Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	L	L	A	M	G	L	V	I	Y	L	A	T	S	K	Y	G	N	I	R	L	G	E	G	K	P	E	Y	S	T	L	S	W	L	F	M	F	I	C	A	G	L	G	S	S	T	L	Y	W	G	V	A	E	W	A	Y	Y	Y	Q
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	P	G	L	N	I	A	P	R	S	Q	Q	A	L	E	F	S	V	P	Y	S	F	F	H	W	G	I	S	A	W	A	T	Y	T	L	A	S	L	I	M	A	Y	H	F	H	V	R	K	N	K	G	L	S	L	S	G	I	I	A	A
Secondary structure
SS confidence
Disorder			?		?		?	?	?																																											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	G	V	R	P	Q	G	P	W	G	K	L	V	D	L	M	F	L	I	A	T	V	G	A	L	T	I	S	L	V	V	T	A	A	T	F	T	R	G	L	S	A	L	T	G	L	P	D	N	F	T	V	Q	A	F	V	I	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	G	G	I	F	C	L	S	S	W	I	G	I	N	N	G	L	Q	R	L	S	K	M	V	G	W	G	A	F	L	L	P	L	L	V	L	I	V	G	P	T	E	F	I	T	N	S	I	I	N	A	I	G	L	T	T	Q	N	F	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	M	S	L	F	T	D	P	L	G	D	G	S	F	T	R	N	W	T	V	F	Y	W	L	W	W	I	S	Y	T	P	G	V	A	M	F	V	T	R	V	S	R	G	R	K	I	K	E	V	I	W	G	L	I	L	G	S	T	V	G
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		C	W	F	F	F	G	V	M	E	S	Y	A	I	H	Q	F	I	N	G	V	I	N	V	P	Q	V	L	E	T	L	G	G	E	T	A	V	Q	Q	V	L	M	S	L	P	A	G	K	L	F	L	A	A	Y	L	G	V	M	I	I	F
Secondary structure
SS confidence
Disorder																			?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	A	S	H	M	D	A	V	A	Y	T	M	A	A	T	S	T	R	N	L	Q	E	G	D	D	P	D	R	G	L	R	L	F	W	C	V	V	I	T	L	I	P	L	S	I	L	F	T	G	A	S	L	E	T	M	K	T	T	V	V
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	T	A	L	P	F	L	V	I	L	L	V	K	V	G	G	F	I	R	W	L	K	Q	D	Y	A	D	I	P	A	H	Q	V	E	H	Y	L	P	Q	T	P	V	E	A	L	E	K	T	P	V	L	P	A	G	T	V	F	K	G	D
Secondary structure
SS confidence
Disorder																								?		?	?	?	?	?	?					?	?	?	?	?	?	?			?	?						?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		N
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hfx chain A Region: 2 - 447 Aligned: 445 Modelled: 445 Confidence: 100.0% Identity: 29% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2w8a chain C Region: 2 - 464 Aligned: 451 Modelled: 460 Confidence: 100.0% Identity: 27% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 2xq2 chain A Region: 80 - 435 Aligned: 338 Modelled: 349 Confidence: 98.3% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 2a65 chain A domain 1 Region: 166 - 450 Aligned: 272 Modelled: 285 Confidence: 97.2% Identity: 14% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 2jln chain A Region: 83 - 462 Aligned: 349 Modelled: 366 Confidence: 97.2% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 3dh4 chain A Region: 80 - 435 Aligned: 337 Modelled: 354 Confidence: 96.7% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 3gia chain A Region: 85 - 452 Aligned: 336 Modelled: 336 Confidence: 90.6% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 85 - 453 Aligned: 319 Modelled: 319 Confidence: 88.3% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 3gzt chain F Region: 253 - 262 Aligned: 10 Modelled: 10 Confidence: 27.0% Identity: 40% PDB header:virus Chain: F: PDB Molecule:outer capsid glycoprotein vp7; PDBTitle: vp7 recoated rotavirus dlp Phyre2 PDB 2kvl chain A Region: 253 - 262 Aligned: 10 Modelled: 10 Confidence: 24.5% Identity: 40% PDB header:viral protein Chain: A: PDB Molecule:major outer capsid protein vp7; PDBTitle: nmr structure of the c-terminal domain of vp7 Phyre2 PDB 2knc chain B Region: 418 - 459 Aligned: 41 Modelled: 42 Confidence: 19.8% Identity: 10% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2f2h chain A domain 1 Region: 20 - 29 Aligned: 10 