Secondary structure and disorder prediction

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Sequence		M	K	I	K	T	T	V	A	A	L	S	V	L	S	V	L	S	F	G	A	F	A	A	D	S	I	D	A	A	Q	A	Q	N	R	E	A	I	G	T	V	S	V	S	G	V	A	S	S	P	M	D	M	R	E	M	L	N	K	K	A
Secondary structure
SS confidence
Disorder		?	?	?	?													?	?			?		?				?					?	?	?	?								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.
Sequence		E	E	K	G	A	T	A	Y	Q	I	T	E	A	R	S	G	D	T	W	H	A	T	A	E	L	Y	K
Secondary structure
SS confidence
Disorder				?	?	?	?										?	?	?									?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2jna chain A domain 1 Region: 1 - 87 Aligned: 86 Modelled: 87 Confidence: 100.0% Identity: 41% Fold: Dodecin subunit-like Superfamily: YdgH-like Family: YdgH-like Phyre2 PDB 2noc chain A domain 1 Region: 1 - 87 Aligned: 85 Modelled: 87 Confidence: 100.0% Identity: 36% Fold: Dodecin subunit-like Superfamily: YdgH-like Family: YdgH-like Phyre2 PDB 1oy8 chain A Region: 4 - 63 Aligned: 60 Modelled: 60 Confidence: 48.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump Phyre2 PDB 2k4q chain A Region: 28 - 85 Aligned: 57 Modelled: 58 Confidence: 39.9% Identity: 14% PDB header:viral protein Chain: A: PDB Molecule:major tail protein v; PDBTitle: the solution structure of gpv, the major tail protein from2 bacteriophage lambda Phyre2 PDB 3dfe chain A Region: 52 - 77 Aligned: 26 Modelled: 26 Confidence: 36.2% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:putative pii-like signaling protein; PDBTitle: crystal structure of a putative pii-like signaling protein2 (yp_323533.1) from anabaena variabilis atcc 29413 at 2.35 a3 resolution Phyre2 PDB 3b9n chain B Region: 47 - 71 Aligned: 25 Modelled: 25 Confidence: 31.1% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:alkane monoxygenase; PDBTitle: crystal structure of long-chain alkane monooxygenase (lada) Phyre2 PDB 1hl8 chain B Region: 54 - 77 Aligned: 24 Modelled: 24 Confidence: 25.4% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of thermotoga maritima alpha-fucosidase Phyre2 PDB 3no4 chain A Region: 38 - 77 Aligned: 38 Modelled: 40 Confidence: 22.3% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:creatinine amidohydrolase; PDBTitle: crystal structure of a creatinine amidohydrolase (npun_f1913) from2 nostoc punctiforme pcc 73102 at 2.00 a resolution Phyre2 PDB 3lub chain E Region: 38 - 77 Aligned: 38 Modelled: 40 Confidence: 21.4% Identity: 11% PDB header:hydrolase Chain: E: PDB Molecule:putative creatinine amidohydrolase; PDBTitle: crystal structure of putative creatinine amidohydrolase2 (yp_211512.1) from bacteroides fragilis nctc 9343 at 2.11 a3 resolution Phyre2 PDB 3k07 chain A Region: 3 - 85 Aligned: 83 Modelled: 83 Confidence: 19.6% Identity: 6% PDB header:transport protein Chain: A: PDB Molecule:cation efflux system protein cusa; PDBTitle: crystal structure of cusa Phyre2 PDB 3dnf chain B Region: 2 - 62 Aligned: 58 Modelled: 61 Confidence: 18.6% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate reductase; PDBTitle: structure of (e)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase,2 the terminal enzyme of the non-mevalonate pathway Phyre2 PDB 1tqx chain A Region: 34 - 70 Aligned: 34 Modelled: 37 Confidence: 18.5% Identity: 26% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: D-ribulose-5-phosphate 3-epimerase Phyre2 PDB 3eyp chain B Region: 54 - 77 Aligned: 24 Modelled: 24 Confidence: 18.2% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of putative