Phyre 2 Results for P39321

Email	l.a.kelley@imperial.ac.uk
Description	P39321
Date	Thu Jan 5 11:59:20 GMT 2012
Unique Job ID	895939f1ed3044d0

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template d1v54g_

Top template information

Fold:Single transmembrane helix
Superfamily:Mitochondrial cytochrome c oxidase subunit VIa
Family:Mitochondrial cytochrome c oxidase subunit VIa

Confidence and coverage

Confidence:

72.3%

Coverage:

25 residues ( 2% of your sequence) have been modelled with 72.3% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Please note: You must be registered and logged in to use Phyrealarm.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S L W K K I S L G V V I V I L L L L G S V A F L V G T T S G L H L V F K A A D R W V P G L D I G K V T G G W R D L T L

Secondary structure

SS confidence

Disorder ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence S D V R Y E Q P G V A V K A G N L H L A V G L E C L W N S S V C I N D L A L K D I Q V N I D S K K M P P S E Q V E E E E

Secondary structure

SS confidence

Disorder
?
?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence D S G P L D L S T P Y P I T L T R V A L D N V N I K I D D T T V S V M D F T S G L N W Q E K T L T L K P T S L K G L L I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
?
?
? ?
? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence A L P K V A E V A Q E E V V E P K I E N P Q P D E K P L G E T L K D L F S R P V L P E M T D V H L P L N L N I E E F K G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E Q L R V T G D T D I T V S T M L L K V S S I D G N T K L D A L D I D S S Q G I V N A S G T A Q L S D N W P V D I T L N

Secondary structure

SS confidence

Disorder
?
?
?
?
?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence S T L N V E P L K G E K V K L K M G G A L R E Q L E I G V N L S G P V D M D L R A Q T R L A E A G L P L N V E V N S K Q

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ?
? ? ?
? ? ? ?
? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence L Y W P F T G E K Q Y Q A D D L K L K L T G K M T D Y T L S M R T A V K G Q E I P P A T I T L D A K G N E Q Q V N L D K

Secondary structure

SS confidence

Disorder ? ? ?
?
? ? ? ? ? ? ? ? ?
? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence L T V A A L E G K T E L K A L L D W Q Q A I S W R G E L T L N G I N T A K E F P D W P S K L N G L I K T R G S L Y G G T

Secondary structure

SS confidence

Disorder
? ? ? ? ?
?
?
? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence W Q M D V P E L K L T G N V K Q N K V N V D G T L K G N S Y M Q W M I P G L H L E L G P N S A E V K G E L G V K D L N L

Secondary structure

SS confidence

Disorder
?
?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence D A T I N A P G L D N A L P G L G G T A K G L V K V R G T V E A P Q L L A D I T A R G L R W Q E L S V A Q V R V E G D I

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence K S T D Q I A G K L D V R V E Q I S Q P D V N I N L V T L N A K G S E K Q H E L Q L R I Q G E P V S G Q L N L A G S F D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ?
?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence R K E E R W K G T L S N T R F Q T P V G P W S L T R D I A L D Y R N K E Q K I S I G P H C W L N P N A E L C V P Q T I D

Secondary structure

SS confidence

Disorder ? ?
?
? ? ? ? ? ? ? ? ?
?
? ?
? ? ?
? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence A G A E G R A V V N L N R F D L A M L K P F M P E T T Q A S G I F T G K A D V A W D T T K E G L P Q G S I T L S G R N V

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Q V T Q T V N D A A L P V A F Q T L N L T A E L R N N R A E L G W T I R L T N N G Q F D G Q V Q V T D P Q G R R N L G G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
?
?
? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence N V N I R N F N L A M I N P I F T R G E K A A G M V S A N L R L G G D V Q S P Q L F G Q L Q V T G V D I D G N F M P F D

Secondary structure

SS confidence

Disorder
?
? ?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence M Q P S Q L A V N F N G M R S T L A G T V R T Q Q G E I Y L N G D A D W S Q I E N W R A R V T A K G S K V R I T V P P M

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence V R M D V S P D V V F E A T P N L F T L D G R V D V P W A R I V V H D L P E S A V G V S S D V V M L N D N L Q P E E P K

Secondary structure

SS confidence

Disorder ?
? ? ?
? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence T A S I P I N S N L I V H V G N N V R I D A F G L K A R L T G D L N V V Q D K Q G L G L N G Q I N I P E G R F H A Y G Q

Secondary structure

SS confidence

Disorder ? ? ? ? ?
?
? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence D L I V R K G E L L F S G P P D Q P Y L N I E A I R N P D A T E D D V I A G V R V T G L A D E P K A E I F S D P A M S Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
?
? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence Q A A L S Y L L R G Q G L E S D Q S D S A A M T S M L I G L G V A Q S G Q I V G K I G E T F G V S N L A L D T Q G V G D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . .

Sequence S S Q V V V S G Y V L P G L Q V K Y G V G I F D S I A T L T L R Y R L M P K L Y L E A V S G V D Q A L D L L Y Q F E F

Secondary structure

SS confidence

Disorder ? ?
? ? ? ? ? ? ?
? ?
?
? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1v54 chain G

Region: 1 - 25
Aligned: 25
Modelled: 25
Confidence: 72.3%
Identity: 16%
Fold: Single transmembrane helix
Superfamily: Mitochondrial cytochrome c oxidase subunit VIa
Family: Mitochondrial cytochrome c oxidase subunit VIa

Phyre2

PDB 3nb3 chain C

Region: 1229 - 1257
Aligned: 29
Modelled: 29
Confidence: 68.0%
Identity: 17%
PDB header:virus
Chain: C: PDB Molecule:outer membrane protein a;
PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components

Phyre2

PDB 1qjp chain A

Region: 1229 - 1257
Aligned: 29
Modelled: 29
Confidence: 67.7%
Identity: 17%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 1pby chain A

Region: 863 - 1001
Aligned: 133
Modelled: 139
Confidence: 38.4%
Identity: 12%
PDB header:oxidoreductase
Chain: A: PDB Molecule:quinohemoprotein amine dehydrogenase 60 kda
PDBTitle: structure of the phenylhydrazine adduct of the2 quinohemoprotein amine dehydrogenase from paracoccus3 denitrificans at 1.7 a resolution

Phyre2

PDB 1p4t chain A

Region: 1229 - 1257
Aligned: 29
Modelled: 29
Confidence: 30.8%
Identity: 17%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 1g90 chain A

Region: 1229 - 1257
Aligned: 29
Modelled: 29
Confidence: 25.8%
Identity: 21%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 1wub chain A

Region: 967 - 1128
Aligned: 145
Modelled: 145
Confidence: 20.3%
Identity: 14%
Fold: Streptavidin-like
Superfamily: YceI-like
Family: YceI-like

Phyre2

PDB 2wjq chain A

Region: 1201 - 1259
Aligned: 59
Modelled: 59
Confidence: 18.7%
Identity: 12%
PDB header:transport protein
Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel
PDBTitle: nanc porin structure in hexagonal crystal form.

Phyre2

PDB 2olu chain A domain 1

Region: 1138 - 1167
Aligned: 30
Modelled: 30
Confidence: 12.3%
Identity: 17%
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Family: PBP transglycosylase domain-like

Phyre2

PDB 2jmm chain A

Region: 1212 - 1244
Aligned: 33
Modelled: 33
Confidence: 11.4%
Identity: 15%
PDB header:membrane protein
Chain: A: PDB Molecule:outer membrane protein a;
PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein

Phyre2

PDB 2oqo chain A domain 1

Region: 1138 - 1166
Aligned: 29
Modelled: 29
Confidence: 11.0%
Identity: 24%
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Family: PBP transglycosylase domain-like

Phyre2

PDB 2lhf chain A

Region: 1228 - 1244
Aligned: 17
Modelled: 17
Confidence: 10.2%
Identity: 12%
PDB header:membrane protein
Chain: A: PDB Molecule:outer membrane protein h1;
PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles

Phyre2

PDB 1xrd chain A domain 1

Region: 2 - 36
Aligned: 35
Modelled: 35
Confidence: 9.8%
Identity: 14%
Fold: Light-harvesting complex subunits
Superfamily: Light-harvesting complex subunits
Family: Light-harvesting complex subunits

Phyre2

PDB 3pet chain A

Region: 857 - 981
Aligned: 114
Modelled: 114
Confidence: 9.4%
Identity: 10%
PDB header:cell adhesion
Chain: A: PDB Molecule:putative adhesin;
PDBTitle: crystal structure of a putative adhesin (bf0245) from bacteroides2 fragilis nctc 9343 at 2.07 a resolution

Phyre2

PDB 2y69 chain Q

Region: 4 - 25
Aligned: 22
Modelled: 22
Confidence: 9.1%
Identity: 14%
PDB header:electron transport
Chain: Q: PDB Molecule:cytochrome c oxidase subunit 4 isoform 1;
PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular2 oxygen

Phyre2

PDB 1v54 chain D

Region: 4 - 25
Aligned: 22
Modelled: 22
Confidence: 8.8%
Identity: 14%
Fold: Single transmembrane helix
Superfamily: Mitochondrial cytochrome c oxidase subunit IV
Family: Mitochondrial cytochrome c oxidase subunit IV