Modelled: 10 Confidence: 10.2% Identity: 40% Fold: Putative glucosidase YicI, C-terminal domain Superfamily: Putative glucosidase YicI, C-terminal domain Family: Putative glucosidase YicI, C-terminal domain Phyre2 PDB 1qmv chain A Region: 18 - 30 Aligned: 13 Modelled: 13 Confidence: 7.5% Identity: 38% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Glutathione peroxidase-like Phyre2 PDB 1qq2 chain A Region: 18 - 30 Aligned: 13 Modelled: 13 Confidence: 7.2% Identity: 31% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Glutathione peroxidase-like Phyre2 PDB 3pcq chain X Region: 386 - 401 Aligned: 16 Modelled: 16 Confidence: 6.6% Identity: 38% PDB header:photosynthesis Chain: X: PDB Molecule:photosystem i 4.8k protein; PDBTitle: femtosecond x-ray protein nanocrystallography Phyre2 PDB 1vpz chain B Region: 18 - 30 Aligned: 13 Modelled: 13 Confidence: 6.5% Identity: 23% PDB header:rna binding protein Chain: B: PDB Molecule:carbon storage regulator homolog; PDBTitle: crystal structure of a putative carbon storage regulator protein2 (csra, pa0905) from pseudomonas aeruginosa at 2.05 a resolution Phyre2 PDB 2jpp chain B Region: 18 - 30 Aligned: 13 Modelled: 13 Confidence: 6.4% Identity: 15% PDB header:translation/rna Chain: B: PDB Molecule:translational repressor; PDBTitle: structural basis of rsma/csra rna recognition: structure of2 rsme bound to the shine-dalgarno sequence of hcna mrna Phyre2 PDB 1jb0 chain X Region: 386 - 401 Aligned: 16 Modelled: 16 Confidence: 6.3% Identity: 38% Fold: Single transmembrane helix Superfamily: Subunit PsaX of photosystem I reaction centre Family: Subunit PsaX of photosystem I reaction centre Phyre2 PDB 1jb0 chain X Region: 386 - 401 Aligned: 16 Modelled: 16 Confidence: 6.3% Identity: 38% PDB header:photosynthesis Chain: X: PDB Molecule:photosystem i subunit psax; PDBTitle: crystal structure of photosystem i: a photosynthetic reaction center2 and core antenna system from cyanobacteria Phyre2 PDB 3kv1 chain A Region: 280 - 290 Aligned: 11 Modelled: 11 Confidence: 6.2% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:transcriptional repressor; PDBTitle: crystal structure of putative sugar-binding domain of transcriptional2 repressor from vibrio fischeri Phyre2 1 c3hfxA_ 2 c2w8aC_ 3 c2xq2A_ 4 d2a65a1 5 c2jlnA_ 6 c3dh4A_ 7 c3giaA_ 8 c3lrcC_ 9 c3gztF_ 10 c2kvlA_ 11 c2kncB_ 12 d2f2ha1 13 d1qmva_ 14 d1qq2a_ 15 c3pcqX_ 16 c1vpzB_ 17 c2jppB_ 18 d1jb0x_ 19 c1jb0X_ 20 c3kv1A_ 21 22 23 24 25 26 27 28 29 30 31

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hfxA_ 100.0 29 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 2 c2w8aC_ 100.0 27 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 3 c2xq2A_ 98.3 10 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 4 d2a65a1 97.2 14 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 5 c2jlnA_ 97.2 11 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 6 c3dh4A_ 96.7 10 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 7 c3giaA_ 90.6 9 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 8 c3lrcC_ 88.3 14 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 9 c3gztF_ 27.0 40 PDB header:virus Chain: F: PDB Molecule:outer capsid glycoprotein vp7; PDBTitle: vp7 recoated rotavirus dlp 10 c2kvlA_ 24.5 40 PDB header:viral protein Chain: A: PDB Molecule:major outer capsid protein vp7; PDBTitle: nmr structure of the c-terminal domain of vp7 11 c2kncB_ 19.8 10 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 