Phyre 2 Results for A1X283

Email	l.a.kelley@imperial.ac.uk
Description	A1X283
Date	Thu Apr 26 09:27:51 BST 2012
Unique Job ID	5ef591bb9fd08c0a

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2dybA_

Top template information

PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)

Confidence and coverage

Confidence:

100.0%

Coverage:

27%

248 residues ( 27% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

491 residues ( 54%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

Warning: 65% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M P P R R S I V E V K V L D V Q K R R V P N K H Y V Y I I R V T W S S G S T E A I Y R R Y S K F F D L Q M Q M L D K F P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence M E G G Q K D P K Q R I I P F L P G K I L F R R S H I R D V A V K R L I P I D E Y C K A L I Q L P P Y I S Q C D E V L Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence F F E T R P E D L N P P K E E H I G K K K S G G D Q T S V D P M V L E Q Y V V V A N Y Q K Q E S S E I S L S V G Q V V D

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?
? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence I I E K N E S G W W F V S T A E E Q G W V P A T C L E G Q D G V Q D E F S L Q P E E E E K Y T V I Y P Y T A R D Q D E M

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence N L E R G A V V E V I Q K N L E G W W K I R Y Q G K E G W A P A S Y L K K N S G E P L P P K P G P G S P S H P G A L D L

Secondary structure

SS confidence

Disorder ?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence D G V S R Q Q N A V G R E K E L L S S Q R D G R F E G R P V P D G D A K Q R S P K M R Q R P P P R R D M T I P R G L N L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence P K P P I P P Q V E E E Y Y T I A E F Q T T I P D G I S F Q A G L K V E V I E K N L S G W W Y I Q I E D K E G W A P A T

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence F I D K Y K K T S N A S R P N F L A P L P H E V T Q L R L G E A A A L E N N T G S E A T G P S R P L P D A P H G V M D S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence G L P W S K D W K G S K D V L R K A S S D M S A S A G Y E E I S D P D M E E K P S L P P R K E S I I K S E G E L L E R E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence R E R Q R T E Q L R G P T P K P P G V I L P M M P A K H I P P A R D S R R P E P K P D K S R L F Q L K N D M G L E C G H

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence K V L A K E V K K P N L R P I S K S K T D L P E E K P D A T P Q N P F L K S R P Q V R P K P A P S P K T E P P Q G E D Q

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence V D I C N L R S K L R P A K S Q D K S L L D G E G P Q A V G G Q D V A F S R S F L P G E G P G R A Q D R T G K Q D G L S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence P K E I S C R A P P R P A K T T D P V S K S V P V P L Q E A P Q Q R P V V P P R R P P P P K K T S S S S R P L P E V R G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence P Q C E G H E S R A A P T P G R A L L V P P K A K P F L S N S L G G Q D D T R G K G S L G P W G T G K I G E N R E K A A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence A A S V P N A D G L K D S L Y V A V A D F E G D K D T S S F Q E G T V F E V R E K N S S G W W F C Q V L S G A P S W E G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 910 .

Sequence W I P S N Y L R K K P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2dyb chain A

Region: 3 - 271
Aligned: 248
Modelled: 269
Confidence: 100.0%
Identity: 21%
PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)

Phyre2

PDB 2l73 chain A

Region: 4 - 147
Aligned: 141
Modelled: 144
Confidence: 100.0%
Identity: 21%
PDB header:oxidoreductase regulator
Chain: A: PDB Molecule:nadph oxidase organizer 1;
PDBTitle: structure of the noxo1b px domain

Phyre2

PDB 1ng2 chain A

Region: 153 - 313
Aligned: 161
Modelled: 161
Confidence: 100.0%
Identity: 34%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 1gri chain A

Region: 156 - 281
Aligned: 121
Modelled: 126
Confidence: 100.0%
Identity: 17%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 1ov3 chain A

Region: 150 - 277
Aligned: 128
Modelled: 128
Confidence: 100.0%
Identity: 42%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 1kq6 chain A

Region: 4 - 139
Aligned: 133
Modelled: 136
Confidence: 100.0%
Identity: 37%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 2l3s chain A

Region: 154 - 280
Aligned: 127
Modelled: 127
Confidence: 100.0%
Identity: 20%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2eyz chain A

Region: 116 - 280
Aligned: 163
Modelled: 165
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 1h6h chain A

Region: 3 - 130
Aligned: 125
Modelled: 128
Confidence: 99.9%
Identity: 27%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 1o7k chain A

Region: 4 - 127
Aligned: 121
Modelled: 124
Confidence: 99.9%
Identity: 37%
Fold: PX domain
Superfamily: PX domain
Family: PX domain

Phyre2

PDB 2rea chain A

Region: 6 - 127
Aligned: 113
Modelled: 122
Confidence: 99.9%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4-phosphate 3-kinase c2
PDBTitle: crystal structures of c2alpha-pi3 kinase px-domain domain2 indicate conformational change associated with ligand3 binding.

Phyre2

PDB 2iwl chain X

Region: 1 - 130
Aligned: 111
Modelled: 121
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: X: PDB Molecule:phosphatidylinositol-4-phosphate 3-kinase c2
PDBTitle: structure of the px domain of phosphoinositide 3-kinase-2 c2alpha

Phyre2

PDB 1mv3 chain A

Region: 711 - 911
Aligned: 201
Modelled: 201
Confidence: 99.9%
Identity: 11%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 2czo chain A

Region: 1 - 127
Aligned: 121
Modelled: 127
Confidence: 99.9%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the px domain of bem1p

Phyre2

PDB 2wwe chain A

Region: 7 - 122
Aligned: 100
Modelled: 116
Confidence: 99.8%
Identity: 22%
PDB header:transferase
Chain: A: PDB Molecule:phosphoinositide-3-kinase, class 2, gamma
PDBTitle: crystal structure of the phox homology domain of human2 phosphoinositide-3-kinase-c2-gamma

Phyre2

PDB 2egc chain A

Region: 852 - 910
Aligned: 59
Modelled: 59
Confidence: 99.7%
Identity: 54%
PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structure of the fifth sh3 domain from human2 kiaa0418 protein

Phyre2

PDB 1ng2 chain A domain 2

Region: 155 - 212
Aligned: 58
Modelled: 58
Confidence: 99.7%
Identity: 31%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1wlp chain B domain 2

Region: 145 - 210
Aligned: 66
Modelled: 66
Confidence: 99.7%
Identity: 42%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2rqr chain A

Region: 796 - 910
Aligned: 113
Modelled: 115
Confidence: 99.7%
Identity: 15%
PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex

Phyre2

PDB 1udl chain A

Region: 195 - 286
Aligned: 92
Modelled: 92
Confidence: 99.7%
Identity: 22%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

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