1a1 not modelled 5.8 17 Fold:Chorismate mutase II Superfamily:Chorismate mutase II Family:Secreted chorismate mutase-like 50 d1bw6a_ not modelled 5.3 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Centromere-binding

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0