Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	K	I	F	E	D	N	S	L	T	I	G	H	T	P	L	V	R	L	N	R	I	G	N	G	R	I	L	A	K	V	E	S	R	N	P	S	F	S	V	K	C	R	I	G	A	N	M	I	W	D	A	E	K	R	G	V	L	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	V	E	L	V	E	P	T	S	G	N	T	G	I	A	L	A	Y	V	A	A	A	R	G	Y	K	L	T	L	T	M	P	E	T	M	S	I	E	R	R	K	L	L	K	A	L	G	A	N	L	V	L	T	E	G	A	K	G	M
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	G	A	I	Q	K	A	E	E	I	V	A	S	N	P	E	K	Y	L	L	L	Q	Q	F	S	N	P	A	N	P	E	I	H	E	K	T	T	G	P	E	I	W	E	D	T	D	G	Q	V	D	V	F	I	A	G	V	G	T	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	L	T	G	V	S	R	Y	I	K	G	T	K	G	K	T	D	L	I	S	V	A	V	E	P	T	D	S	P	V	I	A	Q	A	L	A	G	E	E	I	K	P	G	P	H	K	I	Q	G	I	G	A	G	F	I	P	A	N	L	D
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	K	L	V	D	K	V	I	G	I	T	N	E	E	A	I	S	T	A	R	R	L	M	E	E	E	G	I	L	A	G	I	S	S	G	A	A	V	A	A	A	L	K	L	Q	E	D	E	S	F	T	N	K	N	I	V	V	I	L	P
Secondary structure
SS confidence
Disorder																																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.
Sequence		S	S	G	E	R	Y	L	S	T	A	L	F	A	D	L	F	T	E	K	E	L	Q	Q
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3pc3 chain A Region: 2 - 323 Aligned: 317 Modelled: 322 Confidence: 100.0% Identity: 37% PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate Phyre2 PDB 1jbq chain A Region: 3 - 322 Aligned: 311 Modelled: 320 Confidence: 100.0% Identity: 41% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1jbq chain D Region: 3 - 322 Aligned: 311 Modelled: 320 Confidence: 100.0% Identity: 41% PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein Phyre2 PDB 1z7w chain A domain 1 Region: 2 - 321 Aligned: 311 Modelled: 320 Confidence: 100.0% Identity: 56% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1y7l chain A domain 1 Region: 4 - 312 Aligned: 307 Modelled: 309 Confidence: 100.0% Identity: 70% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1fcj chain A Region: 2 - 303 Aligned: 302 Modelled: 302 Confidence: 100.0% Identity: 97% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2pqm chain A Region: 3 - 312 Aligned: 301 Modelled: 310 Confidence: 100.0% Identity: 49% PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution Phyre2 PDB 3dwg chain A Region: 3 - 319 Aligned: 300 Modelled: 304 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis Phyre2 PDB 1ve1 chain A domain 1 Region: 8 - 313 Aligned: 295 Modelled: 304 Confidence: 100.0% Identity: 48% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2bhs chain A domain 1 Region: 7 - 312 Aligned: 287 Modelled: 293 Confidence: 100.0% Identity: 45% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2q3b chain A Region: 3 - 307 Aligned: 295 Modelled: 305 Confidence: 100.0% Identity: 58% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis Phyre2 PDB 1o58 chain A Region: 5 - 310 Aligned: 293 Modelled: 306 Confidence: 100.0% Identity: 54% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1wkv chain A domain 1 Region: 4 - 313 Aligned: 290 Modelled: 296 Confidence: 100.0% Identity: 27% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2egu chain A Region: 1 - 314 Aligned: 266 Modelled: 269 Confidence: 100.0% Identity: 53% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 Phyre2 PDB 1tdj chain A Region: 2 - 303 Aligned: 287 Modelled: 302 Confidence: 100.0% Identity: 22% PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli Phyre2 PDB 1pwh chain A Region: 12 - 323 Aligned: 301 Modelled: 312 Confidence: 100.0% Identity: 24% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3l6c chain A Region: 1 - 310 Aligned: 302 Modelled: 310 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor Phyre2 PDB 2d1f chain A Region: 1 - 313 Aligned: 304 Modelled: 313 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase Phyre2 PDB 3iau chain A Region: 8 - 320 Aligned: 300 Modelled: 309 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum Phyre2 PDB 1p5j chain A Region: 10 - 321 Aligned: 301 Modelled: 310 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase Phyre2 1 c3pc3A_ 2 d1jbqa_ 3 c1jbqD_ 4 d1z7wa1 5 d1y7la1 6 d1fcja_ 7 c2pqmA_ 8 c3dwgA_ 9 d1ve1a1 10 d2bhsa1 11 c2q3bA_ 12 d1o58a_ 13 d1wkva1 14 c2eguA_ 15 c1tdjA_ 16 d1pwha_ 17 c3l6cA_ 18 c2d1fA_ 19 c3iauA_ 20 c1p5jA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3pc3A_ 100.0 37 PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate 2 d1jbqa_ 100.0 41 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 3 c1jbqD_ 100.0 41 PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein 4 d1z7wa1 100.0 56 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 5 d1y7la1 100.0 70 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 6 d1fcja_ 100.0 