Phyre2

PDB 2x27 chain X

Region: 1228 - 1259
Aligned: 32
Modelled: 32
Confidence: 8.7%
Identity: 19%
PDB header:membrane protein
Chain: X: PDB Molecule:outer membrane protein oprg;
PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa

Phyre2

PDB 1osm chain A

Region: 1203 - 1257
Aligned: 55
Modelled: 55
Confidence: 8.1%
Identity: 18%
Fold: Transmembrane beta-barrels
Superfamily: Porins
Family: Porin

Phyre2

PDB 3lyc chain L

Region: 856 - 981
Aligned: 126
Modelled: 126
Confidence: 7.9%
Identity: 14%
PDB header:cell adhesion
Chain: L: PDB Molecule:putative pectinase;
PDBTitle: crystal structure of putative pectinase (yp_001304412.1) from2 parabacteroides distasonis atcc 8503 at 2.30 a resolution

Phyre2

PDB 1efv chain A domain 2

Region: 1207 - 1221
Aligned: 15
Modelled: 15
Confidence: 7.7%
Identity: 27%
Fold: DHS-like NAD/FAD-binding domain
Superfamily: DHS-like NAD/FAD-binding domain
Family: C-terminal domain of the electron transfer flavoprotein alpha subunit

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	L	W	K	K	I	S	L	G	V	V	I	V	I	L	L	L	L	G	S	V	A	F	L	V	G	T	T	S	G	L	H	L	V	F	K	A	A	D	R	W	V	P	G	L	D	I	G	K	V	T	G	G	W	R	D	L	T	L
Secondary structure
SS confidence
Disorder	?	?	?	?																																													?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	S	D	V	R	Y	E	Q	P	G	V	A	V	K	A	G	N	L	H	L	A	V	G	L	E	C	L	W	N	S	S	V	C	I	N	D	L	A	L	K	D	I	Q	V	N	I	D	S	K	K	M	P	P	S	E	Q	V	E	E	E	E
Secondary structure
SS confidence
Disorder								?																		?		?										?									?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	D	S	G	P	L	D	L	S	T	P	Y	P	I	T	L	T	R	V	A	L	D	N	V	N	I	K	I	D	D	T	T	V	S	V	M	D	F	T	S	G	L	N	W	Q	E	K	T	L	T	L	K	P	T	S	L	K	G	L	L	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?											?																	?		?	?		?	?	?	?	?									?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	A	L	P	K	V	A	E	V	A	Q	E	E	V	V	E	P	K	I	E	N	P	Q	P	D	E	K	P	L	G	E	T	L	K	D	L	F	S	R	P	V	L	P	E	M	T	D	V	H	L	P	L	N	L	N	I	E	E	F	K	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	Q	L	R	V	T	G	D	T	D	I	T	V	S	T	M	L	L	K	V	S	S	I	D	G	N	T	K	L	D	A	L	D	I	D	S	S	Q	G	I	V	N	A	S	G	T	A	Q	L	S	D	N	W	P	V	D	I	T	L	N
Secondary structure
SS confidence
Disorder					?			?		?			?		?										?									?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	S	T	L	N	V	E	P	L	K	G	E	K	V	K	L	K	M	G	G	A	L	R	E	Q	L	E	I	G	V	N	L	S	G	P	V	D	M	D	L	R	A	Q	T	R	L	A	E	A	G	L	P	L	N	V	E	V	N	S	K	Q
Secondary structure
SS confidence
Disorder			?		?	?	?	?	?	?	?	?								?	?	?		?	?	?	?				?	?															?	?											?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	L	Y	W	P	F	T	G	E	K	Q	Y	Q	A	D	D	L	K	L	K	L	T	G	K	M	T	D	Y	T	L	S	M	R	T	A	V	K	G	Q	E	I	P	P	A	T	I	T	L	D	A	K	G	N	E	Q	Q	V	N	L	D	K
Secondary structure
SS confidence
Disorder	?	?	?		?		?	?	?	?	?	?	?	?	?																				?	?	?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	L	T	V	A	A	L	E	G	K	T	E	L	K	A	L	L	D	W	Q	Q	A	I	S	W	R	G	E	L	T	L	N	G	I	N	T	A	K	E	F	P	D	W	P	S	K	L	N	G	L	I	K	T	R	G	S	L	Y	G	G	T
Secondary structure
SS confidence
Disorder				?	?	?	?	?													?															?				?	?	?															?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	W	Q	M	D	V	P	E	L	K	L	T	G	N	V	K	Q	N	K	V	N	V	D	G	T	L	K	G	N	S	Y	M	Q	W	M	I	P	G	L	H	L	E	L	G	P	N	S	A	E	V	K	G	E	L	G	V	K	D	L	N	L
Secondary structure
SS confidence
