Phyre 2 Results for Q5TCZ1

Email	l.a.kelley@imperial.ac.uk
Description	Q5TCZ1
Date	Sat Jun 16 10:24:30 BST 2012
Unique Job ID	8c6fad720bebd53c

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2dybA_

Top template information

PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)

Confidence and coverage

Confidence:

100.0%

Coverage:

24%

270 residues ( 24% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

504 residues ( 44%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

Warning: 68% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M L A Y C V Q D A T V V D V E K R R N P S K H Y V Y I I N V T W S D S T S Q T I Y R R Y S K F F D L Q M Q L L D K F P I

Secondary structure

SS confidence

Disorder ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence E G G Q K D P K Q R I I P F L P G K I L F R R S H I R D V A V K R L K P I D E Y C R A L V R L P P H I S Q C D E V F R F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
?
? ?
? ? ?
? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence F E A R P E D V N P P K E D Y G S S K R K S V W L S S W A E S P K K D V T G A D A T A E P M I L E Q Y V V V S N Y K K Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E N S E L S L Q A G E V V D V I E K N E S G W W F V S T S E E Q G W V P A T Y L E A Q N G T R D D S D I N T S K T G E V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?
?
? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence S K R R K A H L R R L D R R W T L G G M V N R Q H S R E E K Y V T V Q P Y T S Q S K D E I G F E K G V T V E V I R K N L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E G W W Y I R Y L G K E G W A P A S Y L K K A K D D L P T R K K N L A G P V E I I G N I M E I S N L L N K K A S G D K E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence T P P A E G E G H E A P I A K K E I S L P I L C N A S N G S A V G V P D R T V S R L A Q G S P A V A R I A P Q R A Q I S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence S P N L R T R P P P R R E S S L G F Q L P K P P E P P S V E V E Y Y T I A E F Q S C I S D G I S F R G G Q K A E V I D K

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ?
?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence N S G G W W Y V Q I G E K E G W A P A S Y I D K R K K P N L S R R T S T L T R P K V P P P A P P S K P K E A E E G P T G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence A S E S Q D S P R K L K Y E E P E Y D I P A F G F D S E P E L S E E P V E D R A S G E R R P A Q P H R P S P A S S L Q R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence A R F K V G E S S E D V A L E E E T I Y E N E G F R P Y A E D T L S A R G S S G D S D S P G S S S L S L T R K N S P K S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence G S P K S S S L L K L K A E K N A Q A E M G K N H S S A S F S S S I T I N T T C C S S S S S S S S S L S K T S G D L K P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence R S A S D A G I R G T P K V R A K K D A D A N A G L T S C P R A K P S V R P K P F L N R A E S Q S Q E K M D I S T L R R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Q L R P T G Q L R G G L K G S K S E D S E L P P Q T A S E A P S E G S R R S S S D L I T L P A T T P P C P T K K E W E G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence P A T S Y M T C S A Y Q K V Q D S E I S F P A G V E V Q V L E K Q E S G W W Y V R F G E L E G W A P S H Y L V L D E N E

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence Q P D P S G K E L D T V P A K G R Q N E G K S D S L E K I E R R V Q A L N T V N Q S K K A T P P I P S K P P G G F G K T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence S G T P A V K M R N G V R Q V A V R P Q S V F V S P P P K D N N L S C A L R R N E S L T A T D G L R G V R R N S S F S T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence A R S A A A E A K G R L A E R A A S Q G S D S P L L P A Q R N S I P V S P V R P K P I E K S Q F I H N N L K D V Y V S I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . .

Sequence A D Y E G D E E T A G F Q E G V S M E V L E R N P N G W W Y C Q I L D G V K P F K G W V P S N Y L E K K N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
? ?
? ?
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2dyb chain A

Region: 7 - 316
Aligned: 270
Modelled: 287
Confidence: 100.0%
Identity: 19%
PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)

Phyre2

PDB 1ng2 chain A

Region: 167 - 360
Aligned: 164
Modelled: 164
Confidence: 100.0%
Identity: 32%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 1gri chain A

Region: 170 - 327
Aligned: 153
Modelled: 158
Confidence: 100.0%
Identity: 21%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2lqn chain A

Region: 115 - 331
Aligned: 207
Modelled: 217
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1ov3 chain A

Region: 164 - 323
Aligned: 130
Modelled: 129
Confidence: 100.0%
Identity: 41%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 2l3s chain A

Region: 168 - 324
Aligned: 157
Modelled: 157
Confidence: 100.0%
Identity: 15%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2eyz chain A

Region: 115 - 326
Aligned: 195
Modelled: 195
Confidence: 100.0%
Identity: 15%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l73 chain A

Region: 4 - 142
Aligned: 136
Modelled: 136
Confidence: 99.9%
Identity: 20%
PDB header:oxidoreductase regulator
Chain: A: PDB Molecule:nadph oxidase organizer 1;
PDBTitle: structure of the noxo1b px domain

Phyre2

PDB 1kq6 chain A

Region: 5 - 144
Aligned: 137
Modelled: 139
Confidence: 99.9%
Identity: 34%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 1mv3 chain A

Region: 945 - 1131
Aligned: 187
Modelled: 187
Confidence: 99.9%
Identity: 14%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 1o7k chain A

Region: 5 - 126
Aligned: 119
Modelled: 122
Confidence: 99.9%
Identity: 38%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 2egc chain A

Region: 1069 - 1133
Aligned: 65
Modelled: 65
Confidence: 99.8%
Identity: 95%
PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structure of the fifth sh3 domain from human2 kiaa0418 protein

Phyre2

PDB 1h6h chain A

Region: 5 - 128
Aligned: 121
Modelled: 124
Confidence: 99.8%
Identity: 27%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 1ng2 chain A domain 2

Region: 1061 - 1131
Aligned: 67
Modelled: 71
Confidence: 99.8%
Identity: 31%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2dx1 chain A

Region: 1067 - 1133
Aligned: 63
Modelled: 67
Confidence: 99.8%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 2rqr chain A

Region: 1016 - 1133
Aligned: 116
Modelled: 118
Confidence: 99.8%
Identity: 11%
PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex

Phyre2

PDB 2kym chain A

Region: 1072 - 1133
Aligned: 61
Modelled: 62
Confidence: 99.8%
Identity: 11%
PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide

Phyre2

PDB 3nmz chain D

Region: 1057 - 1133
Aligned: 73
Modelled: 77
Confidence: 99.8%
Identity: 19%
PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef

Phyre2

PDB 1ov3 chain A domain 2

Region: 1061 - 1131
Aligned: 67
Modelled: 71
Confidence: 99.8%
Identity: 31%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2rea chain A

Region: 5 - 124
Aligned: 111
Modelled: 120
Confidence: 99.8%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4-phosphate 3-kinase c2
PDBTitle: crystal structures of c2alpha-pi3 kinase px-domain domain2 indicate conformational change associated with ligand3 binding.

Phyre2

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