97 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 7 c2pqmA_ 100.0 49 PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution 8 c3dwgA_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis 9 d1ve1a1 100.0 48 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 10 d2bhsa1 100.0 45 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 11 c2q3bA_ 100.0 58 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis 12 d1o58a_ 100.0 54 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 13 d1wkva1 100.0 27 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 14 c2eguA_ 100.0 53 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 15 c1tdjA_ 100.0 22 PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli 16 d1pwha_ 100.0 24 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 17 c3l6cA_ 100.0 23 PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor 18 c2d1fA_ 100.0 20 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase 19 c3iauA_ 100.0 19 PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum 20 c1p5jA_ 100.0 23 PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase 21 d1p5ja_ not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 22 c2gn0A_ not modelled 100.0 22 PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) 23 d1v71a1 not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 24 d1tdja1 not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 25 c3r0zA_ not modelled 100.0 20 PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium 26 d1v7ca_ not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 27 c1x1qA_ not modelled 100.0 21 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 28 d1qopb_ not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 29 c2rkbE_ not modelled 100.0 23 PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells 30 d1ve5a1 not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 31 d1v8za1 not modelled 100.0 26 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 32 c2zsjB_ not modelled 100.0 22 PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 33 d1e5xa_ not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 34 c2o2jA_ not modelled 100.0 27 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: mycobacterium tuberculosis tryptophan synthase beta chain2 dimer (apoform) 35 d1j0aa_ not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 36 d1f2da_ not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 37 d1tyza_ not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 38 d1vb3a1 not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 39 c3v7nA_ not modelled 100.0 14 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis 40 d1kl7a_ not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 41 d1c1da1 not modelled 92.0 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 42 d1vp8a_ not modelled 91.9 21 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 43 d1o89a2 not modelled 86.0 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 44 c3iupB_ not modelled 85.2 19 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nadph:quinone oxidoreductase; PDBTitle: crystal structure of putative nadph:quinone oxidoreductase2 (yp_296108.1) from ralstonia eutropha jmp134 at 1.70 a resolution 45 d1o8ca2 not modelled 84.6 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 46 d1ml4a2 not modelled 83.7 24 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 47 d1bg6a2 not modelled 81.7 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 48 d1kola2 not modelled 78.1 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 49 d1tt7a2 not modelled 73.9 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 50 d1hyua1 not modelled 70.8 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 51 d1ekxa2 not modelled 69.8 18 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 52 d1llua2 not modelled 68.7 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 53 d1fl2a1 not modelled 67.6 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 54 d1t57a_ not modelled 66.8 21 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 55 d1cdoa2 not modelled 66.4 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 56 d1trba1 not modelled 66.2 25 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 57 c3krtC_ not modelled 65.4 19 PDB header:oxidoreductase Chain: C: PDB Molecule:crotonyl coa reductase; PDBTitle: crystal structure of putative crotonyl coa reductase from streptomyces2 coelicolor a3(2) 58 d1l7da1 not modelled 63.0 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 59 c3p2yA_ not modelled 60.8 15 PDB header:oxidoreductase Chain: A: PDB Molecule:alanine