alpha-l-fucosidase from bacteroides2 thetaiotaomicron Phyre2 PDB 3mo4 chain B Region: 54 - 77 Aligned: 24 Modelled: 24 Confidence: 17.8% Identity: 8% PDB header:hydrolase Chain: B: PDB Molecule:alpha-1,3/4-fucosidase; PDBTitle: the crystal structure of an alpha-(1-3,4)-fucosidase from2 bifidobacterium longum subsp. infantis atcc 15697 Phyre2 PDB 3sdo chain B Region: 47 - 70 Aligned: 24 Modelled: 24 Confidence: 16.7% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:nitrilotriacetate monooxygenase; PDBTitle: structure of a nitrilotriacetate monooxygenase from burkholderia2 pseudomallei Phyre2 PDB 3ke8 chain A Region: 2 - 65 Aligned: 61 Modelled: 64 Confidence: 16.6% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate PDBTitle: crystal structure of isph:hmbpp-complex Phyre2 PDB 3etj chain A domain 1 Region: 35 - 67 Aligned: 31 Modelled: 33 Confidence: 15.9% Identity: 10% Fold: Barrel-sandwich hybrid Superfamily: Rudiment single hybrid motif Family: BC C-terminal domain-like Phyre2 PDB 1kjq chain A domain 1 Region: 28 - 62 Aligned: 33 Modelled: 35 Confidence: 14.8% Identity: 18% Fold: Barrel-sandwich hybrid Superfamily: Rudiment single hybrid motif Family: BC C-terminal domain-like Phyre2 PDB 1v7z chain A Region: 38 - 77 Aligned: 38 Modelled: 40 Confidence: 14.2% Identity: 13% Fold: Creatininase Superfamily: Creatininase Family: Creatininase Phyre2 PDB 1luc chain A Region: 47 - 70 Aligned: 24 Modelled: 24 Confidence: 13.9% Identity: 8% Fold: TIM beta/alpha-barrel Superfamily: Bacterial luciferase-like Family: Bacterial luciferase (alkanal monooxygenase) Phyre2 1 d2jnaa1 2 d2noca1 3 c1oy8A_ 4 c2k4qA_ 5 c3dfeA_ 6 c3b9nB_ 7 c1hl8B_ 8 c3no4A_ 9 c3lubE_ 10 c3k07A_ 11 c3dnfB_ 12 d1tqxa_ 13 c3eypB_ 14 c3mo4B_ 15 c3sdoB_ 16 c3ke8A_ 17 d3etja1 18 d1kjqa1 19 d1v7za_ 20 d1luca_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2jnaa1 100.0 41 Fold:Dodecin subunit-like Superfamily:YdgH-like Family:YdgH-like 2 d2noca1 100.0 36 Fold:Dodecin subunit-like Superfamily:YdgH-like Family:YdgH-like 3 c1oy8A_ 48.0 15 PDB header:membrane protein Chain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump 4 c2k4qA_ 39.9 14 PDB header:viral protein Chain: A: PDB Molecule:major tail protein v; PDBTitle: the solution structure of gpv, the major tail protein from2 bacteriophage lambda 5 c3dfeA_ 36.2 27 PDB header:signaling protein Chain: A: PDB Molecule:putative pii-like signaling protein; PDBTitle: crystal structure of a putative pii-like signaling protein2 (yp_323533.1) from anabaena variabilis atcc 29413 at 2.35 a3 resolution 6 c3b9nB_ 31.1 16 PDB header:oxidoreductase Chain: B: PDB Molecule:alkane monoxygenase; PDBTitle: crystal structure of long-chain alkane monooxygenase (lada) 7 c1hl8B_ 25.4 13 PDB header:hydrolase Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of thermotoga maritima alpha-fucosidase 8 c3no4A_ 22.3 16 PDB header:hydrolase Chain: A: PDB Molecule:creatinine amidohydrolase; PDBTitle: crystal structure of a creatinine amidohydrolase (npun_f1913) from2 nostoc punctiforme pcc 73102 at 2.00 a resolution 9 c3lubE_ 21.4 11 PDB header:hydrolase Chain: E: PDB Molecule:putative creatinine amidohydrolase; PDBTitle: crystal structure of putative creatinine amidohydrolase2 (yp_211512.1) from bacteroides fragilis nctc 9343 at 2.11 a3 resolution 10 c3k07A_ 19.6 6 PDB header:transport protein Chain: A: PDB Molecule:cation efflux system protein cusa; PDBTitle: crystal structure of cusa 11 c3dnfB_ 18.6 16 PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate reductase; PDBTitle: structure of (e)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase,2 the terminal enzyme of the non-mevalonate pathway 12 d1tqxa_ 18.5 26 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 13 c3eypB_ 18.2 13 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of putative alpha-l-fucosidase from bacteroides2 thetaiotaomicron 14 c3mo4B_ 17.8 8 PDB header:hydrolase Chain: B: PDB Molecule:alpha-1,3/4-fucosidase; PDBTitle: the crystal structure of an alpha-(1-3,4)-fucosidase from2 bifidobacterium longum subsp. infantis atcc 15697 15 c3sdoB_ 16.7 13 PDB header:oxidoreductase Chain: B: PDB Molecule:nitrilotriacetate monooxygenase; PDBTitle: structure of a nitrilotriacetate monooxygenase from burkholderia2 pseudomallei 16 c3ke8A_ 16.6 15 PDB header:oxidoreductase Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate PDBTitle: crystal structure of isph:hmbpp-complex 17 d3etja1 15.9 10 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 18 d1kjqa1 14.8 18 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 19 d1v7za_ 14.2 13 Fold:Creatininase Superfamily:Creatininase Family:Creatininase 20 d1luca_ 13.9 8 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Bacterial luciferase (alkanal monooxygenase) 21 d1f07a_ not modelled 13.4 20 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:F420 dependent oxidoreductases 22 d1hl9a2 not modelled 13.4 13 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Putative alpha-L-fucosidase, catalytic domain 23 c3qkbB_ not modelled 12.9 24 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein with unknown function which belongs to2 pfam duf74 family (pepe_0654) from pediococcus pentosaceus atcc 257453 at 2.73 a resolution 24 c2wvsD_ not modelled 12.5 25 PDB header:hydrolase Chain: D: PDB Molecule:alpha-l-fucosidase; PDBTitle: crystal structure of an alpha-l-fucosidase gh29 trapped2 covalent intermediate from bacteroides thetaiotaomicron in3 complex with 2-fluoro-fucosyl fluoride using an e288q4 mutant 25 c3rofA_ not modelled 11.9 12 PDB header:hydrolase Chain: A: PDB Molecule:low molecular weight protein-tyrosine-phosphatase ptpa; PDBTitle: crystal structure of the s. aureus protein tyrosine phosphatase ptpa 26 d1lucb_ not modelled 11.1 12 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Bacterial luciferase (alkanal monooxygenase) 27 d1txka2 not modelled 10.7 21 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:MdoG-like 28 c1txkA_ not modelled 10.3 21 PDB header:biosynthetic protein Chain: A: PDB Molecule:glucans biosynthesis protein g; PDBTitle: crystal structure of escherichia coli opgg 29 c1f02T_ not modelled 9.9 33 PDB header:cell adhesion Chain: T: PDB Molecule:translocated intimin receptor; PDBTitle: crystal structure of c-terminal 282-residue fragment of2 intimin in complex with translocated intimin receptor3 (tir) intimin-binding domain 30 d1nfpa_ not modelled 9.9 13 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Non-fluorescent flavoprotein (luxF, FP390) 31 c2y1bA_ not modelled 9.8 20 PDB header:membrane protein Chain: A: PDB Molecule:putative outer membrane protein, signal; PDBTitle: crystal structure of the e. coli outer membrane lipoprotein2 rcsf 32 c2jz7A_ not modelled 8.5 25 PDB header:selenium-binding protein Chain: A: PDB Molecule:selenium binding protein; PDBTitle: solution nmr structure of selenium-binding protein from2 methanococcus vannielii 33 