12 d2f2ha1 10.2 40 Fold:Putative glucosidase YicI, C-terminal domain Superfamily:Putative glucosidase YicI, C-terminal domain Family:Putative glucosidase YicI, C-terminal domain 13 d1qmva_ 7.5 38 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione peroxidase-like 14 d1qq2a_ 7.2 31 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione peroxidase-like 15 c3pcqX_ 6.6 38 PDB header:photosynthesis Chain: X: PDB Molecule:photosystem i 4.8k protein; PDBTitle: femtosecond x-ray protein nanocrystallography 16 c1vpzB_ 6.5 23 PDB header:rna binding protein Chain: B: PDB Molecule:carbon storage regulator homolog; PDBTitle: crystal structure of a putative carbon storage regulator protein2 (csra, pa0905) from pseudomonas aeruginosa at 2.05 a resolution 17 c2jppB_ 6.4 15 PDB header:translation/rna Chain: B: PDB Molecule:translational repressor; PDBTitle: structural basis of rsma/csra rna recognition: structure of2 rsme bound to the shine-dalgarno sequence of hcna mrna 18 d1jb0x_ 6.3 38 Fold:Single transmembrane helix Superfamily:Subunit PsaX of photosystem I reaction centre Family:Subunit PsaX of photosystem I reaction centre 19 c1jb0X_ 6.3 38 PDB header:photosynthesis Chain: X: PDB Molecule:photosystem i subunit psax; PDBTitle: crystal structure of photosystem i: a photosynthetic reaction center2 and core antenna system from cyanobacteria 20 c3kv1A_ 6.2 27 PDB header:transcription Chain: A: PDB Molecule:transcriptional repressor; PDBTitle: crystal structure of putative sugar-binding domain of transcriptional2 repressor from vibrio fischeri 21 d1jxha_ not modelled 6.2 24 Fold:Ribokinase-like Superfamily:Ribokinase-like Family:Thiamin biosynthesis kinases 22 d1vpza_ not modelled 5.9 23 Fold:CsrA-like Superfamily:CsrA-like Family:CsrA-like 23 c3l09B_ not modelled 5.9 14 PDB header:transcription regulator Chain: B: PDB Molecule:putative transcriptional regulator; PDBTitle: crystal structure of putative transcriptional regulator2 (jann_22dec04_contig27_revised_gene3569) from jannaschia sp. ccs1 at3 2.81 a resolution 24 c3jycA_ not modelled 5.5 11 PDB header:metal transport Chain: A: PDB Molecule:inward-rectifier k+ channel kir2.2; PDBTitle: crystal structure of the eukaryotic strong inward-rectifier2 k+ channel kir2.2 at 3.1 angstrom resolution 25 d2a7sa1 not modelled 5.4 19 Fold:ClpP/crotonase Superfamily:ClpP/crotonase Family:Biotin dependent carboxylase carboxyltransferase domain 26 d1e2ya_ not modelled 5.4 31 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione peroxidase-like 27 d1h6ia_ not modelled 5.4 20 Fold:Aquaporin-like Superfamily:Aquaporin-like Family:Aquaporin-like 28 c3c02A_ not modelled 5.3 16 PDB header:membrane protein Chain: A: PDB Molecule:aquaglyceroporin; PDBTitle: x-ray structure of the aquaglyceroporin from plasmodium falciparum 29 d2axtm1 not modelled 5.3 27 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein M, PsbM Family:PsbM-like 30 c1t3oA_ not modelled 5.2 15 PDB header:rna binding protein Chain: A: PDB Molecule:carbon storage regulator; PDBTitle: solution structure of csra, a bacterial carbon storage2 regulatory protein 31 c2k10A_ not modelled 5.1 36 PDB header:antimicrobial protein Chain: A: PDB Molecule:ranatuerin-2csa; PDBTitle: confirmational analysis of the broad-spectrum antibacterial2 peptide, rantuerin-2csa: identification of a full length3 helix-turn-helix motif

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0