Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	V	Q	S	G	I	L	P	E	H	C	R	A	A	I	W	I	E	A	N	V	K	G	E	V	D	A	L	R	A	A	S	K	T	F	A	D	K	L	A	T	F	E	A	K	F	P	D	A	H	L	G	A	V	V	A	F	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	N	T	W	R	A	L	S	G	G	V	G	A	E	E	L	K	D	F	P	G	Y	G	K	G	L	A	P	T	T	Q	F	D	V	L	I	H	I	L	S	L	R	H	D	V	N	F	S	V	A	Q	A	A	M	E	A	F	G	D	C
Secondary structure
SS confidence
Disorder														?	?		?					?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	E	V	K	E	E	I	H	G	F	R	W	V	E	E	R	D	L	S	G	F	V	D	G	T	E	N	P	A	G	E	E	T	R	R	E	V	A	V	I	K	D	G	V	D	A	G	G	S	Y	V	F	V	Q	R	W	E	H	N	L
Secondary structure
SS confidence
Disorder														?		?											?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	Q	L	N	R	M	S	V	H	D	Q	E	M	V	I	G	R	T	K	E	A	N	E	E	I	D	G	D	E	R	P	E	T	S	H	L	T	R	V	D	L	K	E	D	G	K	G	L	K	I	V	R	Q	S	L	P	Y	G	T	A
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?												?	?	?	?	?	?	?	?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.
Sequence		S	G	T	H	G	L	Y	F	C	A	Y	C	A	R	L	H	N	I	E	Q	Q	L	L	S	M	F	G	D	T	D	G	K	R	D	A	M	L	R	F	T	K	P	V	T	G	G	Y	Y	F	A	P	S	L	D	K	L	M	A	L
Secondary structure
SS confidence
Disorder																														?	?	?																										?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2iiz chain A domain 1 Region: 2 - 299 Aligned: 297 Modelled: 294 Confidence: 100.0% Identity: 37% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Dyp-type peroxidase-like Phyre2 PDB 3qns chain A Region: 4 - 299 Aligned: 296 Modelled: 296 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:dyp peroxidase; PDBTitle: dypb from rhodococcus jostii rha1, crystal form 2 Phyre2 PDB 2gvk chain A domain 1 Region: 5 - 299 Aligned: 292 Modelled: 292 Confidence: 100.0% Identity: 33% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Dyp-type peroxidase-like Phyre2 PDB 2wx6 chain B Region: 3 - 292 Aligned: 278 Modelled: 285 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: B: PDB Molecule:peroxidase ycdb; PDBTitle: x-ray crystallographic structure of e. coli apo-efeb Phyre2 PDB 2d3q chain A domain 1 Region: 1 - 299 Aligned: 297 Modelled: 299 Confidence: 100.0% Identity: 24% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Dyp-type peroxidase-like Phyre2 PDB 3nn4 chain C Region: 89 - 265 Aligned: 143 Modelled: 160 Confidence: 81.8% Identity: 10% PDB header:oxidoreductase Chain: C: PDB Molecule:chlorite dismutase; PDBTitle: structure of chlorite dismutase from candidatus nitrospira defluvii2 r173k mutant Phyre2 PDB 2vxh chain F Region: 90 - 265 Aligned: 144 Modelled: 154 Confidence: 81.1% Identity: 13% PDB header:oxidoreductase Chain: F: PDB Molecule:chlorite dismutase; PDBTitle: the crystal structure of chlorite dismutase: a detox enzyme2 producing molecular oxygen Phyre2 PDB 3dtz chain B Region: 89 - 129 Aligned: 41 Modelled: 41 Confidence: 62.2% Identity: 12% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative chlorite dismutase ta0507; PDBTitle: crystal structure of putative chlorite dismutase ta0507 Phyre2 PDB 1t0t chain V Region: 92 - 129 Aligned: 38 Modelled: 38 Confidence: 47.8% Identity: 18% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Chlorite dismutase-like Phyre2 PDB 2hpg chain B Region: 139 - 194 Aligned: 56 Modelled: 56 Confidence: 40.3% Identity: 13% PDB header:ligand binding protein Chain: B: PDB Molecule:abc transporter, periplasmic substrate-binding PDBTitle: the crystal structure of a thermophilic trap periplasmic2 binding protein Phyre2 PDB 2pfy chain A Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 29.7% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:putative exported protein; PDBTitle: crystal structure of dctp7, a bordetella pertussis2 extracytoplasmic solute receptor binding pyroglutamic acid Phyre2 PDB 3b50 chain A Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 28.6% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:sialic acid-binding periplasmic protein siap; PDBTitle: structure of h. influenzae sialic acid