dehydrogenase/pyridine nucleotide transhydrogenase; PDBTitle: crystal structure of alanine dehydrogenase/pyridine nucleotide2 transhydrogenase from mycobacterium smegmatis 60 d1pg5a2 not modelled 60.0 16 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 61 d1vdca1 not modelled 60.0 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 62 d1ykfa2 not modelled 58.6 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 63 d1xa0a2 not modelled 57.5 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 64 c3s8mA_ not modelled 57.4 20 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 65 d2i0za1 not modelled 55.9 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:HI0933 N-terminal domain-like 66 d3lada1 not modelled 53.8 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 67 c2bryA_ not modelled 53.8 19 PDB header:transport Chain: A: PDB Molecule:nedd9 interacting protein with calponin homology PDBTitle: crystal structure of the native monooxygenase domain of2 mical at 1.45 a resolution 68 c2yrrA_ not modelled 53.3 11 PDB header:transferase Chain: A: PDB Molecule:aminotransferase, class v; PDBTitle: hypothetical alanine aminotransferase (tth0173) from thermus2 thermophilus hb8 69 c2ywlA_ not modelled 51.6 22 PDB header:oxidoreductase Chain: A: PDB Molecule:thioredoxin reductase related protein; PDBTitle: crystal structure of thioredoxin reductase-related protein ttha03702 from thermus thermophilus hb8 70 c2qx7A_ not modelled 51.0 17 PDB header:plant protein Chain: A: PDB Molecule:eugenol synthase 1; PDBTitle: structure of eugenol synthase from ocimum basilicum 71 d1rjwa2 not modelled 50.6 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 72 d1dxla1 not modelled 47.7 33 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 73 c3orqA_ not modelled 46.9 22 PDB header:ligase,biosynthetic protein Chain: A: PDB Molecule:n5-carboxyaminoimidazole ribonucleotide synthetase; PDBTitle: crystal structure of n5-carboxyaminoimidazole synthetase from2 staphylococcus aureus complexed with adp 74 d1ebda1 not modelled 46.5 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 75 d1lvla1 not modelled 46.0 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 76 c2q2qG_ not modelled 45.4 16 PDB header:oxidoreductase Chain: G: PDB Molecule:beta-d-hydroxybutyrate dehydrogenase; PDBTitle: structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida 77 d1p0fa2 not modelled 44.7 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 78 c3allA_ not modelled 44.4 16 PDB header:oxidoreductase Chain: A: PDB Molecule:2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase; PDBTitle: crystal structure of 2-methyl-3-hydroxypyridine-5-carboxylic acid2 oxygenase, mutant y270a 79 d1ojta1 not modelled 43.7 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 80 c3d3kD_ not modelled 43.2 14 PDB header:protein binding Chain: D: PDB Molecule:enhancer of mrna-decapping protein 3; PDBTitle: crystal structure of human edc3p 81 d1ryia1 not modelled 42.9 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain 82 d1neka2 not modelled 42.7 22 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain 83 c1hyuA_ not modelled 42.3 30 PDB header:oxidoreductase Chain: A: PDB Molecule:alkyl hydroperoxide reductase subunit f; PDBTitle: crystal structure of intact ahpf 84 d1v9la1 not modelled 42.0 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 85 c3grkE_ not modelled 41.9 18 PDB header:oxidoreductase Chain: E: PDB Molecule:enoyl-(acyl-carrier-protein) reductase (nadh); PDBTitle: crystal structure of short chain dehydrogenase reductase2 sdr glucose-ribitol dehydrogenase from brucella melitensis 86 d1seza1 not modelled 41.6 23 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain 87 c1d4cB_ not modelled 41.5 29 PDB header:oxidoreductase Chain: B: PDB Molecule:flavocytochrome c fumarate reductase; PDBTitle: crystal structure of the uncomplexed form of the2 flavocytochrome c fumarate reductase of shewanella3 putrefaciens strain mr-1 88 c3d4oA_ not modelled 41.5 16 PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution 89 d2gf3a1 not modelled 41.3 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain 90 c1jrxA_ not modelled 41.3 25 PDB header:oxidoreductase Chain: A: PDB Molecule:flavocytochrome c; PDBTitle: crystal structure of arg402ala mutant flavocytochrome c32 from shewanella frigidimarina 91 d1qo8a2 not modelled 41.2 24 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain 92 c2c7tA_ not modelled 41.0 19 PDB header:transferase Chain: A: PDB Molecule:glutamine-2-deoxy-scyllo-inosose PDBTitle: crystal structure of the plp-bound form of btrr,2 a dual functional aminotransferase involved in butirosin3 biosynthesis. 