Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	N	Y	R	V	E	S	S	S	G	R	A	A	R	K	M	R	L	A	L	M	G	P	A	F	I	A	A	I	G	Y	I	D	P	G	N	F	A	T	N	I	Q	A	G	A	S	F	G	Y	Q	L	L	W	V	V	V	W	A	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	M	A	M	L	I	Q	I	L	S	A	K	L	G	I	A	T	G	K	N	L	A	E	Q	I	R	D	H	Y	P	R	P	V	V	W	F	Y	W	V	Q	A	E	I	I	A	M	A	T	D	L	A	E	F	I	G	A	A	I	G	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	L	I	L	G	V	S	L	L	Q	G	A	V	L	T	G	I	A	T	F	L	I	L	M	L	Q	R	R	G	Q	K	P	L	E	K	V	I	G	G	L	L	L	F	V	A	A	A	Y	I	V	E	L	I	F	S	Q	P	N	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	L	G	K	G	M	V	I	P	S	L	P	T	S	E	A	V	F	L	A	A	G	V	L	G	A	T	I	M	P	H	V	I	Y	L	H	S	S	L	T	Q	H	L	H	G	G	S	R	Q	Q	R	Y	S	A	T	K	W	D	V	A
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	A	M	T	I	A	G	F	V	N	L	A	M	M	A	T	A	A	A	A	F	H	F	S	G	H	T	G	V	A	D	L	D	E	A	Y	L	T	L	Q	P	L	L	S	H	A	A	A	T	V	F	G	L	S	L	V	A	A	G	L
Secondary structure
SS confidence
Disorder																											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	S	T	V	V	G	T	L	A	G	Q	V	V	M	Q	G	F	I	R	F	H	I	P	L	W	V	R	R	T	V	T	M	L	P	S	F	I	V	I	L	M	G	L	D	P	T	R	I	L	V	M	S	Q	V	L	L	S	F	G	I
Secondary structure
SS confidence
Disorder																																										?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.
Sequence		A	L	A	L	V	P	L	L	I	F	T	S	D	S	K	L	M	G	D	L	V	N	S	K	R	V	K	Q	T	G	W	V	I	V	V	L	V	V	A	L	N	I	W	L	L	V	G	T	A	L	G	L
Secondary structure
SS confidence
Disorder																																																		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2xq2 chain A Region: 25 - 400 Aligned: 373 Modelled: 373 Confidence: 99.9% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3dh4 chain A Region: 25 - 398 Aligned: 371 Modelled: 374 Confidence: 99.9% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2jln chain A Region: 3 - 402 Aligned: 397 Modelled: 397 Confidence: 99.7% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 3gia chain A Region: 15 - 411 Aligned: 386 Modelled: 386 Confidence: 99.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 15 - 400 Aligned: 355 Modelled: 355 Confidence: 98.7% Identity: 13% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 2a65 chain A domain 1 Region: 26 - 407 Aligned: 381 Modelled: 381 Confidence: 98.1% Identity: 13% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 2w8a chain C Region: 89 - 387 Aligned: 299 Modelled: 299 Confidence: 92.3% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 3hfx chain A Region: 89 - 381 Aligned: 282 Modelled: 293 Confidence: 84.4% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2eyq chain A Region: 6 - 52 Aligned: 47 Modelled: 47 Confidence: 6.8% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:transcription-repair coupling factor; PDBTitle: crystal structure of escherichia coli transcription-repair2 coupling factor Phyre2 PDB 1m3v chain A domain 2 Region: 15 - 24 Aligned: 10 Modelled: 10 Confidence: 6.7% Identity: 30% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 2rlw chain A Region: 8 - 30 Aligned: 23 Modelled: 23 Confidence: 6.5% Identity: 22% PDB header:toxin Chain: A: PDB Molecule:plnf; PDBTitle: three-dimensional structure of the two peptides that2 constitute the two-peptide bacteriocin plantaracin ef Phyre2 PDB 2voy chain D Region: 16 - 38 Aligned: 23 Modelled: 23 Confidence: 6.4% Identity: 4% PDB header:hydrolase Chain: D: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 2hku chain A domain 2 Region: 36 - 52 Aligned: 17 Modelled: 17 Confidence: 6.4% Identity: 41% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 3mk7 chain F Region: 53 - 110 Aligned: 58 Modelled: 58 Confidence: 6.2% Identity: 10% PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 2kwz chain A Region: 16 - 31 Aligned: 16 Modelled: 16 Confidence: 6.0% Identity: 38% PDB header:viral protein Chain: A: PDB Molecule:protease ns2-3; PDBTitle: solution structure of ns2 [60-99] Phyre2 PDB 3ajf chain A Region: 358 - 381 Aligned: 24 Modelled: 24 Confidence: 5.4% Identity: 8% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: structural insigths into dsrna binding and rna silencing suppression2 by ns3 protein of rice hoja blanca tenuivirus Phyre2 1 c2xq2A_ 2 c3dh4A_ 3 c2jlnA_ 4 c3giaA_ 5 c3lrcC_ 6 d2a65a1 7 c2w8aC_ 8 c3hfxA_ 9 c2eyqA_ 10 d1m3va2 11 c2rlwA_ 12 c2voyD_ 13 d2hkua2 14 c3mk7F_ 15 c2kwzA_ 16 c3ajfA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2xq2A_ 99.9 12 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 2 c3dh4A_ 99.9 12 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 3 c2jlnA_ 99.7 10 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 4 c3giaA_ 99.4 10 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 5 c3lrcC_ 98.7 13 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 6 d2a65a1 98.1 13 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 7 c2w8aC_ 92.3 11 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 8 c3hfxA_ 84.4 12 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 9 c2eyqA_ 6.8 23 PDB header:hydrolase Chain: A: PDB Molecule:transcription-repair coupling factor; PDBTitle: crystal structure of escherichia coli transcription-repair2 coupling factor 10 d1m3va2 6.7 30 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 11 c2rlwA_ 6.5 22 PDB header:toxin Chain: A: PDB Molecule:plnf; PDBTitle: three-dimensional structure of the two peptides that2 constitute the two-peptide bacteriocin plantaracin ef 12 c2voyD_ 6.4 4 PDB header:hydrolase Chain: D: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus 13 d2hkua2 6.4 41 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 14 c3mk7F_ 6.2 10 PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase 15 c2kwzA_ 6.0 38 PDB header:viral protein Chain: A: PDB Molecule:protease ns2-3; PDBTitle: solution structure of ns2 [60-99] 16 c3ajfA_ 5.4 8 PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: structural insigths into dsrna binding and rna silencing suppression2 by ns3 protein of rice hoja blanca tenuivirus

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0