binding protein2 bound to neu5ac. Phyre2 PDB 3gyy chain C Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 24.6% Identity: 22% PDB header:transport protein Chain: C: PDB Molecule:periplasmic substrate binding protein; PDBTitle: the ectoine binding protein of the teaabc trap transporter teaa in the2 apo-state Phyre2 PDB 3fxb chain B Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 23.4% Identity: 22% PDB header:transport protein Chain: B: PDB Molecule:trap dicarboxylate transporter, dctp subunit; PDBTitle: crystal structure of the ectoine-binding protein ueha Phyre2 PDB 2zzx chain D Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 20.7% Identity: 16% PDB header:transport protein Chain: D: PDB Molecule:abc transporter, solute-binding protein; PDBTitle: crystal structure of a periplasmic substrate binding protein in2 complex with lactate Phyre2 PDB 1vdh chain A Region: 92 - 129 Aligned: 38 Modelled: 38 Confidence: 20.1% Identity: 16% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Chlorite dismutase-like Phyre2 PDB 2hzk chain B Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 19.5% Identity: 11% PDB header:ligand binding, transport protein Chain: B: PDB Molecule:trap-t family sorbitol/mannitol transporter, periplasmic PDBTitle: crystal structures of a sodium-alpha-keto acid binding subunit from a2 trap transporter in its open form Phyre2 PDB 2pfz chain A Region: 140 - 194 Aligned: 55 Modelled: 55 Confidence: 17.5% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:putative exported protein; PDBTitle: crystal structure of dctp6, a bordetella pertussis2 extracytoplasmic solute receptor binding pyroglutamic acid Phyre2 PDB 2pie chain A domain 1 Region: 166 - 211 Aligned: 44 Modelled: 46 Confidence: 9.5% Identity: 18% Fold: SMAD/FHA domain Superfamily: SMAD/FHA domain Family: FHA domain Phyre2 PDB 3b0v chain D Region: 94 - 123 Aligned: 30 Modelled: 30 Confidence: 9.5% Identity: 10% PDB header:oxidoreductase/rna Chain: D: PDB Molecule:trna-dihydrouridine synthase; PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna Phyre2 1 d2iiza1 2 c3qnsA_ 3 d2gvka1 4 c2wx6B_ 5 d2d3qa1 6 c3nn4C_ 7 c2vxhF_ 8 c3dtzB_ 9 d1t0tv_ 10 c2hpgB_ 11 c2pfyA_ 12 c3b50A_ 13 c3gyyC_ 14 c3fxbB_ 15 c2zzxD_ 16 d1vdha_ 17 c2hzkB_ 18 c2pfzA_ 19 d2piea1 20 c3b0vD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2iiza1 100.0 37 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Dyp-type peroxidase-like 2 c3qnsA_ 100.0 32 PDB header:oxidoreductase Chain: A: PDB Molecule:dyp peroxidase; PDBTitle: dypb from rhodococcus jostii rha1, crystal form 2 3 d2gvka1 100.0 33 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Dyp-type peroxidase-like 4 c2wx6B_ 100.0 22 PDB header:oxidoreductase Chain: B: PDB Molecule:peroxidase ycdb; PDBTitle: x-ray crystallographic structure of e. coli apo-efeb 5 d2d3qa1 100.0 24 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Dyp-type peroxidase-like 6 c3nn4C_ 81.8 10 PDB header:oxidoreductase Chain: C: PDB Molecule:chlorite dismutase; PDBTitle: structure of chlorite dismutase from candidatus nitrospira defluvii2 r173k mutant 7 c2vxhF_ 81.1 13 PDB header:oxidoreductase Chain: F: PDB Molecule:chlorite dismutase; PDBTitle: the crystal structure of chlorite dismutase: a detox enzyme2 producing molecular oxygen 8 c3dtzB_ 62.2 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative chlorite dismutase ta0507; PDBTitle: crystal structure of putative chlorite dismutase ta0507 9 d1t0tv_ 47.8 18 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Chlorite dismutase-like 10 c2hpgB_ 40.3 13 PDB header:ligand binding protein Chain: B: PDB Molecule:abc transporter, periplasmic substrate-binding PDBTitle: the crystal structure of a thermophilic trap periplasmic2 binding protein 11 c2pfyA_ 29.7 9 PDB header:transport protein Chain: A: PDB Molecule:putative exported protein; PDBTitle: crystal structure of dctp7, a bordetella pertussis2 extracytoplasmic solute receptor binding