Phyre 2 Results for Q96KQ4

Email	l.a.kelley@imperial.ac.uk
Description	Q96KQ4
Date	Wed Jun 6 09:44:33 BST 2012
Unique Job ID	0ca6f4d581c1b1e7

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c1ycsB_

Top template information

PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex

Confidence and coverage

Confidence:

100.0%

Coverage:

18%

193 residues ( 18% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

276 residues ( 25%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M M P M I L T V F L S N N E Q I L T E V P I T P E T T C R D V V E F C K E P G E G S C H L A E V W R G N E R P I P F D H

Secondary structure

SS confidence

Disorder ? ? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence M M Y E H L Q K W G P R R E E V K F F L R H E D S P T E N S E Q G G R Q T Q E Q R T Q R N V I N V P G E K R T E N G V G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence N P R V E L T L S E L Q D M A A R Q Q Q Q I E N Q Q Q M L V A K E Q R L H F L K Q Q E R R Q Q Q S I S E N E K L Q K L K

Secondary structure

SS confidence

Disorder ? ? ?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E R V E A Q E N K L K K I R A M R G Q V D Y S K I M N G N L S A E I E R F S A M F Q E K K Q E V Q T A I L R V D Q L S Q

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Q L E D L K K G K L N G F Q S Y N G K L T G P A A V E L K R L Y Q E L Q I R N Q L N Q E Q N S K L Q Q Q K E L L N K R N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence M E V A M M D K R I S E L R E R L Y G K K I Q L N R V N G T S S P Q S P L S T S G R V A A V G P Y I Q V P S A G S F P V

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence L G D P I K P Q S L S I A S N A A H G R S K S A N D G N W P T L K Q N S S S S V K P V Q V A G A D W K D P S V E G S V K

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence Q G T V S S Q P V P F S A L G P T E K P G I E I G K V P P P I P G V G K Q L P P S Y G T Y P S P T P L G P G S T S S L E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence R R K E G S L P R P S A G L P S R Q R P T L L P A T G S T P Q P G S S Q Q I Q Q R I S V P P S P T Y P P A G P P A F P A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence G D S K P E L P L T V A I R P F L A D K G S R P Q S P R K G P Q T V N S S S I Y S M Y L Q Q A T P P K N Y Q P A A H S A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence L N K S V K A V Y G K P V L P S G S T S P S P L P F L H G S L S T G T P Q P Q P P S E S T E K E P E Q D G P A A P A D G

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence S T V E S L P R P L S P T K L T P I V H S P L R Y Q S D A D L E A L R R K L A N A P R P L K K R S S I T E P E G P G G P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence N I Q K L L Y Q R F N T L A G G M E G T P F Y Q P S P S Q D F M G T L A D V D N G N T N A N G N L E E L P P A Q P T A P

Secondary structure

SS confidence

Disorder
?
?
? ? ? ?
? ?
? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L P A E P A P S S D A N D N E L P S P E P E E L I C P Q T T H Q T A E P A E D N N N N V A T V P T T E Q I P S P V A E A

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?
?
?
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence P S P G E E Q V P P A P L P P A S H P P A T S T N K R T N L K K P N S E R T G H G L R V R F N P L A L L L D A S L E G E

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence F D L V Q R I I Y E V E D P S K P N D E G I T P L H N A V C A G H H H I V K F L L D F G V N V N A A D S D G W T P L H C

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence A A S C N S V H L C K Q L V E S G A A I F A S T I S D I E T A A D K C E E M E E G Y I Q C S Q F L Y G V Q E K L G V M N

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence K G V A Y A L W D Y E A Q N S D E L S F H E G D A L T I L R R K D E S E T E W W W A R L G D R E G Y V P K N L L G L Y P

Secondary structure

SS confidence

Disorder ?
?
? ?
?