Disorder								?										?												?	?														?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	D	A	T	I	N	A	P	G	L	D	N	A	L	P	G	L	G	G	T	A	K	G	L	V	K	V	R	G	T	V	E	A	P	Q	L	L	A	D	I	T	A	R	G	L	R	W	Q	E	L	S	V	A	Q	V	R	V	E	G	D	I
Secondary structure
SS confidence
Disorder											?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	K	S	T	D	Q	I	A	G	K	L	D	V	R	V	E	Q	I	S	Q	P	D	V	N	I	N	L	V	T	L	N	A	K	G	S	E	K	Q	H	E	L	Q	L	R	I	Q	G	E	P	V	S	G	Q	L	N	L	A	G	S	F	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?											?	?	?	?			?																					?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	R	K	E	E	R	W	K	G	T	L	S	N	T	R	F	Q	T	P	V	G	P	W	S	L	T	R	D	I	A	L	D	Y	R	N	K	E	Q	K	I	S	I	G	P	H	C	W	L	N	P	N	A	E	L	C	V	P	Q	T	I	D
Secondary structure
SS confidence
Disorder	?	?		?									?	?	?	?	?	?	?	?	?			?												?	?								?	?	?		?	?	?				?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	A	G	A	E	G	R	A	V	V	N	L	N	R	F	D	L	A	M	L	K	P	F	M	P	E	T	T	Q	A	S	G	I	F	T	G	K	A	D	V	A	W	D	T	T	K	E	G	L	P	Q	G	S	I	T	L	S	G	R	N	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?																?	?	?	?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?									?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Q	V	T	Q	T	V	N	D	A	A	L	P	V	A	F	Q	T	L	N	L	T	A	E	L	R	N	N	R	A	E	L	G	W	T	I	R	L	T	N	N	G	Q	F	D	G	Q	V	Q	V	T	D	P	Q	G	R	R	N	L	G	G
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?																	?									?		?		?	?									?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	N	V	N	I	R	N	F	N	L	A	M	I	N	P	I	F	T	R	G	E	K	A	A	G	M	V	S	A	N	L	R	L	G	G	D	V	Q	S	P	Q	L	F	G	Q	L	Q	V	T	G	V	D	I	D	G	N	F	M	P	F	D
Secondary structure
SS confidence
Disorder				?													?	?			?																			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	M	Q	P	S	Q	L	A	V	N	F	N	G	M	R	S	T	L	A	G	T	V	R	T	Q	Q	G	E	I	Y	L	N	G	D	A	D	W	S	Q	I	E	N	W	R	A	R	V	T	A	K	G	S	K	V	R	I	T	V	P	P	M
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?														?																			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	V	R	M	D	V	S	P	D	V	V	F	E	A	T	P	N	L	F	T	L	D	G	R	V	D	V	P	W	A	R	I	V	V	H	D	L	P	E	S	A	V	G	V	S	S	D	V	V	M	L	N	D	N	L	Q	P	E	E	P	K
Secondary structure
SS confidence
Disorder	?														?	?	?																		?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	T	A	S	I	P	I	N	S	N	L	I	V	H	V	G	N	N	V	R	I	D	A	F	G	L	K	A	R	L	T	G	D	L	N	V	V	Q	D	K	Q	G	L	G	L	N	G	Q	I	N	I	P	E	G	R	F	H	A	Y	G	Q
Secondary structure
SS confidence
Disorder	?	?	?	?	?		?																	?	?													?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	D	L	I	V	R	K	G	E	L	L	F	S	G	P	P	D	Q	P	Y	L	N	I	E	A	I	R	N	P	D	A	T	E	D	D	V	I	A	G	V	R	V	T	G	L	A	D	E	P	K	A	E	I	F	S	D	P	A	M	S	Q
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?		?																					?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	Q	A	A	L	S	Y	L	L	R	G	Q	G	L	E	S	D	Q	S	D	S	A	A	M	T	S	M	L	I	G	L	G	V	A	Q	S	G	Q	I	V	G	K	I	G	E	T	F	G	V	S	N	L	A	L	D	T	Q	G	V	G	D
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?												?					?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.
Sequence	S	S	Q	V	V	V	S	G	Y	V	L	P	G	L	Q	V	K	Y	G	V	G	I	F	D	S	I	A	T	L	T	L	R	Y	R	L	M	P	K	L	Y	L	E	A	V	S	G	V	D	Q	A	L	D	L	L	Y	Q	F	E	F
Secondary structure
SS confidence
Disorder	?	?																			?	?	?	?	?	?	?																			?	?		?									?	?
Disorder confidence