93 d1lpfa1 not modelled 40.9 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 94 c2rgwD_ not modelled 40.6 14 PDB header:transferase Chain: D: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: catalytic subunit of m. jannaschii aspartate2 transcarbamoylase 95 c1ml4A_ not modelled 40.3 21 PDB header:transferase Chain: A: PDB Molecule:aspartate transcarbamoylase; PDBTitle: the pala-liganded aspartate transcarbamoylase catalytic subunit from2 pyrococcus abyssi 96 d2atca2 not modelled 40.0 16 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 97 c3a11D_ not modelled 39.5 15 PDB header:isomerase Chain: D: PDB Molecule:translation initiation factor eif-2b, delta PDBTitle: crystal structure of ribose-1,5-bisphosphate isomerase from2 thermococcus kodakaraensis kod1 98 c2bruB_ not modelled 38.7 15 PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase subunit alpha; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase 99 c2rghA_ not modelled 38.7 33 PDB header:oxidoreductase Chain: A: PDB Molecule:alpha-glycerophosphate oxidase; PDBTitle: structure of alpha-glycerophosphate oxidase from2 streptococcus sp.: a template for the mitochondrial alpha-3 glycerophosphate dehydrogenase 100 c3r3sD_ not modelled 38.4 19 PDB header:oxidoreductase Chain: D: PDB Molecule:oxidoreductase; PDBTitle: structure of the ygha oxidoreductase from salmonella enterica 101 d1reoa1 not modelled 38.2 21 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain 102 d2bs2a2 not modelled 38.2 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain 103 c3gmbB_ not modelled 38.2 17 PDB header:oxidoreductase Chain: B: PDB Molecule:2-methyl-3-hydroxypyridine-5-carboxylic acid PDBTitle: crystal structure of 2-methyl-3-hydroxypyridine-5-carboxylic2 acid oxygenase 104 d2cula1 not modelled 37.8 22 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:GidA-like 105 d1onfa1 not modelled 37.5 33 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 106 c1uarA_ not modelled 37.3 14 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: crystal structure of rhodanese from thermus thermophilus hb8 107 c2vhyB_ not modelled 36.4 22 PDB header:oxidoreductase Chain: B: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of apo l-alanine dehydrogenase from2 mycobacterium tuberculosis 108 d2a0ua1 not modelled 36.4 20 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:IF2B-like 109 d1o69a_ not modelled 36.3 12 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 110 c3v76A_ not modelled 36.2 26 PDB header:flavoprotein Chain: A: PDB Molecule:flavoprotein; PDBTitle: the crystal structure of a flavoprotein from sinorhizobium meliloti 111 d1wyub1 not modelled 36.2 9 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Glycine dehydrogenase subunits (GDC-P) 112 c3cgvA_ not modelled 36.0 26 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:geranylgeranyl reductase related protein; PDBTitle: crystal structure of geranylgeranyl bacteriochlorophyll reductase-like2 fixc homolog (np_393992.1) from thermoplasma acidophilum at 1.60 a3 resolution 113 c3fbsB_ not modelled 35.4 11 PDB header:oxidoreductase Chain: B: PDB Molecule:oxidoreductase; PDBTitle: the crystal structure of the oxidoreductase from agrobacterium2 tumefaciens 114 c2gcgB_ not modelled 35.3 15 PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate reductase/hydroxypyruvate reductase; PDBTitle: ternary crystal structure of human glyoxylate2 reductase/hydroxypyruvate reductase 115 c2xdoC_ not modelled 35.3 13 PDB header:oxidoreductase Chain: C: PDB Molecule:tetx2 protein; PDBTitle: structure of the tetracycline degrading monooxygenase tetx2 from2 bacteroides thetaiotaomicron 116 c3kboB_ not modelled 35.3 11 PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate/hydroxypyruvate reductase a; PDBTitle: 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from2 salmonella typhimurium in complex with nadp 117 c2gqfA_ not modelled 35.2 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hi0933; PDBTitle: crystal structure of flavoprotein hi0933 from haemophilus influenzae2 rd 118 d1jq5a_ not modelled 35.2 10 Fold:Dehydroquinate synthase-like Superfamily:Dehydroquinate synthase-like Family:Iron-containing alcohol dehydrogenase 119 c3f8rD_ not modelled 35.1 15 PDB header:oxidoreductase Chain: D: PDB Molecule:thioredoxin reductase (trxb-3); PDBTitle: crystal structure of sulfolobus solfataricus thioredoxin2 reductase b3 in complex with two nadp molecules 120 d1tuga1 not modelled 34.9 14 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0