Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	Y	L	A	L	A	L	I	A	P	L	L	I	S	C	S	T	T	K	K	G	D	T	Y	N	E	A	W	V	K	D	T	N	G	F	D	I	L	M	G	Q	F	A	H	N	I	E	N	I	W	G	F	K	E	V	V	I	A
Secondary structure
SS confidence
Disorder		?	?	?									?	?	?	?			?	?	?	?		?	?	?		?																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	P	K	D	Y	V	K	Y	T	D	Q	Y	Q	T	R	S	H	I	N	F	D	D	G	T	I	T	I	E	T	I	A	G	T	E	P	A	A	H	L	R	R	A	I	I	K	T	L	L	M	G	D	D	P	S	S	V	D	L	Y	S
Secondary structure
SS confidence
Disorder		?	?	?																												?	?	?	?	?														?				?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	V	D	D	I	T	I	S	K	E	P	F	L	Y	G	Q	V	V	D	N	T	G	Q	P	I	R	W	E	G	R	A	S	N	F	A	D	Y	L	L	K	N	R	L	K	S	R	S	N	G	L	R	I	I	Y	S	V	T	I	N	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																	?																				?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	P	N	H	L	D	K	R	A	H	K	Y	L	G	M	V	R	Q	A	S	R	K	Y	G	V	D	E	S	L	I	L	A	I	M	Q	T	E	S	S	F	N	P	Y	A	V	S	R	S	D	A	L	G	L	M	Q	V	V	Q	H	T
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	K	D	V	F	R	S	Q	G	K	S	G	T	P	S	R	S	F	L	F	D	P	A	S	N	I	D	T	G	T	A	Y	L	A	M	L	N	N	V	Y	L	G	G	I	D	N	P	T	S	R	R	Y	A	V	I	T	A	Y	N
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.
Sequence		G	G	A	G	S	V	L	R	V	F	S	N	D	K	I	Q	A	A	N	I	I	N	T	M	T	P	G	D	V	Y	Q	T	L	T	T	R	H	P	S	A	E	S	R	R	Y	L	Y	K	V	N	T	A	Q	K	S	Y	R	R	R
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?		?																																						?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2y8p chain A Region: 179 - 358 Aligned: 180 Modelled: 180 Confidence: 100.0% Identity: 37% PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli Phyre2 PDB 1sly chain A Region: 191 - 359 Aligned: 150 Modelled: 151 Confidence: 100.0% Identity: 29% PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a Phyre2 PDB 1qsa chain A domain 2 Region: 191 - 358 Aligned: 149 Modelled: 157 Confidence: 100.0% Identity: 30% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 3mgw chain A Region: 186 - 359 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme Phyre2 PDB 3gxk chain B Region: 182 - 359 Aligned: 140 Modelled: 140 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 Phyre2 PDB 1gbs chain A Region: 182 - 359 Aligned: 140 Modelled: 140 Confidence: 100.0% Identity: 22% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: G-type lysozyme Phyre2 PDB 3bkh chain A Region: 194 - 316 Aligned: 122 Modelled: 123 Confidence: 99.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 Phyre2 PDB 1qus chain A Region: 183 - 276 Aligned: 90 Modelled: 94 Confidence: 99.0% Identity: 23% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Bacterial muramidase, catalytic domain Phyre2 PDB 1xsf chain A Region: 204 - 275 Aligned: 67 Modelled: 72 Confidence: 97.3% Identity: 21% PDB header:cell cycle, hydrolase Chain: A: PDB Molecule:probable resuscitation-promoting factor rpfb; PDBTitle: solution structure of a resuscitation promoting factor2 domain from mycobacterium tuberculosis Phyre2 PDB 1xsf chain A domain 1 Region: 212 - 275 Aligned: 59 Modelled: 64 Confidence: 97.2% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: RPF-like Phyre2 PDB 3ct5 chain A Region: 180 - 260 Aligned: 77 Modelled: 81 Confidence: 96.9% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail Phyre2 PDB 3eo5 chain A Region: 212 - 275 Aligned: 59 Modelled: 64 Confidence: 96.6% Identity: 20% PDB header:cell adhesion Chain: A: PDB Molecule:resuscitation-promoting factor rpfb; PDBTitle: crystal structure of the resuscitation promoting factor rpfb Phyre2 PDB 2fbd chain B Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 96.5% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. Phyre2 PDB 1gd6 chain A Region: 196 - 236 Aligned: 41 Modelled: 41 Confidence: 96.4% Identity: 32% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1hhl chain A Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 96.2% Identity: 30% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1iiz chain A Region: 196 - 236 Aligned: 41 Modelled: 41 Confidence: 96.2% Identity: 29% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 2vb1 chain A domain 1 Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 