Disorder confidence

. . . . . . . . . 1090

Sequence R I K P R Q R T L A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1ycs chain B

Region: 888 - 1080
Aligned: 193
Modelled: 193
Confidence: 100.0%
Identity: 81%
PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex

Phyre2

PDB 2vge chain A

Region: 877 - 1083
Aligned: 207
Modelled: 207
Confidence: 99.9%
Identity: 55%
PDB header:transcription
Chain: A: PDB Molecule:rela-associated inhibitor;
PDBTitle: crystal structure of the c-terminal region of human iaspp

Phyre2

PDB 1mv3 chain A

Region: 1015 - 1080
Aligned: 63
Modelled: 66
Confidence: 99.7%
Identity: 29%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 1ycs chain B domain 2

Region: 1018 - 1080
Aligned: 63
Modelled: 63
Confidence: 99.7%
Identity: 73%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1gri chain A

Region: 1000 - 1081
Aligned: 79
Modelled: 82
Confidence: 99.6%
Identity: 22%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2dx1 chain A

Region: 1023 - 1078
Aligned: 53
Modelled: 56
Confidence: 99.6%
Identity: 40%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3nmz chain D

Region: 1018 - 1079
Aligned: 59
Modelled: 62
Confidence: 99.6%
Identity: 36%
PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef

Phyre2

PDB 2rqr chain A

Region: 980 - 1081
Aligned: 98
Modelled: 102
Confidence: 99.6%
Identity: 14%
PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex

Phyre2

PDB 1i1j chain A

Region: 1021 - 1076
Aligned: 56
Modelled: 56
Confidence: 99.6%
Identity: 27%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2lqn chain A

Region: 950 - 1080
Aligned: 128
Modelled: 131
Confidence: 99.5%
Identity: 12%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1ng2 chain A domain 2

Region: 1021 - 1080
Aligned: 57
Modelled: 60
Confidence: 99.5%
Identity: 30%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1wyx chain A

Region: 1023 - 1085
Aligned: 63
Modelled: 63
Confidence: 99.5%
Identity: 37%
PDB header:cell adhesion
Chain: A: PDB Molecule:crk-associated substrate;
PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution

Phyre2

PDB 2eyz chain A

Region: 947 - 1078
Aligned: 129
Modelled: 132
Confidence: 99.5%
Identity: 9%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 1ug1 chain A

Region: 1019 - 1086
Aligned: 68
Modelled: 68
Confidence: 99.5%
Identity: 21%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2dlp chain A

Region: 1015 - 1078
Aligned: 63
Modelled: 64
Confidence: 99.5%
Identity: 30%
PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein

Phyre2

PDB 1x43 chain A

Region: 1011 - 1079
Aligned: 68
Modelled: 69
Confidence: 99.5%
Identity: 29%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:sh3 domain grb2-like protein b1;
PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1)

Phyre2

PDB 2kym chain A

Region: 1019 - 1078
Aligned: 57
Modelled: 60
Confidence: 99.5%
Identity: 32%
PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide

Phyre2

PDB 2l3s chain A

Region: 947 - 1078
Aligned: 129
Modelled: 132
Confidence: 99.5%
Identity: 9%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2dl7 chain A

Region: 1015 - 1084
Aligned: 70
Modelled: 70
Confidence: 99.5%
Identity: 30%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:kiaa0769 protein;
PDBTitle: solution structure of the second sh3 domain of human2 kiaa0769 protein

Phyre2

PDB 2e5k chain A

Region: 1020 - 1084
Aligned: 65
Modelled: 65
Confidence: 99.5%
Identity: 25%
PDB header:protein binding
Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1;
PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1

Phyre2

PDB 2uwq chain A

Region: 1 - 83
Aligned: 83
Modelled: 83
Confidence: 99.5%
Identity: 67%
PDB header:apoptosis
Chain: A: PDB Molecule:apoptosis-stimulating of p53 protein 2;
PDBTitle: solution structure of aspp2 n-terminus

Phyre2

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