Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	Q	V	R	K	N	V	M	D	M	F	I	D	G	A	R	R	G	F	T	I	A	T	T	N	L	L	P	N	V	V	M	A	F	V	I	I	Q	A	L	K	I	T	G	L	L	D	W	V	G	H	I	C	E	P	V	M	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	W	G	L	P	G	E	A	A	T	V	L	L	A	A	L	M	S	M	G	G	A	V	G	V	A	A	S	L	A	T	A	G	A	L	T	G	H	D	V	T	V	L	L	P	A	M	Y	L	M	G	N	P	V	Q	N	V	G	R	C
Secondary structure
SS confidence
Disorder																		?	?			?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.
Sequence		L	G	T	A	E	V	N	A	K	Y	Y	P	H	I	I	T	V	C	V	I	N	A	L	L	S	I	W	V	M	Q	L	I	V
Secondary structure
SS confidence
Disorder									?																								?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3bux chain B domain 3 Region: 6 - 21 Aligned: 16 Modelled: 16 Confidence: 65.0% Identity: 44% Fold: SH2-like Superfamily: SH2 domain Family: SH2 domain Phyre2 PDB 1fbv chain A Region: 6 - 21 Aligned: 16 Modelled: 16 Confidence: 19.9% Identity: 44% PDB header:ligase Chain: A: PDB Molecule:signal transduction protein cbl; PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases Phyre2 PDB 2zif chain B Region: 52 - 88 Aligned: 33 Modelled: 37 Confidence: 7.0% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine Phyre2 PDB 2xpn chain A Region: 25 - 58 Aligned: 33 Modelled: 34 Confidence: 6.8% Identity: 18% PDB header:transcription Chain: A: PDB Molecule:iws1; PDBTitle: crystal structure of a spt6-iws1(spn1) complex from2 encephalitozoon cuniculi, form i Phyre2 PDB 1nw6 chain A Region: 52 - 88 Aligned: 33 Modelled: 37 Confidence: 5.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin Phyre2 1 d3buxb3 2 c1fbvA_ 3 c2zifB_ 4 c2xpnA_ 5 c1nw6A_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d3buxb3 65.0 44 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 2 c1fbvA_ 19.9 44 PDB header:ligase Chain: A: PDB Molecule:signal transduction protein cbl; PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases 3 c2zifB_ 7.0 15 PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine 4 c2xpnA_ 6.8 18 PDB header:transcription Chain: A: PDB Molecule:iws1; PDBTitle: crystal structure of a spt6-iws1(spn1) complex from2 encephalitozoon cuniculi, form i 5 c1nw6A_ 5.7 15 PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0