pyroglutamic acid 12 c3b50A_ 28.6 16 PDB header:transport protein Chain: A: PDB Molecule:sialic acid-binding periplasmic protein siap; PDBTitle: structure of h. influenzae sialic acid binding protein2 bound to neu5ac. 13 c3gyyC_ 24.6 22 PDB header:transport protein Chain: C: PDB Molecule:periplasmic substrate binding protein; PDBTitle: the ectoine binding protein of the teaabc trap transporter teaa in the2 apo-state 14 c3fxbB_ 23.4 22 PDB header:transport protein Chain: B: PDB Molecule:trap dicarboxylate transporter, dctp subunit; PDBTitle: crystal structure of the ectoine-binding protein ueha 15 c2zzxD_ 20.7 16 PDB header:transport protein Chain: D: PDB Molecule:abc transporter, solute-binding protein; PDBTitle: crystal structure of a periplasmic substrate binding protein in2 complex with lactate 16 d1vdha_ 20.1 16 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Chlorite dismutase-like 17 c2hzkB_ 19.5 11 PDB header:ligand binding, transport protein Chain: B: PDB Molecule:trap-t family sorbitol/mannitol transporter, periplasmic PDBTitle: crystal structures of a sodium-alpha-keto acid binding subunit from a2 trap transporter in its open form 18 c2pfzA_ 17.5 9 PDB header:transport protein Chain: A: PDB Molecule:putative exported protein; PDBTitle: crystal structure of dctp6, a bordetella pertussis2 extracytoplasmic solute receptor binding pyroglutamic acid 19 d2piea1 9.5 18 Fold:SMAD/FHA domain Superfamily:SMAD/FHA domain Family:FHA domain 20 c3b0vD_ 9.5 10 PDB header:oxidoreductase/rna Chain: D: PDB Molecule:trna-dihydrouridine synthase; PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna 21 d1uoua3 not modelled 9.0 12 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 22 d1sfea2 not modelled 8.4 18 Fold:Ribonuclease H-like motif Superfamily:Methylated DNA-protein cysteine methyltransferase domain Family:Methylated DNA-protein cysteine methyltransferase domain 23 d2cg4a2 not modelled 8.1 11 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Lrp/AsnC-like transcriptional regulator C-terminal domain 24 d1vjja1 not modelled 7.9 11 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 25 d2q3za1 not modelled 7.6 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 26 d1g0da1 not modelled 7.4 28 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 27 c2e1aD_ not modelled 7.1 8 PDB header:transcription Chain: D: PDB Molecule:75aa long hypothetical regulatory protein asnc; PDBTitle: crystal structure of ffrp-dm1 28 d1s6na_ not modelled 6.5 29 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Class II viral fusion proteins C-terminal domain 29 c2vpnB_ not modelled 6.3 26 PDB header:transport Chain: B: PDB Molecule:periplasmic substrate binding protein; PDBTitle: high-resolution structure of the periplasmic ectoine-2 binding protein from teaabc trap-transporter of halomonas3 elongata 30 c2qdrA_ not modelled 6.3 29 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative dioxygenase (npun_f5605) from nostoc2 punctiforme pcc 73102 at 2.60 a resolution 31 d2i7pa2 not modelled 6.2 22 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Fumble-like 32 d4tsva_ not modelled 6.1 7 Fold:TNF-like Superfamily:TNF-like Family:TNF-like 33 c1ohfB_ not modelled 5.7 39 PDB header:virus Chain: B: PDB Molecule:nudaurelia capensis omega virus capsid protein; PDBTitle: the refined structure of nudaurelia capensis omega virus 34 c2h0pA_ not modelled 5.7 18 PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein; PDBTitle: nmr structure of the dengue-4 virus envelope protein domain2 iii 35 d1ok8a1 not modelled 5.7 26 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Class II viral fusion proteins C-terminal domain 36 d1ex0a1 not modelled 5.3 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 37 c1fuiB_ not modelled 5.1 15 PDB header:isomerase Chain: B: PDB Molecule:l-fucose isomerase; PDBTitle: l-fucose isomerase from escherichia coli

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0