96.2% Identity: 30% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1ghl chain A Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 96.1% Identity: 30% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1jse chain A Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 95.8% Identity: 28% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 PDB 1lmq chain A Region: 196 - 236 Aligned: 40 Modelled: 41 Confidence: 95.8% Identity: 30% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: C-type lysozyme Phyre2 1 c2y8pA_ 2 c1slyA_ 3 d1qsaa2 4 c3mgwA_ 5 c3gxkB_ 6 d1gbsa_ 7 c3bkhA_ 8 d1qusa_ 9 c1xsfA_ 10 d1xsfa1 11 c3ct5A_ 12 c3eo5A_ 13 c2fbdB_ 14 d1gd6a_ 15 d1hhla_ 16 d1iiza_ 17 d2vb1a1 18 d1ghla_ 19 d1jsea_ 20 d1lmqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2y8pA_ 100.0 37 PDB header:lyase Chain: A: PDB Molecule:endo-type membrane-bound lytic murein transglycosylase a; PDBTitle: crystal structure of an outer membrane-anchored endolytic2 peptidoglycan lytic transglycosylase (mlte) from3 escherichia coli 2 c1slyA_ 100.0 29 PDB header:glycosyltransferase Chain: A: PDB Molecule:70-kda soluble lytic transglycosylase; PDBTitle: complex of the 70-kda soluble lytic transglycosylase with2 bulgecin a 3 d1qsaa2 100.0 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 4 c3mgwA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme g; PDBTitle: thermodynamics and structure of a salmon cold-active goose-type2 lysozyme 5 c3gxkB_ 100.0 24 PDB header:hydrolase Chain: B: PDB Molecule:goose-type lysozyme 1; PDBTitle: the crystal structure of g-type lysozyme from atlantic cod2 (gadus morhua l.) in complex with nag oligomers sheds new3 light on substrate binding and the catalytic mechanism.4 native structure to 1.9 6 d1gbsa_ 100.0 22 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:G-type lysozyme 7 c3bkhA_ 99.0 18 PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 8 d1qusa_ 99.0 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 9 c1xsfA_ 97.3 21 PDB header:cell cycle, hydrolase Chain: A: PDB Molecule:probable resuscitation-promoting factor rpfb; PDBTitle: solution structure of a resuscitation promoting factor2 domain from mycobacterium tuberculosis 10 d1xsfa1 97.2 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:RPF-like 11 c3ct5A_ 96.9 23 PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail 12 c3eo5A_ 96.6 20 PDB header:cell adhesion Chain: A: PDB Molecule:resuscitation-promoting factor rpfb; PDBTitle: crystal structure of the resuscitation promoting factor rpfb 13 c2fbdB_ 96.5 25 PDB header:hydrolase Chain: B: PDB Molecule:lysozyme 1; PDBTitle: the crystallographic structure of the digestive lysozyme 1 from musca2 domestica at 1.90 ang. 14 d1gd6a_ 96.4 32 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 15 d1hhla_ 96.2 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 16 d1iiza_ 96.2 29 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 17 d2vb1a1 96.2 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 18 d1ghla_ 96.1 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 19 d1jsea_ 95.8 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 20 d1lmqa_ 95.8 30 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 21 c3csqC_ not modelled 95.7 21 PDB header:hydrolase Chain: C: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall2 degrading enzyme in the bacteriophage phi29 tail 22 c2goiC_ not modelled 95.6 25 PDB header:cell adhesion, sugar binding protein Chain: C: PDB Molecule:sperm lysozyme-like protein 1; PDBTitle: crystal structure of mouse sperm c-type lysozyme-like2 protein 1 23 d1qqya_ not modelled 95.5 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 24 c2z2fA_ not modelled 95.4 25 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme c-2; PDBTitle: x-ray crystal structure of bovine stomach lysozyme 25 d1juga_ not modelled 95.4 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 26 d1lsga1 not modelled 95.3 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 27 c3fi7A_ not modelled 95.0 19 PDB header:hydrolase Chain: A: PDB Molecule:lmo1076 protein; PDBTitle: crystal structure of the autolysin auto (lmo1076) from listeria2 monocytogenes, catalytic