d1rpxa_ not modelled 8.3 23 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 34 c2w1sB_ not modelled 7.8 19 PDB header:hydrolase Chain: B: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: unique ligand binding specificity of a family 322 carbohydrate-binding module from the mu toxin produced by3 clostridium perfringens 35 c3gzaB_ not modelled 7.6 13 PDB header:hydrolase Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of putative alpha-l-fucosidase (np_812709.1) from2 bacteroides thetaiotaomicron vpi-5482 at 1.60 a resolution 36 d1h1ya_ not modelled 7.5 13 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 37 c1z69D_ not modelled 7.2 13 PDB header:oxidoreductase Chain: D: PDB Molecule:coenzyme f420-dependent n(5),n(10)- PDBTitle: crystal structure of methylenetetrahydromethanopterin2 reductase (mer) in complex with coenzyme f420 38 c2i7gA_ not modelled 7.1 13 PDB header:oxidoreductase Chain: A: PDB Molecule:monooxygenase; PDBTitle: crystal structure of monooxygenase from agrobacterium tumefaciens 39 c2k38A_ not modelled 7.0 25 PDB header:antimicrobial protein Chain: A: PDB Molecule:cupiennin-1a; PDBTitle: cupiennin 1a, nmr, minimized average structure 40 c3ir9A_ not modelled 6.9 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:peptide chain release factor subunit 1; PDBTitle: c-terminal domain of peptide chain release factor from2 methanosarcina mazei. 41 d1r3sa_ not modelled 6.7 15 Fold:TIM beta/alpha-barrel Superfamily:UROD/MetE-like Family:Uroporphyrinogen decarboxylase, UROD 42 c3qc3B_ not modelled 6.4 13 PDB header:isomerase Chain: B: PDB Molecule:d-ribulose-5-phosphate-3-epimerase; PDBTitle: crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699)2 from homo sapiens at 2.20 a resolution 43 d2flia1 not modelled 6.3 23 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 44 d1l7ba_ not modelled 6.2 31 Fold:BRCT domain Superfamily:BRCT domain Family:DNA ligase 45 d1nqka_ not modelled 6.2 13 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Ssud-like monoxygenases 46 c2gi4A_ not modelled 6.2 15 PDB header:hydrolase Chain: A: PDB Molecule:possible phosphotyrosine protein phosphatase; PDBTitle: solution structure of the low molecular weight protein2 tyrosine phosphatase from campylobacter jejuni. 47 d1p5vb_ not modelled 6.1 13 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:Pilus subunits 48 c2cokA_ not modelled 6.0 15 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase-1; PDBTitle: solution structure of brct domain of poly(adp-ribose)2 polymerase-1 49 c2zfdB_ not modelled 5.5 15 PDB header:signaling protein/transferase Chain: B: PDB Molecule:putative uncharacterized protein t20l15_90; PDBTitle: the crystal structure of plant specific calcium binding protein atcbl22 in complex with the regulatory domain of atcipk14 50 d1tvla_ not modelled 5.5 8 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Ssud-like monoxygenases 51 c1tvlA_ not modelled 5.5 8 PDB header:oxidoreductase Chain: A: PDB Molecule:protein ytnj; PDBTitle: structure of ytnj from bacillus subtilis 52 d2g39a1 not modelled 5.4 31 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase alpha subunit-like 53 d1mnta_ not modelled 5.3 50 Fold:Ribbon-helix-helix Superfamily:Ribbon-helix-helix Family:Arc/Mnt-like phage repressors 54 d1cdwa2 not modelled 5.1 25 Fold:TBP-like Superfamily:TATA-box binding protein-like Family:TATA-box binding protein (TBP), C-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0