domain 28 d1ivma_ not modelled 94.8 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 29 c2zycA_ not modelled 94.6 16 PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan hydrolase flgj; PDBTitle: crystal structure of peptidoglycan hydrolase from2 sphingomonas sp. a1 30 d2nwdx1 not modelled 94.5 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 31 d2eqla_ not modelled 93.5 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 32 d1f6sa_ not modelled 93.5 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 33 d1b9oa_ not modelled 93.1 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 34 d1hfxa_ not modelled 92.3 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 35 d1yroa1 not modelled 92.3 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 36 d1fkqa_ not modelled 92.2 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 37 d1alca_ not modelled 91.5 31 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:C-type lysozyme 38 d1nvma1 not modelled 37.3 30 Fold:RuvA C-terminal domain-like Superfamily:post-HMGL domain-like Family:DmpG/LeuA communication domain-like 39 d3efxd1 not modelled 22.9 15 Fold:OB-fold Superfamily:Bacterial enterotoxins Family:Bacterial AB5 toxins, B-subunits 40 c3lxuX_ not modelled 18.7 19 PDB header:hydrolase Chain: X: PDB Molecule:tripeptidyl-peptidase 2; PDBTitle: crystal structure of tripeptidyl peptidase 2 (tpp ii) 41 d157la_ not modelled 11.5 12 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 42 d1t8fa_ not modelled 11.3 9 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 43 c1mgtA_ not modelled 11.1 28 PDB header:transferase Chain: A: PDB Molecule:protein (o6-methylguanine-dna methyltransferase); PDBTitle: crystal structure of o6-methylguanine-dna methyltransferase from2 hyperthermophilic archaeon pyrococcus kodakaraensis strain kod1 44 d1jwya1 not modelled 9.2 23 Fold:SH3-like barrel Superfamily:Myosin S1 fragment, N-terminal domain Family:Myosin S1 fragment, N-terminal domain 45 d1jtma_ not modelled 9.0 10 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 46 d176la_ not modelled 8.7 10 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 47 d189la_ not modelled 8.6 10 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 48 c2dbtA_ not modelled 8.5 23 PDB header:hydrolase Chain: A: PDB Molecule:chitinase c; PDBTitle: crystal structure of chitinase c from streptomyces griseus2 hut6037 49 d2cvza1 not modelled 8.4 22 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain 50 d2fp1a1 not modelled 8.1 14 Fold:Chorismate mutase II Superfamily:Chorismate mutase II Family:Secreted chorismate mutase-like 51 c2cooA_ not modelled 7.3 18 PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the e3_binding domain of2 dihydrolipoamide branched chaintransacylase 52 d1mgta1 not modelled 6.7 28 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family:Methylated DNA-protein cysteine methyltransferase, C-terminal domain 53 d191la_ not modelled 6.4 10 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 54 c1fi4A_ not modelled 5.8 14 PDB header:lyase Chain: A: PDB Molecule:mevalonate 5-diphosphate decarboxylase; PDBTitle: the x-ray crystal structure of mevalonate 5-diphosphate decarboxylase2 at 2.3 angstrom resolution. 55 c1umwB_ not modelled 5.8 40 PDB header:kinase Chain: B: PDB Molecule:serine/threonine-protein kinase plk; PDBTitle: structure of a human plk1 polo-box domain/phosphopeptide2 complex 56 c3hbhA_ not modelled 5.7 16 PDB header:hydrolase Chain: A: PDB Molecule:class iv chitinase chia4-pa2; PDBTitle: class iv chitinase structure from picea abies at 2.25a 57 c2eq9C_ not modelled 5.5 18 PDB header:oxidoreductase Chain: C: PDB Molecule:pyruvate dehydrogenase complex, dihydrolipoamide PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdb 58 d2cyua1 not modelled 5.4 24 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 59 c2cjlA_ not modelled 5.2 21 PDB header:hydrolase Chain: A: PDB Molecule:secreted chitinase; PDBTitle: crystal structure and enzymatic properties of a bacterial2 family 19 chitinase reveal differences with plant enzymes 60 d1w4ha1 not modelled 5.1 24 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0